https://m2.mtmt.hu/ eng 2026-09-23 03:40 JournalArticle 36189143 VALIDATED true 0 false 2026-08-06T06:42:17.516+0000 2026-05-20T09:04:54.457+0000 2025-06-12T11:22:05.247+0000 true 10070196 Aldahabi Mohammad /api/author/10070196 Author true 2026-05-26T13:04:47.176+0000 2025-08-21T13:34:10.924+0000 true 10079265 Tomcsik Adrienn /api/admin/10079265 Admin true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-05-20T07:50:17.846+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Heredi, Judit Increased excitatory synapse size in hippocampal place cells compared to silent cells. true true /api/journal/3547 REVIEWED true false 3547 false 3547 true 0027-8424 1091-6490 Journal FOREIGN 122 23 e2505322122 e2505322122 11 2025 Neuronal activity in the hippocampus creates a cognitive map of space that is essential for navigation. In any given environment, a fraction of hippocampal pyramidal cells (PCs) is active at specific locations (place cells), others are sparsely active without spatial tuning, and a significant proportion of the PCs is entirely silent. The mechanisms underlying the vastly different activities of PCs in the rodent hippocampal CA1 area are unknown. Here, we measured the in vivo activity of CA1 PCs using two-photon [Ca2+] imaging in head-restrained mice during navigation in a virtual corridor and then performed in vitro patch-clamp recording to probe their intrinsic electrical properties and anatomical investigation to characterize their input synapses. The active and passive electrical properties of PCs were similar between PCs with different prior in vivo activities. Perisomatic inhibitory synapse density was also comparable among PCs. The average dendritic spine density and spine head area did not correlate with the mean in vivo activity of PCs, but the size of the spines of place cells was significantly larger compared to that of silent cells. Our results are consistent with excitatory synaptic plasticity as a major mechanism underlying spatially tuned activity of place cells in hippocampal networks. 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Celluláris Idegélettani Kutatócsoport (HRN KOKI); Idegi Jelátvitel Kutatócsoport (HRN KOKI) 8 49 3 8 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 126886534 /api/authorship/126886534 1 0.125 true false false Author 10040635 /api/author/10040635 Herédi Judit true 10040635 true Heredi Judit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126886535 /api/authorship/126886535 2 0.125 false false false Author 10040852 /api/author/10040852 Oláh Gáspár true 10040852 true Olah Gaspar true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126886536 /api/authorship/126886536 3 0.125 false false false Author 10012933 /api/author/10012933 Sümegi Máté true 10012933 true Sumegi Mate true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126886537 /api/authorship/126886537 4 0.125 false false false Author 10087422 /api/author/10087422 Lukács István Paul true true Paul Lukacs Istvan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126886538 /api/authorship/126886538 5 0.125 false false false Author 10070196 /api/author/10070196 Aldahabi Mohammad true true Aldahabi Mohammad true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126886539 /api/authorship/126886539 6 0.125 false false false Author 10017153 /api/author/10017153 Ujfalussy Balázs Benedek true 10017153 true Újfalussy Balázs B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126886540 /api/authorship/126886540 7 0.125 false false false Author 146 /api/author/146 Makara Judit true 146 true Makara Judit K true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126886541 /api/authorship/126886541 8 0.125 false true true Author 10000499 /api/author/10000499 Nusser Zoltán true 10000499 true Nusser Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29478384 /api/publicationidentifier/29478384 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1073/pnas.2505322122 https://doi.org/10.1073/pnas.2505322122 false true PublicationIdentifier 29710151 /api/publicationidentifier/29710151 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001510579300001 https://www.webofscience.com/wos/woscc/full-record/001510579300001 false true PublicationIdentifier 32685738 /api/publicationidentifier/32685738 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true 243189 https://real.mtak.hu/243189 false true PublicationIdentifier 29511793 /api/publicationidentifier/29511793 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105007913962 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105007913962 false true PublicationIdentifier 29478383 /api/publicationidentifier/29478383 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40472030 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40472030&dopt=Abstract false true Keyword 1546 /api/keyword/1546 true 1546 true Keyword 2114 /api/keyword/2114 true 2114 true Keyword 6104 /api/keyword/6104 true 6104 true Keyword 6406 /api/keyword/6406 true 6406 true Keyword 1011650 /api/keyword/1011650 true 1011650 true MtaRating 11435140 /api/mtarating/11435140 RatingType 10031 /api/ratingtype/10031 X. 