https://m2.mtmt.hu/ eng 2026-10-25 09:48 JournalArticle 36272775 VALIDATED true 0 false 2026-10-08T11:22:53.187+0000 2026-05-05T12:06:23.329+0000 2025-07-30T07:39:42.862+0000 true 10020565 Varga Máté /api/author/10020565 Author Máté Varga (Fejlődésgenetika, zebrahal fejlődés) true 10020565 2026-10-08T11:18:58.686+0000 2025-08-22T09:44:47.383+0000 true 10071503 Szabó Regina /api/admin/10071503 Admin Regina Szabó (ELTE TTK admin 5) true 2025-12-18T14:56:41.412+0000 true 521 Szuper Admin /api/admin/521 Admin Admin Szuper (admin) true Admin 10003141 /api/admin/10003141 Zsuzsa Aggod (MTMT 2-3, admin) Aggod Zsuzsa true 10003141 true 2026-04-22T08:11:28.331+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Varga, Zoltán K. true true /api/journal/10086915 REVIEWED COMMUNICATIONS BIOLOGY 2399-3642 true false 10086915 false 10086915 true 2399-3642 Journal FOREIGN 8 1 1125 1125 13 2025 Zebrafish have revolutionised physiological screening in vertebrates, however, their strong sociality present challenges for interpreting behavioural assays conducted on individual subjects. To retain the advantages of the zebrafish model while addressing its limitations, we propose the use of a solitary species—the paradise fish—as a complementary model system. We compared paradise fish and zebrafish of late larval stage in social and non-social exploratory tasks, anxiety tests and in a working memory assay to assess their performance in these individual-based challenges. We found that in contrast to zebrafish, paradise fish did not show social approach in sociability tests, their exploratory behaviour was unaffected by the presence of a conspecific, and social isolation did not impair their performance during anxiety tests. Intra- and intertest variability measures of different anxiety tests revealed that, compared to zebrafish, paradise fish express more consistent, repeatable patterns of exploratory and risk-avoidance behaviour across time and contexts. We also showed that paradise fish exploration of the Y-maze is dominated by arm alternations, suggesting advanced working memory. Considering the results of this systematic comparison and the natural history of the two species we recommend prioritizing zebrafish in social tasks, while favouring paradise fish in individual-based behavioural assays. Funding 2055889 /api/funding/2055889 (1783-3/2018/FEKUTSRAT) Funder: Ministry of Human Capacities false true Funding 2055890 /api/funding/2055890 (RRF-2.3.1-21-2022-00011) false true Funding 2055891 /api/funding/2055891 (BO/00555/22/8) false true true true 2025 true true true false true false GOLD 2026-10-08 true https://doi.org/10.1038/s42003-025-08556-0 1 0 1 0 0 1 1 1 1 1 1 0 0 0 1 0 1 0 1 0 0 12 12 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 0 1 0 D1 false false false false 2025-08-10T09:45:51.903+0000 Doktori Iskola (SE); Etológiai Tanszék (ELTE / TTK / Bio_I); Genetikai Tanszék (ELTE / TTK / Bio_I); Transzlációs Magatartás Idegtudomány Kutatócsoport (HRN KOKI) 5 35 4 6 0 true 10003141 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 127443522 /api/authorship/127443522 Varga, Zoltán K. ✉ [Varga, Zoltán Kristóf (Biológia), author] Translational Behavioural Neuroscience Group 1 0.167 true false true Author 10060719 /api/author/10060719 Zoltán Kristóf Varga (Biológia) Varga Zoltán Kristóf true 10060719 true Varga Zoltán K. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 127443523 /api/authorship/127443523 Pejtsik, Diána [Pejtsik, Diána (Biológia), author] Translational Behavioural Neuroscience Group; School of PhD Studies (SU) 2 0.167 false false false Author 10068698 /api/author/10068698 Diána Pejtsik (Biológia) Pejtsik Diána true true Pejtsik Diána true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 127443524 /api/authorship/127443524 Csorvási, Tímea 3 0.16666667 false false false Csorvási Tímea true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 127443525 /api/authorship/127443525 Mikics, Éva [Mikics, Éva (Neuroendokrinológ...), author] Translational Behavioural Neuroscience Group 4 0.16666667 false false false Author 10012928 /api/author/10012928 Éva Mikics (Neuroendokrinológia, viselkedésbiológia) Mikics Éva true 10012928 true Mikics Éva true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 127443526 /api/authorship/127443526 Miklósi, Ádám [Miklósi, Ádám (Biológia), author] Department of Ethology (ELTE / ELU FoS / Bio_I) 5 0.167 false false false Author 10009117 /api/author/10009117 Ádám Miklósi (Biológia) Miklósi Ádám true 10009117 