https://m2.mtmt.hu/ hun 2026-09-21 03:10 JournalArticle 36249180 VALIDATED true * Megosztott szerzőség 0 false 2026-08-27T09:45:43.169+0000 2026-05-22T14:34:25.142+0000 2025-07-15T13:22:15.877+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Milánkovics Róbert (PTE ÁOK admin 4) true 10039043 2026-08-27T09:44:16.922+0000 2026-05-22T14:34:25.392+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Milánkovics Róbert (PTE ÁOK admin 4) true 10039043 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin (MTMT Központi admin) Lévayné Deseő Katalin true 10025544 true 2026-06-09T18:54:13.371+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Tóth, Norbert true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 26 14 6695 6695 17 2025 Endometriosis is the extrauterine engraftment of endometrium-like tissue, causing chronic pain. Complex sensory–vascular–immune interactions, including growth factors, cytokines, and neuropeptides, are implicated in its pathophysiology, but the mechanisms remain unknown. Here, epidermal growth factor (EGF), vascular endothelial growth factor, interleukins (IL-1β, IL-6, IL-8), macrophage migration inhibitory factor (MIF), calcitonin gene-related peptide, and somatostatin were measured in the serum of endometriosis patients with different disease severities, menstruation cycle- and pharmacotherapy-related hormonal status compared with controls. Mediator levels in deep-infiltrating rectosigmoid nodules were also compared with those in non-endometriotic colon tissues. Pain was assessed by the visual analogue scale. Serum EGF was significantly lower in mild endometriosis and in the secretory phase. MIF and IL-6 were higher in stage I–IV endometriosis, with MIF also higher in the secretory phase and in patients not receiving oral contraceptives. Somatostatin was lower in mild endometriosis than that in healthy individuals and the severe endometriosis group. No tissue-level differences were found. A strong positive correlation between serum EGF and somatostatin levels and dysmenorrhea and dysuria was detected in mild cases. It is concluded that certain serum alterations may be related to severity- and hormone status-dependent endometriosis mechanisms, but their diagnostic/prognostic value seems to be limited due to variability and lack of specificity. Funding 2055366 /api/funding/2055366 Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Támogató: NKFIH false true Funding 2055367 /api/funding/2055367 (TKP2021-EGA-13) false true Funding 2055368 /api/funding/2055368 (GYTK KA-2024-02) false true Funding 2055369 /api/funding/2055369 (NKFIH K 138046) false true Funding 2055370 /api/funding/2055370 (BO/00496/21/5) Támogató: Bolyai János Kutatási Ösztöndíj false true true 2025 true true true false false GOLD 2026-08-27 true https://doi.org/10.3390/ijms26146695 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 9 D1 false 10037331 false false false 2025-07-14T13:42:57.102+0000 Bioanalitikai Intézet (PTE / ÁOK); Farmakológiai és Farmakoterápiai Intézet (PTE / ÁOK); Gyógyszerhatástani Tanszék (PTE / GYTK); HUN-REN-PTE Krónikus Fájdalom Kutatócsoport (PTE / KCS); Orvosi Biológiai Intézet (PTE / ÁOK); Szülészeti és Nőgyógyászati Klinika Baross utca... (SE / AOK / K / SZSZNK); Élettani és biokémiai tanszék (ÁTE / ATI) 8 47 7 8 0 true 10025544 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 127276524 /api/authorship/127276524 Tóth, Norbert [Tóth, Norbert (Biotechnológia), szerző] Farmakológiai és Farmakoterápiai Intézet (PTE / ÁOK) 1 0.125 true false false Author 10082224 /api/author/10082224 Tóth Norbert (Biotechnológia) Tóth Norbert true true Tóth Norbert true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127276525 /api/authorship/127276525 Brubel, Réka* [Brubel, Réka (szülészet-nőgyógy...), szerző] Szülészeti és Nőgyógyászati Klinika Baross utca... (SE / AOK / K / SZSZNK) 2 0.125 true false false Author 10021063 /api/author/10021063 Brubel Réka (szülészet-nőgyógyászat, Orvostudomány) Brubel Réka true 10021063 true Brubel Réka true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127276526 /api/authorship/127276526 Bokor, Attila [Bokor, Attila (szülészet, nőgyóg...), szerző] Szülészeti és Nőgyógyászati Klinika Baross utca... (SE / AOK / K / SZSZNK) 3 0.125 false false false Author 10026013 /api/author/10026013 Bokor Attila (szülészet, nőgyógyászat) Bokor Attila true 10026013 true Bokor Attila true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127276527 /api/authorship/127276527 Kemény, Ágnes [Kemény, Ágnes (Molekuláris biológia), szerző] Farmakológiai és Farmakoterápiai Intézet (PTE / ÁOK); Orvosi Biológiai Intézet (PTE / ÁOK); Élettani és biokémiai tanszék (ÁTE / ATI) 4 0.125 false false false Author 10018850 /api/author/10018850 Kemény Ágnes (Molekuláris biológia) Kemény Ágnes true 10018850 true Kemény Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127276528 /api/authorship/127276528 Farkas, Nelli [Borbásné Farkas, Kornélia (Membránbiokémia, ...), szerző] Bioanalitikai Intézet (PTE / ÁOK) 5 0.125 false false false Author 10015357 /api/author/10015357 Borbásné Farkas Kornélia (Membránbiokémia, biostatisztika) Borbásné Farkas Kornélia true 10015357 true Farkas Nelli true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127276529 /api/authorship/127276529 Pál, Tibor [Pál, Tibor (Pszichiátria), szerző] Farmakológiai és Farmakoterápiai Intézet (PTE / ÁOK) 6 0.125 false false false Author 10104306 /api/author/10104306 Pál Tibor (Pszichiátria) Pál Tibor true true Pál Tibor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127276530 /api/authorship/127276530 Helyes, Zsuzsanna ✉ [Helyes, Zsuzsanna (Neurofarmakológia), szerző] HUN-REN-PTE Krónikus Fájdalom Kutatócsoport (PTE / KCS); Farmakológiai és Farmakoterápiai Intézet (PTE / ÁOK) 7 0.125 false false true Author 10001426 /api/author/10001426 Helyes Zsuzsanna (Neurofarmakológia) Helyes Zsuzsanna true 10001426 true