https://m2.mtmt.hu/ hun 2026-09-22 16:52 JournalArticle 36291690 VALIDATED true 0 false 2026-09-15T12:51:42.121+0000 2025-09-08T09:59:47.630+0000 2025-08-18T15:20:17.150+0000 true 10095366 Havas Petra Gabriella /api/admin/10095366 Admin Havas Petra Gabriella (SE_KK_Idegsebeszet_Admin5_HP, admin) true 2025-09-04T11:01:20.716+0000 2025-09-04T11:01:20.716+0000 2025-09-04T11:01:24.463+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin (MTMT Központi admin) Lévayné Deseő Katalin true 10025544 true 2026-06-09T18:54:35.691+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Nagy, Zoltán true true /api/journal/10050685 REVIEWED ANTIBIOTICS 2079-6382 2079-6382 true false 10050685 false 10050685 true 2079-6382 2079-6382 Journal FOREIGN 14 8 830 830 11 2025 Background: Surgical site infections (SSIs) are a significant postoperative complication in instrumented lumbar spine surgery, and the selection and duration of appropriate prophylactic antibiotics are key to their prevention. The aim of our study was to evaluate the effectiveness of various prophylactic antibiotics, primarily cefazolin and clindamycin, as well as the role of the duration of antibiotic prophylaxis in the development of SSI in instrumented lumbar spine surgeries through retrospective analysis. Methods: We performed a retrospective analysis of data from 915 patients who underwent instrumented lumbar spine surgery between 2016 and 2024 in a university center database. We examined the incidence of SSI according to the type of antibiotic used (cefazolin 1 g or 2 g, or clindamycin 0.6 g) and the duration of prophylaxis (single dose versus 72 h administration). We used the Fisher test and Welch test as a statistical analysis to examine the differences between SSI rates. Results: The incidence of SSI was 11.7%. We measured a significantly lower infection rate with cefazolin compared to clindamycin (OR = 0.45; 95% CI: 0.23–0.94; p = 0.0206), regardless of the duration of antibiotic administration. The 72 h cefazolin prophylaxis showed a slight but statistically insignificant advantage over single dose prophylaxis. The risk of SSI was significantly higher in multi-segment surgeries (p = 0.0005). Conclusions: Cefazolin is a more effective prophylactic antibiotic than clindamycin during instrumented lumbar spine surgery. The duration of antibiotic administration has less influence on the risk of SSI development; therefore, short-term, adequate-dose cefazolin prophylaxis is recommended, which also minimizes the risk of antimicrobial resistance and side effects. Funding 2056717 /api/funding/2056717 (HUN-REN-SU Human Microbiota Research Group No “0272”.) false true true true 2025 true true true false true false GOLD 2026-09-15 false http://www.mdpi.com/journal/antibiotics 4 0 4 4 0 4 4 3 3 3 3 3 3 4 0 0 4 4 4 4 0 0 0 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 4 4 4 4 D1 false 10010682 false false false 2025-09-03T11:01:24.136+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); HUN-REN-SE Humán Mikrobiota Kutatócsoport (SE / AOK / I / OMI); Idegsebészeti Tanszék (SE / AOK / K / INK); Idegsebészeti és Neurointervenciós Klinika (SE / AOK / K); Orvosi Mikrobiológiai Intézet (SE / AOK / I) 7 25 5 11 0 true 10025544 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 127544935 /api/authorship/127544935 Nagy, Zoltán [Nagy, Zoltán (idegsebészet), szerző] Idegsebészeti és Neurointervenciós Klinika (SE / AOK / K); Idegsebészeti Tanszék (SE / AOK / K / INK) 1 0.091 true false false Author 10077790 /api/author/10077790 Nagy Zoltán (idegsebészet) Nagy Zoltán true true Nagy Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127544936 /api/authorship/127544936 Szabó, Dóra* ✉ [Szabó, Dóra (Mikrobiológia), szerző] Idegsebészeti és Neurointervenciós Klinika (SE / AOK / K); HUN-REN-SE Humán Mikrobiota Kutatócsoport (SE / AOK / I / OMI); Orvosi Mikrobiológiai Intézet (SE / AOK / I) 2 0.091 true false true Author 10003357 /api/author/10003357 Szabó Dóra (Mikrobiológia) Szabó Dóra true 10003357 true Szabó Dóra true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127544937 /api/authorship/127544937 Agócs, Gergely [Agócs, Gergely (biofizika), szerző] Biofizikai és Sugárbiológiai Intézet (SE / AOK / I) 3 0.091 false false false Author 10029423 /api/author/10029423 Agócs Gergely (biofizika) Agócs Gergely true 10029423 true Agócs Gergely true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127544938 /api/authorship/127544938 Szilágyi, Konrád 4 0.09090909 false false false Szilágyi Konrád true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127544939 /api/authorship/127544939 Rojcsik, Zsanett 5 0.09090909 false false false Rojcsik Zsanett true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127544940 /api/authorship/127544940 Budai, József 6 0.09090909 false false false Budai József true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127544941 /api/authorship/127544941 Papp, Zoltán [Papp, Zoltán Attila (idegsebészet), szerző] Idegsebészeti és Neurointervenciós Klinika (SE / AOK / K) 7 0.091 false false false Author 10049882 /api/author/10049882 Papp Zoltán Attila (idegsebészet) Papp Zoltán Attila true 10049882 true Papp Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127544942 /api/authorship/127544942 Padányi, Csaba 8 0.09090909 false false false Padányi Csaba true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127544943 /api/authorship/127544943 Erőss, Loránd [Erőss, Loránd (Idegsebészet, ide...), szerző] Idegsebészeti és Neurointervenciós Klinika (SE / AOK / K); Idegsebészeti Tanszék (SE / AOK / K / INK) 9 0.091 false false false Author 10026870 /api/author/10026870 Erőss Loránd (Idegsebészet, ideggyógyászat) Erőss Loránd true 10026870 true Erőss Loránd true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127544944 /api/authorship/127544944 Sipos, László** [Sipos, László (Idegsebészet, neu...), szerző] Idegsebészeti és Neurointervenciós Klinika (SE / AOK / K); Idegsebészeti Tanszék (SE / AOK / K / INK) 10 0.091 false true false Author 10010682 /api/author/10010682 Sipos László (Idegsebészet, neuro-onkológia) Sipos László true 10010682 true Sipos László true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127544945 /api/authorship/127544945 Banczerowski, Péter [Banczerowski, Péter (Idegsebészet), szerző] Idegsebészeti és Neurointervenciós Klinika (SE / AOK / K); Idegsebészeti Tanszék (SE / AOK / K / INK) 11 0.091 false true false Author 10011382 /api/author/10011382 Banczerowski Péter (Idegsebészet) Banczerowski Péter true 