https://m2.mtmt.hu/ hun 2026-09-23 08:36 JournalArticle 36223454 VALIDATED true Funding Agency and Grant Number: Gedeon Richter Talentum Foundation in the framework of Gedeon Richter Excellence PhD Scholarship; Doctoral College of Semmelweis University [EFOP-3.6.3-VEKOP-16-2017-00009]; Hungarian Scientific Research Fund [143627]; OTKA [FK134751]; National Research, Development and Innovation Fund [TKP2021-EGA-25]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [TKP2021-EGA]; Austrian Science Fund [p33799]; L. Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria; National Research, Development and Innovation Office of Hungary (NKFIH) [2022-1.1.1-KK-2022-00005, VEKOP-2.3.3-15-2016-00006, K132695, RGH151414]; National Laboratories Program; Hungarian Thematic Excellence Program [2022-2.1.1-NL-2022-00010, TKP2021-EGA-44, 2024-2.1.1-EKO<spacing diaeresis>P-2024-00004, EKOP-2024-182]; HUN-REN Hungarian Research Network [1500207]; Hungarian Academy of Sciences; NextGeneration EU [RRF-2.3.1-21-2022-00003]; Austrian Science Fund (FWF) [P33799] Funding Source: Austrian Science Fund (FWF) Funding text: The scientific research and results published in this article were achieved with the sponsorship of Gedeon Richter Talentum Foundation in the framework of Gedeon Richter Excellence PhD Scholarship (to M. K.) . The project was also generously supported by the Doctoral College of Semmelweis University (EFOP-3.6.3-VEKOP-16-2017-00009, to M. K.) , by the Hungarian Scientific Research Fund (OTKA grant 143627, to A.A.; OTKA grant FK134751, to Z.V.V.) , by the National Research, Development and Innovation Fund (TKP2021-EGA-25 grant, to A.A.) ; TKP2021-EGA-25 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA funding scheme. This research was co-funded by the Austrian Science Fund (FWF; project #p33799 for the L. Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria, to A.V.K.) , by the National Research, Development and Innovation Office of Hungary (NKFIH; grant 2022-1.1.1-KK-2022-00005, to Z.V.V.; VEKOP-2.3.3-15-2016-00006, to P.F.; K132695, to T.A.; RGH151414, to D.M.) under the National Laboratories Program and the Hungarian Thematic Excellence Program (2022-2.1.1-NL-2022-00010 and TKP2021-EGA-44, to P.N. and R.Sz.) , by the 2024-2.1.1-EKO<spacing diaeresis>P-2024-00004 (to C.K.) and by the EKO<spacing diaeresis>P-2024-182 University Research Scholarship (to N.V.S.) , by the HUN-REN Hungarian Research Network (grant 1500207, to P.N.) , by a Momentum Research Grant from the Hungarian Academy of Sciences (to. Z.V.V.) , and by a NextGeneration EU grant on project RRF-2.3.1-21-2022-00003 (to Z.V.V.) . The antibody against the E3 protein was a kind gift of Dr. Christos Chinopoulos (Semmelweis University, Department of Biochemistry, Budapest, Hungary) . The authors also thank Katalin Taka<acute accent>cs and Andrea Va<acute accent>rnagy for their excellent technical assistance, Attila Angyal for animal handling, Ga<acute accent>bor Sze<acute accent>na<acute accent>si for the help with the animal ethical permission, and Viktoria Zaharov for assisting in the graphical abstract. The graphical abstract was created with images of Servier Medical Art (c) (open field, mitochondria, and proteins were slightly changed for better adaptation) . 0 false 2026-09-15T12:30:35.194+0000 2026-07-13T08:53:25.098+0000 2025-07-02T06:20:19.768+0000 true 10086190 Bara Eszter /api/admin/10086190 Admin true 2026-08-05T14:38:06.414+0000 2026-02-25T08:40:47.642+0000 true 10086190 Bara Eszter /api/admin/10086190 Admin true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-05-20T07:50:21.173+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kokas, Márton Microgliosis, neuronal death, minor behavioral abnormalities and reduced endurance performance in alpha-ketoglutarate dehydrogenase complex deficient mice true true /api/journal/10031450 REVIEWED true false 10031450 false 10031450 true 2213-2317 Journal FOREIGN 85 103743 103743 19 2025 The alpha-ketoglutarate dehydrogenase complex (KGDHc), also known as the 2-oxoglutarate dehydrogenase complex, plays a crucial role in oxidative metabolism. It catalyzes a key step in the tricarboxylic acid (TCA) cycle, producing NADH (primarily for oxidative phosphorylation) and succinyl-CoA (for substrate-level phosphorylation, among others). Additionally, KGDHc is also capable of generating reactive oxygen species, which contribute to mitochondrial oxidative stress. Hence, the KGDHc and its dysfunction are implicated in various pathological conditions, including selected neurodegenerative diseases. The pathological roles of KGDHc in these diseases are generally still obscure. The aim of this study was to assess whether the mitochondrial malfunctions