https://m2.mtmt.hu/ hun 2026-09-21 07:33 JournalArticle 36216612 APPROVED true B-M.B.: Supported by the EKÖP-2024-128 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. G.T.: This work was funded by the National Research, Development, and Innovation Office, Hungary (grant: NKFIH FK 146930). S.K.: This work was supported by EKÖP-24-4-I-BME-127 University Research Fellowship Programme of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. G.T.: This work was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. 0 false 2026-09-16T09:29:48.075+0000 2026-02-06T10:30:04.305+0000 2025-06-30T06:38:45.785+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin true 10015206 2026-09-16T09:28:32.220+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Benkő, B.-M. Development of Low-Dose Disulfiram Rectal Suppository Intended for Application in Post-Treatment Lyme Disease Syndrome true true /api/journal/10022148 REVIEWED true false 10022148 false 10022148 true 1999-4923 Journal FOREIGN 17 7 849 849 25 2025 Background/Objectives: Early diagnosis and oral or, in severe cases, intravenous antibiotics are usually effective for Lyme disease, but some patients have persistent symptoms unresponsive to standards of care, requiring alternative therapies. Disulfiram (DIS), a drug for alcoholism, is under investigation as a potential adjunctive treatment, but its low bioavailability, rapid metabolism, and safety concerns urge the development of improved formulations for clinical translation. Methods: Screening dissolution and permeation studies were investigated for vehicle and excipient selection, following the pharmacopeia perspectives to develop and optimize the low-dose DIS rectal suppository intended for application in post-treatment Lyme disease syndrome (PTLDS). Further characterizations were carried out by differential scanning calorimetry, X-ray diffraction, and infrared spectroscopy. Results: Cyclodextrin (CD) encapsulation was investigated to improve the aqueous solubility of the hydrophobic drug. The dissolution of DIS from fatty base suppository was very slow; it was remarkably improved by the molecular encapsulation of the drug with CDs. The dissolution of DIS from a water-soluble base was more favorable, but incomplete. In the polyethylene glycol (PEG) based suppositories, the addition of CDs already in a physical mixture ensured the dissolution of the drug. The presented drug delivery system relates to a novel preparation for rectal administration comprising a low-dose disulfiram with improved solubility and permeability by the PEG and hydroxypropyl-β-cyclodextrin (HPBCD) synergistic matrix. Conclusions: The rectal dosage form containing the drug and CD in the physical mixture is advantageous, avoiding the hepatic first-pass effect, minimizing dose-limiting toxicity, simplifying production, and fasting the availability of the repositioned drug. Funding 2055824 /api/funding/2055824 false true Funding 2055825 /api/funding/2055825 false true Funding 2055826 /api/funding/2055826 false true Funding 2055827 /api/funding/2055827 false true true 2025 true true true false true false GOLD 2026-09-16 true https://doi.org/10.3390/pharmaceutics17070849 1 0 1 0 1 1 1 1 1 1 1 0 0 0 1 0 1 0 1 0 0 3 3 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 0 1 0 D1 false false false false 2025-07-07T13:50:31.145+0000 CycloLab Cyclodextrin Research and Development ...; Egis Gyógyszergyár Zrt.; Egyetemi Gyógyszertár Gyógyszerügyi Szervezési ... (SE / GYTK); Farmakológiai és Gyógyszerkutatás-fejlesztési K... (SE / KSZE); Gyógyszerészi Kémiai Intézet (SE / GYTK); Szerves Kémia és Technológia Tanszék (BME / VBK) 8 21 6 9 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 127052688 /api/authorship/127052688 1 0.111 true false Author 10080598 /api/author/10080598 Benkő Beáta Mária true true Benkő B.-M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127052689 /api/authorship/127052689 2 0.11111111 false false Szabó B.-I. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127052690 /api/authorship/127052690 3 0.111 false false Author 10073811 /api/author/10073811 Kádár Szabina true true Kádár S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127052691 /api/authorship/127052691 4 0.111 false false Author 10062688 /api/author/10062688 Szabó Edina true 10062688 true Szabó E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127052692 /api/authorship/127052692 5 0.111 false false Author 10028950 /api/author/10028950 Tóth Gergő true 10028950 true Tóth G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127052693 /api/authorship/127052693 6 0.11111111 false false Author 10008597 /api/author/10008597 Szente Lajos true 10008597 true Szente L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127052694 /api/authorship/127052694 7 0.11111111 false false Author 10103947 /api/author/10103947 Tonka-Nagy Péter true true Tonka-Nagy P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127052695 /api/authorship/127052695 8 0.111 false false true Author 10002587 /api/author/10002587 Zelkó Romána true 10002587 true Zelkó R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127052696 /api/authorship/127052696 9 0.111 false true true Author 10035401 /api/author/10035401 Sebe István true 10035401 true Sebe I. