https://m2.mtmt.hu/ hun 2026-10-25 11:53 BookChapter 36259295 APPROVED true 0 false 2025-07-21T12:13:44.375+0000 2025-07-21T12:12:29.533+0000 2025-07-21T12:12:19.676+0000 true 10098688 Lantos Jonatán /api/admin/10098688 Admin Lantos Jonatán (Egis admin5) true 2025-07-21T12:12:29.781+0000 2025-07-21T12:12:29.781+0000 false false true 25 25 /api/publicationtype/25 PublicationType Könyvrészlet 2 true 25 BookChapter true 10000398 Chapter true 25 25 /api/publicationtype/25 PublicationType Könyvrészlet 2 true 25 BookChapter /api/subtype/10000398 Könyvfejezet SubType Könyvfejezet (Könyvrészlet) 220 true 10000398 true 1 /api/category/1 Category Tudományos true 1 Pessina, Daniele 2504 2509 2504 6 2025 Biomacromolecules have intricate crystallisation behaviour due to their size and many interactions in solution and can often only crystallise in narrow ranges of experimental conditions. High solute concentrations are needed for crystal nucleation and growth, exceeding those eluted upstream and therefore preventing the adoption of crystallisation in downstream separation steps. By promoting molecular aggregation and nucleation via a lowered energy barrier, heterogeneous surfaces or templates can relax the supersaturation requirements and widen the crystallisation operating space. Though templates are promising candidates for process optimisation, their experimental testing has generally been limited to small-volume experiments, and quantification of their impact on process intensification and quality metrics at higher volumes remains unexplored. To address the knowledge gap, a model-based investigation of template-induced protein crystallisation systems through evaluation of key metrics is presented. Porous silica nano-particles with three chemical functionalisations (hydroxyl, carboxyl and butyl) are added to batch lysozyme crystallisation experiments at 40ml. Crystallisation population balance models are parametrised with an experimentally-validated parameter estimation methodology and further experiments are simulated. The templates appear to lower the estimated interfacial energy compared to the homogeneous case, leading to nucleation rate profiles which are less dependent on supersaturation. For this reason, the templates can crystallize quicker than the homogeneous system, particularly at lower initial concentrations. The simulation results highlight the ability of heteronucleants to alter nucleation rate profiles, and their potential to be used as process optimisation and intensification tools for biomacromolecule purification. true 2025 true true true false false false NONE 2025-07-21 false 0 0 0 0 0 0 0 0 0 0 0 0 1 1 false false false false 2025-10-19T12:12:29.390+0000 7 15 0 7 0 true 2376 true 10002 English /api/language/10002 Angol Language Angol true 2 false true 11683 true 10021 /api/country/10021 Country Kanada true 17 /api/city/11683 City Hamilton, Kanada true 10000965 true 29553251 /api/publicationidentifier/29553251 https://doi.org/10.69997/sct.173479 10.69997/sct.173479 PublicationIdentifier DOI: 10.69997/sct.173479 true 6 DOI https://doi.org/@@@ /api/publicationsource/6 DOI PlainSource DOI true true 10001 /api/publicationsourcetype/10001 PublicationSourceType DOI true true 6 true false true 29553252 /api/publicationidentifier/29553252 https://www.worldcat.org/search?q=isbn%3A9781777940331 9781777940331 PublicationIdentifier ISBN: 9781777940331 true 122 ISBN https://www.worldcat.org/search?q=isbn%3A@@@ /api/publicationsource/122 ISBN PlainSource ISBN true true 10002 /api/publicationsourcetype/10002 PublicationSourceType Egyéb true false 122 true false /api/publication/36226279 VanImpe J. Proceedings of the 35th European Symposium on Computer Aided Process Engineering (ESCAPE 35). (2025) ISBN:9781777940331 true true 23 23 /api/publicationtype/23 PublicationType Könyv 3 true 23 Book false false 36226279 false true true true true 10000144 Conference proceedings true 23 23 /api/publicationtype/23 PublicationType Könyv 3 true 23 Book /api/subtype/10000144 Konferenciakötet SubType Konferenciakötet (Könyv) 345 true 10000144 false Book 2025 true 1 /api/category/1 Category Tudományos true 1 false Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 127351085 /api/authorship/127351085 Pessina, Daniele 1 0.14285715 true false false Pessina Daniele true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127351086 /api/authorship/127351086 Anda, Jorge Calderon de 2 0.14285715 false false false Anda Jorge Calderon de true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127351087 /api/authorship/127351087 Heffernan, Claire 3 0.14285715 false false false Heffernan Claire true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127351088 /api/authorship/127351088 Tian, Tony 4 0.14285715 false false false Tian Tony true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127351089 /api/authorship/127351089 Watson, Oliver 5 0.14285715 false false false Watson Oliver true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127351090 /api/authorship/127351090 Heng, Jerry Y. 6 0.14285715 false false false Heng Jerry Y. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127351091 /api/authorship/127351091 Papathanasiou, Maria M. 7 0.14285715 false true false Papathanasiou Maria M. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 29628782 /api/publicationidentifier/29628782 DOI: 10.69997/sct.131246 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true 10.69997/sct.131246 https://doi.org/10.69997/sct.131246 false true PublicationIdentifier 29628783 /api/publicationidentifier/29628783 Egyéb URL: https://PSEcommunity.org/LAPSE:2025.0554 PlainSource 40 /api/publicationsource/40 Egyéb URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true DIFFERENT https://PSEcommunity.org/LAPSE:2025.0554 https://PSEcommunity.org/LAPSE:2025.0554 false true Reference 66998751 /api/reference/66998751 1. 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(2025) Megjelent: Proceedings of the 35th European Symposium on Computer Aided Process Engineering (ESCAPE 35) pp. 2504-2509<div class="BookChapter Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Pessina Daniele </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Anda Jorge Calderon de </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heffernan Claire </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tian Tony </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Watson Oliver </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heng Jerry Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Papathanasiou Maria M. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36259295" target="_blank">Model-based approach to template-induced macromolecule crystallisation</a></div> <div class="InBook"><div class="chapter-in">In:</div> <div class="authors"> <div class="autype autype-1"> <span class="author-name" >VanImpe J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Léonard G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bhonsale SS </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Polanska M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Logist F </span> (szerk.) </div> </div> <div class="booktitle"><a href="/gui2/?mode=browse&params=publication;36226279" target="_blank">Proceedings of the 35th European Symposium on Computer Aided Process Engineering (ESCAPE 35) </a></div> <div class="conference"> Konferencia helye, ideje: <span class="location">Ghent, Belgium <span class="conference-date">2025.07.06. - 2025.07.09.</span> </div> <span class="publishedAt">Hamilton: <span class="publishers">PSE Press</span>, <span class="page"> pp 2504-2509 </span> <span class="year">(2025)</span> ( <span class="seriesTitle">Systems and Control Transactions</span> <span class="issn">2818-4734</span> <span class="seriesVolume">; 4</span>) </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.69997/sct.131246" target="_blank" href="https://doi.org/10.69997/sct.131246"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://PSEcommunity.org/LAPSE:2025.0554" target="_blank" href="https://PSEcommunity.org/LAPSE:2025.0554"> Egyéb URL </a> </span> </span> <span class="bookchapter-ids">Befoglaló link(ek):</span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.69997/sct.173479" target="_blank" href="https://doi.org/10.69997/sct.173479"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <span class="isbnOrIssn"> ISBN: </span> <a style="color:black" title="9781777940331" target="_blank" href="https://www.worldcat.org/search?q=isbn%3A9781777940331"> 9781777940331 </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36259295&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36259295</span> | <span class="status-data status-APPROVED"> Nyilvános </span> <span class="long-book-mtid">Befoglaló: 36226279</span> Idéző | <span class="type-subtype">Könyvrészlet ( Könyvfejezet ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData"></span> </div> <div class="lastModified">Utolsó módosítás: 2025.07.21. 14:12 Lantos Jonatán (Egis admin5) </div> </div> </div>