https://m2.mtmt.hu/ eng 2026-07-28 08:34 JournalArticle 36319466 VALIDATED true Case report 0 false 2026-05-25T00:54:59.226+0000 2026-01-29T09:31:10.029+0000 2025-09-05T08:55:48.007+0000 true 10067747 Reményiné Kállai Zsuzsa /api/admin/10067747 Admin Zsuzsa Reményiné Kállai (DE admin 4) true 2025-12-03T12:50:06.976+0000 2025-12-03T12:50:06.976+0000 2025-10-27T07:23:20.302+0000 true 10099440 Csernyik Rita /api/admin/10099440 Admin Rita Csernyik (MTMT központi admin) true Admin 10099440 /api/admin/10099440 Rita Csernyik (MTMT központi admin) Csernyik Rita true true 2025-10-21T01:37:28.906+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 18 Note, Short, Rapid communications true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/18 Rövid közlemény SubType Note, Short, Rapid communications (Journal Article) 103 true 18 true 1 /api/category/1 Category Scientific true 1 Ranjbar, Yasamin true true /api/journal/10017543 REVIEWED JOURNAL OF CLINICAL MEDICINE 2077-0383 true false 10017543 false 10017543 true 2077-0383 Journal FOREIGN 14 16 5652 5652 8 2025 Central nervous system (CNS) involvement is an extremely rare manifestation in eosinophilic granulomatosis with polyangiitis (EGPA), associated with a poor prognosis. Here we present a case of 50-year-old female patient with long-term asthma treatment who presented initially with extreme eosinophilia (56%) and severe progressive ascending paresis, similar to Guillain–Barré syndrome, leading to tetraplegia. After navigating through diagnostic mazes, the diagnosis of EGPA was established based on eosinophilia, myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) positivity, asthma, eosinophil granulomatosis in the gastrointestinal tract, and severe peripheral nervous system involvement, complicated with rare central nervous granulomas and ischemia. With combined immunosuppressive and immunomodulatory treatment including high-dose corticosteroids, rituximab and intravenous immunoglobulin along with symptomatic treatment and planned rehabilitation over 6 months, our patient recovered gradually from tetraplegia and adverse events such as severe infections and osteoporotic fractures. Now, from a 2-year perspective, we can conclude a successful treatment leading to decrease in all of her symptoms. Due to persistent eosinophilia after steroid tapering, she was switched to mepolizumab maintenance treatment and demonstrated continuous improvement of motor and sensory functions. Thanks to periodically repeated rehabilitation, she became self-sufficient and returned to her previous job. Our case highlights that EGPA patients should be treated in a center of expertise due to the rarity of the disease and complexity of diagnosis and treatment. Careful multidisciplinary cooperation, the huge effort of the patient, and a supportive environment can show a way back from immune-mediated tetraplegia. true 2025 true true true false true false GOLD 2026-05-25 false http://www.mdpi.com/journal/jcm 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q2 false false false false 2025-10-26T07:23:20.219+0000 C épület (DE / KK / BelgyKL); Klinikai Immunológiai Tanszék (DE / ÁOK / BelgyI); Neurológiai Tanszék (DE / ÁOK) 4 14 3 6 0 true 10099440 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 127736715 /api/authorship/127736715 Ranjbar, Yasamin 1 0.16666667 true false false Ranjbar Yasamin true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 127736716 /api/authorship/127736716 Árokszállási, Tamás [Árokszállási, Tamás (neurológia), author] Department of Neurology (UD) 2 0.167 false false false Author 10078095 /api/author/10078095 Tamás Árokszállási (neurológia) Árokszállási Tamás true true Árokszállási Tamás true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 127736717 /api/authorship/127736717 Szinay, Dorottya [Szinay, Dorottya (belgyógyászat, im...), author] Klinikai Immunológiai Tanszék (UD / BelgyI); Institute of Internal Medicine Building C (UD / KK / BelgyKL) 3 0.16666667 false false false Author 10103823 /api/author/10103823 Dorottya Szinay (belgyógyászat, immunológia) Szinay Dorottya true true Szinay Dorottya true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 127736718 /api/authorship/127736718 Nagy, Edit B. 4 0.16666667 false false false Nagy Edit B. