https://m2.mtmt.hu/ hun 2026-09-21 11:44 JournalArticle 36352060 VALIDATED true Export Date: 06 November 2025; Cited By: 0; Correspondence Address: K.V. Nagy; Heart and Vascular Center, Semmelweis University, Budapest, Hungary; email: nagyklaudiavivien@gmail.com 0 false 2026-09-02T11:37:27.188+0000 2025-11-06T13:50:51.745+0000 2025-09-27T15:10:38.137+0000 true 10090482 Boga Márton /api/author/10090482 Author Boga Márton (Kardiológia, szív-elektrofiziológia) true 2026-09-02T11:31:14.222+0000 2025-10-20T06:09:47.891+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Összefoglaló cikk (Folyóiratcikk) 102 true 1134514 true 1 /api/category/1 Category Tudományos true 1 Nagy, Klaudia Vivien true true /api/journal/10062301 REVIEWED FRONTIERS IN CARDIOVASCULAR MEDICINE 2297-055X 2297-055X true false 10062301 false 10062301 true 2297-055X 2297-055X Journal FOREIGN 12 1664386 1664386 5 2025 Atrial fibrillation (AF) is the most common supraventricular arrhythmia and a major cause of stroke and systemic embolism. The left arial appendage (LAA) is the predominant site of thrombus formation in AF. According to current guidelines, oral anticoagulant (OAC) therapy is recommended in patients with elevated thromboembolic risk. Non-vitamin K antagonist oral anticoagulants (NOACs) are currently preferred over Vitamin K antagonists (VKAs) due to favorable safety profiles. Nevertheless, a subset of patients develop LAA thrombi despite optimal anticoagulant therapy, a clinical scenario not addressed by current guidelines. Recent retrospective studies, including our own cohort analysis, suggest, that modifying antithrombotic regimen may improve thrombus resolution in these cases. However, no prospective trials have yet defined the optimal strategy. This mini-review summarizes the available evidence, highlights the limitations of current practice, and proposes directions for future research in this underrecognized clinical dilemma. Funding 2057770 /api/funding/2057770 (RRF2.3.1-21-2022-00003) false true true true 2025 true true true false true false GOLD 2026-09-02 true https://doi.org/10.3389/fcvm.2025.1664386 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 Q1 false false false false 2025-09-28T08:15:51.254+0000 Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Repülõ- és Űrorvostani Tanszék (SE / AOK / K); Sportorvostan Tanszék (SE / AOK / K); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 5 29 4 5 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 127924940 /api/authorship/127924940 Nagy, Klaudia Vivien ✉ [Nagy, Klaudia Vivien (orvostudományok), szerző] Repülõ- és Űrorvostani Tanszék (SE / AOK / K); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K) 1 0.2 true false true Author 10026732 /api/author/10026732 Nagy Klaudia Vivien (orvostudományok) Nagy Klaudia Vivien true 10026732 true Nagy Klaudia Vivien true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127924941 /api/authorship/127924941 Arnóth, Bence* [Arnóth, Bence (kardiológia), szerző] Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 2 0.2 true false false Author 10086461 /api/author/10086461 Arnóth Bence (kardiológia) Arnóth Bence true true Arnóth Bence true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127924942 /api/authorship/127924942 Komlósi, Ferenc [Komlósi, Ferenc (kardiológia, elek...), szerző] Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 3 0.2 false false false Author 10081610 /api/author/10081610 Komlósi Ferenc (kardiológia, elektrofiziológia) Komlósi Ferenc true true Komlósi Ferenc true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127924943 /api/authorship/127924943 Gellér, László [Gellér, László Alajos (Kardiológia, Elek...), szerző] Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K) 4 0.2 false false false Author 10013950 /api/author/10013950 Gellér László Alajos (Kardiológia, Elektrofiziológia) Gellér László Alajos true 10013950 true Gellér László true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127924944 /api/authorship/127924944 Merkely, Béla [Merkely, Béla Péter (Kardiológia), szerző] Repülõ- és Űrorvostani Tanszék (SE / AOK / K); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Sportorvostan Tanszék (SE / AOK / K) 5 0.2 false true false Author 10002691 /api/author/10002691 Merkely Béla Péter (Kardiológia) Merkely Béla Péter true 10002691 true Merkely Béla true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 29910304 /api/publicationidentifier/29910304 DOI: 10.3389/fcvm.2025.1664386 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3389/fcvm.2025.1664386 https://doi.org/10.3389/fcvm.2025.1664386 false true PublicationIdentifier 30026028 /api/publicationidentifier/30026028 WoS: 001590500500001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001590500500001 https://www.webofscience.com/wos/woscc/full-record/001590500500001 false true PublicationIdentifier 30069519 /api/publicationidentifier/30069519 Scopus: 105018800674 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105018800674 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105018800674 true true PublicationIdentifier 30026029 /api/publicationidentifier/30026029 PubMed: 41079579 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41079579 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41079579&dopt=Abstract false true Classification 12139 /api/classification/12139 Szív és érrendszer true true SjrRating 11563331 /api/sjrrating/11563331 sjr:Q1 (2025) Scopus - Cardiology and Cardiovascular Medicine FRONTIERS IN CARDIOVASCULAR MEDICINE 2297-055X 2297-055X 99 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2705 /api/classificationexternal/2705 Scopus - Cardiology and Cardiovascular Medicine true 2705 true Q1 DIRECT true true Reference 68467461 /api/reference/68467461 1. 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(2025) FRONTIERS IN CARDIOVASCULAR MEDICINE 2297-055X 2297-055X 12<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10026732"><a href="/gui2/?type=authors&mode=browse&sel=10026732" target="_blank">Nagy Klaudia Vivien ✉ (<span class="authorship-author-name">Nagy Klaudia Vivien</span> <span class="authorAux-mtmt"> orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Repülõ- és Űrorvostani Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10086461"><a href="/gui2/?type=authors&mode=browse&sel=10086461" target="_blank">Arnóth Bence^* (<span class="authorship-author-name">Arnóth Bence</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081610"><a href="/gui2/?type=authors&mode=browse&sel=10081610" target="_blank">Komlósi Ferenc (<span class="authorship-author-name">Komlósi Ferenc</span> <span class="authorAux-mtmt"> kardiológia, elektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013950"><a href="/gui2/?type=authors&mode=browse&sel=10013950" target="_blank">Gellér László (<span class="authorship-author-name">Gellér László Alajos</span> <span class="authorAux-mtmt"> Kardiológia, Elektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002691"><a href="/gui2/?type=authors&mode=browse&sel=10002691" target="_blank">Merkely Béla (<span class="authorship-author-name">Merkely Béla Péter</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Repülõ- és Űrorvostani Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Sportorvostan Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36352060" target="_blank">Overcoming NOAC-resistant left atrial appendage thrombus in atrial fibrillation: clinical gaps and therapeutic insights</a></div> <div> <span class="journal-title">FRONTIERS IN CARDIOVASCULAR MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2297-055X">2297-055X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2297-055X">2297-055X</a>)</span>: <span class="journal-volume">12</span> <span class="page"> Paper 1664386. 5 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fcvm.2025.1664386" target="_blank" href="https://doi.org/10.3389/fcvm.2025.1664386"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001590500500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001590500500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105018800674" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105018800674"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41079579" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41079579&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36352060&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36352060</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (RRF2.3.1-21-2022-00003) </div> <div class="lastModified">Utolsó módosítás: 2025.11.06. 14:50 Kondor Zóra (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 06 November 2025; Cited By: 0; Correspondence Address: K.V. Nagy; Heart and Vascular Center, Semmelweis University, Budapest, Hungary; email: nagyklaudiavivien@gmail.com</pre> </div></div>