https://m2.mtmt.hu/ hun 2026-09-22 23:33 JournalArticle 36278077 VALIDATED true Funding Agency and Grant Number: Dr. Rolf M. Schwiete Foundation Funding text: The Rapid Service Fee for publication was funded by the Dr. Rolf M. Schwiete Foundation. The funding organization had no role in the conduct of this article. 0 false 2026-09-14T07:57:07.699+0000 2026-05-27T07:18:48.322+0000 2025-08-03T19:43:33.516+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-06-18T17:17:24.579+0000 2026-05-27T07:18:48.636+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Tóth, Gábor Outcomes of Trabeculectomy and Glaucoma Drainage Device Surgery in Congenital Aniridia-Associated Glaucoma: A Systematic Review and Meta-Analysis true true /api/journal/10066996 REVIEWED true false 10066996 false 10066996 true 2193-8245 2193-6528 Journal FOREIGN 14 10 2323 2343 2323 21 2025 This study aimed to compare the surgical outcomes of trabeculectomy and glaucoma drainage device (GDD) implantation in patients with congenital aniridia.Eligible studies were retrieved from Embase, MEDLINE (via PubMed), and the Cochrane Central Register of Controlled Trials (CENTRAL) up to December 15, 2024. Studies were included if they reported clinical outcomes following trabeculectomy or GDD implantation in individuals with aniridic glaucoma. Outcomes of interest included success rates, best spectacle-corrected visual acuity (BSCVA), intraocular pressure (IOP), use of glaucoma medications, and postoperative complications. Data extraction and synthesis were conducted according to the Cochrane Handbook. Meta-analyses were performed using a random-effects model. Heterogeneity among studies was evaluated using the Q test and I2 statistic.Twenty-two of the 1039 screened studies were included in the meta-analysis. Pooled complete success rates were not significantly different between trabeculectomy and GDD treatments (p = 0.88). However, the qualified success rate was significantly higher following GDDs compared to trabeculectomy (p < 0.001) in patients with aniridia. Cox frailty regression analysis of individual success data showed similar results: the hazard ratio of failure was significantly higher after trabeculectomy than after GDD (HR 5.684 from 1.46 to 22.14, p = 0.012). No significant differences were observed between the two procedures in terms of IOP reduction (p = 0.53), percentage change in IOP (p = 0.24), or reduction in glaucoma medications (p = 0.56) at final follow-up. Additionally, there was no significant difference in the change in BSCVA between the two groups (p = 0.72).Regarding complete success rates, trabeculectomy does not seem to provide a significant benefit over GDDs in treating aniridic glaucoma. However, the qualified success rate is greater with GDD implantation than with trabeculectomy. Both surgical approaches show similar effectiveness in lowering intraocular pressure, reducing the need for glaucoma medications, and maintaining visual acuity. true INTERNATIONAL 2025 true true true false true false GOLD 2026-09-14 true https://doi.org/10.1007/s40123-025-01215-x 1 0 1 0 1 1 1 1 1 1 1 0 0 0 1 0 1 0 1 0 0 2 2 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 0 1 0 Q1 false false false false 2025-08-20T09:07:27.297+0000 Pankreász Betegségek Intézete (SE / AOK / K); Sztochasztika Tanszék (BME / TTK / MI); Transzlációs Medicina Központ (SE / KSZE) 5 46 3 8 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 127473049 /api/authorship/127473049 1 0.125 true false true Tóth Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127473050 /api/authorship/127473050 2 0.125 false false false Liu Shanhe true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127473051 /api/authorship/127473051 3 0.125 false false false Li Shuailin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127473052 /api/authorship/127473052 4 0.125 false false false Author 10071961 /api/author/10071961 Váncsa Szilárd true true Váncsa Szilárd true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127463316 /api/authorship/127463316 5 0.125 false false false Author 10089354 /api/author/10089354 Paczkó Mátyás true true Paczkó Mátyás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127473054 /api/authorship/127473054 6 0.125 false false false Author 10042217 /api/author/10042217 Kói Tamás true 10042217 true Kói Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127473055 /api/authorship/127473055 7 0.125 false false false Author 10002629 /api/author/10002629 Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127473056 /api/authorship/127473056 8 0.125 false true false Author 10000048 /api/author/10000048 Szentmáry Nóra true 10000048 true Szentmáry Nóra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29685468 /api/publicationidentifier/29685468 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1007/s40123-025-01215-x