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 127736719 /api/authorship/127736719 Tarr, Tünde [Tarr, Tünde (klinikai orvostud...), author] Klinikai Immunológiai Tanszék (UD / BelgyI) 5 0.167 false false false Author 10030122 /api/author/10030122 Tünde Tarr (klinikai orvostudomány) Tarr Tünde true 10030122 true Tarr Tünde true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 127736720 /api/authorship/127736720 Nagy-Vincze, Melinda ✉ [Nagy-Vincze, Melinda (orvostudomány), author] Klinikai Immunológiai Tanszék (UD / BelgyI) 6 0.167 false true true Author 10046165 /api/author/10046165 Melinda Nagy-Vincze (orvostudomány) Nagy-Vincze Melinda true 10046165 true Nagy-Vincze Melinda true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 29801698 /api/publicationidentifier/29801698 DOI: 10.3390/jcm14165652 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true 10.3390/jcm14165652 https://doi.org/10.3390/jcm14165652 false true PublicationIdentifier 29801700 /api/publicationidentifier/29801700 WoS: 001557797100001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true 001557797100001 https://www.webofscience.com/wos/woscc/full-record/001557797100001 false true PublicationIdentifier 29801701 /api/publicationidentifier/29801701 Scopus: 105014423937 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105014423937 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105014423937 false true PublicationIdentifier 29801699 /api/publicationidentifier/29801699 Other URL: https://www.mdpi.com/2077-0383/14/16/5652 PlainSource 40 /api/publicationsource/40 Other URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true https://www.mdpi.com/2077-0383/14/16/5652 https://www.mdpi.com/2077-0383/14/16/5652 false true SjrRating 11603514 /api/sjrrating/11603514 sjr:Q2 (2025) Scopus - Medicine (miscellaneous) JOURNAL OF CLINICAL MEDICINE 2077-0383 638 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true Q2 DIRECT true true Reference 67903346 /api/reference/67903346 1. 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(2025) JOURNAL OF CLINICAL MEDICINE 2077-0383 14 16<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Ranjbar Yasamin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078095"><a href="/gui2/?type=authors&mode=browse&sel=10078095" target="_blank">Árokszállási Tamás (<span class="authorship-author-name">Árokszállási Tamás</span> <span class="authorAux-mtmt"> neurológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Neurology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10103823"><a href="/gui2/?type=authors&mode=browse&sel=10103823" target="_blank">Szinay Dorottya (<span class="authorship-author-name">Szinay Dorottya</span> <span class="authorAux-mtmt"> belgyógyászat, immunológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Belgyógyászati Intézet">BelgyI</span>/Klinikai Immunológiai Tanszék; <span title="University of Debrecen">UD</span>/<span title="Klinikai Központ">KK</span>/<span title="Belgyógyászati Klinika">BelgyKL</span>/Institute of Internal Medicine Building C</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nagy Edit B. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030122"><a href="/gui2/?type=authors&mode=browse&sel=10030122" target="_blank">Tarr Tünde (<span class="authorship-author-name">Tarr Tünde</span> <span class="authorAux-mtmt"> klinikai orvostudomány</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Belgyógyászati Intézet">BelgyI</span>/Klinikai Immunológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10046165"><a href="/gui2/?type=authors&mode=browse&sel=10046165" target="_blank">Nagy-Vincze Melinda ✉ (<span class="authorship-author-name">Nagy-Vincze Melinda</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Belgyógyászati Intézet">BelgyI</span>/Klinikai Immunológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36319466" target="_blank">The Way Back from Tetraplegia or, Rare Neurological Manifestations of Eosinophil Granulomatosis with Polyangiitis</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL MEDICINE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0383">2077-0383</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">16</span> <span class="page"> Paper 5652. 8 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.3390/jcm14165652" target="_blank" href="https://doi.org/10.3390/jcm14165652"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="001557797100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001557797100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105014423937" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105014423937"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://www.mdpi.com/2077-0383/14/16/5652" target="_blank" href="https://www.mdpi.com/2077-0383/14/16/5652"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="mtid"><span class="long-pub-mtid">Publication: 36319466</span> | <span class="status-data status-VALIDATED"> Validated </span> Core | <span class="type-subtype">Journal Article ( Note, Short, Rapid communications ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData"></span> </div> <div class="lastModified">Last Modified: 2026.01.29. 10:31 Anikó Paszternák (DE/KK/BelgyKL/Cép, DE/ÁOK/BelgyI/GnoT, DE/ÁOK/BelgyI/KlImmT, DE/ÁOK/BelgyI/ReumT admin 5) </div> <div class="lockedBy">Centrally managed 2025.10.21. 03:37 Rita Csernyik (MTMT központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Case report</pre> </div></div>