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      <comment>Semmelweis Egyetem, Department of Obstetrics and Gynecology, Budapest, Hungary            
            Semmelweis Egyetem, Workgroup of Research Management, Budapest, Hungary            
            Department of Urology, Budapest, Hungary            
            Szegedi Tudományegyetem (SZTE), Department of Obstetrics and Gynecology, Szeged, Hungary            
            Export Date: 18 November 2025; Cited By: 1; Correspondence Address: M. Keszthelyi; Department of Obstetrics and Gynecology, Semmelweis University, Budapest, 1082, Hungary; email: keszthelyi.marton@semmelweis.hu</comment>
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      <title>The Platelet-to-Lymphocyte Ratio (PLR) as a Non-Invasive Biomarker for Cervical Malignancy in Conization Patients</title>
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      <abstractText>Background: Cervical cancer continues to pose a significant global health challenge, particularly in low-resource regions with limited access to advanced diagnostics. Cervical conization can occasionally uncover invasive carcinoma in patients initially suspected of having only pre-invasive lesions. This study assessed the platelet-to-lymphocyte ratio (PLR) as a potential predictive biomarker for identifying invasive disease in patients undergoing a loop electrosurgical excision procedure (LEEP). Methods: A retrospective study was conducted on 371 patients who underwent LEEP conization for cervical dysplasia. Preoperative PLR values were collected and compared across final histopathological categories (negative, low-grade, high-grade, invasive carcinoma) using the Kruskal–Wallis test, followed by Mann–Whitney U tests for pairwise comparisons. Receiver operating characteristic (ROC) analysis was used to evaluate diagnostic accuracy. Results: PLR values above 7.7 were significantly associated with HPV positivity, increasing with histopathological severity. There were significant PLR differences across the outcome groups (p = 0.005), with notably higher values in cases of invasive carcinoma (p &lt; 0.01). ROC analysis showed moderate diagnostic utility (AUC ≈ 0.72); at a PLR cutoff of ~11.9, sensitivity was 65% and specificity 81%. Conclusions: The PLR cutoff of 7.7 was associated with HPV positivity, while a higher cutoff of 11.93 was identified for predicting invasive cervical cancer. These findings support that preoperative PLR is a non-invasive, clinically relevant marker correlated with lesion severity, offering potential for preoperative risk stratification, particularly where advanced diagnostics are limited.</abstractText>
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      <label>Kalas Noémi et al. The Platelet-to-Lymphocyte Ratio (PLR) as a Non-Invasive Biomarker for Cervical Malignancy in Conization Patients. (2025) LIFE-BASEL 2075-1729 15 6</label><template>&lt;div class=&quot;JournalArticle Publication short-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;span class=&quot;author-name&quot; mtid=&quot;10101167&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10101167&quot; target=&quot;_blank&quot;&gt;Kalas, Noémi&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10101950&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10101950&quot; target=&quot;_blank&quot;&gt;Szabó, Verita&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10098630&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10098630&quot; target=&quot;_blank&quot;&gt;Vida, Balázs&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; 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		&lt;div class=&quot;autype autype0&quot;&gt;				&lt;span class=&quot;author-name&quot; mtid=&quot;10101167&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10101167&quot; target=&quot;_blank&quot;&gt;Kalas Noémi
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Kalas Noémi Zita&lt;/span&gt;
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Faculty of Medicine&quot;&gt;FM&lt;/span&gt;/&lt;span title=&quot;Clinical&quot;&gt;C&lt;/span&gt;/Department of Obsterics and Gynecology&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10101950&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10101950&quot; target=&quot;_blank&quot;&gt;Szabó Verita
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Szabó Verita&lt;/span&gt;
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Faculty of Medicine&quot;&gt;FM&lt;/span&gt;/&lt;span title=&quot;Clinical&quot;&gt;C&lt;/span&gt;/Department of Obsterics and Gynecology&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10098630&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10098630&quot; target=&quot;_blank&quot;&gt;Vida Balázs
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Vida Balázs&lt;/span&gt;
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;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10099913&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10099913&quot; target=&quot;_blank&quot;&gt;Tóth Zsófia
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Tóth Zsófia&lt;/span&gt;
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			&lt;/a&gt;
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Faculty of Medicine&quot;&gt;FM&lt;/span&gt;/&lt;span title=&quot;Clinical&quot;&gt;C&lt;/span&gt;/&lt;span title=&quot;Department of Obsterics and Gynecology&quot;&gt;DOG&lt;/span&gt;/Department of Obsterics and Gynecology Üllői Street Department&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10092560&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10092560&quot; target=&quot;_blank&quot;&gt;Lőczi Lotti
