https://m2.mtmt.hu/ hun 2026-09-22 17:38 JournalArticle 36317799 VALIDATED true Export Date: 08 December 2025; Cited By: 0; Correspondence Address: C. Chinopoulos; Department of Biochemistry, Semmelweis University, Budapest, Hungary; email: chinopoulos.christos@semmelweis.hu 0 false 2026-09-07T09:53:03.911+0000 2026-01-27T12:24:05.391+0000 2025-09-04T10:45:17.199+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-04-20T09:46:25.595+0000 2025-09-04T10:48:31.320+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Chinopoulos, Christos Underestimation of mitochondrial respiratory capacity in gray matter voxels of the human brain map due to limited OXPHOS and TCA cycle in astrocytes true true /api/journal/10015931 REVIEWED true false 10015931 false 10015931 true 1662-5102 Journal FOREIGN 19 1661231 1661231 4 2025 Considering that the aerobic energetic landscape of the brain is shaped by its mitochondria, Mosharov et al. generated an atlas of mitochondrial content and enzymatic OXPHOS activities at a resolution comparable to MRI by physically voxelizing frozen human brain tissue. However, astrocytes in the adult human brain lack expression of several TCA cycle and OXPHOS enzymes. Therefore, their formula expressing mitochondrial respiratory capacity (MRC) -defined as tissue respiratory capacity normalized to mitochondrial density- underestimates actual values by a factor proportional to the square root of the fraction of respiration-capable cells (primarily neurons) in gray matter voxels. true true 2025 true true true false false GOLD 2026-09-07 false http://www.frontiersin.org/cellular_neuroscience 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 Q2 false false false false 2025-09-03T10:48:31.214+0000 Biokémiai Tanszék (SE / AOK / I / BMBI) 1 9 1 1 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 127729777 /api/authorship/127729777 1 1.0 true false true Author 10016754 /api/author/10016754 Chinopoulos Christos true 10016754 true Chinopoulos Christos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29795708 /api/publicationidentifier/29795708 PlainSource 6 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src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10016754"><a href="/gui2/?type=authors&mode=browse&sel=10016754" target="_blank">Chinopoulos Christos ✉ (<span class="authorship-author-name">Chinopoulos Christos</span> <span class="authorAux-mtmt"> Bioenergetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Biokémiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36317799" target="_blank">Underestimation of mitochondrial respiratory capacity in gray matter voxels of the human brain map due to limited OXPHOS and TCA cycle in astrocytes</a></div> <div> <span class="journal-title">FRONTIERS IN CELLULAR NEUROSCIENCE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1662-5102">1662-5102</a>)</span>: <span class="journal-volume">19</span> <span class="page"> Paper 1661231. 4 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3389/fncel.2025.1661231" target="_blank" href="https://doi.org/10.3389/fncel.2025.1661231"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001556986000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001556986000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105014936116" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105014936116"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40881627" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40881627&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105014936116&doi=10.3389%2Ffncel.2025.1661231&partnerID=40&md5=3e6ab62c0e222a6143090145605b3a86" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105014936116&doi=10.3389%2Ffncel.2025.1661231&partnerID=40&md5=3e6ab62c0e222a6143090145605b3a86"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36317799&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36317799</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.01.27. 13:24 Kajtár Virág Anna (SE_AOK_Biokemia_Admin5_KV, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 08 December 2025; Cited By: 0; Correspondence Address: C. Chinopoulos; Department of Biochemistry, Semmelweis University, Budapest, Hungary; email: chinopoulos.christos@semmelweis.hu</pre> </div></div>