https://m2.mtmt.hu/ hun 2026-09-23 10:26 JournalArticle 36142021 VALIDATED true 0 false 2026-08-04T13:01:34.481+0000 2026-04-13T08:55:53.833+0000 2025-05-15T06:55:04.392+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin true 10015206 2026-08-04T12:51:59.779+0000 2025-09-01T11:54:01.898+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-05-20T07:50:14.915+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Kristóf, Zsüliet From Childhood Woes to Adult Blues: Unmasking the Role of Early Traumas, P2X7 Receptor, and Neuroinflammation in Anxiety and Depression true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 26 10 4687 4687 20 2025 Early-life stress may increase the risk of neuropsychiatric disorders via immune activation. While the purinergic signaling pathway is implicated in psychiatric disorders, the specific role of the P2X7 receptor (P2X7R) in anxiety, depression, and childhood trauma still requires further clarification. Upon chronic stress, excessive ATP release activates purinergic P2X7R signalling in the brain contributing to long-lasting neuroinflammation, which potentially promotes the development of psychiatric disorders. There is also a putative link between the P2X7 receptor gene, located on chromosome 12q24, and the development of anxiety and depression. This review aims to systematically examine how P2X7R contributes to the pathophysiology of anxiety and depressive disorders, with a particular focus on early-life stress (ELS). It offers a comprehensive synthesis of the current findings, emphasizing the previously unexplored intersections between P2X7R signaling, early-life stress, and psychiatric disorders. These interactions may shape long-term neuroinflammation, contributing to the development of anxiety and depression, and offer new insights into potential therapeutic targets. The review integrates the role of P2X7R regarding both indirect mechanisms—such as the modulation and long-term transmission of neuroinflammation following environmental stressors and vulnerability—and direct genetic associations with psychiatric conditions, including the influence of single-nucleotide polymorphisms (SNPs), haplotypes, and other variants within the P2X7 gene. Special emphasis is placed on the impact of early-life stress, drawing primarily on preclinical findings to elucidate underlying mechanisms. Funding 2053846 /api/funding/2053846 false true Funding 2053847 /api/funding/2053847 false true Funding 2053848 /api/funding/2053848 false true true true 2025 true true true false true false GOLD 2026-08-04 true https://real.mtak.hu/243184 4 0 4 4 0 4 3 3 3 3 3 3 3 4 0 0 4 4 4 4 0 12 12 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 1 1 1 2026 0 3 3 3 3 D1 false false false false 2025-06-05T09:26:25.420+0000 Doktori Iskola (SE); Farmakológiai és Gyógyszerkutatás-fejlesztési K... (SE / KSZE); Gyógyszerhatástani Intézet (SE / GYTK); Klinikai Pszichológia Tanszék (SE / AOK / K / PPK); Molekuláris Farmakológia Kutatócsoport (HRN KOKI); NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport (SE / GYTK / GYHATAS); Pszichiátriai és Pszichoterápiás Klinika (SE / AOK / K) 5 34 7 5 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 126526726 /api/authorship/126526726 1 0.2 true false false Author 10067777 /api/author/10067777 Kristóf Zsüliet true true Kristóf Zsüliet true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126526727 /api/authorship/126526727 2 0.2 true false false Author 10067769 /api/author/10067769 Szabó Dorottya true true Szabó Dorottya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126526728 /api/authorship/126526728 3 0.2 false false false Author 10008942 /api/author/10008942 Sperlágh Beáta true 10008942 true Sperlágh 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<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10067777"><a href="/gui2/?type=authors&mode=browse&sel=10067777" target="_blank">Kristóf Zsüliet (<span class="authorship-author-name">Kristóf Zsüliet</span> <span class="authorAux-mtmt"> pszichológia, pszichiátria</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067769"><a href="/gui2/?type=authors&mode=browse&sel=10067769" target="_blank">Szabó Dorottya<sup>*</sup> (<span class="authorship-author-name">Szabó Dorottya</span> <span class="authorAux-mtmt"> neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Molekuláris Farmakológia Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008942"><a href="/gui2/?type=authors&mode=browse&sel=10008942" target="_blank">Sperlágh Beáta (<span class="authorship-author-name">Sperlágh Beáta</span> <span class="authorAux-mtmt"> Neurofarmakológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Molekuláris Farmakológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075294"><a href="/gui2/?type=authors&mode=browse&sel=10075294" target="_blank">Török Dóra (<span class="authorship-author-name">Török Dóra</span> <span class="authorAux-mtmt"> pszichiátriai genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003491"><a href="/gui2/?type=authors&mode=browse&sel=10003491" target="_blank">Gonda Xénia ✉ (<span class="authorship-author-name">Gonda Xénia</span> <span class="authorAux-mtmt"> Pszichiátria, pszichiátriai genetika, farmakoló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerhatástani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/<span title="Gyógyszerhatástani Intézet">GYHATAS</span>/NAP3.0-SE Neuropszichofarmakológiai Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Pszichiátriai és Pszichoterápiás Klinika">PPK</span>/Klinikai Pszichológia Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36142021" target="_blank">From Childhood Woes to Adult Blues: Unmasking the Role of Early Traumas, P2X7 Receptor, and Neuroinflammation in Anxiety and Depression</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">10</span> <span class="page"> Paper 4687. 20 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms26104687" target="_blank" href="https://doi.org/10.3390/ijms26104687"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001496247000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001496247000001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="243184" target="_blank" href="https://real.mtak.hu/243184"> REAL </a> 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<span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hungarian Brain Research Program(NAP2022-I-1/2022), National Laboratory of Translational Neuroscience (TINL)(RRF-2.3.1-21-2022-00011), (EKÖP-2024-68) </div> <div class="lastModified">Utolsó módosítás: 2026.04.13. 10:55 Turek Márta (KOKI admin 4) </div> <div class="lockedBy">Központi kezelésű 2026.05.20. 09:50 Lévayné Deseő Katalin (MTMT Központi admin) </div> </div></div>