https://m2.mtmt.hu/ hun 2026-09-22 09:44 JournalArticle 36227770 VALIDATED true Funding Agency and Grant Number: Semmelweis University; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [TKP2021-NKTA-47]; National Cardiovascular Laboratory Program by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [RRF-2.3.1-21-2022-00003]; European University for Well-Being (EUniWell) program [101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1]; Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund [EKOP-2024-9] Funding text: Open access funding was provided by Semmelweis University. This work was supported by TKP2021-NKTA-47, implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-NKTA funding scheme and by funding through the National Cardiovascular Laboratory Program (RRF-2.3.1-21-2022-00003) provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund. Additional support was provided by the European University for Well-Being (EUniWell) program (grant agreement number: 101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1). A.L. was supported by the EKOP-2024-9 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. The funding sources had no role in the study design; the data's collection, analysis, and interpretation; the writing of the report; or the decision to submit this article for publication. 0 false 2026-09-21T16:46:08.165+0000 2026-06-23T12:57:21.014+0000 2025-07-04T08:02:44.106+0000 true 10093553 Fi Tamás /api/admin/10093553 Admin true 2026-07-09T11:21:53.647+0000 2026-06-01T12:43:07.820+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Varga, Péter The Role of Magnesium in Depression, Migraine, Alzheimer’s Disease, and Cognitive Health: A Comprehensive Review true true /api/journal/10016563 REVIEWED true false 10016563 false 10016563 true 2072-6643 Journal FOREIGN 17 13 2216 2216 27 2025 Magnesium is an essential mineral involved in hundreds of biochemical reactions, with particular relevance to maintaining neural homeostasis, modulating neurotransmitter systems, and regulating inflammatory and oxidative stress mechanisms. This comprehensive review aims to evaluate the potential role of magnesium in the pathophysiology and treatment of three prevalent neurological and psychiatric disorders—depression, migraine, and Alzheimer’s disease—as well as its broader implications for cognitive health. Current research suggests that magnesium deficiency is associated with the development of depression, as magnesium influences glutamatergic and GABAergic neurotransmission, as well as the activity of the hypothalamic–pituitary–adrenal (HPA) axis, both of which play critical roles in stress responses and mood regulation. Additionally, magnesium’s anti-inflammatory properties may contribute to the alleviation of depressive symptoms. In the context of migraine’s pathophysiology, magnesium plays a role in regulating cerebral vascular tone, modulating the trigeminovascular system, and reducing neuronal hyperexcitability, which may explain the observed correlation between magnesium levels and the incidence of migraines. Regarding Alzheimer’s disease, preclinical and epidemiological studies suggest that magnesium may contribute to modulating neurodegenerative processes and preserving cognitive function; however, due to the heterogeneity of the current findings, further longitudinal and interventional studies are necessary to determine its precise clinical relevance. This review aims to enhance the understanding of the relationship between magnesium and these disorders through a narrative review of relevant clinical studies. The findings may provide insights into the potential therapeutic applications of magnesium and guide the future directions of the research into the prevention and treatment of depression, migraine, and Alzheimer’s disease and overall cognitive health. 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/api/classificationexternal/1106 true 1106 true D1 DIRECT true true /api/publication/36227770 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10081446"><a href="/gui2/?type=authors&mode=browse&sel=10081446" target="_blank">Varga Péter (<span class="authorship-author-name">Varga Péter</span> <span class="authorAux-mtmt"> foglalkozás-orvostan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089009"><a href="/gui2/?type=authors&mode=browse&sel=10089009" target="_blank">Lehoczki Andrea<sup>*</sup> (<span class="authorship-author-name">Lehoczki Andrea Marianna</span> <span class="authorAux-mtmt"> hematológia, belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058020"><a href="/gui2/?type=authors&mode=browse&sel=10058020" target="_blank">Fekete Mónika<sup>*</sup> (<span class="authorship-author-name">Fekete Mónika</span> <span class="authorAux-mtmt"> Népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10101204"><a href="/gui2/?type=authors&mode=browse&sel=10101204" target="_blank">Jarecsny Tamás<sup>*</sup> (<span class="authorship-author-name">Jarecsny Tamás</span> <span class="authorAux-mtmt"> neurológia</span>) </a> </span> <span class="author-affil">Észak-Közép-budai Centrum, Új Szent János Kórház és Szakrendelő</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kryczyk-Poprawa Agata<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060634"><a href="/gui2/?type=authors&mode=browse&sel=10060634" target="_blank">Zábó Virág (<span class="authorship-author-name">Zábó Virág</span> <span class="authorAux-mtmt"> Pszichológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080371"><a href="/gui2/?type=authors&mode=browse&sel=10080371" target="_blank">Major Dávid (<span class="authorship-author-name">Major Dávid</span> <span class="authorAux-mtmt"> Megelőző orvostan, társadalomegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035785"><a href="/gui2/?type=authors&mode=browse&sel=10035785" target="_blank">Fazekas-Pongor Vince (<span class="authorship-author-name">Fazekas-Pongor Vince</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055259"><a href="/gui2/?type=authors&mode=browse&sel=10055259" target="_blank">Csípő Tamás (<span class="authorship-author-name">Csípő Tamás</span> <span class="authorAux-mtmt"> kardiológia, vaszkuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028758"><a href="/gui2/?type=authors&mode=browse&sel=10028758" target="_blank">Varga János T. ✉ (<span class="authorship-author-name">Varga János Tamás</span> <span class="authorAux-mtmt"> pulmonológia, pulm. rehabilitáció</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pulmonológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36227770" target="_blank">The Role of Magnesium in Depression, Migraine, Alzheimer’s Disease, and Cognitive Health: A Comprehensive Review</a></div> <div> <span class="journal-title">NUTRIENTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6643">2072-6643</a>)</span>: <span class="journal-volume">17</span> <span class="journal-issue">13</span> <span class="page"> Paper 2216. 27 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/nu17132216" target="_blank" href="https://doi.org/10.3390/nu17132216"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001526260600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001526260600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105010650091" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105010650091"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40647320" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40647320&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Food Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Nutrition and Dietetics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 37</span> | Független: 25 | Függő: 12 | Nem jelölt: 0 | WoS jelölt: 11 | Scopus jelölt:&nbsp;11 | WoS/Scopus jelölt:&nbsp;13 | DOI jelölt:&nbsp;22 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36227770&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36227770</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University), (TKP2021-NKTA-47), Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Támogató: NKFIH, (101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1), (EKÖP-2024-9) </div> <div class="lastModified">Utolsó módosítás: 2026.06.23. 14:57 Kondor Zóra (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Semmelweis University; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [TKP2021-NKTA-47]; National Cardiovascular Laboratory Program by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [RRF-2.3.1-21-2022-00003]; European University for Wel...</pre> </div></div>