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      <abstractText>Schizophrenia is a lifelong mental disorder associated with cognitive dysfunctions. Comorbid metabolic dysregulations, such as diabetes and insulin resistance, may further deteriorate cognitive functions. It is therefore essential to investigate the effects of these metabolic disturbances on cognition in this population. A systematic review and meta-analysis following PRISMA guidelines was conducted using data from five databases: Medline, Embase, CENTRAL, Scopus, and Web of science. Of the 26 studies included, 9 were meta-analyzed with random effects model. The search was completed on November 23, 2023 and updated on April 2, 2025. We examined the cognitive functions of schizophrenia patients with and without diabetes or insulin resistance, using standardized mean differences (SMD) or mean differences (MD) as outcomes. The review section provides an overview of the literature on the relationship between glucose homeostasis and cognitive functions. The risk of bias was assessed using the QUIPS tool. There is a clear trend suggesting that diabetes exacerbates cognitive dysfunction in schizophrenia (global cognition: SMD=-0.26; P = 0.1087; 95% CI, -0.59 to 0.08), particularly in domains such as reasoning (SMD=-0.40; P = 0.0109, 95% CI -0.58 to -0.22) and processing speed (SMD=-0.43; P = 0.0005, 95% CI -0.52 to -0.35). Conflicting results were observed in studies on insulin resistance (global cognition: SMD=-0.12; P = 0.5890; 95% CI -0.91 to 0.68). Our findings suggest that glucose metabolism dysregulations might worsen cognitive dysfunctions in schizophrenia. However, further research is needed with larger samples and less heterogeneous studies to investigate if the effect is statistically significant. Addressing these metabolic issues could help improve cognitive and functional outcomes in schizophrenia patients.</abstractText>
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&lt;span class=&quot;authorAux-mtmt&quot;&gt; Pszichiátria&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10082452&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10082452&quot; target=&quot;_blank&quot;&gt;Virág-Tulassay Eszter Éva (&lt;span class=&quot;authorship-author-name&quot;&gt;Virág-Tulassay Eszter&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; ortopédia&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Ortopédiai Klinika; 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target=&quot;_blank&quot;&gt;Kiss-Dala Szilvia (&lt;span class=&quot;authorship-author-name&quot;&gt;Kiss-Dala Szilvia&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Statisztika&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10055054&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10055054&quot; target=&quot;_blank&quot;&gt;Horváth András Attila (&lt;span class=&quot;authorship-author-name&quot;&gt;Horváth András Attila&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; neurológia&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Intézet&quot;&gt;I&lt;/span&gt;/Anatómiai, Szövet- és Fejlődéstani Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ; &lt;span title=&quot;HUN-REN Természettudományi Kutatóközpont&quot;&gt;HRN TTK&lt;/span&gt;/&lt;span title=&quot;Kognitív Idegtudományi és Pszichológiai Intézet&quot;&gt;KPI&lt;/span&gt;/Integratív Idegtudományi Kutatócsoport; Nyírő Gyula Országos Pszichiátriai és Addiktológiai Intézet&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10002629&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10002629&quot; target=&quot;_blank&quot;&gt;Hegyi Péter (&lt;span class=&quot;authorship-author-name&quot;&gt;Hegyi Péter&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Gasztroenterológia&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Pécsi Tudományegyetem&quot;&gt;PTE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;ÁOK&lt;/span&gt;/Transzlációs Medicina Intézet; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Általános Orvostudományi Kar&quot;&gt;AOK&lt;/span&gt;/&lt;span title=&quot;Klinikum&quot;&gt;K&lt;/span&gt;/Pankreász Betegségek Intézete; &lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10010441&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10010441&quot; target=&quot;_blank&quot;&gt;Kéri Szabolcs ✉ (&lt;span class=&quot;authorship-author-name&quot;&gt;Kéri Szabolcs&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; Pszichiátria&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis Egyetem&quot;&gt;SE&lt;/span&gt;/&lt;span title=&quot;Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)&quot;&gt;KSZE&lt;/span&gt;/Transzlációs Medicina Központ; &lt;span title=&quot;Szegedi Tudományegyetem&quot;&gt;SZTE&lt;/span&gt;/&lt;span title=&quot;Szent-Györgyi Albert Orvostudományi Kar&quot;&gt;SZAOK&lt;/span&gt;/Élettani Intézet; &lt;span title=&quot;Tokaj-Hegyalja Egyetem&quot;&gt;THE&lt;/span&gt;/Sztárai Intézet&lt;/span&gt; &lt;/div&gt; &lt;/div&gt; &lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;36229839&quot; target=&quot;_blank&quot;&gt;Glucose homeostasis and cognitive functions in schizophrenia: a systematic review and meta-analysis&lt;/a&gt;&lt;/div&gt; &lt;div&gt; &lt;span class=&quot;journal-title&quot;&gt;SCIENTIFIC REPORTS&lt;/span&gt; &lt;span class=&quot;journal-issn&quot;&gt;( &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/2045-2322&quot;&gt;2045-2322&lt;/a&gt;)&lt;/span&gt;: &lt;span class=&quot;journal-volume&quot;&gt;15&lt;/span&gt; &lt;span class=&quot;journal-issue&quot;&gt;1&lt;/span&gt; &lt;span class=&quot;page&quot;&gt; Paper 22898. 14 p. &lt;/span&gt; &lt;span class=&quot;year&quot;&gt;(2025)&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;pub-footer&quot;&gt;  &lt;span class=&quot;language&quot; xmlns=&quot;http://www.w3.org/1999/html&quot;&gt;Nyelv: Angol | &lt;/span&gt; &lt;span class=&quot;identifiers&quot;&gt; &lt;span class=&quot;id identifier oa_GOLD&quot; title=&quot; Gold &quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;10.1038/s41598-025-06225-0&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1038/s41598-025-06225-0&quot;&gt; DOI &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;001523022000009&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/001523022000009&quot;&gt; WoS &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;105009550076&quot; target=&quot;_blank&quot; href=&quot;http://www.scopus.com/record/display.url?origin=inward&amp;eid=2-s2.0-105009550076&quot;&gt; Scopus &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;40594261&quot; target=&quot;_blank&quot; href=&quot;http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=40594261&amp;dopt=Abstract&quot;&gt; PubMed &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_GREEN&quot; title=&quot; Green &quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;39547&quot; target=&quot;_blank&quot; href=&quot;http://publicatio.bibl.u-szeged.hu/39547&quot;&gt; SZTE Publicatio &lt;/a&gt; &lt;/span&gt; &lt;/span&gt; &lt;OnlyViewableByAuthor&gt;&lt;div class=&quot;ratings&quot;&gt; &lt;div class=&quot;journal-subject&quot;&gt;Folyóirat szakterülete: Scopus - Multidisciplinary&amp;nbsp;&amp;nbsp;&amp;nbsp;SJR indikátor:&amp;nbsp;Q1&lt;/div&gt; &lt;div class=&quot;journal-subject&quot;&gt;Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&amp;nbsp;&amp;nbsp;&amp;nbsp;A nemzetközi&lt;/div&gt; &lt;div class=&quot;journal-subject&quot;&gt;Regionális Tudományok Bizottsága IXGJO RTB [1901-]&amp;nbsp;&amp;nbsp;&amp;nbsp;B nemzetközi&lt;/div&gt; &lt;/div&gt;&lt;/OnlyViewableByAuthor&gt; &lt;div class=&quot;publication-citation&quot; style=&quot;margin-left: 0.5cm;&quot;&gt; &lt;span title=&quot;Nyilvános idézőközlemények összesen, említések nélkül&quot; class=&quot;citingPub-count&quot;&gt;Nyilvános idéző összesen: 9&lt;/span&gt; | Független: 9 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt:&amp;nbsp;6 | WoS/Scopus jelölt:&amp;nbsp;6 | DOI jelölt:&amp;nbsp;8 &lt;/div&gt;   &lt;div class=&quot;publication-citation&quot;&gt; &lt;a target=&quot;_blank&quot; href=&quot;/api/publication?cond=citations.related;eq;36229839&amp;sort=publishedYear,desc&amp;sort=title&quot;&gt; Idézett közlemények száma: 3 &lt;/a&gt; &lt;/div&gt; &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Közlemény: 36229839&lt;/span&gt; | &lt;span class=&quot;status-data status-VALIDATED&quot;&gt; Egyeztetett &lt;/span&gt; Forrás Idéző | &lt;span class=&quot;type-subtype&quot;&gt;Folyóiratcikk ( Összefoglaló cikk ) &lt;/span&gt; | &lt;span class=&quot;pub-category&quot;&gt;Tudományos&lt;/span&gt; | &lt;span class=&quot;publication-sourceOfData&quot;&gt;PubMed XML&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;lastModified&quot;&gt;Utolsó módosítás: 2026.06.07. 10:37 Döme Péter (Nyírő OPAI 4 admin) &lt;/div&gt; &lt;div class=&quot;lockedBy&quot;&gt;Központi kezelésű 2026.05.30. 20:27 Lévayné Deseő Katalin (MTMT Központi admin) &lt;/div&gt; &lt;/div&gt;&lt;/div&gt;</template2>
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