https://m2.mtmt.hu/ hun 2026-09-21 18:38 JournalArticle 36310359 APPROVED true Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7, Budapest, 1092, Hungary Center for Pharmacology and Drug Research & Development, Semmelweis University, Üllői Str. 26, Budapest, 1085, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter Str. 50/A, Budapest, 1083, Hungary Department of Biophysics and Radiation Biology, Semmelweis University, Tűzoltó Str. 37–47, Budapest, 1094, Hungary Export Date: 02 June 2026; Cited By: 1; Correspondence Address: I. Antal; Department of Pharmaceutics, Semmelweis University, Budapest, Hőgyes E. Str. 7, 1092, Hungary; email: antal.istvan@semmelweis.hu 0 false 2026-09-17T12:36:40.364+0000 2026-09-15T11:13:24.468+0000 2025-09-01T07:27:58.339+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin true 10015206 2026-09-15T11:13:24.747+0000 2026-09-15T11:13:24.747+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Vlahovic, Kristina Microenvironmental pH-Modulated Dissolution of Albendazole Layered on Tartaric Acid Starter Pellet Cores true true /api/journal/10022148 REVIEWED true false 10022148 false 10022148 true 1999-4923 Journal FOREIGN 17 9 1133 1133 21 2025 Background/Objectives: To improve the therapeutic efficacy of albendazole (ABZ) for ileocolonic diseases, its low solubility at higher pH levels should be enhanced. Organic acids have been widely used as pH modifiers to improve the solubility of weakly basic drugs. To achieve an adequate effect of the acidic microenvironmental pH during the drug release, pH modifiers should not leach out from the formulation. In the present work, we aimed to demonstrate that 100% tartaric acid pellets (TAP) can be used as pH-modifier cores, providing an acidic microenvironmental pH to enhance the solubility of albendazole at a higher pH. Methods: This study develops multilayer-coated pellets using TAP as starter cores in a bottom-spray-configured fluidized bed apparatus. The drug-layered TAP were coated with time-dependent and pH-dependent layers. Results: The release of ABZ from tartaric acid-based coated pellets was enhanced compared to that from pellets with the same layering structure but with an inert core of sugar or microcrystalline cellulose (MCC). In vitro experiments showed that tartaric acid remained in the pellet core during the dissolution test at a pH 6.8 medium, which resulted in an enhanced release of albendazole at a higher pH. The application of a combination of time-dependent and pH-dependent polymers aimed not only to prevent the release of albendazole at lower pH levels but also to protect TAP from premature release from the formulation. Conclusions: The application of 100% ready-to-use tartaric acid pellets (TAP) with the applied combination of coatings enhanced the solubility of the weakly basic drug albendazole at higher intestinal pH. true true 2025 true true true false true false GOLD 2026-09-17 false http://www.mdpi.com/journal/pharmaceutics/ 3 0 3 1 1 3 3 3 3 3 3 1 1 1 2 0 3 1 3 1 0 5 5 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 3 1 3 1 D1 false false false false 2025-10-05T06:52:23.709+0000 Farmakológiai és Gyógyszerkutatás-fejlesztési K... (SE / KSZE); Gyógyszerészeti Intézet (SE / GYTK); Információs Technológiai és Bionikai Kar (PPKE) 7 15 3 7 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 127681585 /api/authorship/127681585 1 0.143 true false false Author 10087474 /api/author/10087474 Vlahovic Kristina true true Vlahovic Kristina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127681586 /api/authorship/127681586 2 0.143 true false false Author 10020628 /api/author/10020628 Lengyel Miléna true 10020628 true Lengyel Miléna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127681587 /api/authorship/127681587 3 0.143 false false false Author 10083304 /api/author/10083304 Petszulat Fleck true true Fleck Christian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127681588 /api/authorship/127681588 4 0.143 false false false Author 10020629 /api/author/10020629 Kállai-Szabó Nikolett true 10020629 true Kállai-Szabó Nikolett true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127681589 /api/authorship/127681589 5 0.143 false false false Author 10020627 /api/author/10020627 Bertalanné Balogh Emese true 10020627 true Balogh Emese true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127681590 /api/authorship/127681590 6 0.143 false false true Author 10029874 /api/author/10029874 Laki András József true 10029874 true Laki András József true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127681591 /api/authorship/127681591 7 0.143 false true true Author 10020626 /api/author/10020626 Antal