https://m2.mtmt.hu/ hun 2026-04-30 20:57 JournalArticle 36210503 APPROVED true 0 false 2026-03-27T11:06:49.780+0000 2026-03-27T11:04:52.483+0000 2025-06-25T10:55:23.928+0000 true 10035838 Szulyákné Kovács Mariann /api/admin/10035838 Admin Szulyákné Kovács Mariann (DE/TTK admin 5) true 10035838 2025-06-25T10:55:29.418+0000 2025-06-25T10:55:29.418+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Stoyanova, Stela true true /api/journal/10056880 REVIEWED TOXICS 2305-6304 true false 10056880 false 10056880 true 2305-6304 Journal FOREIGN 13 7 518 518 25 2025 This study evaluated the histopathological impact of three commonly used pesticides—pirimiphos-methyl, propamocarb hydrochloride, and 2,4-dichlorophenoxyacetic acid (2,4-D)—on the kidneys of common carp (Cyprinus carpio Linnaeus, 1758) after 96-h acute exposure. The histopathological analysis demonstrated that all three tested pesticides induced structural changes. The histopathological changes were assessed using a semi-quantitative scoring system and categorised into circulatory, degenerative, proliferative, and inflammatory alterations. While circulatory alterations were absent in all treatments, clear and statistically significant degenerative, proliferative, and inflammatory responses were recorded, which escalated with increasing pesticide concentrations. Additionally, various statistical analyses were conducted to evaluate the lesions in kidney structure and function. Before the statistical analysis, normality and variance homogeneity were assessed using the Shapiro–Wilk and Levene’s tests, respectively. Due to non-normal data distribution, non-parametric methods were applied. Hence, the non-parametric statistical methods showed distinct group-level differences in the kidney damage indices. The Kruskal–Wallis test revealed significant differences across treatments (p < 0.001), and Mann–Whitney U tests identified specific pairwise differences. The degenerative and proliferative lesions were most prominent in fish exposed to 2,4-D at 100 µg/L (IK = 34), followed by pirimiphos-methyl and propamocarb hydrochloride. Inflammatory changes were mainly observed in the pirimiphos-methyl groups. The histopathological lesions were concentration-dependent, with 2,4-D causing irreversible renal damage at higher concentrations. These findings highlight the nephrotoxic risks posed by common pesticides and validate that the use of histopathological indices, combined with robust non-parametric testing, provides a reliable approach to evaluating organ-specific pesticide toxicity. These biomarkers offer sensitive early warning indicators of environmental risk, reinforcing the suitability of common carp as a model species for ecotoxicological assessment. true 2025 true true true false true false GOLD 2026-03-27 false http://www.mdpi.com/journal/toxics 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 D1 false false false false 2025-09-23T10:55:29.216+0000 Hidrobiológiai Tanszék (DE / TTK / BOI); Juhász-Nagy Pál Doktori Iskola (DE / TMTDT) 5 7 2 9 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 127009597 /api/authorship/127009597 Stoyanova, Stela 1 0.11111111 true false false Stoyanova Stela true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127009598 /api/authorship/127009598 Georgieva, Elenka 2 0.11111111 false false false Georgieva Elenka true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127009599 /api/authorship/127009599 Kovacheva, Eleonora 3 0.11111111 false false false Kovacheva Eleonora true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127009600 /api/authorship/127009600 Antal, László [Antal, László (Hal- és halászatb...), szerző] Hidrobiológiai Tanszék (DE / TTK / BOI) 4 0.111 false false false Author 10013864 /api/author/10013864 Antal László (Hal- és halászatbiológia) Antal László true 10013864 true Antal László true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127009601 /api/authorship/127009601 Somogyi, Dóra [Somogyi, Dóra (hidrobiológia), szerző] Hidrobiológiai Tanszék (DE / TTK / BOI) 5 0.111 false false false Author 10068587 /api/author/10068587 Somogyi Dóra (hidrobiológia) Somogyi Dóra true true Somogyi Dóra true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127009602 /api/authorship/127009602 Uzochukwu, Ifeanyi Emmanuel [Uzochukwu, Ifeanyi Emmanuel (Hydrobiology), szerző] Hidrobiológiai Tanszék (DE / TTK / BOI); Juhász-Nagy Pál Doktori Iskola (DE / TMTDT) 6 0.111 false false false Author 10083838 /api/author/10083838 Uzochukwu Ifeanyi Emmanuel (Hydrobiology) Uzochukwu Ifeanyi Emmanuel true true Uzochukwu Ifeanyi Emmanuel true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127009603 /api/authorship/127009603 Nagy, László [Nagy, László (Hidrobiológia), szerző] Hidrobiológiai Tanszék (DE / TTK / BOI); Juhász-Nagy Pál Doktori Iskola (DE / TMTDT) 7 0.111 false false false Author 10088820 /api/author/10088820 Nagy László (Hidrobiológia) Nagy László true true Nagy László true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127009604 /api/authorship/127009604 Nyeste, Krisztián ✉ [Nyeste, Krisztián József (Hidrobiológia), szerző] Hidrobiológiai Tanszék (DE / TTK / BOI) 8 0.111 false false true Author 10046231 /api/author/10046231 Nyeste Krisztián József (Hidrobiológia) Nyeste Krisztián József true 10046231 true Nyeste Krisztián true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 127009605 /api/authorship/127009605 Yancheva, Vesela 9 0.11111111 false true false Yancheva Vesela true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 29525909 /api/publicationidentifier/29525909 DOI: 10.3390/toxics13070518 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/toxics13070518 https://doi.org/10.3390/toxics13070518 false true PublicationIdentifier 29525911 /api/publicationidentifier/29525911 DEA: 394356 PlainSource 38 /api/publicationsource/38 DEA PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true DEA http://hdl.handle.net/2437/@@@ true true 38 true IDENTICAL 394356 http://hdl.handle.net/2437/394356 false true PublicationIdentifier 31718291 /api/publicationidentifier/31718291 Scopus: 105011763613 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105011763613 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105011763613 true true PublicationIdentifier 29525910 /api/publicationidentifier/29525910 Egyéb URL: https://www.mdpi.com/2305-6304/13/7/518 PlainSource 40 /api/publicationsource/40 Egyéb URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://www.mdpi.com/2305-6304/13/7/518 https://www.mdpi.com/2305-6304/13/7/518 false true Classification 10545 /api/classification/10545 Biológiai tudományok true true SjrRating 11564639 /api/sjrrating/11564639 sjr:Q1 (2025) Scopus - Chemical Health and Safety TOXICS 2305-6304 3 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1504 /api/classificationexternal/1504 Scopus - Chemical Health and Safety true 1504 true Q1 FROM_LAST_YEAR true true Reference 66549583 /api/reference/66549583 1. 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(2025) TOXICS 2305-6304 13 7<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Stoyanova Stela </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Georgieva Elenka </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kovacheva Eleonora </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013864"><a href="/gui2/?type=authors&mode=browse&sel=10013864" target="_blank">Antal László (<span class="authorship-author-name">Antal László</span> <span class="authorAux-mtmt"> Hal- és halászatbiológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi és Technológiai Kar">TTK</span>/<span title="Biológiai és Ökológiai Intézet">BOI</span>/Hidrobiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068587"><a href="/gui2/?type=authors&mode=browse&sel=10068587" target="_blank">Somogyi Dóra (<span class="authorship-author-name">Somogyi Dóra</span> <span class="authorAux-mtmt"> hidrobiológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi és Technológiai Kar">TTK</span>/<span title="Biológiai és Ökológiai Intézet">BOI</span>/Hidrobiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10083838"><a href="/gui2/?type=authors&mode=browse&sel=10083838" target="_blank">Uzochukwu Ifeanyi Emmanuel (<span class="authorship-author-name">Uzochukwu Ifeanyi Emmanuel</span> <span class="authorAux-mtmt"> Hydrobiology</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi és Technológiai Kar">TTK</span>/<span title="Biológiai és Ökológiai Intézet">BOI</span>/Hidrobiológiai Tanszék; <span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi és Műszaki Tudományi Doktori Tanács">TMTDT</span>/Juhász-Nagy Pál Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10088820"><a href="/gui2/?type=authors&mode=browse&sel=10088820" target="_blank">Nagy László (<span class="authorship-author-name">Nagy László</span> <span class="authorAux-mtmt"> Hidrobiológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi és Technológiai Kar">TTK</span>/<span title="Biológiai és Ökológiai Intézet">BOI</span>/Hidrobiológiai Tanszék; <span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi és Műszaki Tudományi Doktori Tanács">TMTDT</span>/Juhász-Nagy Pál Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10046231"><a href="/gui2/?type=authors&mode=browse&sel=10046231" target="_blank">Nyeste Krisztián ✉ (<span class="authorship-author-name">Nyeste Krisztián József</span> <span class="authorAux-mtmt"> Hidrobiológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Természettudományi és Technológiai Kar">TTK</span>/<span title="Biológiai és Ökológiai Intézet">BOI</span>/Hidrobiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yancheva Vesela </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36210503" target="_blank">Kidneys Under Siege: Pesticides Impact Renal Health in the Freshwater Fish Common Carp (Cyprinus carpio Linnaeus, 1758)</a></div> <div> <span class="journal-title">TOXICS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2305-6304">2305-6304</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">7</span> <span class="page"> Paper 518. 25 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/toxics13070518" target="_blank" href="https://doi.org/10.3390/toxics13070518"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="394356" target="_blank" href="http://hdl.handle.net/2437/394356"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105011763613" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105011763613"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.mdpi.com/2305-6304/13/7/518" target="_blank" href="https://www.mdpi.com/2305-6304/13/7/518"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Chemical Health and Safety&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Health, Toxicology and Mutagenesis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Toxicology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36210503</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData"></span> </div> <div class="lastModified">Utolsó módosítás: 2026.03.27. 12:04 Szendrei László (DE/BTK admin5) </div> </div></div>