10011382 true Banczerowski Péter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 29722758 /api/publicationidentifier/29722758 DOI: 10.3390/antibiotics14080830 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/antibiotics14080830 https://doi.org/10.3390/antibiotics14080830 false true PublicationIdentifier 29795955 /api/publicationidentifier/29795955 WoS: 001557134500001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001557134500001 https://www.webofscience.com/wos/woscc/full-record/001557134500001 true true PublicationIdentifier 29810396 /api/publicationidentifier/29810396 Scopus: 105014461000 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105014461000 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105014461000 true true PublicationIdentifier 29771753 /api/publicationidentifier/29771753 PubMed: 40868024 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40868024 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40868024&dopt=Abstract true true SjrRating 11612611 /api/sjrrating/11612611 sjr:D1 (2025) Scopus - Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ANTIBIOTICS 2079-6382 2079-6382 5 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 3001 /api/classificationexternal/3001 Scopus - Pharmacology, Toxicology and Pharmaceutics (miscellaneous) true 3001 true D1 DIRECT true true Reference 67467958 /api/reference/67467958 1. 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(2025) ANTIBIOTICS 2079-6382 2079-6382 14 8<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10077790"><a href="/gui2/?type=authors&mode=browse&sel=10077790" target="_blank">Nagy Zoltán (<span class="authorship-author-name">Nagy Zoltán</span> <span class="authorAux-mtmt"> idegsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Idegsebészeti és Neurointervenciós Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Idegsebészeti és Neurointervenciós Klinika">INK</span>/Idegsebészeti Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003357"><a href="/gui2/?type=authors&mode=browse&sel=10003357" target="_blank">Szabó Dóra^* ✉ (<span class="authorship-author-name">Szabó Dóra</span> <span class="authorAux-mtmt"> Mikrobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Idegsebészeti és Neurointervenciós Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Orvosi Mikrobiológiai Intézet">OMI</span>/HUN-REN-SE Humán Mikrobiota Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Orvosi Mikrobiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029423"><a href="/gui2/?type=authors&mode=browse&sel=10029423" target="_blank">Agócs Gergely (<span class="authorship-author-name">Agócs Gergely</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szilágyi Konrád </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rojcsik Zsanett </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Budai József </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10049882"><a href="/gui2/?type=authors&mode=browse&sel=10049882" target="_blank">Papp Zoltán (<span class="authorship-author-name">Papp Zoltán Attila</span> <span class="authorAux-mtmt"> idegsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Idegsebészeti és Neurointervenciós Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Padányi Csaba </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026870"><a href="/gui2/?type=authors&mode=browse&sel=10026870" target="_blank">Erőss Loránd (<span class="authorship-author-name">Erőss Loránd</span> <span class="authorAux-mtmt"> Idegsebészet, ideggyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Idegsebészeti és Neurointervenciós Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Idegsebészeti és Neurointervenciós Klinika">INK</span>/Idegsebészeti Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010682"><a href="/gui2/?type=authors&mode=browse&sel=10010682" target="_blank">Sipos László^** (<span class="authorship-author-name">Sipos László</span> <span class="authorAux-mtmt"> Idegsebészet, neuro-onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Idegsebészeti és Neurointervenciós Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Idegsebészeti és Neurointervenciós Klinika">INK</span>/Idegsebészeti Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011382"><a href="/gui2/?type=authors&mode=browse&sel=10011382" target="_blank">Banczerowski Péter (<span class="authorship-author-name">Banczerowski Péter</span> <span class="authorAux-mtmt"> Idegsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Idegsebészeti és Neurointervenciós Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Idegsebészeti és Neurointervenciós Klinika">INK</span>/Idegsebészeti Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36291690" target="_blank">Antibiotic Prophylaxis in Instrumented Lumbar Spine Surgery: Cefazolin Outperforms Clindamycin Regardless of Duration</a></div> <div> <span class="journal-title">ANTIBIOTICS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2079-6382">2079-6382</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2079-6382">2079-6382</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">8</span> <span class="page"> Paper 830. 11 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/antibiotics14080830" target="_blank" href="https://doi.org/10.3390/antibiotics14080830"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001557134500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001557134500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105014461000" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105014461000"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40868024" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40868024&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology, Toxicology and Pharmaceutics (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Infectious Diseases&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Microbiology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Microbiology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 4 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;4 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36291690</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData"></span> </div> <div class="funder"> (HUN-REN-SU Human Microbiota Research Group No “0272”.) </div> <div class="lastModified">Utolsó módosítás: 2025.09.08. 11:59 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <div class="lockedBy">Központi kezelésű 2026.06.09. 20:54 Lévayné Deseő Katalin (MTMT Központi admin) </div> </div></div>