https://m2.mtmt.hu/ hun 2026-09-21 13:37 JournalArticle 36158616 VALIDATED true Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Institute of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Directorate of Drug Substance Development, Egis Pharmaceuticals Plc., Budapest, Hungary Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary Faculty of Science and Informatics, Department of Applied & Environmental Chemistry, University of Szeged, Szeged, Hungary Department of Oto-Rhino-Laryngology and Head-Neck Surgery, University of Szeged, Szeged, Hungary Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Budapest, Hungary Department of Physical Chemistry and Materials Science, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Budapest, Hungary Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, Hungary Center for Pharmacology and Drug Research & Development, Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, Hungary Export Date: 02 June 2026; Cited By: 4; Correspondence Address: G. Katona; Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Szeged, Eötvös Str. 6, H-6720, Hungary; email: katona.gabor@szte.hu; G.T. Balogh; Department of Pharmaceutical Chemistry, Semmelweis University, Budapest, Hőgyes Endre Str. 9, H-1092, Hungary; email: balogh.gyorgy.tibor@semmelweis.hu 0 false 2026-08-31T08:21:10.876+0000 2026-06-02T09:21:57.330+0000 2025-05-22T11:33:57.682+0000 true 10045672 Katona Gábor /api/author/10045672 Author true 10045672 2026-08-25T11:07:11.270+0000 2025-07-29T09:17:08.772+0000 true 10097129 Vékony-Pap Lili /api/admin/10097129 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Salamah, Maryana Preparation, and ex vivo and in vivo Characterization of Favipiravir-Loaded Aspasomes and Niosomes for Nose-to-Brain Administration true true /api/journal/10007040 REVIEWED true false 10007040 false 10007040 true 1176-9114 1178-2013 Journal FOREIGN 20 6489 6514 6489 26 2025 Purpose: The present study aimed to develop and compare the intranasal applicability of favipiravir-loaded aspasomes (FAV-ASPs) using film hydration method, and favipiravir-loaded niosomes (FAV-NIOs) using ethanol injection method. Methods: The FAV-ASP and FAV-NIO formulations were characterized according to nanoparticulate characteristics (DLS, drug loading, drug encapsulation efficacy, droplet size distribution), drug release and permeability behavior. Results: The optimized FAV-ASP formulation (FAV-ASP8) consisted of FAV, ascorbyl palmitate, Span® 60 and cholesterol (30:25:25:50 w/w) with nano-scale size range (292.06 ± 2.10 nm), narrow polydispersity index (PDI) value (0.36 ± 0.03), adequate zeta potential (− 74.73 ± 3.28 mV) and acceptable encapsulation efficiency (55.33 ± 0.41%). The optimized FAV-NIO formulation (FAV-NIO9) contained FAV, Span® 60 and cholesterol (30:30:40 w/w) with nano-scale size range (167.13 ± 1.60 nm), narrow PDI value (0.07 ± 0.01), adequate zeta potential (− 27.1 ± 1.24 mV) and acceptable encapsulation efficiency (51.30 ± 0.69%). FAV-ASP8 and FAV-NIO9 were suitable for spraying into the nasal cavity (droplet size distribution < 200 μm). In vitro drug release and permeability studies demonstrated enhanced solubility and increased blood–brain barrier (BBB) permeability of FAV formulations, respectively. The ex vivo human nasal permeability study revealed that FAV diffusion from FAV-ASP8 was higher than from FAV-NIO9 or initial FAV. Furthermore, the in vivo animal study showed that FAV-ASP8 had a higher BBB penetration compared to FAV-NIO9 and pure FAV. The in vitro–in vivo correlation study showed good correlation between the in vitro and the in vivo pharmacokinetic data. Conclusion: FAV-ASP8 for nose-to-brain delivery system could be a promising formulation to improve FAV bioavailability compared to FAV-NIO9. Funding 2053849 /api/funding/2053849 false true true 2025 true true true false true false GOLD 2026-08-31 true https://doi.org/10.2147/IJN.S518486 6 0 5 3 3 5 5 4 4 4 4 2 2 3 3 0 6 3 5 3 0 9 9 Folyóiratcikk Journal Article 24 5 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 4 1 4 1 2026 0 2 2 2 2 D1 false false false false 2025-05-28T08:07:47.759+0000 Alkalmazott és Környezeti Kémiai Tanszék (SZTE / TTIK / KI); Egis Gyógyszergyár Zrt.; Farmakológiai és Gyógyszerkutatás-fejlesztési K... 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10.1007/BF02256054 false true Reference 65947016 /api/reference/65947016 122 false true Reference 65947017 /api/reference/65947017 123 10.1016/j.xphs.2022.10.026 false true Reference 65947018 /api/reference/65947018 124 10.1080/10717544.2016.1259371 false true Reference 65947019 /api/reference/65947019 125 10.21873/ANTICANRES.11238 false true Reference 65947020 /api/reference/65947020 126 10.1016/J.INTIMP.2024.111915 false true Reference 65947021 /api/reference/65947021 127 10.1080/02652040400015403 false true /api/publication/36158616 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10082096"><a href="/gui2/?type=authors&mode=browse&sel=10082096" target="_blank">Salamah Maryana (<span class="authorship-author-name">Salamah Maryana</span> <span class="authorAux-mtmt"> Maryana Salamah</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszertechnológiai és Gyógyszerfelügyeleti Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani és Biofarmáciai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012714"><a href="/gui2/?type=authors&mode=browse&sel=10012714" target="_blank">Volk Balázs (<span class="authorship-author-name">Volk Balázs</span> <span class="authorAux-mtmt"> Hatóanyag gyártóeljárás-fejlesztés, heterociklu...</span>) </a> </span> <span class="author-affil">Egis Gyógyszergyár Zrt.