Psoriasis is a chronic inflammatory skin disease characterised by increased oxidative
stress, the overproliferation of keratinocytes, the accumulation of inflammatory mediators,
and skin barrier damage. Although a number of therapeutic options are available, finding
long-term treatments that are well-tolerated and patient-friendly treatments remains
a challenge. Tapinarof is a new type of aryl hydrocarbon receptor (AhR) modulator
that has recently attracted attention as a promising non-steroidal alternative. However,
its application may be limited by its poor water solubility and low degree of skin
penetration. Nanotechnology-based drug carriers, specially nanogels, offer new opportunities
to overcome these limitations by combining the advantages of targeted drug delivery
and enhanced skin penetration. Furthermore, nanogel formulations can improve skin
hydration and support the restoration of skin barrier function, which are important
in the treatment of psoriasis. This review focuses on current and emerging therapeutic
approaches, with particular emphasis on the potential of incorporating tapinarof into
nanogel formulations as a novel alternative to topical psoriasis treatment.
