https://m2.mtmt.hu/ hun 2026-09-22 16:57 JournalArticle 36322158 VALIDATED true Cardiovascular Imaging Research Center, Division of Cardiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States Heart and Vascular Center, Semmelweis University, Budapest, Hungary Leiden University Medical Center, Cardiology Department, Leiden, Netherlands Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, United States Division of Cardiology, Hospital of the University of Pennsylvania, Philadelphia, PA, United States Cardiology Division, Brigham and Women’s Hospital, Boston, MA, United States Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States Baim Institute for Clinical Research, Boston, MA, United States Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States Division of Cardiology, McGill University Hospital, Montreal, QC, Canada Department of Radiology, Brigham and Women’s Hospital, Boston, MA, United States Export Date: 30 June 2026; Cited By: 2; Correspondence Address: V. Juhasz; Cardiovascular Imaging Research Center, Massachusetts General Hospital, Boston, 165 Cambridge St, Ste 400, 02114, United States; email: vjuhasz@mgh.harvard.edu; CODEN: JCMRF 0 false 2026-07-01T12:42:11.853+0000 2026-06-30T08:23:13.295+0000 2025-09-08T07:56:41.905+0000 true 10061268 Drobni Zsófia /api/author/10061268 Author true 10061268 2026-06-30T08:23:13.136+0000 2026-05-07T12:16:20.547+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Juhász, Vencel Atorvastatin and Left Atrial Function During Anthracycline-based Chemotherapy true true /api/journal/23803 REVIEWED true false 23803 false 23803 true 1097-6647 1532-429X Journal FOREIGN 27 2 101946 101946 9 2025 Structural and functional abnormalities of the left atrium (LA) predict adverse outcomes such as heart failure and mortality in many patients with heart disease. However, the effect of anthracyclines on LA structural and functional abnormalities remains incompletely characterized. Further, atorvastatin prevented the anthracycline-associated decline in the left ventricular ejection fraction; however, whether atorvastatin protects against anthracycline-associated impairment of LA structure and function is currently unknown.In the STOP-CA randomized clinical trial, participants with lymphoma treated with anthracyclines were randomized to placebo (n=150) or atorvastatin (n=150) for 12 months. In post-hoc analyses, CMR-derived LA volumetric and functional measurements (reservoir [GLS], conduit, and booster strain) were measured at baseline and 12 months using feature tracking (FT). The primary endpoint was the difference in the proportion of participants with a ≥1SD decrease in LA GLS between the atorvastatin and placebo groups. The secondary endpoint was a ≥20% relative decrease in LA GLS. Other exploratory endpoints included volume indices and emptying fractions.Of 300 participants, 158 (mean age 51±16 years, 48% female, 83 with atorvastatin) had paired CMR-derived LA strain and volumetric data at baseline and follow-up. Both groups had similar baseline characteristics and cancer treatment. All LA strain and volumetric measures were similar between the two groups at baseline. Among the placebo group, LA GLS decreased from baseline to follow-up (35.5±8.8 vs. 32.4±8.2%, p=0.007). A ≥1SD absolute decrease in LA GLS (8.8% units) was observed among 24% with atorvastatin and 28% with placebo (p=0.59). Similarly, a ≥20% relative decrease in GLS was observed in 25% vs. 31% (p=0.48). Participants over 50 had an almost 10% (9.9%, 95% confidence interval: -18.75, -1.12) greater relative decrease in LA GLS with anthracyclines. There were no differences between cardiac hospitalization rates with a ≥1SD absolute decrease (5% vs. 8%, p=0.72) in LA GLS at 24 months. Among other indices of LA structure and function, the LA total emptying fraction also decreased from baseline to follow-up, with no differences between groups at follow-up.Atorvastatin did not attenuate the decline in CMR-derived LA GLS among lymphoma patients undergoing anthracycline-based chemotherapy.NCT02943590; https://clinicaltrials.gov/study/NCT02943590. true true 2025 true true true false true false GOLD 2026-07-01 false http://www.jcmr-online.com/home 2 0 2 1 1 2 2 2 2 2 2 1 1 1 1 0 2 1 2 1 0 2 2 Folyóiratcikk Journal Article 24 2 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 1 1 1 2026 0 1 0 1 0 D1 false false false false 2025-12-15T09:11:45.091+0000 Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 2 14 1 18 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 127758525 /api/authorship/127758525 1 0.056 true false true Author 10077410 /api/author/10077410 Juhász Vencel true true Juhász Vencel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127758526 /api/authorship/127758526 2 0.056 false false false Author 10061268 /api/author/10061268 Drobni Zsófia true 10061268 true Drobni Zsófia D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127758527 /api/authorship/127758527 3 0.055555556 false false false 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true 0 true false true PersonAuthorship 127758533 /api/authorship/127758533 9 0.055555556 false false false Han Yuchi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127758534 /api/authorship/127758534 10 0.055555556 false false false Ky Bonnie true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127758535 /api/authorship/127758535 11 0.055555556 false false false Kwong Raymond Y true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127758536 /api/authorship/127758536 12 0.055555556 false false false Januzzi James L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127758537 /api/authorship/127758537 13 0.055555556 false false false Asnani Aarti true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127758538 /api/authorship/127758538 14 0.055555556 false false false Mousavi Negareh true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127758539 /api/authorship/127758539 15 0.055555556 false false false Redd Robert A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127758540 /api/authorship/127758540 16 0.055555556 false false false Jerosch-Herold Michael true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127758541 /api/authorship/127758541 17 0.055555556 false false false Scherrer-Crosbie Marielle true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127758542 /api/authorship/127758542 18 0.055555556 false true false Neilan Tomas G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29809379 /api/publicationidentifier/29809379 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 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long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10077410"><a href="/gui2/?type=authors&mode=browse&sel=10077410" target="_blank">Juhász Vencel ✉ (<span class="authorship-author-name">Juhász Vencel</span> <span class="authorAux-mtmt"> Kardiológia, Sportorvostan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061268"><a href="/gui2/?type=authors&mode=browse&sel=10061268" target="_blank">Drobni Zsófia D (<span class="authorship-author-name">Drobni Zsófia</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Quinaglia Thiago </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gilman Hannah K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Suero-Abreu Giselle Alexandra </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ghamari Azin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heemelaar Julius C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Neuberg Donna S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Han Yuchi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ky Bonnie </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kwong Raymond Y </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Januzzi James L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Asnani Aarti </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mousavi Negareh </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Redd Robert A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jerosch-Herold Michael </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Scherrer-Crosbie Marielle </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Neilan Tomas G </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36322158" target="_blank">Atorvastatin and Left Atrial Function During Anthracycline-based Chemotherapy</a></div> <div> <span class="journal-title">JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-6647">1097-6647</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-429X">1532-429X</a>)</span>: <span class="journal-volume">27</span> <span class="journal-issue">2</span> <span class="page"> Paper 101946. 9 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.jocmr.2025.101946" target="_blank" href="https://doi.org/10.1016/j.jocmr.2025.101946"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001633328900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001633328900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105023708544" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105023708544"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40876541" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40876541&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Family Practice&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Radiology, Nuclear Medicine and Imaging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Radiological and Ultrasound Technology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 1 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36322158&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36322158</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="lastModified">Utolsó módosítás: 2026.06.30. 10:23 Kondor Zóra (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cardiovascular Imaging Research Center, Division of Cardiology, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States Heart and Vascular Center, Semmelweis University, Budapest, Hungary Leiden University Medical Center, Cardiology Department, Leiden, Netherlands Departmen...</pre> </div></div>