https://m2.mtmt.hu/ hun 2026-10-25 08:12 JournalArticle 36310409 VALIDATED true 0 false 2026-05-25T00:45:22.245+0000 2025-12-09T12:36:40.637+0000 2025-09-01T07:41:23.428+0000 true 10081340 Pirmann Tamás /api/admin/10081340 Admin true 2025-12-09T12:36:32.810+0000 2025-12-09T12:36:32.810+0000 2025-12-09T12:36:40.804+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Jánváry, Zsolt Levente Long-term clinical results of early-stage lung cancer patients treated with risk-adapted stereotactic body radiotherapy using LINAC or CyberKnife A single-institution analysis of more than 400 cases true true /api/journal/31780 REVIEWED true false 31780 false 31780 true 0179-7158 1439-099X Journal FOREIGN 201 11 1208 1218 1208 11 2025 The aim of the study was to evaluate the clinical efficacy and side effects of stereotactic body radiotherapy (SBRT) using a gantry-based linear accelerator (LINAC) or robotic technique in a large cohort of consecutively treated medically inoperable early-stage lung cancer patients.Between March 2015 and February 2023, 401 early-stage (T1-2 N0 M0) primary lung cancer patients were treated using either LINACs (Varian VitalBeam® and TrueBeam®; Varian, Palo Alto, CA, USA) or CyberKnife® (Accuray, Madison, WI, USA). Median age was 70 years (range 44-90). Diagnosis was based on biopsy for 37.4% of patients, while pathological confirmation was unavailable due to high risk for 62.6%. 18F‑fluorodeoxyglucose positron-emission tomography (18-FDG-PET) was part of the pretreatment diagnostic workup in 96% (n = 386) of the total cohort. Tumor stage distribution was T1a in 32 (8%), T1b in 179 (44.6%), T1c in 112 (27.9%), T2a in 67 (16.7%), and T2b in 11 (2.7%) patients. Applied dose schemes were identical for both LINAC and CyberKnife treatments, using risk-adapted doses of 45-60 Gy in 3 to 8 fractions, (biologically effective dose ranging from 86 to 151.2 Gy BED10).At a median follow-up of 32 months (range 2-104), the crude survival rate was 58%. Median overall survival (OS) was 63 months (95% CI: 51.1-74.8) the 2‑, 3‑, and 4‑year OS rates were 79, 68, and 56%, respectively. Actuarial local control (LC) rates were 94% at 2 years, 90% at 3 years, and 87% at 4 years. Median LC was not reached. Median local progression-free survival (LPFS) and progression-free survival (PFS) rates were 49.5 months (95% CI: 42.8-56.3) and 37 months (95% CI: 31.2.-42.8), respectively. Actuarial 2‑, 3‑, and 4‑year LPFS and PFS rates were 75, 60, and 51% and 66, 51, and 42%, respectively. On multivariate analysis, BED10 ≥ 132 Gy predicted improved LPFS, while earlier tumor stage and better ECOG performance status were associated with improved OS. No grade 3 or higher acute side effects were observed. Grade 3 late side effects occurred in 4 patients (1%), including grade 3 late pulmonary fibrosis in 3 cases and potentially treatment-related grade 3 pneumothorax in 1 patient. Rib fracture was observed in 14 cases (3%).Clinical results after SBRT at a national comprehensive cancer center demonstrate high LC and LPFS rates and favorable PFS and OS, comparable to published studies. Application of a BED10 of 132 Gy or higher shows a potential benefit in terms of LPFS and may thus be recommended in the absence of conflict with organ at risk constraints. SBRT with either LINAC or CK is proven to be a well-tolerated but still highly effective treatment for the elderly, medically inoperable early-stage lung cancer population. Funding 2058876 /api/funding/2058876 false true Funding 2058877 /api/funding/2058877 false true true INTERNATIONAL 2025 true true true false true false GOLD 2026-05-25 true https://doi.org/10.1007/s00066-025-02455-3 2 0 2 2 0 2 2 2 0 2 2 2 2 2 0 0 2 2 2 2 0 1 1 Folyóiratcikk Journal Article 24 2 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 2 2 2 2 Q2 false false false false 2025-09-07T14:31:21.520+0000 Nukleáris Technika Tanszék (BME / TTK / NTI); Onkológiai Tanszék (SE / AOK / K); Országos Onkológiai Intézet 10 21 3 12 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 127681690 /api/authorship/127681690 1 0.083 true false true Author 10047664 /api/author/10047664 Jánváry Zsolt Levente true 10047664 true Jánváry Zsolt Levente true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127681691 /api/authorship/127681691 2 0.083 false false false Author 10057580 /api/author/10057580 Bajcsay András true 10057580 true Bajcsay András true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127681692 /api/authorship/127681692 3 0.083 false false false Author 10042823 /api/author/10042823 Stelczer Gábor true 10042823 true Stelczer Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127681693 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Classification 12306 /api/classification/12306 true true Keyword 19546 /api/keyword/19546 true 19546 true Keyword 1464007 /api/keyword/1464007 true 1464007 true Keyword 1838706 /api/keyword/1838706 true true Keyword 1999357 /api/keyword/1999357 true true Keyword 3902404 /api/keyword/3902404 true true