https://m2.mtmt.hu/ hun 2026-09-20 15:29 JournalArticle 36230128 VALIDATED true 0 false 2026-08-06T08:59:46.642+0000 2026-08-06T08:56:42.948+0000 2025-07-07T06:32:56.918+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-08-06T08:45:53.161+0000 2026-08-06T08:45:53.161+0000 2026-08-06T08:56:43.270+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Horváth, Hanga Réka A national survey of four decades of hereditary angioedema prophylaxis: Efficacy and safety of old and new drugs true true /api/journal/16674 REVIEWED true false 16674 false 16674 true 1521-6616 1521-7035 Journal FOREIGN 279 110542 110542 11 2025 Background: Hereditary angioedema (HAE) imposes a significant burden on patients due to the unpredictability of attacks. Long-term prophylaxis (LTP) aims to prevent these episodes and improve quality of life. Over the past five decades, LTP options have evolved from non-specific treatments (fresh frozen plasma, attenuated androgens, antifibrinolytics) to more targeted therapies (intravenous or subcutaneous C1 inhibitor (C1INH), lanadelumab, berotralstat). Objective: To assess the use, efficacy, and safety of various LTP therapies among Hungarian HAE patients. Methods: Data from the Hungarian HAE Registry (1979-2023) were analysed, including LTP usage, attack rates, side effects, and laboratory parameters. Results: Danazol and tranexamic acid use increased over the first 30 years but has declined in the last decade. Conversely, the use of modern LTP therapies and the proportion of patients relying solely on on-demand medication have significantly increased over the past decade. Danazol and tranexamic acid reduced attack rates in 60 % of patients without significant changes in the laboratory parameters at the lowest effective doses. Furthermore, 100 % of patients on subcutaneous C1INH, lanadelumab, and berotralstat experienced fewer attacks and improved quality of life compared to pre-treatment periods, with no serious side effects or significant laboratory abnormalities. Conclusion: Modern prophylaxis usage is increasing among Hungarian HAE-C1INH patients, following the global trends. Both modern and traditional LTP options proved safe and effective in our patient population when used with appropriate monitoring. Funding 2054875 /api/funding/2054875 false true true true 2025 true true true false true false NONE 2026-08-06 false 4 0 4 3 1 4 4 4 4 4 4 3 3 3 1 0 4 3 4 3 0 18 18 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 3 3 3 3 2026 0 1 0 1 0 Q2 false false false false 2025-07-06T06:41:27.916+0000 Belgyógyászati és Hematológiai Klinika (SE / AOK / K); Gyermekgyógyászati Klinika (SE / AOK / K); Reumatológiai és Immunológiai Klinika (SE / KKP) 8 26 3 8 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 127142385 /api/authorship/127142385 1 0.125 true false false Author 10064520 /api/author/10064520 Horváth Hanga Réka true 10064520 true Horváth Hanga Réka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127142386 /api/authorship/127142386 2 0.125 false false false Author 10053408 /api/author/10053408 Visy Beáta true 10053408 true Visy Beáta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127142387 /api/authorship/127142387 3 0.125 false false false Author 10048193 /api/author/10048193 Kőhalmi Kinga Viktória true 10048193 true Kőhalmi Kinga Viktória true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127142388 /api/authorship/127142388 4 0.125 false false false Author 10072564 /api/author/10072564 Balla Zsuzsanna Erika true true Balla Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127142389 /api/authorship/127142389 5 0.125 false false false Author 10075769 /api/author/10075769 Andrási Noémi true true Andrási Noémi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127142390 /api/authorship/127142390 6 0.125 false false false Author 10032279 /api/author/10032279 Czaller Ibolya true 10032279 true Czaller Ibolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127142391 /api/authorship/127142391 7 0.125 false false false Author 10048036 /api/author/10048036 Zotter Zsuzsanna true 10048036 true Zotter Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127142392 /api/authorship/127142392 8 0.125 false true true Author 10009711 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/api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105010136544 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105010136544 true true PublicationIdentifier 29561342 /api/publicationidentifier/29561342 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40513629 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40513629&dopt=Abstract