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Földtudományok Osztálya HAS Section of Earth Sciences (X.) true 70 true true true A true true MtaRating 11551102 /api/mtarating/11551102 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true A nemzetközi false true MtaRating 519088 /api/mtarating/519088 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19088 true SjrRating 11736298 /api/sjrrating/11736298 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true D1 DIRECT true true /api/publication/36189143 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10040635"><a href="/gui2/?type=authors&mode=browse&sel=10040635" target="_blank">Heredi Judit (<span class="authorship-author-name">Herédi Judit</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040852"><a href="/gui2/?type=authors&mode=browse&sel=10040852" target="_blank">Olah Gaspar (<span class="authorship-author-name">Oláh Gáspár</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012933"><a href="/gui2/?type=authors&mode=browse&sel=10012933" target="_blank">Sumegi Mate (<span class="authorship-author-name">Sümegi Máté</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10087422"><a href="/gui2/?type=authors&mode=browse&sel=10087422" target="_blank">Paul Lukacs Istvan (<span class="authorship-author-name">Lukács István Paul</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070196"><a href="/gui2/?type=authors&mode=browse&sel=10070196" target="_blank">Aldahabi Mohammad (<span class="authorship-author-name">Aldahabi Mohammad</span> <span class="authorAux-mtmt"> Synaptic neurotransmission</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017153"><a href="/gui2/?type=authors&mode=browse&sel=10017153" target="_blank">Újfalussy Balázs B (<span class="authorship-author-name">Ujfalussy Balázs Benedek</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/ Laboratory of Biological Computatio</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="146"><a href="/gui2/?type=authors&mode=browse&sel=146" target="_blank">Makara Judit K (<span class="authorship-author-name">Makara Judit</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Neuronal Signaling</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000499"><a href="/gui2/?type=authors&mode=browse&sel=10000499" target="_blank">Nusser Zoltan ✉ (<span class="authorship-author-name">Nusser Zoltán</span> <span class="authorAux-mtmt"> Celluláris idegélettan</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Laboratory of Cellular Neurophysiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36189143" target="_blank">Increased excitatory synapse size in hippocampal place cells compared to silent cells.</a></div> <div> <span class="journal-title">PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0027-8424">0027-8424</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1091-6490">1091-6490</a>)</span>: <span class="journal-volume">122</span> <span class="journal-issue">23</span> <span class="page"> p. e2505322122. 11 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1073/pnas.2505322122" target="_blank" href="https://doi.org/10.1073/pnas.2505322122"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001510579300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001510579300001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="243189" target="_blank" href="https://real.mtak.hu/243189"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105007913962" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105007913962"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40472030" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40472030&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">HAS Section of Earth Sciences (X.) HASSESX&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 1</span> | Independent citation: 1 | Self citation: 0 | Unknown citation: 0 | Number of citations in Scopus:&nbsp;1 | WoS/Scopus assigned:&nbsp;1 | Number of citations with DOI:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36189143&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36189143</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hungarian Brain Research Program(NAP2022-I-1/2022), International Research Scholar Program of the Howard Hughes Medical Institute(55008740), European Research Council Consolidator Grant(ERC-CoG 771849), European Research Council Advanced Grant(ERC-AG 787157) </div> <div class="lastModified">Last Modified: 2026.05.20. 11:04 Katalin Lévayné Deseő (MTMT Központi admin) </div> <div class="lockedBy">Centrally managed 2026.05.20. 09:50 Katalin Lévayné Deseő (MTMT Központi admin) </div> </div></div>