SjrRating 11609356 /api/sjrrating/11609356 203 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2730 /api/classificationexternal/2730 true 2730 true Q2 DIRECT true true /api/publication/36310409 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10047664"><a href="/gui2/?type=authors&mode=browse&sel=10047664" target="_blank">Jánváry Zsolt Levente ✉ (<span class="authorship-author-name">Jánváry Zsolt Levente</span> <span class="authorAux-mtmt"> Sugárterápiás onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057580"><a href="/gui2/?type=authors&mode=browse&sel=10057580" target="_blank">Bajcsay András (<span class="authorship-author-name">Bajcsay András</span> <span class="authorAux-mtmt"> Sugárterápia, Klinikai Onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042823"><a href="/gui2/?type=authors&mode=browse&sel=10042823" target="_blank">Stelczer Gábor (<span class="authorship-author-name">Stelczer Gábor</span> <span class="authorAux-mtmt"> Orvosfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Nukleáris Technikai Intézet">NTI</span>/Nukleáris Technika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058437"><a href="/gui2/?type=authors&mode=browse&sel=10058437" target="_blank">Kontra Gábor (<span class="authorship-author-name">Kontra Gábor</span> <span class="authorAux-mtmt"> klinikai sugárfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042822"><a href="/gui2/?type=authors&mode=browse&sel=10042822" target="_blank">Pócza Tamás (<span class="authorship-author-name">Pócza Tamás</span> <span class="authorAux-mtmt"> Orvosi fizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061739"><a href="/gui2/?type=authors&mode=browse&sel=10061739" target="_blank">Gerdán Mercédesz (<span class="authorship-author-name">Gerdán Mercédesz</span> <span class="authorAux-mtmt"> Klinikai sugárfizika, Szociológia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Nukleáris Technikai Intézet">NTI</span>/Nukleáris Technika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026872"><a href="/gui2/?type=authors&mode=browse&sel=10026872" target="_blank">Lövey József (<span class="authorship-author-name">Lövey József</span> <span class="authorAux-mtmt"> Sugárterápia, onkológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020433"><a href="/gui2/?type=authors&mode=browse&sel=10020433" target="_blank">Kocsis Zsuzsa S (<span class="authorship-author-name">Kocsis Zsuzsa</span> <span class="authorAux-mtmt"> sugárbiológia, onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ladányi Katalin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pap Éva </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044386"><a href="/gui2/?type=authors&mode=browse&sel=10044386" target="_blank">Major Tibor (<span class="authorship-author-name">Major Tibor</span> <span class="authorAux-mtmt"> klinikai sugárfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013383"><a href="/gui2/?type=authors&mode=browse&sel=10013383" target="_blank">Polgár Csaba (<span class="authorship-author-name">Polgár Csaba</span> <span class="authorAux-mtmt"> Sugárterápia, klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36310409" target="_blank">Long-term clinical results of early-stage lung cancer patients treated with risk-adapted stereotactic body radiotherapy using LINAC or CyberKnife : A single-institution analysis of more than 400 cases.</a></div> <div> <span class="journal-title">STRAHLENTHERAPIE UND ONKOLOGIE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0179-7158">0179-7158</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1439-099X">1439-099X</a>)</span>: <span class="journal-volume">201</span> <span class="journal-issue">11</span> <span class="page"> pp 1208-1218 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s00066-025-02455-3" target="_blank" href="https://doi.org/10.1007/s00066-025-02455-3"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001556033500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001556033500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105014012194" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105014012194"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40853545" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40853545&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://link.springer.com/10.1007/s00066-025-02455-3" target="_blank" href="https://link.springer.com/10.1007/s00066-025-02455-3"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Radiology, Nuclear Medicine and Imaging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 2 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 2 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36310409&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36310409</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (National Tumor Biology Laboratory (2022–2.1.1-NL-2022-00010))), ETT-TUKEB(BM/1754-2/2024) </div> <div class="lastModified">Utolsó módosítás: 2025.12.09. 13:36 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> </div></div>