https://m2.mtmt.hu/ hun 2026-09-21 13:44 JournalArticle 36290083 VALIDATED true Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7–9, Budapest, 1092, Hungary Center for Pharmacology and Drug Research & Development, Semmelweis University, Budapest, 1085, Hungary Export Date: 02 June 2026; Cited By: 1; Correspondence Address: I. Antal; Department of Pharmaceutics, Semmelweis University, Budapest, Hőgyes E. Str. 7–9, 1092, Hungary; email: antal.istvan@semmelweis.hu; N. Kállai-Szabó; Department of Pharmaceutics, Semmelweis University, Budapest, Hőgyes E. Str. 7–9, 1092, Hungary; email: kallai.nikolett@semmelweis.hu 0 false 2026-09-18T10:35:33.929+0000 2026-06-02T11:39:29.662+0000 2025-08-16T09:49:38.333+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin Áncsán Gizella (SE admin) true 10015206 2026-09-18T10:32:04.731+0000 2025-09-08T06:53:14.296+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Kovács, Andrea true true /api/journal/10022148 REVIEWED PHARMACEUTICS 1999-4923 true false 10022148 false 10022148 true 1999-4923 Journal FOREIGN 17 8 1063 1063 19 2025 Background/Objectives: The melt-spinning process has seen limited application in the pharmaceutical industry. However, nano- and microfibrous structures show significant potential for novel drug delivery systems, due to their high specific surface area. To facilitate broader adoption in pharmaceutical technology, critical parameters influencing fiber quality and yield must be investigated. In this study, we aimed to develop an isomalt-based microfibrous carrier system for active pharmaceutical ingredients. Methods: The effects of different isomalt compositions—specifically, varying ratios of GPS (6-O-α-d-glucopyranosyl-d-sorbitol) and GPM (1-O-α-d-glucopyranosyl-d-mannitol)—as well as key process parameters, were systematically investigated to optimize fiber formation. The prepared fibers underwent different treatments. Morphological changes were monitored with a microscope, and microstructural changes were studied using a differential scanning calorimeter and X-ray diffractometer. The macroscopic behavior of the fibers was evaluated by image analysis under monitored conditions. Results: Statistical analysis was used to determine the optimal setting to produce isomalt-based fibers. We found that storage over ethanol vapor has a positive effect on the stability of the fibers. We successfully prepared ibuprofen sodium-containing fibers that remained stable after alcohol treatment and enabled drug release within 15 s. Conclusions: It was found that the applied GPS:GPM isomalt ratio significantly influenced fiber formation and that storage over ethanol positively influenced the processability and stability of the fibrous structure. An isomalt-based microfibrous system with advantageous physicochemical and structural properties was successfully developed as a potential drug carrier. The system is also resistant to the destructive effects of ambient humidity, enabling preparation of suitable dosage forms. true true 2025 true true true false false GOLD 2026-09-18 false http://www.mdpi.com/journal/pharmaceutics/ 1 0 1 0 1 1 1 1 1 1 1 0 0 0 1 0 1 0 1 0 0 11 11 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 0 1 0 D1 false false false false 2025-09-07T06:53:13.946+0000 Farmakológiai és Gyógyszerkutatás-fejlesztési K... (SE / KSZE); Gyógyszerészeti Intézet (SE / GYTK) 7 8 2 7 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 127538446 /api/authorship/127538446 Kovács, Andrea [Kovács, Andrea (Gyógyszertechnológia), szerző] Gyógyszerészeti Intézet (SE / GYTK) 1 0.143 true false false Author 10055679 /api/author/10055679 Kovács Andrea (Gyógyszertechnológia) Kovács Andrea true 10055679 true Kovács Andrea true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127538447 /api/authorship/127538447 Kecskés, Bálint Attila* [Kecskés, Bálint Attila (gyógyszertechnológia), szerző] Gyógyszerészeti Intézet (SE / GYTK) 2 0.143 true false Author 10097177 /api/author/10097177 Kecskés Bálint Attila (gyógyszertechnológia) Kecskés Bálint Attila true true Kecskés Bálint Attila true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127538448 /api/authorship/127538448 Filipszki, Gábor [Filipszki, Gábor (gyógyszertechnológia), szerző] Gyógyszerészeti Intézet (SE / GYTK) 3 0.143 false false false Author 10097176 /api/author/10097176 Filipszki Gábor (gyógyszertechnológia) Filipszki Gábor true true Filipszki Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127538449 /api/authorship/127538449 Farkas, Dóra [Farkas, Dóra (gyógyszertechnológia), szerző] Gyógyszerészeti Intézet (SE / GYTK) 4 0.143 false false false Author 10061229 /api/author/10061229 Farkas Dóra (gyógyszertechnológia) Farkas Dóra true 10061229 true Farkas Dóra true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127538450 /api/authorship/127538450 Tóth, Bence [Tóth, Bence (gyógyszertechnoló...), szerző] Gyógyszerészeti Intézet (SE / GYTK) 5 0.143 false false false Author 10096413 /api/author/10096413 Tóth Bence (gyógyszertechnológia - porröntgen (XRD); szilárd és félszilárd gyógyszerformák; reológia) Tóth Bence true true Tóth Bence true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127538451 /api/authorship/127538451 Antal, István ✉ [Antal, István (Gyógyszertechnológia), szerző] Farmakológiai és Gyógyszerkutatás-fejlesztési K... (SE / KSZE); Gyógyszerészeti Intézet (SE / GYTK) 6 0.143 false false true Author 10020626 /api/author/10020626 Antal István (Gyógyszertechnológia) Antal István true 10020626 true Antal István true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127538452 /api/authorship/127538452 