https://doi.org/10.1007/s40123-025-01215-x false true PublicationIdentifier 29715054 /api/publicationidentifier/29715054 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001541021300001 https://www.webofscience.com/wos/woscc/full-record/001541021300001 true true PublicationIdentifier 29912222 /api/publicationidentifier/29912222 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105012244102 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105012244102 true true PublicationIdentifier 29685467 /api/publicationidentifier/29685467 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40736869 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40736869&dopt=Abstract false true PublicationIdentifier 29679668 /api/publicationidentifier/29679668 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://link.springer.com/10.1007/s40123-025-01215-x https://link.springer.com/10.1007/s40123-025-01215-x false true Classification 12311 /api/classification/12311 true true Keyword 1011951 /api/keyword/1011951 true 1011951 true Keyword 1011959 /api/keyword/1011959 true 1011959 true Keyword 1283669 /api/keyword/1283669 true 1283669 true Keyword 1570910 /api/keyword/1570910 true true Keyword 3894816 /api/keyword/3894816 true true SjrRating 11609707 /api/sjrrating/11609707 16 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2731 /api/classificationexternal/2731 true 2731 true Q1 DIRECT true true /api/publication/36278077 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Tóth Gábor ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Liu Shanhe </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Li Shuailin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071961"><a href="/gui2/?type=authors&mode=browse&sel=10071961" target="_blank">Váncsa Szilárd (<span class="authorship-author-name">Váncsa Szilárd</span> <span class="authorAux-mtmt"> Orvostudomány, egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pankreász Betegségek Intézete; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089354"><a href="/gui2/?type=authors&mode=browse&sel=10089354" target="_blank">Paczkó Mátyás (<span class="authorship-author-name">Paczkó Mátyás</span> <span class="authorAux-mtmt"> elméleti és evolúcióbiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042217"><a href="/gui2/?type=authors&mode=browse&sel=10042217" target="_blank">Kói Tamás (<span class="authorship-author-name">Kói Tamás</span> <span class="authorAux-mtmt"> információelmélet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ; <span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Matematika Intézet">MI</span>/Sztochasztika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pankreász Betegségek Intézete; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000048"><a href="/gui2/?type=authors&mode=browse&sel=10000048" target="_blank">Szentmáry Nóra (<span class="authorship-author-name">Szentmáry Nóra</span> <span class="authorAux-mtmt"> Szemészet</span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36278077" target="_blank">Outcomes of Trabeculectomy and Glaucoma Drainage Device Surgery in Congenital Aniridia-Associated Glaucoma: A Systematic Review and Meta-Analysis</a></div> <div> <span class="journal-title">OPHTHALMOLOGY AND THERAPY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2193-8245">2193-8245</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2193-6528">2193-6528</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">10</span> <span class="page"> pp 2323-2343 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s40123-025-01215-x" target="_blank" href="https://doi.org/10.1007/s40123-025-01215-x"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001541021300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001541021300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105012244102" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105012244102"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40736869" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40736869&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://link.springer.com/10.1007/s40123-025-01215-x" target="_blank" href="https://link.springer.com/10.1007/s40123-025-01215-x"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Ophthalmology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 0 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36278077&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36278077</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.05.27. 09:18 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Dr. Rolf M. Schwiete Foundation Funding text: The Rapid Service Fee for publication was funded by the Dr. Rolf M. Schwiete Foundation. The funding organization had no role in the conduct of this article.</pre> </div></div>