https://m2.mtmt.hu/ eng 2026-10-25 00:16 JournalArticle 36168436 VALIDATED true Funding Agency and Grant Number: National Institute on Aging Funding text: The 4.0 version of ChatGPT, developed by OpenAI, and Gemini, developed by Google, were used as a tool to refine our writing and enhance the clarity of our work. Biorender.com was used to create illustrated figures. 0 false 2026-10-22T07:51:57.858+0000 2026-05-12T08:06:12.281+0000 2025-05-29T08:47:55.973+0000 true 10090847 Horváth Viktória /api/admin/10090847 Admin true 2026-09-16T15:49:38.962+0000 2025-11-25T10:06:19.441+0000 true 10090847 Horváth Viktória /api/admin/10090847 Admin true 2025-12-20T02:10:10.362+0000 true 521 Szuper Admin /api/admin/521 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Gulej, R. Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 47 6207 6376 6207 170 2025 Aging is a complex biological process that detrimentally affects the brain and cerebrovascular system, contributing to the pathogenesis of age-related diseases like vascular cognitive impairment and dementia (VCID) and Alzheimer’s disease (AD). While cell-autonomous mechanisms that occur within cells, independent of external signals from neighboring cells or systemic factors, account for some aspects of aging, they cannot explain the entire aging process. Non-autonomous, paracrine and endocrine, pathways also play a crucial role in orchestrating brain and vascular aging. The systemic milieu modulates aging through pro-geronic and anti-geronic circulating factors that mediate age-related decline or confer rejuvenative effects. This review explores the impact of systemic factors on cerebrovascular and brain aging, with a particular focus on findings from heterochronic parabiosis, blood exchange, and plasma transfer experiments. We discuss how these factors influence fundamental cellular and molecular processes of aging and impact cerebrovascular endothelial function, neurovascular coupling mechanisms, blood–brain barrier integrity, neuroinflammation, capillary density, and amyloid pathologies, with significant consequences for cognitive function. Additionally, we address the translational potential and challenges of modifying the systemic milieu to promote brain health and prevent age-related cognitive impairment. © The Author(s) 2025. 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8 14 8 D1 true false false false 2025-08-27T08:55:53.168+0000 Doktori Iskola (SE); Megelőző Orvostani és Népegészségtani Intézet (SE / AOK / I); Transzlációs Medicina Intézet (SE / AOK / I) 8 39 3 12 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 126743643 /api/authorship/126743643 1 0.083 true false false Author 10092932 /api/author/10092932 Gulej Rafal true true Gulej R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126743644 /api/authorship/126743644 2 0.083 false false false Author 10052983 /api/author/10052983 Patai Roland true 10052983 true Patai R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126743645 /api/authorship/126743645 3 0.083 false false true Author 10090858 /api/author/10090858 Ungvári Anna Sára true true Ungvari A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126743646 /api/authorship/126743646 4 0.083 false false false Author 10096992 /api/author/10096992 Kállai Attila true true Kallai A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126743647 /api/authorship/126743647 5 0.083 false false false Author 10074557 /api/author/10074557 Tarantini Stefano true true Tarantini S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126743648 /api/authorship/126743648 6 0.083 false false false Author 10095385 /api/author/10095385 Yabluchanskiy Andriy true true Yabluchanskiy A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126743649 /api/authorship/126743649 7 0.083333336 false false false Huffman D.M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126743650 /api/authorship/126743650 8 0.083333336 false false false Conboy M.J. true false false AuthorshipType 1 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1402638 true Keyword 1576333 /api/keyword/1576333 true true Keyword 1593101 /api/keyword/1593101 true true Keyword 1624378 /api/keyword/1624378 true true Keyword 2031420 /api/keyword/2031420 true true Keyword 3699180 /api/keyword/3699180 true true Keyword 3874051 /api/keyword/3874051 true true Keyword 3874052 /api/keyword/3874052 true true SjrRating 11627782 /api/sjrrating/11627782 2 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3401 /api/classificationexternal/3401 true 3401 true D1 DIRECT true true /api/publication/36168436 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10092932"><a href="/gui2/?type=authors&mode=browse&sel=10092932" target="_blank">Gulej R. (<span class="authorship-author-name">Gulej Rafal</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052983"><a href="/gui2/?type=authors&mode=browse&sel=10052983" target="_blank">Patai R. (<span class="authorship-author-name">Patai Roland</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090858"><a href="/gui2/?type=authors&mode=browse&sel=10090858" target="_blank">Ungvari A. ✉ (<span class="authorship-author-name">Ungvári Anna Sára</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10096992"><a href="/gui2/?type=authors&mode=browse&sel=10096992" target="_blank">Kallai A. (<span class="authorship-author-name">Kállai Attila</span> <span class="authorAux-mtmt"> Népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini S. (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10095385"><a href="/gui2/?type=authors&mode=browse&sel=10095385" target="_blank">Yabluchanskiy A. (<span class="authorship-author-name">Yabluchanskiy Andriy</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Huffman D.M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Conboy M.J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Conboy I.M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kivimäki M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar A. (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Z. (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36168436" target="_blank">Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">47</span> <span class="page"> pp 6207-6376 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s11357-025-01657-y" target="_blank" href="https://doi.org/10.1007/s11357-025-01657-y"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001493354400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001493354400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105005773223" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105005773223"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40407975" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40407975&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Aging&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 18</span> | Independent citation: 11 | Self citation: 7 | Unknown citation: 0 | Number of citations in WoS: 17 | Number of citations in Scopus:&nbsp;18 | WoS/Scopus assigned:&nbsp;18 | Number of citations with DOI:&nbsp;18 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36168436&sort=publishedYear,desc&sort=title"> Number of cited publications: 142 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36168436</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (TKP2021-NKTA-47), (RRF- 2.3.1-21-2022-00003), (Open access funding provided by Semmelweis University) </div> <div class="lastModified">Last Modified: 2026.05.12. 10:06 Edit Csajbók (SE_KK_Admin5_CSE, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: National Institute on Aging Funding text: The 4.0 version of ChatGPT, developed by OpenAI, and Gemini, developed by Google, were used as a tool to refine our writing and enhance the clarity of our work. Biorender.com was used to create illustrated figures.</pre> </div></div>