https://m2.mtmt.hu/ hun 2026-09-23 07:47 JournalArticle 36175313 VALIDATED true Department of Obstetrics and Gynecology, Semmelweis University, Budapest, 1082, Hungary Workgroup of Research Management, Doctoral School, Semmelweis University, Budapest, 1085, Hungary Department of Urology, Semmelweis University, Budapest, 1082, Hungary Department of Obstetrics and Gynecology, University of Szeged, Szeged, 6725, Hungary Export Date: 01 July 2025; Cited By: 0; Correspondence Address: M. Keszthelyi; Department of Obstetrics and Gynecology, Semmelweis University, Budapest, 1082, Hungary; email: keszthelyi.marton@semmelweis.hu 0 false 2026-09-09T10:07:29.651+0000 2026-08-13T23:53:34.495+0000 2025-06-03T11:24:11.125+0000 true 10084159 Balázsné Balogh Ildikó /api/admin/10084159 Admin true 2026-08-03T20:03:07.077+0000 2026-08-03T20:03:07.077+0000 2025-06-25T06:43:31.369+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Vida, Balázs The Neutrophil-to-Lymphocyte Ratio (NLR) as A Potential Predictor in Conization Outcomes for Cervical Cancer true true /api/journal/10032813 REVIEWED true false 10032813 false 10032813 true 2072-6694 Journal FOREIGN 17 11 1856 1856 16 2025 Background:Cervical cancer is a major global health concern, particularly in low-resource settings where access to advanced diagnostics is limited. The neutrophil-to-lymphocyte ratio (NLR), a systemic inflammatory marker, has shown prognostic significance in various malignancies. However, its role in predicting cervical cancer in patients undergoing conization remains unclear. Objectives: This study evaluated NLR’s diagnostic and predictive value in identifying malignancy in conization outcomes. Methods: This retrospective study analyzed 374 patients from the SCOPE study. Preoperative NLR levels were assessed with conization histopathology outcomes using the Kruskal–Wallis test, Mann–Whitney U test, logistic regression, and receiver operating characteristic (ROC) curve analysis. Results: NLR levels were significantly higher in patients with malignant conization outcomes (χ2 = 15.988, p = 0.001). A cut-off NLR ≥ 2.86 significantly predicted cervical cancer presence (p = 0.045). Logistic regression showed that each unit increase in the NLR increased cancer likelihood by 37.2% (p = 0.008). ROC analysis demonstrated moderate diagnostic accuracy (AUC = 0.734), with an optimal NLR cut-off of ≥1.865 yielding 87.0% sensitivity and 53.8% specificity. Conclusions: Our findings suggest that the NLR may serve as a promising, easily accessible, non-invasive biomarker with modest predictive value for cervical cancer in patients undergoing conization. Future studies should focus on validating the NLR in combination with other biomarkers, such as HPV genotyping and molecular markers, to improve diagnostic accuracy, particularly in low-resource settings. true true 2025 true true true false true false GOLD 2026-09-09 false http://www.mdpi.com/journal/cancers/ 14 0 14 5 9 14 14 13 12 13 13 4 4 5 9 0 14 5 14 5 0 2 2 Folyóiratcikk Journal Article 24 14 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 4 1 4 1 2026 0 10 4 10 4 Q1 false false false false 2025-06-15T11:42:09.321+0000 Doktori Iskola (SE); Szülészeti és Nőgyógyászati Klinika (SE / AOK / K); Szülészeti és Nőgyógyászati Klinika (SZTE / SZAOK); Szülészeti és Nőgyógyászati Klinika Üllői úti r... 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https://www.scopus.com/inward/record.uri?eid=2-s2.0-105007736080&doi=10.3390%2Fcancers17111856&partnerID=40&md5=0782cbf6fd338841f6d30480d59adf7b false true Classification 12306 /api/classification/12306 true true Classification 12217 /api/classification/12217 true true SjrRating 11609292 /api/sjrrating/11609292 92 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2730 /api/classificationexternal/2730 true 2730 true Q1 DIRECT true true /api/publication/36175313 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10098630"><a href="/gui2/?type=authors&mode=browse&sel=10098630" target="_blank">Vida Balázs (<span class="authorship-author-name">Vida Balázs</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10100385"><a href="/gui2/?type=authors&mode=browse&sel=10100385" target="_blank">Keszthelyi Emese<sup>*</sup> (<span class="authorship-author-name">Keszthelyi Emese Ágnes</span> <span class="authorAux-mtmt"> orvosi tudományok</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10099913"><a href="/gui2/?type=authors&mode=browse&sel=10099913" target="_blank">Tóth Zsófia (<span class="authorship-author-name">Tóth Zsófia</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10092560"><a