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Keszthelyi Lotti Lúcia&lt;/span&gt;
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/School of PhD Studies; &lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Faculty of Medicine&quot;&gt;FM&lt;/span&gt;/&lt;span title=&quot;Clinical&quot;&gt;C&lt;/span&gt;/&lt;span title=&quot;Department of Obsterics and Gynecology&quot;&gt;DOG&lt;/span&gt;/Department of Obsterics and Gynecology Üllői Street Department&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10089138&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10089138&quot; target=&quot;_blank&quot;&gt;Sebők Barbara
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Sebők Barbara&lt;/span&gt;
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							&lt;span class=&quot;author-name&quot; mtid=&quot;10079318&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10079318&quot; target=&quot;_blank&quot;&gt;Merkely Petra
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Merkely Petra&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; szülészet&lt;/span&gt;)
			&lt;/a&gt;
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&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Faculty of Medicine&quot;&gt;FM&lt;/span&gt;/&lt;span title=&quot;Clinical&quot;&gt;C&lt;/span&gt;/&lt;span title=&quot;Department of Obsterics and Gynecology&quot;&gt;DOG&lt;/span&gt;/Department of Obsterics and Gynecology Üllői Street Department&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10036681&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10036681&quot; target=&quot;_blank&quot;&gt;Lintner Balázs
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Lintner Balázs&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Szülészet-Nőgyógyászat&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Faculty of Medicine&quot;&gt;FM&lt;/span&gt;/&lt;span title=&quot;Clinical&quot;&gt;C&lt;/span&gt;/&lt;span title=&quot;Department of Obsterics and Gynecology&quot;&gt;DOG&lt;/span&gt;/Department of Obsterics and Gynecology Üllői Street Department&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10013998&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10013998&quot; target=&quot;_blank&quot;&gt;Ács Nándor
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Ács Nándor&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Szülészet-nőgyógyászat&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Faculty of Medicine&quot;&gt;FM&lt;/span&gt;/&lt;span title=&quot;Clinical&quot;&gt;C&lt;/span&gt;/&lt;span title=&quot;Department of Obsterics and Gynecology&quot;&gt;DOG&lt;/span&gt;/Department of Obsterics and Gynecology Üllői Street Department&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10024659&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10024659&quot; target=&quot;_blank&quot;&gt;Keszthelyi Attila
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Keszthelyi Attila&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; urológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Faculty of Medicine&quot;&gt;FM&lt;/span&gt;/&lt;span title=&quot;Clinical&quot;&gt;C&lt;/span&gt;/Department of Urology&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10011316&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10011316&quot; target=&quot;_blank&quot;&gt;Várbíró Szabolcs
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Várbíró Szabolcs&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Keringésélettan&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/School of PhD Studies; &lt;span title=&quot;University of Szeged&quot;&gt;SZTE&lt;/span&gt;/&lt;span title=&quot;Albert Szent-Györgyi Medical School&quot;&gt;ASZMS&lt;/span&gt;/Department of Obstetrics and Gynecology&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10089733&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10089733&quot; target=&quot;_blank&quot;&gt;Tóth Richárd&lt;sup&gt;**&lt;/sup&gt;
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Tóth Richárd&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Szülészet, nőgyógyászat, nőgyógyászati onkológia&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Faculty of Medicine&quot;&gt;FM&lt;/span&gt;/&lt;span title=&quot;Clinical&quot;&gt;C&lt;/span&gt;/&lt;span title=&quot;Department of Obsterics and Gynecology&quot;&gt;DOG&lt;/span&gt;/Department of Obsterics and Gynecology Üllői Street Department&lt;/span&gt;
;&amp;nbsp;&amp;nbsp;&amp;nbsp;
							&lt;span class=&quot;author-name&quot; mtid=&quot;10072753&quot;&gt;&lt;a 
																				   href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10072753&quot; target=&quot;_blank&quot;&gt;Keszthelyi Márton ✉
	            (&lt;span class=&quot;authorship-author-name&quot;&gt;Keszthelyi Márton&lt;/span&gt;
	            &lt;span class=&quot;authorAux-mtmt&quot;&gt; Szülészet-nőgyógyászat&lt;/span&gt;)
			&lt;/a&gt;
    &lt;/span&gt;
&lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;Semmelweis University&quot;&gt;SU&lt;/span&gt;/&lt;span title=&quot;Faculty of Medicine&quot;&gt;FM&lt;/span&gt;/&lt;span title=&quot;Clinical&quot;&gt;C&lt;/span&gt;/&lt;span title=&quot;Department of Obsterics and Gynecology&quot;&gt;DOG&lt;/span&gt;/Department of Obsterics and Gynecology Üllői Street Department&lt;/span&gt;