István true 10020626 true Antal István true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29773212 /api/publicationidentifier/29773212 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/pharmaceutics17091133 https://doi.org/10.3390/pharmaceutics17091133 false true PublicationIdentifier 29950376 /api/publicationidentifier/29950376 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001579866200001 https://www.webofscience.com/wos/woscc/full-record/001579866200001 false true PublicationIdentifier 29950377 /api/publicationidentifier/29950377 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105017027700 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105017027700 false true PublicationIdentifier 29950378 /api/publicationidentifier/29950378 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41012470 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41012470&dopt=Abstract false true PublicationIdentifier 30014705 /api/publicationidentifier/30014705 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://www.mdpi.com/1999-4923/17/9/1133 https://www.mdpi.com/1999-4923/17/9/1133 false true SjrRating 11611771 /api/sjrrating/11611771 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3003 /api/classificationexternal/3003 true 3003 true D1 DIRECT true true /api/publication/36310359 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10087474"><a href="/gui2/?type=authors&mode=browse&sel=10087474" target="_blank">Vlahovic Kristina (<span class="authorship-author-name">Vlahovic Kristina</span> <span class="authorAux-mtmt"> gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020628"><a href="/gui2/?type=authors&mode=browse&sel=10020628" target="_blank">Lengyel Miléna<sup>*</sup> (<span class="authorship-author-name">Lengyel Miléna</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10083304"><a href="/gui2/?type=authors&mode=browse&sel=10083304" target="_blank">Fleck Christian (<span class="authorship-author-name">Petszulat Fleck</span> <span class="authorAux-mtmt"> Pharmacy</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020629"><a href="/gui2/?type=authors&mode=browse&sel=10020629" target="_blank">Kállai-Szabó Nikolett (<span class="authorship-author-name">Kállai-Szabó Nikolett</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020627"><a href="/gui2/?type=authors&mode=browse&sel=10020627" target="_blank">Balogh Emese (<span class="authorship-author-name">Bertalanné Balogh Emese</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029874"><a href="/gui2/?type=authors&mode=browse&sel=10029874" target="_blank">Laki András József ✉ (<span class="authorship-author-name">Laki András József</span> <span class="authorAux-mtmt"> Microfluidika</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020626"><a href="/gui2/?type=authors&mode=browse&sel=10020626" target="_blank">Antal István ✉ (<span class="authorship-author-name">Antal István</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36310359" target="_blank">Microenvironmental pH-Modulated Dissolution of Albendazole Layered on Tartaric Acid Starter Pellet Cores</a></div> <div> <span class="journal-title">PHARMACEUTICS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1999-4923">1999-4923</a>)</span>: <span class="journal-volume">17</span> <span class="journal-issue">9</span> <span class="page"> Paper 1133. 21 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/pharmaceutics17091133" target="_blank" href="https://doi.org/10.3390/pharmaceutics17091133"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001579866200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001579866200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105017027700" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105017027700"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41012470" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41012470&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.mdpi.com/1999-4923/17/9/1133" target="_blank" href="https://www.mdpi.com/1999-4923/17/9/1133"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 1 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36310359&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36310359</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">DOI XML</span> </div> <div class="lastModified">Utolsó módosítás: 2026.09.15. 13:13 Sifter Viktória (PPKE ITK admin 5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7, Budapest, 1092, Hungary Center for Pharmacology and Drug Research & Development, Semmelweis University, Üllői Str. 26, Budapest, 1085, Hungary Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Práter Str. 50/A, Budapest, 1083, Hungary ...</pre> </div></div>