Background: Odontogenic cysts can damage the surrounding bone tissue as they grow,
making it essential to implement effective regenerative strategies tailored to each
patient. Personalised approaches in oral surgery, such as selecting the most suitable
bone graft materials, can lead to improved treatment outcomes. Filling the bone defect
created after cyst removal, root resection, or extraction with a bone graft material
can stabilise the weakened tooth and promote faster bone regeneration. This article
shares our experiences with the therapeutic effects of albumin-coated bone allograft
(BoneAlbumin®) placed in the bone defect following cyst removal in the oral cavity,
compared to cases where the defect was left untreated (controls). Methods: The study
involved thirty patients who underwent the removal of maxillary odontogenic cysts.
In 15 of these patients, the bone defect was filled with albumin-coated bone allograft
(BoneAlbumin®, OrthoSera, Budapest, Hungary). In the control group, which consisted
of 15 patients, the defect was left untreated. A consistent surgical protocol was
adhered to throughout the study. Follow-up periapical X-rays were taken immediately
after surgery as well as at 6 and 12 weeks post-surgery, using a standardised template.
These images were used to assess the shrinkage and healing of the defect caused by
the cyst. Measurements were adjusted to reference points to account for potential
distortions in the X-rays. Results: The control and study groups exhibited no statistically
significant differences in their basic parameters. Additionally, there was no notable
difference in the sizes of postoperative defects between the two groups. However,
statistical analysis revealed a significant difference in the changes in defect size
(∆defect size) between the groups at both 6 weeks (p < 0.000001) and 12 weeks (p =
0.000296). This suggests that the BoneAlbumin®-graft group experienced significantly
greater changes in defect size over time. Conclusions: The use of BoneAlbumin® graft
leads to a markedly better reduction in defect size as time progresses, although these
changes have only been compared to graft-free healing.