				    &lt;/div&gt;
&lt;/div&gt;
&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;36204498&quot; target=&quot;_blank&quot;&gt;The Platelet-to-Lymphocyte Ratio (PLR) as a Non-Invasive Biomarker for Cervical Malignancy in Conization Patients&lt;/a&gt;&lt;/div&gt;    &lt;div&gt;		&lt;span class=&quot;journal-title&quot;&gt;LIFE-BASEL&lt;/span&gt;

        &lt;span class=&quot;journal-issn&quot;&gt;( &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/2075-1729&quot;&gt;2075-1729&lt;/a&gt;)&lt;/span&gt;:
		&lt;span class=&quot;journal-volume&quot;&gt;15&lt;/span&gt; &lt;span class=&quot;journal-issue&quot;&gt;6&lt;/span&gt;
&lt;span class=&quot;page&quot;&gt;
		Paper 971.
	 13 p. 
&lt;/span&gt;		 &lt;span class=&quot;year&quot;&gt;(2025)&lt;/span&gt;  
    &lt;/div&gt;
&lt;div class=&quot;pub-footer&quot;&gt;
    

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									DOI
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							&lt;a style=&quot;color:blue&quot; title=&quot;001517136100001&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/001517136100001&quot;&gt;
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									Scopus
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						&lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt;
							
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									PubMed
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	&lt;OnlyViewableByAuthor&gt;&lt;div class=&quot;ratings&quot;&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Journal subject: Scopus - Ecology, Evolution, Behavior and Systematics&amp;nbsp;&amp;nbsp;&amp;nbsp;Rank:&amp;nbsp;Q1&lt;/div&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Journal subject: Scopus - Paleontology&amp;nbsp;&amp;nbsp;&amp;nbsp;Rank:&amp;nbsp;Q1&lt;/div&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&amp;nbsp;&amp;nbsp;&amp;nbsp;Rank:&amp;nbsp;Q2&lt;/div&gt;
				&lt;div class=&quot;journal-subject&quot;&gt;Journal subject: Scopus - Space and Planetary Science&amp;nbsp;&amp;nbsp;&amp;nbsp;Rank:&amp;nbsp;Q2&lt;/div&gt;
			&lt;div class=&quot;journal-subject&quot;&gt;Norwegian Register for Scientific Journals&lt;/div&gt;
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	&lt;div class=&quot;publication-citation&quot; style=&quot;margin-left: 0.5cm;&quot;&gt;
		&lt;span title=&quot;&quot; class=&quot;citingPub-count&quot;&gt;Citing papers: 11&lt;/span&gt;
		| Independent citation: 1
		| Self citation: 10
		| Unknown citation: 0
		| Number of citations in WoS: 11 
		|  Number of citations in Scopus:&amp;nbsp;10 
		|  WoS/Scopus assigned:&amp;nbsp;11 
		|  Number of citations with DOI:&amp;nbsp;11 
		
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		&lt;a target=&quot;_blank&quot; href=&quot;/api/publication?cond=citations.related;eq;36204498&amp;sort=publishedYear,desc&amp;sort=title&quot;&gt;
			Number of cited publications: 4
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    &lt;div class=&quot;mtid&quot;&gt;&lt;span class=&quot;long-pub-mtid&quot;&gt;Publication: 36204498&lt;/span&gt;
    | &lt;span class=&quot;status-data status-VALIDATED&quot;&gt; 	Validated
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Core	 Citing
	
	
    | &lt;span class=&quot;type-subtype&quot;&gt;Journal Article
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      		| &lt;span class=&quot;pub-category&quot;&gt;Scientific&lt;/span&gt;
	| &lt;span class=&quot;publication-sourceOfData&quot;&gt;WOS TAGGED&lt;/span&gt;
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&lt;div class=&quot;lastModified&quot;&gt;Last Modified: 2026.08.27. 11:03 Éva Miskolczi (SE_KK_Admin5_DME, admin)
&lt;/div&gt;




	&lt;pre class=&quot;comment&quot; style=&quot;margin-top: 0; margin-bottom: 0;&quot;&gt;&lt;u&gt;Comments&lt;/u&gt;: Semmelweis Egyetem, Department of Obstetrics and Gynecology, Budapest, Hungary            
            Semmelweis Egyetem, Workgroup of Research Management, Budapest, Hungary            
            Department of Urology, Budapest, Hungary            
            Szegedi Tudományegyetem (SZTE), Department of Obstetrics and Gynecology, Szeged, Hungary            
            Export Date: 18 Nove...&lt;/pre&gt;

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