https://m2.mtmt.hu/ hun 2026-09-21 03:31 JournalArticle 36162478 VALIDATED true 0 false 2026-09-13T19:30:58.297+0000 2026-03-11T08:19:40.846+0000 2025-05-26T10:21:07.454+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin Áncsán Gizella (SE admin) true 10015206 2026-09-03T11:44:27.889+0000 2025-08-15T08:24:47.903+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin (MTMT Központi admin) Lévayné Deseő Katalin true 10025544 true 2026-05-28T10:32:37.521+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Nemeth, Zoltan true true /api/journal/10024487 REVIEWED LIFE-BASEL 2075-1729 true false 10024487 false 10024487 true 2075-1729 Journal FOREIGN 15 6 856 856 22 2025 Increases in flow elicit dilations in the basilar artery (BA) supplied by the posterior cerebral circulation (PCC), and ensuring efficient blood supply to the circle of Willis in which blood flow and pressure can distribute and equalize, and thus provide the appropriate supply for the daughter branches to reach certain brain areas. In contrast, increases in flow elicit constrictions in the middle cerebral artery (MCA), supplied by the anterior cerebral circulation (ACC) and regulating the blood pressure and flow in distal cerebral circulation. Mediators of flow-dependent responses include arachidonic acid (AA) metabolites and nitric oxide (NO). We hypothesized that mediators of flow-dependent responses are differentially expressed in cerebral arteries of the PCC (CAPCC) and ACC (CAACC). The expressions of key enzymes of the AA pathway—cyclooxygenases (COX1/COX2), cytochrome P450 hydroxylases (Cyp450), thromboxane synthase (TXAS), thromboxane A2 (TP) receptor, prostacyclin synthase (PGIS), prostacyclin (IP) receptor (IP); neuronal nitric oxide synthase (nNOS), and endothelial nitric oxide synthase (eNOS)—in the BA and MCA from rats (n = 20) were determined by western blotting. Transcriptome analysis in CAPCC and CAACC from rats (n = 25) was assessed by RNA sequencing. In BA compared to MCA, COX1/2 and Cyp450 protein expressions were lower, PGIS was higher, TXAS and nNOS/eNOS were similar, TP receptors were lower, and IP receptors were higher. Gene expressions of vasodilator canonical pathways were higher in CAPCC; vasoconstriction canonical pathways were higher in CAACC. Mediators of flow-dependent vasomotor signaling are differentially expressed in cerebral arteries of the posterior and anterior circulation, corresponding to their vasomotor function. Funding 2055025 /api/funding/2055025 TKP2021-EGA-37(TKP2021-EGA-37) false true Funding 2055026 /api/funding/2055026 (K132596) Támogató: OTKA false true true true 2025 true true true false true false GOLD 2026-09-13 true https://doi.org/10.3390/life15060856 1 0 1 0 1 1 1 1 1 1 1 0 0 0 1 0 1 0 1 0 0 12 12 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 0 1 0 Q1 484279 false false false false 2025-05-29T14:42:23.553+0000 Bioinformatika Tanszék (SE / AOK / I); Biokémiai és Orvosi Kémiai Intézet (PTE / ÁOK); HUN-REN-SE Cerebrovaszkuláris és Neurokognitív ... (SE / AOK / I / KKI); Kísérletes kardiológiai kutatócsoport (PTE / SZKK); Molekuláris Élettudományi Intézet (HRN TTK); Morfológiai és Fiziológiai Tanszék (SE / ETK2007); Regeneratív Science, Sport és Medicina Kutatócs... (PTE / SZKK); Sport- és Egészségtudományi Intézet (MTSE); Transzlációs Medicina Intézet (SE / AOK / I) 4 53 9 4 0 true 10025544 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 126713115 /api/authorship/126713115 Nemeth, Zoltan [Németh, Zoltán (Kísérletes orvost...), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 1 0.25 true false false Author 10027596 /api/author/10027596 Németh Zoltán (Kísérletes orvostudományok) Németh Zoltán true 10027596 true Nemeth Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126713116 /api/authorship/126713116 Eros, Krisztian [Erős, Krisztián (Biokémia és molek...), szerző] Biokémiai és Orvosi Kémiai Intézet (PTE / ÁOK); Kísérletes kardiológiai kutatócsoport (PTE / SZKK); Regeneratív Science, Sport és Medicina Kutatócs... (PTE / SZKK) 2 0.25 false false false Author 10040808 /api/author/10040808 Erős Krisztián (Biokémia és molekuláris biológia) Erős Krisztián true 10040808 true Eros Krisztian true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126713117 /api/authorship/126713117 Munkacsy, Gyongyi [Munkácsy, Gyöngyi (onkológia), szerző] Bioinformatika Tanszék (SE / AOK / I); Molekuláris Élettudományi Intézet (HRN TTK) 3 0.25 false false false Author 10024232 /api/author/10024232 Munkácsy Gyöngyi (onkológia) Munkácsy Gyöngyi true 10024232 true Munkacsy Gyongyi true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126713118 /api/authorship/126713118 Koller, Akos ✉ [Koller, Ákos (Szív és vérkeringés), szerző] Morfológiai és Fiziológiai Tanszék (SE / ETK2007); HUN-REN-SE Cerebrovaszkuláris és Neurokognitív ... 