https://m2.mtmt.hu/ eng 2026-10-23 09:44 JournalArticle 36238550 VALIDATED true 0 false 2026-09-07T10:06:25.515+0000 2026-08-18T10:52:11.297+0000 2025-07-09T09:30:04.797+0000 true 10000649 Buday László /api/author/10000649 Author true 10000649 2026-08-18T10:52:11.563+0000 2026-08-18T10:52:11.563+0000 2025-08-29T13:09:49.640+0000 true 10019782 Csámer Iván /api/admin/10019782 Admin true 10019782 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-05-28T10:32:43.016+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 László, L. Integrative analysis of RAS signaling effectors reveals stage-dependent oncogenic patterns in colon adenocarcinoma true false /api/journal/10037136 REVIEWED true false 10037136 true 10037136 true 2215-017X Journal FOREIGN 47 e00902 e00902 18 2025 Cancer rarely results from a single gene defect but emerges from disruptions in complex cellular networks. The Network Medicine perspective guides our investigation of cancer-driving interactions, particularly focusing on RAS signaling pathways that are key mediator for cancer development. We analyzed gene expression patterns in colon and lung cancers to identify stage-specific molecular drivers. Using computational modelling combined with patient tissue analysis, we discovered five key genes that are specifically altered in early-stage colon cancer: RAF1, PLCE1, RGL1, RIN1, and GRB7. These genes work as RAS effectors in signaling and can effectively distinguish between normal and cancerous colon tissue. Our approach combines network analysis with gene expression studies to understand how RAS signaling disruption contributes to colon cancer development. These findings suggest that targeting early-stage RAS-related changes could offer therapeutic opportunities before cancer becomes more complex and harder to treat. © 2025 Funding 2055044 /api/funding/2055044 false true Funding 2055045 /api/funding/2055045 false true Funding 2055046 /api/funding/2055046 false true Funding 2055047 /api/funding/2055047 false true true true 2025 true true true false true false GOLD 2026-09-07 true https://doi.org/10.1016/j.btre.2025.e00902 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 3 3 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 1 1 1 Q1 false 10076637 false false false 2025-08-21T07:55:33.653+0000 Biológia Doktori Iskola (ELTE / TTK); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI); Molekuláris Élettudományi Intézet (HRN TTK) 6 22 3 6 0 false 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 127194029 /api/authorship/127194029 1 0.167 true false false Author 10076637 /api/author/10076637 László Loretta true true László L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127194030 /api/authorship/127194030 2 0.167 false false true Author 10047923 /api/author/10047923 Lovrics Anna true 10047923 true Lovrics A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127194031 /api/authorship/127194031 3 0.167 false false false Author 10082437 /api/author/10082437 Tilajka Álmos true true Tilajka Á. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127194032 /api/authorship/127194032 4 0.167 false false false Author 10076635 /api/author/10076635 Takács Tamás true true Takács T. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127194033 /api/authorship/127194033 5 0.167 false false false Author 10000649 /api/author/10000649 Buday László true 10000649 true Buday L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127194034 /api/authorship/127194034 6 0.167 false true true Author 10000695 /api/author/10000695 Vas Virág true 10000695 true Vas V. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29579181 /api/publicationidentifier/29579181 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1016/j.btre.2025.e00902 https://doi.org/10.1016/j.btre.2025.e00902 false true PublicationIdentifier 29579180 /api/publicationidentifier/29579180 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105009224478 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105009224478 false true PublicationIdentifier 29731050 /api/publicationidentifier/29731050 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://linkinghub.elsevier.com/retrieve/pii/S2215017X25000293 https://linkinghub.elsevier.com/retrieve/pii/S2215017X25000293 false true Keyword 1016383 /api/keyword/1016383 true 1016383 true Keyword 1048091 /api/keyword/1048091 true 1048091 true Keyword 1898726 /api/keyword/1898726 true true Keyword 1903386 /api/keyword/1903386 true true Keyword 2119665 /api/keyword/2119665 true true Keyword 2518051 /api/keyword/2518051 true true Keyword 2628664 /api/keyword/2628664 true true Keyword 3271984 /api/keyword/3271984 true true Keyword 3505617 /api/keyword/3505617 true true Keyword 3886494 /api/keyword/3886494 true true Keyword 3886495 /api/keyword/3886495 true true SjrRating 11556171 /api/sjrrating/11556171 24 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2402 /api/classificationexternal/2402 true 2402 true Q1 DIRECT true true /api/publication/36238550 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10076637"><a href="/gui2/?type=authors&mode=browse&sel=10076637" target="_blank">László L. (<span class="authorship-author-name">László Loretta</span> <span class="authorAux-mtmt"> természettudomány</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences; <span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/Doctoral School of Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10047923"><a href="/gui2/?type=authors&mode=browse&sel=10047923" target="_blank">Lovrics A. ✉ (<span class="authorship-author-name">Lovrics Anna</span> <span class="authorAux-mtmt"> matematikai modellezés</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10082437"><a href="/gui2/?type=authors&mode=browse&sel=10082437" target="_blank">Tilajka Á. (<span class="authorship-author-name">Tilajka Álmos</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076635"><a href="/gui2/?type=authors&mode=browse&sel=10076635" target="_blank">Takács T. (<span class="authorship-author-name">Takács Tamás</span> <span class="authorAux-mtmt"> Természettudomány</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences; <span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/Doctoral School of Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000649"><a href="/gui2/?type=authors&mode=browse&sel=10000649" target="_blank">Buday L. (<span class="authorship-author-name">Buday László</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000695"><a href="/gui2/?type=authors&mode=browse&sel=10000695" target="_blank">Vas V. ✉ (<span class="authorship-author-name">Vas Virág</span> <span class="authorAux-mtmt"> Őssejt biológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/Institute of Molecular Life Sciences</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36238550" target="_blank">Integrative analysis of RAS signaling effectors reveals stage-dependent oncogenic patterns in colon adenocarcinoma</a></div> <div> <span class="journal-title">BIOTECHNOLOGY REPORTS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2215-017X">2215-017X</a> )</span>: <span class="journal-volume">47</span> <span class="page"> Paper e00902. 18 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.btre.2025.e00902" target="_blank" href="https://doi.org/10.1016/j.btre.2025.e00902"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105009224478" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105009224478"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://linkinghub.elsevier.com/retrieve/pii/S2215017X25000293" target="_blank" href="https://linkinghub.elsevier.com/retrieve/pii/S2215017X25000293"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Applied Microbiology and Biotechnology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Biotechnology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 1</span> | Independent citation: 1 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 1 | Number of citations in Scopus:&nbsp;1 | WoS/Scopus assigned:&nbsp;1 | Number of citations with DOI:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36238550&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36238550</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (K124045) Funder: NKFIH, (2020–1.1.6-JÖVŐ-2021-00004), (153377), Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Funder: NRDIO </div> <div class="lastModified">Last Modified: 2026.08.18. 12:52 András Balázs (MTMT Központ, admin) </div> <div class="lockedBy">Centrally managed 2026.05.28. 12:32 Katalin Lévayné Deseő (MTMT Központi admin) </div> </div></div>