observed in the dihydrolipoamide succinyltransferase (DLST) and dihydrolipoamide dehydrogenase (DLD) double heterozygous knockout (DLST+/--DLD+/-, DKO) mice are associated with neuronal and/or metabolic abnormalities. In the DKO animals, the mitochondrial O2 consumption and ATP production rates both decreased in a substrate-specific manner. Reduced H2O2 production was also observed, either due to Complex I inhibition with α-ketoglutarate or reverse electron transfer with succinate, which is significant in ischaemia-reperfusion injury. Middle-aged DKO mice exhibited minor cognitive decline, associated with microgliosis in the cerebral cortex and neuronal death in the Cornu Ammonis subfield 1 (CA1) of the hippocampus, indicating neuroinflammation. This was supported by increased levels of dynamin-related protein 1 (Drp1) and reduced levels of mitofusin 2 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in DKO mice. Observations on activity, food and oxygen consumption, and blood amino acid and acylcarnitine profiles revealed no significant differences. However, middle-aged DKO animals showed decreased performance in the treadmill fatigue-endurance test as compared to wild-type animals, accompanied by subtle resting cardiac impairment, but not skeletal muscle fibrosis. In conclusion, DKO animals compensate well the double-heterozygous knockout condition at the whole-body level with no major phenotypic changes under resting physiological conditions. However, under high energy demand, middle-aged DKO mice exhibited reduced performance, suggesting a decline in metabolic compensation. Additionally, microgliosis, neuronal death, decreased mitochondrial biogenesis, and altered mitochondrial dynamics were observed in DKO animals, resulting in minor cognitive decline. This is the first study to highlight the in vivo changes of this combined genetic modification. It demonstrates that unlike single knockout rodents, double knockout mice exhibit phenotypical alterations that worsen under stress situations. Funding 2054755 /api/funding/2054755 false true Funding 2054752 /api/funding/2054752 false true Funding 2054753 /api/funding/2054753 false true Funding 2054754 /api/funding/2054754 false true Funding 2054751 /api/funding/2054751 false true Funding 2054756 /api/funding/2054756 false true Funding 2054757 /api/funding/2054757 false true Funding 2054758 /api/funding/2054758 false true Funding 2054759 /api/funding/2054759 false true Funding 2054760 /api/funding/2054760 false true Funding 2054761 /api/funding/2054761 false true Funding 2054762 /api/funding/2054762 false true Funding 2054763 /api/funding/2054763 false true Funding 2065115 /api/funding/2065115 false true true 2025 true true true false true false GOLD 2026-09-15 true https://real.mtak.hu/220837 5 0 5 4 1 5 5 5 4 5 5 4 4 4 1 0 5 4 5 4 0 30 30 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 5 4 5 4 D1 false 10056712 false false false 2025-07-01T07:35:11.034+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Biokémiai Tanszék (SE / AOK / I / BMBI); Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Farmakológiai és Gyógyszerkutatás-fejlesztési K... (SE / KSZE); Gyermekgyógyászati Klinika (SE / AOK / K); HUN-REN-ÁTE Redoxbiológiai Laboratórium Kutatócso (ÁTE / ATI / ASZT); Integratív Neuroendokrinológiai Kutatócsoport (HRN KOKI); Kémiai Intézet (DE / TTK); MTA-SE Momentum Kardio-Onkológia és Kardioimmun... (SE / AOK / I / FFI); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI); Molekuláris Edzésélettani Kutató Központ (MTSE / SETI); Molekuláris Élettudományi Intézet (HRN TTK); Országos Onkológiai Intézet; Patológiai, Igazságügyi és Biztosítási Orvostan... 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<div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10078190"><a href="/gui2/?type=authors&mode=browse&sel=10078190" target="_blank">Kokas Márton (<span class="authorship-author-name">Kokas Márton</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Biokémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052727"><a href="/gui2/?type=authors&mode=browse&sel=10052727" target="_blank">Budai András (<span class="authorship-author-name">Budai András</span> <span class="authorAux-mtmt"> Sebészet, Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="205"><a href="/gui2/?type=authors&mode=browse&sel=205" target="_blank">Kádár Andrea (<span class="authorship-author-name">Kádár Andrea</span> <span class="authorAux-mtmt"> Integratív neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078013"><a href="/gui2/?type=authors&mode=browse&sel=10078013" target="_blank">Mozaffaritabar Soroosh (<span class="authorship-author-name">Mozaffaritabar Soroosh</span> <span class="authorAux-mtmt"> Orvosi