https://m2.mtmt.hu/ hun 2026-09-22 11:58 JournalArticle 36213678 VALIDATED true 0 false 2026-05-24T22:17:59.017+0000 2026-01-25T17:06:39.007+0000 2025-06-27T06:46:17.392+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-01-25T17:06:39.228+0000 2026-01-25T17:06:39.228+0000 2025-07-07T09:30:18.300+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Harsanyi, Laszlo Food passageway-related sequelae in the RefluxStop prospective multicenter trial: patient-centric outcomes of dysphagia, odynophagia, gas-bloating, and inability to belch and/or vomit at 5 years true true /api/journal/4186 REVIEWED true false 4186 false 4186 true 0930-2794 1432-2218 Journal FOREIGN 39 7 4615 4627 4615 13 2025 IntroductionStandard surgical management of GERD may result in troublesome postoperative food passageway-related sequelae (i.e., dysphagia, odynophagia, gas-bloat syndrome, inability to belch/vomit), significantly impacting quality of life. Five-year results after the RefluxStop procedure are presented, involving reconstruction of the anti-reflux barrier without encircling the food passageway, reducing such related sequelae.MethodsRefluxStop surgery was evaluated in a prospective, single-arm, multicenter study with 50 GERD subjects. This report focuses on food passageway-related outcomes. Other basic outcomes (e.g., 24-h pH, PPI usage) are presented in a separate report with brief clinical correlation herein.ResultsForty-four subjects completed 5-year follow-up; three participants were missing due to COVID-19 (i.e., two deaths and one bedbound with long-COVID) and three terminated early. Data from 3- and 4-year follow-up were carried forward in COVID-affected cases. Food passageway-related adverse events (AEs) between 2 weeks of surgical recovery and 5-year follow-up included: one case (2.1%) of dysphagia (and another case, mild dysphagia for 2 weeks postoperatively, viewed as normal recovery); one case (2.1%) of odynophagia; zero (0%) cases of inability to belch/vomit; and gas-bloating none/improved in 42 cases with only two worsening. These outcomes were well-aligned with improvement in total GERD-HRQL score (i.e., median 29.5 at baseline to 3.0 at 5 years), PPI usage (2.1%), and 24-h pH monitoring (i.e., mean 1.57% acid exposure time at 5 years).ConclusionRefluxStop surgery resulted in a favorable profile of food passageway-related outcomes throughout the 5-year study: no AE dysphagia in 97.9% of subjects; no AE odynophagia in 97.9%; whereof at 5 years: gas-bloating none/improved in 95.7%, and no inability to belch/vomit in 100%. For clinical correlation, 97.9% of subjects did not take PPIs at 5 years. These outcomes add resolution to the overall treatment effect of RefluxStop and may show potential preference in GERD patients who prioritize minimization of postoperative sequelae. Funding 2054688 /api/funding/2054688 false true true true INTERNATIONAL 2025 true true true false true false GOLD 2026-05-25 true https://doi.org/10.1007/s00464-025-11818-x 5 0 5 3 1 5 5 5 4 5 5 3 3 3 2 0 5 3 5 3 0 3 3 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 3 1 3 1 2026 0 2 2 2 2 Q1 false false false false 2025-07-06T09:30:18.072+0000 Sebészeti, Transzplantációs és Gasztroenterológ... (SE / AOK / K) 1 7 1 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 127036695 /api/authorship/127036695 1 0.2 true false true Author 10007491 /api/author/10007491 Harsányi László true 10007491 true Harsanyi Laszlo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127036696 /api/authorship/127036696 2 0.2 false false false Kincses Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127036697 /api/authorship/127036697 3 0.2 false false false Veselinovic Milan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127036698 /api/authorship/127036698 4 0.2 false false false Zehetner Joerg true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 127036699 /api/authorship/127036699 5 0.2 false true false Altorjay Aron true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29533053 /api/publicationidentifier/29533053 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1007/s00464-025-11818-x https://doi.org/10.1007/s00464-025-11818-x false true PublicationIdentifier 29533054 /api/publicationidentifier/29533054 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001512257800001 https://www.webofscience.com/wos/woscc/full-record/001512257800001 false true PublicationIdentifier 29538608 /api/publicationidentifier/29538608 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105008645268 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105008645268 true true PublicationIdentifier 29533055 /api/publicationidentifier/29533055 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40542141 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40542141&dopt=Abstract false true Classification 12253 /api/classification/12253 true true Keyword 137 /api/keyword/137 true 137 true Keyword 338 /api/keyword/338 true 338 true Keyword 9645 /api/keyword/9645 true 9645 true Keyword 12710 /api/keyword/12710 true 12710 true Keyword 19843 /api/keyword/19843 true 19843 true Keyword 19857 /api/keyword/19857 true 19857 true Keyword 1129988 /api/keyword/1129988 true 1129988 true Keyword 1162171 /api/keyword/1162171 true 1162171 true Keyword 1225221 /api/keyword/1225221 true 1225221 true Keyword 2170486 /api/keyword/2170486 true true Keyword 2784703 /api/keyword/2784703 true true Keyword 3883528 /api/keyword/3883528 true true Keyword 3883529 /api/keyword/3883529 true true Keyword 3883530 /api/keyword/3883530 true true SjrRating 11626254 /api/sjrrating/11626254 66 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2746 /api/classificationexternal/2746 true 2746 true Q1 DIRECT true true /api/publication/36213678 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10007491"><a href="/gui2/?type=authors&mode=browse&sel=10007491" target="_blank">Harsanyi Laszlo ✉ (<span class="authorship-author-name">Harsányi László</span> <span class="authorAux-mtmt"> Sebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kincses Zsolt </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Veselinovic Milan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zehetner Joerg </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Altorjay Aron </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36213678" target="_blank">Food passageway-related sequelae in the RefluxStop prospective multicenter trial: patient-centric outcomes of dysphagia, odynophagia, gas-bloating, and inability to belch and/or vomit at 5 years</a></div> <div> <span class="journal-title">SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0930-2794">0930-2794</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1432-2218">1432-2218</a>)</span>: <span class="journal-volume">39</span> <span class="journal-issue">7</span> <span class="page"> pp 4615-4627 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s00464-025-11818-x" target="_blank" href="https://doi.org/10.1007/s00464-025-11818-x"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001512257800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001512257800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105008645268" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105008645268"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40542141" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40542141&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Surgery&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 5</span> | Független: 3 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 5 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;5 | DOI jelölt:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36213678&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36213678</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (Open access funding provided by Semmelweis University) </div> <div class="lastModified">Utolsó módosítás: 2026.01.25. 18:06 Berhidi Anna (SE_ÁOK_Sebészet_Admin5_BA, admin) </div> </div></div>