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      <abstractText>IntroductionVitiligo, a chronic depigmenting disorder affecting 1-2% of the global population, is caused by immune-mediated melanocyte destruction. While its pathogenesis is multifactorial, the relationship between vitiligo and malignancy risk remains controversial. Some studies suggest an increased cancer risk, while others propose a potential protective effect, particularly against skin cancers. This study provides a comprehensive evaluation of malignancy risks in patients with vitiligo.MethodsThis systematic review and meta-analysis followed PRISMA 2020 guidelines and was registered with PROSPERO (CRD42023483130). A comprehensive search was conducted across Medline, EMBASE, and Cochrane databases. Studies reporting hazard ratios for malignancy incidence in patients with vitiligo were included. Data extraction and risk of bias assessment were performed using the Cochrane ROBINS-E tool.ResultsOf 7753 records identified, 6378 remained after duplicates were removed, and 12 studies were included in the final review. Quantitative analysis was performed on six studies. The combined sample comprised 3,267,951 participants, including 289,322 patients with vitiligo. Three meta-analyses were conducted for melanoma, non-melanoma skin cancer, and lymphoma. The pooled hazard ratio (HR) for lymphoma was 1.00 (95% CI 0.40-2.53), for melanoma 0.80 (95% CI 0.27-2.34), and for non-melanoma skin cancer 0.38 (95% CI 0.00-732.76), suggesting no consistent associations.ConclusionThis meta-analysis did not identify significant differences in cancer risk across the examined subgroups. While a protective effect of vitiligo against some malignancies cannot be excluded, substantial heterogeneity among studies warrants cautious interpretation. Further high-quality research is needed to clarify these associations.</abstractText>
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      <label>Mohammed Alzahra A. et al. Cancer Risk in Vitiligo: No Evidence of Increased Prevalence-A Systematic Review and Meta-analysis. 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																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10100258&quot; target=&quot;_blank&quot;&gt;Mohammed Alzahra A.
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Mohammed Alzahra Ahmed&lt;/span&gt;
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							&lt;span class=&quot;author-name&quot; mtid=&quot;10087211&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10087211&quot; target=&quot;_blank&quot;&gt;Lengyel Anna S.
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;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10079444&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10079444&quot; target=&quot;_blank&quot;&gt;Meznerics Fanni A.
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Bőr-, Nemikórtani és Bőronkológiai Klinika; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10089672&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10089672&quot; target=&quot;_blank&quot;&gt;Szondy Istvan
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Szondy István&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Hidradenitis suppurativa korszerű kezelése&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10105957&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10105957&quot; target=&quot;_blank&quot;&gt;Walter Anna
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Walter Anna&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Biostatisztika&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Pécsi Tudományegyetem&quot;&gt;PTE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Transzlációs Medicina Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; &gt;Nagy Benedek
    &lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; &gt;Csabi Zsofia
    &lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10037621&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10037621&quot; target=&quot;_blank&quot;&gt;Banvolgyi Andras
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Bánvölgyi András&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; bőrgyógyászat&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Bőr-, Nemikórtani és Bőronkológiai Klinika; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10054754&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10054754&quot; target=&quot;_blank&quot;&gt;Kiss Norbert
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Kiss Norbert&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Orvostudomány&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Bőr-, Nemikórtani és Bőronkológiai Klinika; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10002629&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10002629&quot; target=&quot;_blank&quot;&gt;Hegyi Peter
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Hegyi Péter&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gasztroenterológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Pankreász Betegségek Intézete; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ; &lt;span title=&quot;Pécsi Tudományegyetem&quot;&gt;PTE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Transzlációs Medicina Intézet&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; &gt;Kurgyis Zsuzsanna&lt;sup&gt;**&lt;/sup&gt; ✉
    &lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10040817&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10040817&quot; target=&quot;_blank&quot;&gt;Kemeny Lajos V. ✉
            (&lt;span class=&quot;authorship-author-name&quot;&gt;Kemény Lajos Vince&lt;/span&gt;
            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Bőrgyógyászat, onkológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Bőr-, Nemikórtani és Bőronkológiai Klinika; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Élettani Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/&lt;span title=&quot;Bőr-, Nemikórtani és Bőronkológiai Klinika&quot;&gt;BNBK&lt;/span&gt;/HCEMM-SE Transzlációs Dermatológiai Kutatócsoport; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ&lt;/span&gt;