tudományok</span>) </a> </span> <span class="author-affil"><span title="Magyar Testnevelési és Sporttudományi Egyetem">MTSE</span>/<span title="Sport- és Egészségtudományi Intézet">SETI</span>/Molekuláris Edzésélettani Kutató Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10083356"><a href="/gui2/?type=authors&mode=browse&sel=10083356" target="_blank">Zhou Lei (<span class="authorship-author-name">Zhou Lei</span> <span class="authorAux-mtmt"> Sport Science</span>) </a> </span> <span class="author-affil"><span title="Magyar Testnevelési és Sporttudományi Egyetem">MTSE</span>/<span title="Sport- és Egészségtudományi Intézet">SETI</span>/Molekuláris Edzésélettani Kutató Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10056712"><a href="/gui2/?type=authors&mode=browse&sel=10056712" target="_blank">Téglás Tímea (<span class="authorship-author-name">Téglás Tímea</span> <span class="authorAux-mtmt"> Táplálkozástudomány, Sporttudomány</span>) </a> </span> <span class="author-affil"><span title="Magyar Testnevelési és Sporttudományi Egyetem">MTSE</span>/<span title="Sport- és Egészségtudományi Intézet">SETI</span>/Molekuláris Edzésélettani Kutató Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10100939"><a href="/gui2/?type=authors&mode=browse&sel=10100939" target="_blank">Orova Rebeka Sára (<span class="authorship-author-name">Orova Rebeka Sára</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Biokémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gáspár Dániel </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078426"><a href="/gui2/?type=authors&mode=browse&sel=10078426" target="_blank">Németh Kristóf (<span class="authorship-author-name">Németh Kristóf</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025949"><a href="/gui2/?type=authors&mode=browse&sel=10025949" target="_blank">Toth Daniel Marton (<span class="authorship-author-name">Tóth Dániel Márton</span> <span class="authorAux-mtmt"> Gyógyszertudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074459"><a href="/gui2/?type=authors&mode=browse&sel=10074459" target="_blank">Sayour Nabil V. (<span class="authorship-author-name">Sayour Viktor Nabil</span> <span class="authorAux-mtmt"> farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Momentum Kardio-Onkológia és Kardioimmunológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069239"><a href="/gui2/?type=authors&mode=browse&sel=10069239" target="_blank">Kovácsházi Csenger (<span class="authorship-author-name">Kovácsházi Csenger</span> <span class="authorAux-mtmt"> Gyógyszertudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090624"><a href="/gui2/?type=authors&mode=browse&sel=10090624" target="_blank">Xue Andrea (<span class="authorship-author-name">Xue Andrea</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szatmári Réka Zsuzsanna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003430"><a href="/gui2/?type=authors&mode=browse&sel=10003430" target="_blank">Törőcsik Beáta (<span class="authorship-author-name">Törőcsik Beáta</span> <span class="authorAux-mtmt"> orvosi biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Biokémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054788"><a href="/gui2/?type=authors&mode=browse&sel=10054788" target="_blank">Máthé Domokos (<span class="authorship-author-name">Máthé Domokos</span> <span class="authorAux-mtmt"> Molekuláris képalkotás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042835"><a href="/gui2/?type=authors&mode=browse&sel=10042835" target="_blank">Kovács Noémi (<span class="authorship-author-name">Stelczerné Kovács Noémi</span> <span class="authorAux-mtmt"> orvos fizikus</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013859"><a href="/gui2/?type=authors&mode=browse&sel=10013859" target="_blank">Szigeti Krisztián (<span class="authorship-author-name">Szigeti Krisztián</span> <span class="authorAux-mtmt"> Biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021022"><a href="/gui2/?type=authors&mode=browse&sel=10021022" target="_blank">Nagy Péter (<span class="authorship-author-name">Nagy Péter</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Állatorvostudományi Egyetem">ÁTE</span>/<span title="Alaptudományi Intézet">ATI</span>/<span title="Anatómiai és Szövettani Tanszék">ASZT</span>/HUN-REN-ÁTE Redoxbiológiai Laboratórium Kutatócso; <span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi és Technológiai Kar">TTK</span>/Kémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011494"><a href="/gui2/?type=authors&mode=browse&sel=10011494" target="_blank">Szatmári Ildikó (<span class="authorship-author-name">Szatmári Ildikó</span> <span class="authorAux-mtmt"> Örökletes anyagcsere betegségek, újszülöttkori ...