</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017713"><a href="/gui2/?type=authors&mode=browse&sel=10017713" target="_blank">Lekli István (<span class="authorship-author-name">Lekli István</span> <span class="authorAux-mtmt"> Kísérletes farmakológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002395"><a href="/gui2/?type=authors&mode=browse&sel=10002395" target="_blank">Bak István (<span class="authorship-author-name">Bak István</span> <span class="authorAux-mtmt"> kísérletes farmakológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10047921"><a href="/gui2/?type=authors&mode=browse&sel=10047921" target="_blank">Gyöngyösi Alexandra (<span class="authorship-author-name">Gyöngyösi Alexandra</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035080"><a href="/gui2/?type=authors&mode=browse&sel=10035080" target="_blank">Kozma Gábor (<span class="authorship-author-name">Kozma Gábor</span> <span class="authorAux-mtmt"> Nanotechnológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Alkalmazott és Környezeti Kémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000005"><a href="/gui2/?type=authors&mode=browse&sel=10000005" target="_blank">Kónya Zoltán (<span class="authorship-author-name">Kónya Zoltán</span> <span class="authorAux-mtmt"> Nanotechnológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Alkalmazott és Környezeti Kémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081756"><a href="/gui2/?type=authors&mode=browse&sel=10081756" target="_blank">Szalenkó-Tőkés Ágnes (<span class="authorship-author-name">Szalenko-Tőkés Ágnes</span> <span class="authorAux-mtmt"> fül-orr-gégészet</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057998"><a href="/gui2/?type=authors&mode=browse&sel=10057998" target="_blank">Kiricsi Ágnes (<span class="authorship-author-name">Kiricsi Ágnes</span> <span class="authorAux-mtmt"> fül-orr-gégészet, allergológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025879"><a href="/gui2/?type=authors&mode=browse&sel=10025879" target="_blank">Rovó László (<span class="authorship-author-name">Rovó László</span> <span class="authorAux-mtmt"> Fül-orr-gégészet</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042617"><a href="/gui2/?type=authors&mode=browse&sel=10042617" target="_blank">Balogh-Weiser Diána (<span class="authorship-author-name">Balogh Weiser Diána</span> <span class="authorAux-mtmt"> szerves kémia, anyagtudomány, nanobiotechnológia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék; <span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Fizikai Kémia és Anyagtudományi Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001074"><a href="/gui2/?type=authors&mode=browse&sel=10001074" target="_blank">Zupkó István (<span class="authorship-author-name">Zupkó István</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani és Biofarmáciai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002576"><a href="/gui2/?type=authors&mode=browse&sel=10002576" target="_blank">Csóka Ildikó (<span class="authorship-author-name">Pannonhalminé Csóka Ildikó</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszertechnológiai és Gyógyszerfelügyeleti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045672"><a href="/gui2/?type=authors&mode=browse&sel=10045672" target="_blank">Katona Gábor<sup>**</sup> ✉ (<span class="authorship-author-name">Katona Gábor</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszertechnológiai és Gyógyszerfelügyeleti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011949"><a href="/gui2/?type=authors&mode=browse&sel=10011949" target="_blank">Balogh György Tibor ✉ (<span class="authorship-author-name">Balogh György Tibor</span> <span class="authorAux-mtmt"> Gyógyszerkémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Kémiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36158616" target="_blank">Preparation, and ex vivo and in vivo Characterization of Favipiravir-Loaded Aspasomes and Niosomes for Nose-to-Brain Administration</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF NANOMEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1176-9114">1176-9114</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1178-2013">1178-2013</a>)</span>: <span class="journal-volume">20</span> <span class="page"> pp 6489-6514 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.2147/IJN.S518486" target="_blank" href="https://doi.org/10.2147/IJN.S518486"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001495885500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001495885500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="390476" target="_blank" href="http://hdl.handle.net/2437/390476"> DEA </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105006949828" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105006949828"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40420912" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40420912&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://www.dovepress.com/preparation-and-ex-vivo-and-in-vivo-characterization-of-favipiravir-lo-peer-reviewed-fulltext-article-IJN" target="_blank" href="https://www.dovepress.com/preparation-and-ex-vivo-and-in-vivo-characterization-of-favipiravir-lo-peer-reviewed-fulltext-article-IJN"> Egyéb URL </a> </span> <span class="id identifier oa_RESTRICTED" title=" Korlátozott "> <a style="color:blue" title="36898" target="_blank" href="http://publicatio.bibl.u-szeged.hu/36898"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biophysics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Bioengineering&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biomaterials&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Drug Discovery&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Nanoscience and Nanotechnology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 3 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;5 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36158616&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36158616</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Ministry of Innovation and Technology of Hungary from the NKFIH Fund,(KP2021-EGA-32 NKFIH Fund) </div> <div class="lastModified">Utolsó módosítás: 2026.06.02. 11:21 Kondor Zóra (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Institute of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary Directorate of Drug Substance Development, Egis Pharmaceuticals Plc., Budapest, Hungary Departmen...</pre> </div></div>