href="/gui2/?type=authors&mode=browse&sel=10092560" target="_blank">Lőczi Lotti (<span class="authorship-author-name">Keszthelyi Lotti Lúcia</span> <span class="authorAux-mtmt"> Szülészet, nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Szülészeti és Nőgyógyászati Klinika">SZSZNK</span>/Szülészeti és Nőgyógyászati Klinika Üllői úti részleg</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089138"><a href="/gui2/?type=authors&mode=browse&sel=10089138" target="_blank">Sebők Barbara (<span class="authorship-author-name">Sebők Barbara</span> <span class="authorAux-mtmt"> Klinikai informatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10079318"><a href="/gui2/?type=authors&mode=browse&sel=10079318" target="_blank">Merkely Petra (<span class="authorship-author-name">Merkely Petra</span> <span class="authorAux-mtmt"> szülészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036681"><a href="/gui2/?type=authors&mode=browse&sel=10036681" target="_blank">Lintner Balázs (<span class="authorship-author-name">Lintner Balázs</span> <span class="authorAux-mtmt"> Szülészet-Nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009719"><a href="/gui2/?type=authors&mode=browse&sel=10009719" target="_blank">Bánhidy Ferenc (<span class="authorship-author-name">Bánhidy Ferenc</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024659"><a href="/gui2/?type=authors&mode=browse&sel=10024659" target="_blank">Keszthelyi Attila (<span class="authorship-author-name">Keszthelyi Attila</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Urológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011316"><a href="/gui2/?type=authors&mode=browse&sel=10011316" target="_blank">Várbíró Szabolcs (<span class="authorship-author-name">Várbíró Szabolcs</span> <span class="authorAux-mtmt"> Keringésélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Szülészeti és Nőgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089733"><a href="/gui2/?type=authors&mode=browse&sel=10089733" target="_blank">Tóth Richárd<sup>**</sup> (<span class="authorship-author-name">Tóth Richárd</span> <span class="authorAux-mtmt"> Szülészet, nőgyógyászat, nőgyógyászati onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072753"><a href="/gui2/?type=authors&mode=browse&sel=10072753" target="_blank">Keszthelyi Márton ✉ (<span class="authorship-author-name">Keszthelyi Márton</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szülészeti és Nőgyógyászati Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36175313" target="_blank">The Neutrophil-to-Lymphocyte Ratio (NLR) as A Potential Predictor in Conization Outcomes for Cervical Cancer</a></div> <div> <span class="journal-title">CANCERS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6694">2072-6694</a>)</span>: <span class="journal-volume">17</span> <span class="journal-issue">11</span> <span class="page"> Paper 1856. 16 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/cancers17111856" target="_blank" href="https://doi.org/10.3390/cancers17111856"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001505666500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001505666500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105007736080" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105007736080"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40507335" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40507335&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:black" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105007736080&doi=10.3390%2Fcancers17111856&partnerID=40&md5=0782cbf6fd338841f6d30480d59adf7b" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105007736080&doi=10.3390%2Fcancers17111856&partnerID=40&md5=0782cbf6fd338841f6d30480d59adf7b"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 14</span> | Független: 5 | Függő: 9 | Nem jelölt: 0 | WoS jelölt: 13 | Scopus jelölt:&nbsp;12 | WoS/Scopus jelölt:&nbsp;13 | DOI jelölt:&nbsp;14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36175313&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36175313</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2026.08.14. 01:53 Keszthelyi Emese Ágnes (orvosi tudományok) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Obstetrics and Gynecology, Semmelweis University, Budapest, 1082, Hungary Workgroup of Research Management, Doctoral School, Semmelweis University, Budapest, 1085, Hungary Department of Urology, Semmelweis University, Budapest, 1082, Hungary Department of Obstetrics and Gynecology, University of Szeged, Szeged...</pre> </div></div>