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      <title>Association of neonatal and fetal malformations with polyhydramnios and oligohydramnios - introduction of a new "association factor"</title>
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      <abstractText>Background
Our aim was to investigate the association of different neonatal and fetal anatomical abnormalities with polyhydramnios or oligohydramnios during prenatal ultrasonography.

Methods
In our study, we processed prenatal sonographic and postnatal neonatal clinical and pathological data from 2,622 fetuses with malformations over a 12-year period. We investigated the association of neonatal and fetal abnormalities with polyhydramnios or oligohydramnios. To characterize the prevalence of association between a given disorder and polyhydramnios or oligohydramnios, we used our proprietary “association factor” (AF) for statistical calculations.

Results
Amniotic fluid volume abnormalities were most frequently detected in urogenital, abdominal, and abdominal wall anomalies. In urogenital anomalies, amniotic fluid volume abnormalities were found in more than half of the fetuses, 54.86% (oligohydramnios 34.72%, polyhydramnios 20.14%). In abdominal and abdominal wall anomalies, 43.82% of fetuses had abnormalities in the volume of amniotic fluid (polyhydramnios 31.44%, oligohydramnios 12.38%). Overall, we found abnormalities in the volume of amniotic fluid in over 30% of the fetuses with craniospinal, thoracic and pulmonary anomalies, limb anomalies, and ossification disorders. In craniofacial and cardiovascular anomalies, amniotic fluid volume abnormalities were only detectable in around 20%. For polyhydramnios, the “Association Factor” (AF) was very high for craniospinal, abdominal, and abdominal wall disorders, and it was high for cardiovascular, urogenital, limb, and ossification disorders. For oligohydramnios, the association factor (AF) was very high for urogenital disorders.