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29539071 /api/publicationidentifier/29539071 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/pharmaceutics17070849 https://doi.org/10.3390/pharmaceutics17070849 false true PublicationIdentifier 29709324 /api/publicationidentifier/29709324 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001540113100001 https://www.webofscience.com/wos/woscc/full-record/001540113100001 true true PublicationIdentifier 29887407 /api/publicationidentifier/29887407 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40733058&dopt=Abstract true true PublicationIdentifier 29853599 /api/publicationidentifier/29853599 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://www.mdpi.com/1999-4923/17/7/849 https://www.mdpi.com/1999-4923/17/7/849 false true SjrRating 11611771 /api/sjrrating/11611771 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3003 /api/classificationexternal/3003 true 3003 true D1 DIRECT true true /api/publication/36216612 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10080598"><a href="/gui2/?type=authors&mode=browse&sel=10080598" target="_blank">Benkő B.-M. (<span class="authorship-author-name">Benkő Beáta Mária</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szabó B.-I. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073811"><a href="/gui2/?type=authors&mode=browse&sel=10073811" target="_blank">Kádár S. (<span class="authorship-author-name">Kádár Szabina</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062688"><a href="/gui2/?type=authors&mode=browse&sel=10062688" target="_blank">Szabó E. (<span class="authorship-author-name">Szabó Edina</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028950"><a href="/gui2/?type=authors&mode=browse&sel=10028950" target="_blank">Tóth G. (<span class="authorship-author-name">Tóth Gergő</span> <span class="authorAux-mtmt"> gyógyszerkémia/analitika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Kémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008597"><a href="/gui2/?type=authors&mode=browse&sel=10008597" target="_blank">Szente L. (<span class="authorship-author-name">Szente Lajos</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> <span class="author-affil">CycloLab Cyclodextrin Research and Development Laboratory Ltd.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10103947"><a href="/gui2/?type=authors&mode=browse&sel=10103947" target="_blank">Tonka-Nagy P. (<span class="authorship-author-name">Tonka-Nagy Péter</span> <span class="authorAux-mtmt"> Analitikai kémia, gyógyszeranalitika</span>) </a> </span> <span class="author-affil">Egis Gyógyszergyár Zrt.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002587"><a href="/gui2/?type=authors&mode=browse&sel=10002587" target="_blank">Zelkó R. ✉ (<span class="authorship-author-name">Zelkó Romána</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035401"><a href="/gui2/?type=authors&mode=browse&sel=10035401" target="_blank">Sebe I. ✉ (<span class="authorship-author-name">Sebe István</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet; Egis Gyógyszergyár Zrt.</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36216612" target="_blank">Development of Low-Dose Disulfiram Rectal Suppository Intended for Application in Post-Treatment Lyme Disease Syndrome</a></div> <div> <span class="journal-title">PHARMACEUTICS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1999-4923">1999-4923</a>)</span>: <span class="journal-volume">17</span> <span class="journal-issue">7</span> <span class="page"> Paper 849. 25 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/pharmaceutics17070849" target="_blank" href="https://doi.org/10.3390/pharmaceutics17070849"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001540113100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001540113100001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="224605" target="_blank" href="https://real.mtak.hu/224605"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105011490074" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105011490074"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40733058" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40733058&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.mdpi.com/1999-4923/17/7/849" target="_blank" href="https://www.mdpi.com/1999-4923/17/7/849"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 0 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36216612&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36216612</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (EKÖP-2024-128), (NKFIH FK 146930) Támogató: NKFIH, (EKÖP-24-4-I-BME-127), (János Bolyai Research Scholarship of the Hungarian Academy of Sciences.) </div> <div class="lastModified">Utolsó módosítás: 2026.02.06. 11:30 Nádas Orsolya (Egis admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: B-M.B.: Supported by the EKÖP-2024-128 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. G.T.: This work was funded by the National Research, Development, and Innovation Office, Hungary (grant: NKFIH FK 146930). S.K.: This work was supported by EKÖP-24-4-I-BME-127 University Research Fellowship P...</pre> </div></div>