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012354"><a href="/gui2/?type=authors&mode=browse&sel=10012354" target="_blank">Fekete Csaba (<span class="authorship-author-name">Fekete Csaba</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012617"><a href="/gui2/?type=authors&mode=browse&sel=10012617" target="_blank">Arányi Tamás (<span class="authorship-author-name">Arányi Tamás</span> <span class="authorAux-mtmt"> Génexpresszió szabályozás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028393"><a href="/gui2/?type=authors&mode=browse&sel=10028393" target="_blank">Varga Zoltán V. (<span class="authorship-author-name">Varga Zoltán</span> <span class="authorAux-mtmt"> kardiovaszkuláris kutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Momentum Kardio-Onkológia és Kardioimmunológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003262"><a href="/gui2/?type=authors&mode=browse&sel=10003262" target="_blank">Radák Zsolt (<span class="authorship-author-name">Radák Zsolt</span> <span class="authorAux-mtmt"> Sporttudomány</span>) </a> </span> <span class="author-affil"><span title="Magyar Testnevelési és Sporttudományi Egyetem">MTSE</span>/<span title="Sport- és Egészségtudományi Intézet">SETI</span>/Molekuláris Edzésélettani Kutató Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kozlov Andrey V. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015508"><a href="/gui2/?type=authors&mode=browse&sel=10015508" target="_blank">Tretter László (<span class="authorship-author-name">Tretter László</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Biokémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062767"><a href="/gui2/?type=authors&mode=browse&sel=10062767" target="_blank">Komlódi Tímea<sup>**</sup> ✉ (<span class="authorship-author-name">Komlódi Tímea</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Biokémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000177"><a href="/gui2/?type=authors&mode=browse&sel=10000177" target="_blank">Ambrus Attila (<span class="authorship-author-name">Ambrus Attila</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Biokémiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36223454" target="_blank">Microgliosis, neuronal death, minor behavioral abnormalities and reduced endurance performance in alpha-ketoglutarate dehydrogenase complex deficient mice</a></div> <div> <span class="journal-title">REDOX BIOLOGY</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2213-2317">2213-2317</a>)</span>: <span class="journal-volume">85</span> <span class="page"> Paper 103743. 19 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="10.1016/j.redox.2025.103743" target="_blank" href="https://doi.org/10.1016/j.redox.2025.103743"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="220837" target="_blank" href="https://real.mtak.hu/220837"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001527016500002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001527016500002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105009502537" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105009502537"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40609475" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40609475&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Clinical Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 5</span> | Független: 4 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;5 | DOI jelölt:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36223454&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 30 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36223454</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (2022-1.1.1-KK-2022-00005), (OTKA-FK-134751), (TKP2021-EGA-25), (TKP2021-EGA), OTKA(143627), (VEKOP-2.3.3-15-2016-00006), (K-132695), (National Tumor Biology Laboratory project—2022-2.1.1-NL-2022-00010), Hungarian Thematic Excellence Program((TKP2021-EGA-44)), (RRF-2.3.1-21-2022-00003), HUN-REN Hungarian Research Network(1500207), (EKÖP-2024-182), (2024-2.1.1.-EKÖP-2024-00004), Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP </div> <div class="lastModified">Utolsó módosítás: 2026.07.13. 10:53 Kósa Ilona (MTMT központi Admin, admin) </div> <div class="lockedBy">Központi kezelésű 2026.05.20. 09:50 Lévayné Deseő Katalin (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Gedeon Richter Talentum Foundation in the framework of Gedeon Richter Excellence PhD Scholarship; Doctoral College of Semmelweis University [EFOP-3.6.3-VEKOP-16-2017-00009]; Hungarian Scientific Research Fund [143627]; OTKA [FK134751]; National Research, Development and Innovation Fund [TKP2021-EGA-25]; Ministry of Innovation and Technology of Hungary from the N...</pre> </div></div>