https://m2.mtmt.hu/ eng 2026-10-23 21:42 JournalArticle 36271633 VALIDATED true 0 false 2026-10-07T11:48:51.889+0000 2026-04-13T10:02:52.431+0000 2025-07-29T11:43:06.561+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin Tamásné Gere (SE_KK_Admin5_GT, admin) true 10062062 2026-08-31T11:30:24.518+0000 2025-09-12T09:33:45.316+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin Márta Molnár-Taga (SE 4-es admin) true 10062250 Admin 10025544 /api/admin/10025544 Katalin Lévayné Deseő (MTMT Központi admin) Lévayné Deseő Katalin true 10025544 true 2026-05-20T07:50:23.719+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Survey paper (Journal Article) 102 true 1134514 true 1 /api/category/1 Category Scientific true 1 Szabó, Dorottya true true /api/journal/10009651 REVIEWED JOURNAL OF NEUROINFLAMMATION 1742-2094 true false 10009651 false 10009651 true 1742-2094 Journal FOREIGN 22 1 192 192 17 2025 Immune activation in the prenatal and early postnatal periods is increasingly implicated in the aetiology of neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia, by disrupting critical neurodevelopmental processes. The impact of immune activation on brain development can be influenced by the type, timing, location, and severity of the infection. Viral, bacterial, and parasitic infections, as well as maternal autoimmune diseases, can lead to the activation of the purinergic P2X7 receptors, thereby contributing to neuroinflammation. Upon activation, P2X7 induces the assembly of the NLRP3 inflammasome, leading to the release of the pro-inflammatory cytokine IL-1β. Besides activation of additional inflammatory mediators, excessive IL-1β during critical periods of brain development can disrupt neuronal migration, synapse formation, dendritic morphology and blood-brain barrier integrity, contributing to a range of neurodevelopmental abnormalities. Animal studies have shown that inhibiting the components of the P2X7/NLRP3/IL-1β pathway can mitigate these adverse effects. This review examines the role of the P2X7/NLRP3/IL-1β pathway in mediating the effects of infection and neuronal inflammation on brain development. We discuss the therapeutic potential of targeting this pathway with a balanced approach that reduces long-term neuronal inflammation while preserving essential immune functions. Funding 2055626 /api/funding/2055626 (NAP2022-I-1/2022) Funder: HBR false true Funding 2055627 /api/funding/2055627 (RRF-2.3.1-21-2022-00011) false true Funding 2055628 /api/funding/2055628 Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Funder: NRDIO false true Funding 2055799 /api/funding/2055799 (Open access funding provided by Semmelweis University) false true true 2025 true true true false true false GOLD 2026-10-07 true https://doi.org/10.1186/s12974-025-03509-0 7 0 7 7 0 7 7 7 7 7 7 7 7 7 0 0 7 7 7 7 0 12 12 Folyóiratcikk Journal Article 24 7 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 7 7 7 7 D1 false 10008942 false false false 2025-08-06T07:53:36.133+0000 Doktori Iskola (SE); Molekuláris Farmakológia Kutatócsoport (HRN KOKI) 3 14 2 3 0 true 10025544 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 127436663 /api/authorship/127436663 Szabó, Dorottya [Szabó, Dorottya (neurofarmakológia), author] Laboratory of Molecular Pharmacology; School of PhD Studies (SU) 1 0.333 true false false Author 10067769 /api/author/10067769 Dorottya Szabó (neurofarmakológia) Szabó Dorottya true true Szabó Dorottya true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 127436664 /api/authorship/127436664 Otrokocsi, Lilla [Bereczkiné Otrokocsi, Lilla (élettudomány), author] Laboratory of Molecular Pharmacology 2 0.333 false false false Author 10055678 /api/author/10055678 Lilla Bereczkiné Otrokocsi (élettudomány) Bereczkiné Otrokocsi Lilla true 10055678 true Otrokocsi Lilla true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 127436665 /api/authorship/127436665 Sperlágh, Beáta ✉ [Sperlágh, Beáta (Neurofarmakológia), author] Laboratory of Molecular Pharmacology; 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The role of maternal infections in neurodevelopmental psychiatric disorders: focus on the P2X7/NLRP3/IL-1β signalling pathway. (2025) JOURNAL OF NEUROINFLAMMATION 1742-2094 22 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10067769"><a href="/gui2/?type=authors&mode=browse&sel=10067769" target="_blank">Szabó Dorottya (<span class="authorship-author-name">Szabó Dorottya</span> <span class="authorAux-mtmt"> neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Molecular Pharmacology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055678"><a href="/gui2/?type=authors&mode=browse&sel=10055678" target="_blank">Otrokocsi Lilla (<span class="authorship-author-name">Bereczkiné Otrokocsi Lilla</span> <span class="authorAux-mtmt"> élettudomány</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Molecular Pharmacology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008942"><a href="/gui2/?type=authors&mode=browse&sel=10008942" target="_blank">Sperlágh Beáta ✉ (<span class="authorship-author-name">Sperlágh Beáta</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Molecular Pharmacology; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36271633" target="_blank">The role of maternal infections in neurodevelopmental psychiatric disorders: focus on the P2X7/NLRP3/IL-1β signalling pathway</a></div> <div> <span class="journal-title">JOURNAL OF NEUROINFLAMMATION</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1742-2094">1742-2094</a>)</span>: <span class="journal-volume">22</span> <span class="journal-issue">1</span> <span class="page"> Paper 192. 17 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/s12974-025-03509-0" target="_blank" href="https://doi.org/10.1186/s12974-025-03509-0"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001538004900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001538004900001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="243215" target="_blank" href="https://real.mtak.hu/243215"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105011942907" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105011942907"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40713568" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40713568&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105011942907&doi=10.1186%2Fs12974-025-03509-0&partnerID=40&md5=678b5d3babd56c1ac66071f8973e7bc4" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105011942907&doi=10.1186%2Fs12974-025-03509-0&partnerID=40&md5=678b5d3babd56c1ac66071f8973e7bc4"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Immunology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Neurology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 7</span> | Independent citation: 7 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus:&nbsp;7 | WoS/Scopus assigned:&nbsp;7 | Number of citations with DOI:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36271633&sort=publishedYear,desc&sort=title"> Number of cited publications: 12 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36271633</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (NAP2022-I-1/2022) Funder: HBR, (RRF-2.3.1-21-2022-00011), Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Funder: NRDIO, (Open access funding provided by Semmelweis University) </div> <div class="lastModified">Last Modified: 2026.04.13. 12:02 Márta Turek (KOKI admin 4) </div> <div class="lockedBy">Centrally managed 2026.05.20. 09:50 Katalin Lévayné Deseő (MTMT Központi admin) </div> </div></div>