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(2025) LIFE-BASEL 2075-1729 15 6<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10027596"><a href="/gui2/?type=authors&mode=browse&sel=10027596" target="_blank">Nemeth Zoltan (<span class="authorship-author-name">Németh Zoltán</span> <span class="authorAux-mtmt"> Kísérletes orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040808"><a href="/gui2/?type=authors&mode=browse&sel=10040808" target="_blank">Eros Krisztian (<span class="authorship-author-name">Erős Krisztián</span> <span class="authorAux-mtmt"> Biokémia és molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biokémiai és Orvosi Kémiai Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Szentágothai János Kutatóközpont">SZKK</span>/Kísérletes kardiológiai kutatócsoport; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Szentágothai János Kutatóközpont">SZKK</span>/Regeneratív Science, Sport és Medicina Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024232"><a href="/gui2/?type=authors&mode=browse&sel=10024232" target="_blank">Munkacsy Gyongyi (<span class="authorship-author-name">Munkácsy Gyöngyi</span> <span class="authorAux-mtmt"> onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002221"><a href="/gui2/?type=authors&mode=browse&sel=10002221" target="_blank">Koller Akos ✉ (<span class="authorship-author-name">Koller Ákos</span> <span class="authorAux-mtmt"> Szív és vérkeringés</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Egészségtudományi Kar">ETK2007</span>/Morfológiai és Fiziológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Klinikai Kórélettani Intézet">KKI</span>/HUN-REN-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Magyar Testnevelési és Sporttudományi Egyetem">MTSE</span>/Sport- és Egészségtudományi Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36162478" target="_blank">Differential Gene and Protein Expressions Responsible for Vasomotor Signaling Provide Mechanistic Bases for the Opposite Flow-Induced Responses of Pre- and Post-Circle of Willis Arteries</a></div> <div> <span class="journal-title">LIFE-BASEL</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2075-1729">2075-1729</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">6</span> <span class="page"> Paper 856. 22 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/life15060856" target="_blank" href="https://doi.org/10.3390/life15060856"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001541389800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001541389800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105009103436" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105009103436"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40566510" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40566510&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Ecology, Evolution, Behavior and Systematics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Paleontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Space and Planetary Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Norvég listás folyóirat</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 0 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36162478&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 12 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36162478</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> TKP2021-EGA-37(TKP2021-EGA-37), (K132596) Támogató: OTKA </div> <div class="lastModified">Utolsó módosítás: 2026.03.11. 09:19 Milánkovics Róbert (PTE ÁOK admin 4) </div> <div class="lockedBy">Központi kezelésű 2026.05.28. 12:32 Lévayné Deseő Katalin (MTMT Központi admin) </div> </div></div>