https://m2.mtmt.hu/ eng 2026-10-25 01:03 JournalArticle 36189735 VALIDATED true Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary HCEMM-SU Translational Dermatology Research Group, Semmelweis University, Budapest, Hungary Department of Physiology, Semmelweis University, Budapest, Hungary Institute of Clinical Pharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary Export Date: 03 June 2026; Cited By: 4; Correspondence Address: P. Holló; Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, Budapest, Mária Street 41, 1085, Hungary; email: hollo.peter@semmelweis.hu; CODEN: JEAVE 0 false 2026-10-09T16:56:54.676+0000 2026-06-03T03:03:42.534+0000 2025-06-12T13:56:34.890+0000 true 10083379 Belházyné Szombathelyi Ágnes /api/admin/10083379 Admin Ágnes Belházyné Szombathelyi (SZTE admin5) true 2026-06-18T17:17:49.820+0000 2025-09-27T19:10:52.867+0000 true 10083379 Belházyné Szombathelyi Ágnes /api/admin/10083379 Admin Ágnes Belházyné Szombathelyi (SZTE admin5) true true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Survey paper (Journal Article) 102 true 1134514 true 1 /api/category/1 Category Scientific true 1 Galajda, Noémi Ágnes true true /api/journal/23995 REVIEWED JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 0926-9959 1468-3083 true false 23995 false 23995 true 0926-9959 1468-3083 Journal FOREIGN 39 10 1760 1772 1760 13 2025 Current therapeutic guidelines for immune-mediated inflammatory diseases (IMIDs) contraindicate the administration of tumour necrosis factor inhibitors (TNFis) in advanced heart failure (HF) and highlight the potential risk for new-onset HF. The current evidence has low certainty, and the results of studies in the past two decades have even challenged the recommendations regarding the impact of TNFis on the risk of HF.The objective was to systematically synthesize data on the risk of HF in TNFi-treated groups compared to non-treated controls in IMIDs.A systematic search was conducted in August 2023. Randomized controlled trials (RCTs) and non-randomized observational studies of IMID patients comparing groups receiving TNFis to non-TNFi-exposed controls were included. The outcome was the incidence of worsening, de novo, and composite HF. Random-effects meta-analysis was conducted using risk ratios (RR) with 95% confidence intervals (CIs) to pool data.The systematic search identified 49 studies, with 45 included in the quantitative analysis. For the worsening of HF, the pooled results of non-randomized studies showed no statistically significant risk-increasing effect of TNFis (RR = 1.18, 95% CI: 0.69-2.00). Analyses from both RCTs and non-randomized data indicated no increased risk of de novo HF in the TNFi-group compared to controls (RR = 0.87, 95% CI: 0.60-1.25 and RR = 0.86, 95% CI: 0.64-1.14, respectively). Similarly, no increased risk was found for composite (worsening and de novo) HF in the TNFi-treated group versus controls, pooling non-randomized data.Our findings indicate that TNFi-treated IMID patients do not have an increased risk for developing de novo HF, and no statistically significant risk enhancement could be observed in the risk of worsening HF with TNFis. Updating IMID guidelines should be considered regarding TNFis' non-risk increasing effect on de novo HF, whereas further validating data on the risk of worsening HF in TNFi-treated IMID patients is needed. true 2025 true true true false true false GOLD 2026-10-09 true https://doi.org/10.1111/jdv.20786 6 0 6 5 1 6 6 5 6 6 6 5 5 5 1 0 6 5 6 5 0 4 4 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 1 1 1 2026 0 5 4 5 4 D1 false false false false 2025-09-10T13:56:40.597+0000 Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K); HCEMM-SE Transzlációs Dermatológiai Kutatócsoport (SE / AOK / K / BNBK); Klinikai Gyógyszerészeti Intézet (SZTE / GYTK); Pankreász Betegségek Intézete (SE / AOK / K); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE); Élettani Intézet (SE / AOK / I) 10 42 7 11 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 126889140 /api/authorship/126889140 Galajda, Noémi Ágnes [Galajda, Noémi Ágnes (Bőrgyógyászat), author] Department of Dermatology, Dermatooncology and ... 