true Miklósi Ádám true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 127443527 /api/authorship/127443527 Varga, Máté ✉ [Varga, Máté (Fejlődésgenetika,...), author] Department of Genetics (ELTE / ELU FoS / Bio_I) 6 0.167 false true true Author 10020565 /api/author/10020565 Máté Varga (Fejlődésgenetika, zebrahal fejlődés) Varga Máté true 10020565 true Varga Máté true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 29669084 /api/publicationidentifier/29669084 DOI: 10.1038/s42003-025-08556-0 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s42003-025-08556-0 https://doi.org/10.1038/s42003-025-08556-0 false true PublicationIdentifier 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(2025) COMMUNICATIONS BIOLOGY 2399-3642 8 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10060719"><a href="/gui2/?type=authors&mode=browse&sel=10060719" target="_blank">Varga Zoltán K. ✉ (<span class="authorship-author-name">Varga Zoltán Kristóf</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Translational Behavioural Neuroscience Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068698"><a href="/gui2/?type=authors&mode=browse&sel=10068698" target="_blank">Pejtsik Diána (<span class="authorship-author-name">Pejtsik Diána</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Translational Behavioural Neuroscience Group; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Csorvási Tímea </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012928"><a href="/gui2/?type=authors&mode=browse&sel=10012928" target="_blank">Mikics Éva (<span class="authorship-author-name">Mikics Éva</span> <span class="authorAux-mtmt"> Neuroendokrinológia, viselkedésbiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Translational Behavioural Neuroscience Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009117"><a href="/gui2/?type=authors&mode=browse&sel=10009117" target="_blank">Miklósi Ádám (<span class="authorship-author-name">Miklósi Ádám</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Ethology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020565"><a href="/gui2/?type=authors&mode=browse&sel=10020565" target="_blank">Varga Máté ✉ (<span class="authorship-author-name">Varga Máté</span> <span class="authorAux-mtmt"> Fejlődésgenetika, zebrahal fejlődés</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/<span title="Institute of Biology">Bio_I</span>/Department of Genetics</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36272775" target="_blank">Paradise fish (Macropodus opercularis) as a complementary translational model for emotional and cognitive function</a></div> <div> <span class="journal-title">COMMUNICATIONS BIOLOGY</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2399-3642">2399-3642</a>)</span>: <span class="journal-volume">8</span> <span class="journal-issue">1</span> <span class="page"> Paper 1125. 13 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s42003-025-08556-0" target="_blank" href="https://doi.org/10.1038/s42003-025-08556-0"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001539751200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001539751200001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="120238" target="_blank" href="https://edit.elte.hu/handle/10831/120238"> EDIT </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="243204" target="_blank" href="https://real.mtak.hu/243204"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105012155079" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105012155079"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40731061" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40731061&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Agricultural and Biological Sciences (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 1</span> | Independent citation: 0 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 1 | Number of citations in Scopus:&nbsp;1 | WoS/Scopus assigned:&nbsp;1 | Number of citations with DOI:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36272775&sort=publishedYear,desc&sort=title"> Number of cited publications: 12 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36272775</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (1783-3/2018/FEKUTSRAT) Funder: Ministry of Human Capacities, (RRF-2.3.1-21-2022-00011), (BO/00555/22/8) </div> <div class="lastModified">Last Modified: 2026.05.05. 14:06 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2026.04.22. 10:11 Zsuzsa Aggod (MTMT 2-3, admin) </div> </div></div>