https://m2.mtmt.hu/ hun 2026-09-23 10:26 JournalArticle 36216117 ADMIN_APPROVED true Funding Agency and Grant Number: Semmelweis University; ELIXIR Hungary Funding text: The 4.0 version of ChatGPT, developed by OpenAI, and Gemini, developed by Google, were used as a tool to refine our writing and enhance the clarity of our work. The authors acknowledge the support of ELIXIR Hungary (www.bioinformatics.hu). 0 false 2026-09-17T19:04:55.449+0000 2026-05-18T14:40:47.944+0000 2025-06-29T09:36:11.500+0000 true 10058020 Fekete Mónika /api/author/10058020 Author true 10058020 2026-08-26T14:43:14.141+0000 2026-04-01T11:50:44.523+0000 true 10093553 Fi Tamás /api/admin/10093553 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Ungvari, Zoltan PCSK9 expression and cancer survival: a prognostic biomarker at the intersection of oncology and geroscience true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 48 1 435 449 435 15 2026 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is primarily recognized for its role in cholesterol metabolism; however, emerging evidence suggests it plays a broader role in the regulation of cellular aging mechanisms and the pathogenesis of age-related diseases. Given that cancer is an age-related disease, PCSK9 has garnered attention for its potential impact on tumor progression and patient survival. In this study, we conducted a comprehensive analysis of PCSK9 expression across multiple tumor types, assessing its prognostic significance using RNA sequencing data from The Cancer Genome Atlas (TCGA) and gene expression microarray data from the Gene Expression Omnibus (GEO). Cox proportional hazards regression models and Kaplan–Meier survival analyses were employed to evaluate overall survival (OS) associations. Our findings reveal that elevated PCSK9 expression is associated with improved OS in breast and ovarian cancers, particularly in Luminal B breast cancer subtypes. Conversely, high PCSK9 expression correlates with worse OS in bladder cancer, renal clear cell carcinoma, melanoma, and pancreatic cancer. Notably, while PCSK9 expression is significantly upregulated in melanoma and bladder tumors, it is downregulated in renal clear cell carcinoma, yet relatively higher expression among renal tumors still predicts poorer survival. No significant associations between PCSK9 expression and OS were observed in colon, liver, gastric, lung, prostate, head and neck cancers, or low-grade gliomas in the available datasets.In conclusion, our study identifies PCSK9 as a prognostic biomarker with distinct, tumor-specific survival implications. Its dual role—associating with improved survival in some cancers while correlating with worse outcomes in others—suggests that PCSK9 may influence cancer progression through context-dependent mechanisms. Future research should focus on elucidating the mechanistic underpinnings of these associations and exploring the diagnostic and therapeutic potential of targeting PCSK9 in oncology. 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10.1016/j.atherosclerosis.2014.07.010 false true Reference 66624370 /api/reference/66624370 50 10.1155/2013/908048 false true Reference 66624371 /api/reference/66624371 51 10.3390/biomedicines8040092 false true Reference 66624372 /api/reference/66624372 52 10.4149/gpb_2017047 false true /api/publication/36216117 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045338"><a href="/gui2/?type=authors&mode=browse&sel=10045338" target="_blank">Menyhart Otília (<span class="authorship-author-name">Menyhárt Otília</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Onkológiai Biomarker Kutatócsoport (Lendület)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089009"><a href="/gui2/?type=authors&mode=browse&sel=10089009" target="_blank">Lehoczki Andrea ✉ (<span class="authorship-author-name">Lehoczki Andrea Marianna</span> <span class="authorAux-mtmt"> hematológia, belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058020"><a href="/gui2/?type=authors&mode=browse&sel=10058020" target="_blank">Fekete Monika (<span class="authorship-author-name">Fekete Mónika</span> <span class="authorAux-mtmt"> Népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bianchini Giampaolo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Onkológiai Biomarker Kutatócsoport (Lendület); <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biofizikai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36216117" target="_blank">PCSK9 expression and cancer survival: a prognostic biomarker at the intersection of oncology and geroscience</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">48</span> <span class="journal-issue">1</span> <span class="page"> pp 435-449 </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s11357-025-01733-3" target="_blank" href="https://doi.org/10.1007/s11357-025-01733-3"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001518302900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001518302900001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="246671" target="_blank" href="https://real.mtak.hu/246671"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105009094271" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105009094271"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40576911" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40576911&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://link.springer.com/10.1007/s11357-025-01733-3" target="_blank" href="https://link.springer.com/10.1007/s11357-025-01733-3"> Egyéb URL </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/105009094271?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/105009094271?origin=resultslist"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 15</span> | Független: 11 | Függő: 4 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt:&nbsp;8 | WoS/Scopus jelölt:&nbsp;9 | DOI jelölt:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36216117&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36216117</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (National Institute of Neurological Disorders and Stroke (R01NS100782)), (FK147194), Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Támogató: NKFIH, (TKP2021-NKTA-47), Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Támogató: NKFIH, (TKCS-2021/32) </div> <div class="lastModified">Utolsó módosítás: 2026.05.18. 16:40 Sonnevend Kinga (SE_AOK_Adm5_Élet_kutcsop, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Semmelweis University; ELIXIR Hungary Funding text: The 4.0 version of ChatGPT, developed by OpenAI, and Gemini, developed by Google, were used as a tool to refine our writing and enhance the clarity of our work. The authors acknowledge the support of ELIXIR Hungary (www.bioinformatics.hu).</pre> </div></div>