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(SU / FM / C); HCEMM-SU Translational Dermatology Research Group (SU / FM / C / DDDV); Centre for Translational Medicine (SU / KSZE) 5 0.091 false false false Author 10087211 /api/author/10087211 Anna Sára Lengyel (bőrgyógyászat) Lengyel Anna Sára true true Lengyel Anna Sára true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126889145 /api/authorship/126889145 Kolonics, Mária Veronika [Kolonics, Mária Veronika (bőrgyógyászat, ve...), author] Department of Dermatology, Dermatooncology and ... (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 6 0.091 false false false Author 10087519 /api/author/10087519 Mária Veronika Kolonics (bőrgyógyászat, venerológia) Kolonics Mária Veronika true true Kolonics Mária Veronika true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126889146 /api/authorship/126889146 Kemény, Lajos Vince [Kemény, Lajos Vince (Bőrgyógyászat, on...), author] Department of Dermatology, Dermatooncology and ... (SU / FM / C); Department of Physiology (SU / FM / I); HCEMM-SU Translational Dermatology Research Group (SU / FM / C / DDDV); Centre for Translational Medicine (SU / KSZE) 7 0.091 false false false Author 10040817 /api/author/10040817 Lajos Vince Kemény (Bőrgyógyászat, onkológia) Kemény Lajos Vince true 10040817 true Kemény Lajos Vince true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126889147 /api/authorship/126889147 Csupor, Dezső [Csupor, Dezső (Klinikai gyógysze...), author] Department of Clinical Pharmacy (SZTE / FP); Institute for Translational Medicine (UP / UPMS); Centre for Translational Medicine (SU / KSZE) 8 0.091 false false false Author 10001143 /api/author/10001143 Dezső Csupor (Klinikai gyógyszerészet; Fitokémia) Csupor Dezső true 10001143 true Csupor Dezső true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126889148 /api/authorship/126889148 Hegyi, Péter [Hegyi, Péter (Gasztroenterológia), author] Institute for Translational Medicine (UP / UPMS); Institute of Pancreatic Diseases (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 9 0.091 false false false Author 10002629 /api/author/10002629 Péter Hegyi (Gasztroenterológia) Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126889149 /api/authorship/126889149 Holló, Péter** ✉ [Holló, Péter (Bőrgyógyászat), author] Department of Dermatology, Dermatooncology and ... (SU / FM / C) 10 0.091 false true true Author 10019467 /api/author/10019467 Péter Holló (Bőrgyógyászat) Holló Péter true 10019467 true Holló Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 126889150 /api/authorship/126889150 Bánvölgyi, András [Bánvölgyi, András (bőrgyógyászat), author] Department of Dermatology, Dermatooncology and ... (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 11 0.091 false true false Author 10037621 /api/author/10037621 András Bánvölgyi (bőrgyógyászat) Bánvölgyi András true 10037621 true Bánvölgyi András true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 29479601 /api/publicationidentifier/29479601 DOI: 10.1111/jdv.20786 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1111/jdv.20786 https://doi.org/10.1111/jdv.20786 false true PublicationIdentifier 29488009 /api/publicationidentifier/29488009 WoS: 001506289600001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001506289600001 https://www.webofscience.com/wos/woscc/full-record/001506289600001 false true PublicationIdentifier 29509640 /api/publicationidentifier/29509640 Scopus: 105007821821 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105007821821 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105007821821 true true PublicationIdentifier 29479600 /api/publicationidentifier/29479600 PubMed: 40497591 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40497591 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40497591&dopt=Abstract false true PublicationIdentifier 29479616 /api/publicationidentifier/29479616 SZTE Publicatio: 36977 SwordSource 90 /api/publicationsource/90 SZTE Publicatio PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true SZTE Publicatio SZTE Publicatio http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true GREEN true IDENTICAL 36977 http://publicatio.bibl.u-szeged.hu/36977 false true Keyword 3375201 /api/keyword/3375201 [Meta-analysis] true true SjrRating 11572512 /api/sjrrating/11572512 sjr:D1 (2025) Scopus - Dermatology JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 0926-9959 1468-3083 3 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2708 /api/classificationexternal/2708 Scopus - Dermatology true 2708 true D1 DIRECT true true /api/publication/36189735 Galajda Noémi Ágnes et al. Evaluation of the risk of heart failure with tumour necrosis factor inhibitors: A large-scale meta-analysis in immune-mediated inflammatory diseases. (2025) JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY 0926-9959 1468-3083 39 10 1760-1772<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10079523"><a href="/gui2/?type=authors&mode=browse&sel=10079523" target="_blank">Galajda Noémi Ágnes (<span class="authorship-author-name">Galajda Noémi Ágnes</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Dermatology, Dermatooncology and Venerology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10079444"><a href="/gui2/?type=authors&mode=browse&sel=10079444" target="_blank">Meznerics Fanni Adél (<span class="authorship-author-name">Meznerics