Helyes Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127276531 /api/authorship/127276531 Pohóczky, Krisztina [Pohóczky, Krisztina (Molekuláris bioló...), szerző] Gyógyszerhatástani Tanszék (PTE / GYTK); HUN-REN-PTE Krónikus Fájdalom Kutatócsoport (PTE / KCS); Farmakológiai és Farmakoterápiai Intézet (PTE / ÁOK) 8 0.125 false true false Author 10037331 /api/author/10037331 Pohóczky Krisztina (Molekuláris biológia, Farmakológia) Pohóczky Krisztina true 10037331 true Pohóczky Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 29603024 /api/publicationidentifier/29603024 DOI: 10.3390/ijms26146695 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms26146695 https://doi.org/10.3390/ijms26146695 false true PublicationIdentifier 29700665 /api/publicationidentifier/29700665 WoS: 001535870300001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001535870300001 https://www.webofscience.com/wos/woscc/full-record/001535870300001 true true PublicationIdentifier 29698447 /api/publicationidentifier/29698447 Scopus: 105011871374 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105011871374 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105011871374 true true PublicationIdentifier 29700666 /api/publicationidentifier/29700666 PubMed: 40724945 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40724945 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40724945&dopt=Abstract true true SjrRating 11593300 /api/sjrrating/11593300 sjr:D1 (2025) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 5 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 66897544 /api/reference/66897544 1. 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Disease Severity- and Hormonal Status-Dependent Alterations of EGF and MIF in the Serum of Endometriosis Patients. (2025) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 26 14<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10082224"><a href="/gui2/?type=authors&mode=browse&sel=10082224" target="_blank">Tóth Norbert (<span class="authorship-author-name">Tóth Norbert</span> <span class="authorAux-mtmt"> Biotechnológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021063"><a href="/gui2/?type=authors&mode=browse&sel=10021063" target="_blank">Brubel Réka^* (<span class="authorship-author-name">Brubel Réka</span> <span class="authorAux-mtmt"> szülészet-nőgyógyászat, Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Baross utcai részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026013"><a href="/gui2/?type=authors&mode=browse&sel=10026013" target="_blank">Bokor Attila (<span class="authorship-author-name">Bokor Attila</span> <span class="authorAux-mtmt"> szülészet, nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Baross utcai részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018850"><a href="/gui2/?type=authors&mode=browse&sel=10018850" target="_blank">Kemény Ágnes (<span class="authorship-author-name">Kemény Ágnes</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Biológiai Intézet; <span title="Állatorvostudományi Egyetem">ÁTE</span>/<span title="Alaptudományi Intézet">ATI</span>/Élettani és biokémiai tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015357"><a href="/gui2/?type=authors&mode=browse&sel=10015357" target="_blank">Farkas Nelli (<span class="authorship-author-name">Borbásné Farkas Kornélia</span> <span class="authorAux-mtmt"> Membránbiokémia, biostatisztika</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Bioanalitikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10104306"><a href="/gui2/?type=authors&mode=browse&sel=10104306" target="_blank">Pál Tibor (<span class="authorship-author-name">Pál Tibor</span> <span class="authorAux-mtmt"> Pszichiátria</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001426"><a href="/gui2/?type=authors&mode=browse&sel=10001426" target="_blank">Helyes Zsuzsanna ✉ (<span class="authorship-author-name">Helyes Zsuzsanna</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Kutatócsoportok">KCS</span>/HUN-REN-PTE Krónikus Fájdalom Kutatócsoport; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037331"><a href="/gui2/?type=authors&mode=browse&sel=10037331" target="_blank">Pohóczky Krisztina (<span class="authorship-author-name">Pohóczky Krisztina</span> <span class="authorAux-mtmt"> Molekuláris biológia, Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Tanszék; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Kutatócsoportok">KCS</span>/HUN-REN-PTE Krónikus Fájdalom Kutatócsoport; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36249180" target="_blank">Disease Severity- and Hormonal Status-Dependent Alterations of EGF and MIF in the Serum of Endometriosis Patients</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">14</span> <span class="page"> Paper 6695. 17 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms26146695" target="_blank" href="https://doi.org/10.3390/ijms26146695"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001535870300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001535870300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105011871374" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105011871374"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40724945" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40724945&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36249180&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36249180</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">DOI XML</span> </div> <div class="funder"> Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Támogató: NKFIH, (TKP2021-EGA-13), (GYTK KA-2024-02), (NKFIH K 138046), (BO/00496/21/5) Támogató: Bolyai János Kutatási Ösztöndíj </div> <div class="lastModified">Utolsó módosítás: 2026.05.22. 16:34 Milánkovics Róbert (PTE ÁOK admin 4) </div> <div class="lockedBy">Központi kezelésű 2026.06.09. 20:54 Lévayné Deseő Katalin (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div>