false true Classification 12146 /api/classification/12146 true true Keyword 183 /api/keyword/183 true 183 true Keyword 4591 /api/keyword/4591 true 4591 true Keyword 6489 /api/keyword/6489 true 6489 true Keyword 16815 /api/keyword/16815 true 16815 true Keyword 1003532 /api/keyword/1003532 true 1003532 true Keyword 1019682 /api/keyword/1019682 true 1019682 true Keyword 1020136 /api/keyword/1020136 true 1020136 true Keyword 1020145 /api/keyword/1020145 true 1020145 true Keyword 1020191 /api/keyword/1020191 true 1020191 true Keyword 1605148 /api/keyword/1605148 true true Keyword 1897247 /api/keyword/1897247 true true Keyword 1897247 /api/keyword/1897247 true true Keyword 2327733 /api/keyword/2327733 true true Keyword 3132209 /api/keyword/3132209 true true Keyword 3321282 /api/keyword/3321282 true true Keyword 3885541 /api/keyword/3885541 true true SjrRating 11591414 /api/sjrrating/11591414 69 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2403 /api/classificationexternal/2403 true 2403 true Q2 DIRECT true true /api/publication/36230128 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10064520"><a href="/gui2/?type=authors&mode=browse&sel=10064520" target="_blank">Horváth Hanga Réka (<span class="authorship-author-name">Horváth Hanga Réka</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053408"><a href="/gui2/?type=authors&mode=browse&sel=10053408" target="_blank">Visy Beáta (<span class="authorship-author-name">Visy Beáta</span> <span class="authorAux-mtmt"> Csecsemő- és gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048193"><a href="/gui2/?type=authors&mode=browse&sel=10048193" target="_blank">Kőhalmi Kinga Viktória (<span class="authorship-author-name">Kőhalmi Kinga Viktória</span> <span class="authorAux-mtmt"> immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Klinikai Központ (karhoz nem tartozó egységek)">KKP</span>/Reumatológiai és Immunológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072564"><a href="/gui2/?type=authors&mode=browse&sel=10072564" target="_blank">Balla Zsuzsanna (<span class="authorship-author-name">Balla Zsuzsanna Erika</span> <span class="authorAux-mtmt"> Fül- orr- gégészet, fej- nyaksebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075769"><a href="/gui2/?type=authors&mode=browse&sel=10075769" target="_blank">Andrási Noémi (<span class="authorship-author-name">Andrási Noémi</span> <span class="authorAux-mtmt"> gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032279"><a href="/gui2/?type=authors&mode=browse&sel=10032279" target="_blank">Czaller Ibolya (<span class="authorship-author-name">Czaller Ibolya</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048036"><a href="/gui2/?type=authors&mode=browse&sel=10048036" target="_blank">Zotter Zsuzsanna (<span class="authorship-author-name">Zotter Zsuzsanna</span> <span class="authorAux-mtmt"> orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009711"><a href="/gui2/?type=authors&mode=browse&sel=10009711" target="_blank">Farkas Henriette ✉ (<span class="authorship-author-name">Farkas Henriette</span> <span class="authorAux-mtmt"> klinikai immunológus, allergológus</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36230128" target="_blank">A national survey of four decades of hereditary angioedema prophylaxis: Efficacy and safety of old and new drugs</a></div> <div> <span class="journal-title">CLINICAL IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1521-6616">1521-6616</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1521-7035">1521-7035</a>)</span>: <span class="journal-volume">279</span> <span class="page"> Paper 110542. 11 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.clim.2025.110542" target="_blank" href="https://doi.org/10.1016/j.clim.2025.110542"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001514034400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001514034400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105010136544" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105010136544"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40513629" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40513629&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 3 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36230128&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 18 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36230128</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (EKÖP-2024-31) </div> <div class="lastModified">Utolsó módosítás: 2026.08.06. 10:56 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> </div></div>