Fanni Adél</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Dermatology, Dermatooncology and Venerology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045289"><a href="/gui2/?type=authors&mode=browse&sel=10045289" target="_blank">Mátrai Péter (<span class="authorship-author-name">Mátrai Péter</span> <span class="authorAux-mtmt"> Statisztika</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fazekas Alíz </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10087211"><a href="/gui2/?type=authors&mode=browse&sel=10087211" target="_blank">Lengyel Anna Sára (<span class="authorship-author-name">Lengyel Anna Sára</span> <span class="authorAux-mtmt"> bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Dermatology, Dermatooncology and Venerology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Dermatology, Dermatooncology and Venerology">DDDV</span>/HCEMM-SU Translational Dermatology Research Group; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10087519"><a href="/gui2/?type=authors&mode=browse&sel=10087519" target="_blank">Kolonics Mária Veronika (<span class="authorship-author-name">Kolonics Mária Veronika</span> <span class="authorAux-mtmt"> bőrgyógyászat, venerológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Dermatology, Dermatooncology and Venerology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040817"><a href="/gui2/?type=authors&mode=browse&sel=10040817" target="_blank">Kemény Lajos Vince (<span class="authorship-author-name">Kemény Lajos Vince</span> <span class="authorAux-mtmt"> Bőrgyógyászat, onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Dermatology, Dermatooncology and Venerology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Dermatology, Dermatooncology and Venerology">DDDV</span>/HCEMM-SU Translational Dermatology Research Group; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001143"><a href="/gui2/?type=authors&mode=browse&sel=10001143" target="_blank">Csupor Dezső (<span class="authorship-author-name">Csupor Dezső</span> <span class="authorAux-mtmt"> Klinikai gyógyszerészet; Fitokémia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Clinical Pharmacy; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Institute of Pancreatic Diseases; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019467"><a href="/gui2/?type=authors&mode=browse&sel=10019467" target="_blank">Holló Péter^** ✉ (<span class="authorship-author-name">Holló Péter</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Dermatology, Dermatooncology and Venerology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037621"><a href="/gui2/?type=authors&mode=browse&sel=10037621" target="_blank">Bánvölgyi András (<span class="authorship-author-name">Bánvölgyi András</span> <span class="authorAux-mtmt"> bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Dermatology, Dermatooncology and Venerology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36189735" target="_blank">Evaluation of the risk of heart failure with tumour necrosis factor inhibitors: A large-scale meta-analysis in immune-mediated inflammatory diseases</a></div> <div> <span class="journal-title">JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0926-9959">0926-9959</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1468-3083">1468-3083</a>)</span>: <span class="journal-volume">39</span> <span class="journal-issue">10</span> <span class="page"> pp 1760-1772 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1111/jdv.20786" target="_blank" href="https://doi.org/10.1111/jdv.20786"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001506289600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001506289600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105007821821" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105007821821"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40497591" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40497591&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="36977" target="_blank" href="http://publicatio.bibl.u-szeged.hu/36977"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Dermatology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Infectious Diseases&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 6</span> | Independent citation: 5 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 5 | Number of citations in Scopus:&nbsp;6 | WoS/Scopus assigned:&nbsp;6 | Number of citations with DOI:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36189735&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36189735</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2026.06.03. 05:03 Róbert Milánkovics (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary HCEMM-SU Translational Dermatology Rese...</pre> </div></div>