				    &lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;36298812&quot; target=&quot;_blank&quot;&gt;Cancer Risk in Vitiligo: No Evidence of Increased Prevalence-A Systematic Review and Meta-analysis&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;DERMATOLOGY AND THERAPY&lt;/span&gt;

        &lt;span class=&quot;journal-issn&quot;&gt;(&lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/2193-8210&quot;&gt;2193-8210&lt;/a&gt; &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/2190-9172&quot;&gt;2190-9172&lt;/a&gt;)&lt;/span&gt;:
		&lt;span class=&quot;journal-volume&quot;&gt;15&lt;/span&gt; &lt;span class=&quot;journal-issue&quot;&gt;10&lt;/span&gt;
&lt;span class=&quot;page&quot;&gt;
	pp 3009-3024
			
&lt;/span&gt;		 &lt;span class=&quot;year&quot;&gt;(2025)&lt;/span&gt;  
    &lt;/div&gt;
&lt;div class=&quot;pub-footer&quot;&gt;
    

	&lt;span class=&quot;language&quot; xmlns=&quot;http://www.w3.org/1999/html&quot;&gt;Nyelv:
			Angol
		 |  &lt;/span&gt;

	&lt;span class=&quot;identifiers&quot;&gt;
						&lt;span class=&quot;id identifier oa_GOLD&quot; title=&quot;	Gold
&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;10.1007/s13555-025-01520-0&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1007/s13555-025-01520-0&quot;&gt;
									DOI
							&lt;/a&gt;
						&lt;/span&gt;
						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;001551679000001&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/001551679000001&quot;&gt;
									WoS
							&lt;/a&gt;
						&lt;/span&gt;
						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;105013635594&quot; target=&quot;_blank&quot; href=&quot;http://www.scopus.com/record/display.url?origin=inward&amp;eid=2-s2.0-105013635594&quot;&gt;
									Scopus
							&lt;/a&gt;
						&lt;/span&gt;
						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
							&lt;a style=&quot;color:blue&quot; title=&quot;40824517&quot; target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=40824517&amp;dopt=Abstract&quot;&gt;
									PubMed
							&lt;/a&gt;
						&lt;/span&gt;
	&lt;/span&gt;


	&lt;OnlyViewableByAuthor&gt;&lt;div class=&quot;ratings&quot;&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Dermatology&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;D1&lt;/div&gt;
    &lt;/div&gt;&lt;/OnlyViewableByAuthor&gt;


	&lt;div class=&quot;publication-citation&quot; style=&quot;margin-left: 0.5cm;&quot;&gt;
		&lt;span title=&quot;Nyilvános idézőközlemények összesen, említések nélkül&quot; class=&quot;citingPub-count&quot;&gt;Nyilvános idéző összesen: 2&lt;/span&gt;
		| Független: 2
		| Függő: 0
		| Nem jelölt: 0
		| WoS jelölt: 2 
		|  Scopus jelölt:&amp;nbsp;2 
		|  WoS/Scopus jelölt:&amp;nbsp;2 
		|  DOI jelölt:&amp;nbsp;2 
		
	&lt;/div&gt;
    
    
	&lt;div class=&quot;publication-citation&quot;&gt;
		&lt;a target=&quot;_blank&quot; href=&quot;/api/publication?cond=citations.related;eq;36298812&amp;sort=publishedYear,desc&amp;sort=title&quot;&gt;
			Idézett közlemények száma: 4
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	&lt;/div&gt;



    &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Közlemény: 36298812&lt;/span&gt;
    | &lt;span class=&quot;status-data status-VALIDATED&quot;&gt; 	Egyeztetett
  &lt;/span&gt;
        
	
	
Forrás	 Idéző
	
	
    | &lt;span class=&quot;type-subtype&quot;&gt;Folyóiratcikk
			( Összefoglaló cikk
			
			)
		&lt;/span&gt;
      		| &lt;span class=&quot;pub-category&quot;&gt;Tudományos&lt;/span&gt;
	| &lt;span class=&quot;publication-sourceOfData&quot;&gt;WOS TAGGED&lt;/span&gt;
&lt;/div&gt;

&lt;div class=&quot;funder&quot;&gt; (FK138696) Támogató: OTKA,    (LP2024-12/2024)   &lt;/div&gt;
&lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.07.08. 13:50 Milánkovics Róbert (PTE ÁOK admin 4)
&lt;/div&gt;




	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Megjegyzés&lt;/u&gt;: * Megosztott szerzőség&lt;/pre&gt;
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