Kállai-Szabó, Nikolett ✉ [Kállai-Szabó, Nikolett (Gyógyszertechnológia), szerző] Farmakológiai és Gyógyszerkutatás-fejlesztési K... (SE / KSZE); Gyógyszerészeti Intézet (SE / GYTK) 7 0.143 false true true Author 10020629 /api/author/10020629 Kállai-Szabó Nikolett (Gyógyszertechnológia) Kállai-Szabó Nikolett true 10020629 true Kállai-Szabó Nikolett true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 29717861 /api/publicationidentifier/29717861 DOI: 10.3390/pharmaceutics17081063 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/pharmaceutics17081063 https://doi.org/10.3390/pharmaceutics17081063 false true PublicationIdentifier 29809021 /api/publicationidentifier/29809021 WoS: 001559639700001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001559639700001 https://www.webofscience.com/wos/woscc/full-record/001559639700001 false true PublicationIdentifier 29809023 /api/publicationidentifier/29809023 Scopus: 105014339365 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105014339365 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105014339365 false true PublicationIdentifier 29809022 /api/publicationidentifier/29809022 PubMed: 40871083 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40871083 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40871083&dopt=Abstract false true PublicationIdentifier 31383733 /api/publicationidentifier/31383733 Egyéb URL: https://www.mdpi.com/1999-4923/17/8/1063 PlainSource 40 /api/publicationsource/40 Egyéb URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://www.mdpi.com/1999-4923/17/8/1063 https://www.mdpi.com/1999-4923/17/8/1063 false true Classification 12197 /api/classification/12197 Gyógyszerészet, farmakogenomika, gyógyszerkutatás és tervezés, gyógyszeres kezelés true true SjrRating 11611771 /api/sjrrating/11611771 sjr:D1 (2025) Scopus - Pharmaceutical Science PHARMACEUTICS 1999-4923 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 3003 /api/classificationexternal/3003 Scopus - Pharmaceutical Science true 3003 true D1 DIRECT true true Reference 67439735 /api/reference/67439735 1. 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(2025) PHARMACEUTICS 1999-4923 17 8<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10055679"><a href="/gui2/?type=authors&mode=browse&sel=10055679" target="_blank">Kovács Andrea (<span class="authorship-author-name">Kovács Andrea</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10097177"><a href="/gui2/?type=authors&mode=browse&sel=10097177" target="_blank">Kecskés Bálint Attila^* (<span class="authorship-author-name">Kecskés Bálint Attila</span> <span class="authorAux-mtmt"> gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10097176"><a href="/gui2/?type=authors&mode=browse&sel=10097176" target="_blank">Filipszki Gábor (<span class="authorship-author-name">Filipszki Gábor</span> <span class="authorAux-mtmt"> gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061229"><a href="/gui2/?type=authors&mode=browse&sel=10061229" target="_blank">Farkas Dóra (<span class="authorship-author-name">Farkas Dóra</span> <span class="authorAux-mtmt"> gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10096413"><a href="/gui2/?type=authors&mode=browse&sel=10096413" target="_blank">Tóth Bence (<span class="authorship-author-name">Tóth Bence</span> <span class="authorAux-mtmt"> gyógyszertechnológia - porröntgen (XRD); szilár...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020626"><a href="/gui2/?type=authors&mode=browse&sel=10020626" target="_blank">Antal István ✉ (<span class="authorship-author-name">Antal István</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020629"><a href="/gui2/?type=authors&mode=browse&sel=10020629" target="_blank">Kállai-Szabó Nikolett ✉ (<span class="authorship-author-name">Kállai-Szabó Nikolett</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészeti Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36290083" target="_blank">Fabrication and Evaluation of Isomalt-Based Microfibers as Drug Carrier Systems</a></div> <div> <span class="journal-title">PHARMACEUTICS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1999-4923">1999-4923</a>)</span>: <span class="journal-volume">17</span> <span class="journal-issue">8</span> <span class="page"> Paper 1063. 19 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/pharmaceutics17081063" target="_blank" href="https://doi.org/10.3390/pharmaceutics17081063"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001559639700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001559639700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105014339365" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105014339365"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40871083" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40871083&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.mdpi.com/1999-4923/17/8/1063" target="_blank" href="https://www.mdpi.com/1999-4923/17/8/1063"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 0 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36290083&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36290083</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.06.02. 13:39 Molnár-Taga Márta (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Pharmaceutics, Semmelweis University, Hőgyes E. Str. 7–9, Budapest, 1092, Hungary Center for Pharmacology and Drug Research & Development, Semmelweis University, Budapest, 1085, Hungary Export Date: 02 June 2026; Cited By: 1; Correspondence Address: I. Antal; Department of Pharmaceutics, Semmelweis University, Budapest, Hőgyes E. Str...</pre> </div></div>