Conclusions
If the amniotic fluid volume during ultrasonography is less or more than average, special attention should be paid to the ultrasound examination of the fetus’ urogenital system, abdominal organs, skull, spine, chest, lungs, as well as limbs and skeletal system. In the case of polyhydramnios, fetal echocardiography is recommended.</abstractText>
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      <label>Beke Artur et al. Association of neonatal and fetal malformations with polyhydramnios and oligohydramnios - introduction of a new "association factor". (2025) BMC PREGNANCY AND CHILDBIRTH 1471-2393 1471-2393 25 1</label><template>&lt;div class=&quot;JournalArticle Publication short-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;span class=&quot;author-name&quot; mtid=&quot;10000568&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10000568&quot; target=&quot;_blank&quot;&gt;Beke, Artur ✉&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10061557&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10061557&quot; target=&quot;_blank&quot;&gt;Simonyi, Atene&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; &lt;/div &gt;&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;36255302&quot; mtid=&quot;36255302&quot; target=&quot;_blank&quot;&gt;Association of neonatal and fetal malformations with polyhydramnios and oligohydramnios - introduction of a new &quot;association factor&quot;&lt;/a&gt;&lt;/div&gt; &lt;div class=&quot;pub-info&quot;&gt; &lt;span class=&quot;journal-title&quot;&gt;BMC PREGNANCY AND CHILDBIRTH&lt;/span&gt; &lt;span class=&quot;journal-volume&quot;&gt;25&lt;/span&gt; : &lt;span class=&quot;journal-issue&quot;&gt;1&lt;/span&gt; &lt;span class=&quot;page&quot;&gt; Paper: 707 , 14 p. &lt;/span&gt; &lt;span class=&quot;year&quot;&gt;(2025)&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;pub-end&quot;&gt;&lt;div class=&quot;identifier-list&quot;&gt; &lt;span class=&quot;identifiers&quot;&gt; &lt;span class=&quot;id identifier oa_GOLD&quot; title=&quot; Gold &quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;10.1186/s12884-025-07797-5&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1186/s12884-025-07797-5&quot;&gt; DOI &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;001522896000001&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/001522896000001&quot;&gt; 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&lt;span class=&quot;deleted-record&quot;&gt;Központi kezelésű&lt;/span&gt; &lt;span class=&quot;short-pub-mtid&quot;&gt; Közlemény:36255302 &lt;/span&gt; &lt;span class=&quot;status-holder&quot;&gt;&lt;span class=&quot;status-data status-VALIDATED&quot;&gt; Egyeztetett &lt;/span&gt;&lt;/span&gt; &lt;span class=&quot;pub-core&quot;&gt;Forrás &lt;/span&gt; &lt;span class=&quot;pub-type&quot;&gt;Folyóiratcikk (Szakcikk ) &lt;/span&gt; &lt;!-- &amp;&amp; !record.category.scientific --&gt; &lt;span class=&quot;pub-category&quot;&gt;Tudományos&lt;/span&gt; &lt;/div&gt; &lt;/div&gt; &lt;/div&gt;</template><template2>&lt;div class=&quot;JournalArticle Publication long-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;img title=&quot;Forrásközlemény&quot; style=&quot;float: left&quot; src=&quot;/frontend/resources/grid/publication-core-icon.png&quot;&gt; &lt;div class=&quot;autype autype0&quot;&gt; &lt;span class=&quot;author-name&quot; mtid=&quot;10000568&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10000568&quot; target=&quot;_blank&quot;&gt;Beke Artur ✉ (&lt;span class=&quot;authorship-author-name&quot;&gt;Beke Artúr&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Genetika, Szülészeti genetika, Szülészet-Nőgyóg...&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/&lt;span title=&quot;Szülészeti és Nőgyógyászati Klinika&quot;&gt;SZSZNK&lt;/span&gt;/Szülészeti és Nőgyógyászati Klinika Baross utcai részleg&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10061557&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10061557&quot; target=&quot;_blank&quot;&gt;Simonyi Atene (&lt;span class=&quot;authorship-author-name&quot;&gt;Simonyi Aténé Szandra&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Biológus, Doktorandusz&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/&lt;span title=&quot;Szülészeti és Nőgyógyászati Klinika&quot;&gt;SZSZNK&lt;/span&gt;/Szülészeti és Nőgyógyászati Klinika Baross utcai részleg&lt;/span&gt; &lt;/div&gt; &lt;/div&gt; &lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;36255302&quot; target=&quot;_blank&quot;&gt;Association of neonatal and fetal malformations with polyhydramnios and oligohydramnios - introduction of a new &quot;association factor&quot;&lt;/a&gt;&lt;/div&gt; &lt;div&gt; &lt;span class=&quot;journal-title&quot;&gt;BMC PREGNANCY AND CHILDBIRTH&lt;/span&gt; &lt;span class=&quot;journal-issn&quot;&gt;(&lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/1471-2393&quot;&gt;1471-2393&lt;/a&gt; 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PubMed &lt;/a&gt; &lt;/span&gt; &lt;/span&gt; &lt;OnlyViewableByAuthor&gt;&lt;div class=&quot;ratings&quot;&gt; &lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Obstetrics and Gynecology&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q1&lt;/div&gt; &lt;/div&gt;&lt;/OnlyViewableByAuthor&gt;   &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Közlemény: 36255302&lt;/span&gt; | &lt;span class=&quot;status-data status-VALIDATED&quot;&gt; Egyeztetett &lt;/span&gt; Forrás | &lt;span class=&quot;type-subtype&quot;&gt;Folyóiratcikk ( Szakcikk ) &lt;/span&gt; | &lt;span class=&quot;pub-category&quot;&gt;Tudományos&lt;/span&gt; | &lt;span class=&quot;publication-sourceOfData&quot;&gt;WOS TAGGED&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;funder&quot;&gt; (Open access funding provided by Semmelweis University) &lt;/div&gt; &lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.02.04. 12:18 Kovács Marcell (MTMT Közp., admin) &lt;/div&gt; 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