https://m2.mtmt.hu/ eng 2026-05-30 16:50 JournalArticle 36187396 APPROVED true Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan Graduate School of Science and Technology, University of Tsukuba, Tsukuba, Japan Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan Department of Anatomy and Molecular Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan Division of Multicellular Circuit Dynamics, National Institute for Physiological Sciences, Myodaiji Okazaki, Japan Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan Department of Anatomy, Keio University School of Medicine, Tokyo, Japan Department of Anatomy, The Jikei University School of Medicine, Tokyo, Japan School of Integrative and Global Majors, University of Tsukuba, Tsukuba, Japan College of Biological Sciences, School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan Institute of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan Department of Life Sciences, School of Agriculture, Meiji University, Kawasaki, Japan Department of Physiological Sciences, Graduate University for Advanced Studies SOKENDAI, Hayama, Japan Department of Systems Science, Center of Optical Scattering Image Science, Kobe University, Kobe, Japan International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo, Tokyo, Japan Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo Minato-ku, Tokyo, Japan Information and Communication Research Division, Mizuho Research and Technologies Ltd., Tokyo, Japan Faculty of Mathematical Informatics, Meiji Gakuin University, Yokohama, Japan Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan Center for Quantum and Information Life Sciences, University of Tsukuba, Tsukuba, Japan Chugai Life Science Park Yokohama, Chugai Pharmaceutical Co. Ltd., Yokohama, Japan Export Date: 11 June 2025; Cited By: 1; Correspondence Address: F. Tsuruta; School of Integrative and Global Majors, University of Tsukuba, Tsukuba, Japan; email: tsuruta.fuminori.fn@u.tsukuba.ac.jp; CODEN: NANEF 0 false 2025-10-17T13:28:42.436+0000 2025-10-17T13:25:33.882+0000 2025-06-11T14:21:15.158+0000 true 10065463 Turek Márta /api/admin/10065463 Admin true 2026-05-22T10:35:22.580+0000 2026-05-22T10:35:22.580+0000 false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Yano, S. Propagation of neuronal micronuclei regulates microglial characteristics true true /api/journal/19517 REVIEWED true false 19517 false 19517 true 1097-6256 1546-1726 Journal FOREIGN 28 3 487 498 12540 487, 12540 12 2025 Microglia—resident immune cells in the central nervous system—undergo morphological and functional changes in response to signals from the local environment and mature into various homeostatic states. However, niche signals underlying microglial differentiation and maturation remain unknown. Here, we show that neuronal micronuclei (MN) transfer to microglia, which is followed by changing microglial characteristics during the postnatal period. Neurons passing through a dense region of the developing neocortex give rise to MN and release them into the extracellular space, before being incorporated into microglia and inducing morphological changes. Two-photon imaging analyses have revealed that microglia incorporating MN tend to slowly retract their processes. Loss of the cGAS gene alleviates effects on micronucleus-dependent morphological changes. Neuronal MN-harboring microglia also exhibit unique transcriptome signatures. 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src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Yano S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Asami N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kishi Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Takeda I. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kubotani H. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hattori Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kitazawa A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hayashi K. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kubo K.-I. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Saeki M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Maeda C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hiraki C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Teruya R.-I. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Taketomi T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Akiyama K. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Okajima-Takahashi T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sato B. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wake H. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gotoh Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nakajima K. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ichinohe T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nagata T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chiba T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tsuruta F. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36187396" target="_blank">Propagation of neuronal micronuclei regulates microglial characteristics</a></div> <div> <span class="journal-title">NATURE NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-6256">1097-6256</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1546-1726">1546-1726</a>)</span>: <span class="journal-volume">28</span> <span class="journal-issue">3</span> <span class="page"> pp 487-498 Paper 12540. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1038/s41593-024-01863-5" target="_blank" href="https://doi.org/10.1038/s41593-024-01863-5"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001399482500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001399482500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="85217183771" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85217183771"> Scopus </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36187396&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36187396</span> | <span class="status-data status-APPROVED"> Published </span> Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Last Modified: 2025.10.17. 15:25 György Wolf (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan Graduate School of Science and Technology, University of Tsukuba, Tsukuba, Japan Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, ...</pre> </div></div>