https://m2.mtmt.hu/ hun 2026-09-22 00:11 JournalArticle 36137255 VALIDATED true Funding Agency and Grant Number: National Research, Development and Innovation Office (National Brain Research Program (NAP) [2017-1.2.1-NKP-2017-00002]; Hungarian Scientific Research Fund (OTKA) [K-128369]; National Research, Development and Innovation Office; [TKP2021-EGA-25]; [2024-1.1.1-KKV_FKUSZ-2024-00022]; [GINOP-2.1.1-15-2015-00369] Funding text: This work was supported by the National Research, Development and Innovation Office (National Brain Research Program (NAP) 2017-1.2.1-NKP-2017-00002 to J.M.R., Hungarian Scientific Research Fund (OTKA) K-128369 to & Aacute;.A., the thematic grant TKP2021-EGA-25 to J.M.R., 2024-1.1.1-KKV_F & Oacute;KUSZ-2024-00022 to Z.E. and GINOP-2.1.1-15-2015-00369 to A.& Aacute;.); the National Research, Development and Innovation Office had no further role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication. 0 false 2026-05-28T10:35:22.465+0000 2025-05-23T08:47:41.989+0000 2025-05-14T08:50:21.232+0000 true 10100373 Farkas Kiara Gitta /api/author/10100373 Author true 2026-05-27T13:25:31.024+0000 2026-05-27T13:25:31.024+0000 2025-05-23T08:47:41.997+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-05-28T10:32:34.006+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Farkas, Kiara Gitta Functional Analysis of Antipsychotics in Human iPSC-Based Neural Progenitor 2D and 3D Schizophrenia Models true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 26 9 4444 4444 17 2025 Schizophrenia is a complex psychiatric disorder of complex etiology. Despite decades of antipsychotic drug development and treatment, the mechanisms underlying cellular drug effects remain incompletely understood. Induced pluripotent stem cell (iPSC)-based disease and pharmacological modelling offer new avenues for drug development. In this study, we explored the development of two- and three-dimensional neural progenitor cultures and the impact of different antipsychotics in a schizophrenia model. Four human iPSC lines, including two carrying a de novo ZMYND11 gene mutation associated with schizophrenia, were differentiated into hippocampal neural progenitor cells (NPCs), cultured either in monolayers or as 3D spheroids. While in monolayers the proliferation of the NPCs was similar, spheroids showed significant differences in scattered cell number and outgrowth size between schizophrenia mutant and wild-type NPCs. Since there is only limited information about the effects of antipsychotic agents on neural progenitor cell proliferation and differentiation, we investigated the effects of three molecules, representing three subgroups of antipsychotics, in the 2D and 3D NPC models. Our findings suggest that cell adhesion may play a crucial role in the molecular disease pathways of schizophrenia, highlighting the value of spheroid models for mechanistic and drug development studies. These studies may significantly help our understanding of the effects of schizophrenia on neural development and the response of progenitors to antipsychotic medications. 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/api/reference/65808982 42 10.1016/j.schres.2019.04.009 false true Reference 65808983 /api/reference/65808983 43 10.1016/j.stem.2013.07.001 false true Reference 65808984 /api/reference/65808984 44 10.1038/nature22403 false true Reference 65808985 /api/reference/65808985 45 10.1186/s13287-020-01980-5 false true Reference 65808986 /api/reference/65808986 46 10.1007/s00406-004-0556-4 false true Reference 65808987 /api/reference/65808987 47 10.1176/ajp.149.4.500 false true Reference 65808988 /api/reference/65808988 48 10.1080/15622970701361255 false true /api/publication/36137255 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10100373"><a href="/gui2/?type=authors&mode=browse&sel=10100373" target="_blank">Farkas Kiara Gitta (<span class="authorship-author-name">Farkas Kiara Gitta</span> <span class="authorAux-mtmt"> Őssejtbiológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070227"><a href="/gui2/?type=authors&mode=browse&sel=10070227" target="_blank">Vincze Katalin (<span class="authorship-author-name">Vincze Katalin</span> <span class="authorAux-mtmt"> Pszichiátriai genetika.</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077215"><a href="/gui2/?type=authors&mode=browse&sel=10077215" target="_blank">Tordai Csongor (<span class="authorship-author-name">Tordai Csongor Balázs</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Özgen Ece İlay </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gürler Derin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Deli Vera </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073890"><a href="/gui2/?type=authors&mode=browse&sel=10073890" target="_blank">Lilienberg Julianna (<span class="authorship-author-name">Lilienberg Julianna</span> <span class="authorAux-mtmt"> Molekuláris és sejtbiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034299"><a href="/gui2/?type=authors&mode=browse&sel=10034299" target="_blank">Erdei Zsuzsa (<span class="authorship-author-name">Erdei Zsuzsa</span> <span class="authorAux-mtmt"> fiatal kutató</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi Balázs (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021998"><a href="/gui2/?type=authors&mode=browse&sel=10021998" target="_blank">Réthelyi János Miklós (<span class="authorship-author-name">Réthelyi János</span> <span class="authorAux-mtmt"> Pszichiátria- kognítiv idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027529"><a href="/gui2/?type=authors&mode=browse&sel=10027529" target="_blank">Apáti Ágota ✉ (<span class="authorship-author-name">Apáti Ágota</span> <span class="authorAux-mtmt"> Őssejt kutatás</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/Molekuláris Élettudományi Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36137255" target="_blank">Functional Analysis of Antipsychotics in Human iPSC-Based Neural Progenitor 2D and 3D Schizophrenia Models</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">9</span> <span class="page"> Paper 4444. 17 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms26094444" target="_blank" href="https://doi.org/10.3390/ijms26094444"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001486427700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001486427700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105004923104" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105004923104"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40362679" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40362679&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 2 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36137255&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36137255</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), (K128369), (TKP2021-EGA-25), (2024-1.1.1-KKV_FÓKUSZ-2024-00022), (GINOP-2.1.1-15-2015-00369) </div> <div class="lastModified">Utolsó módosítás: 2025.05.23. 10:47 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <div class="lockedBy">Központi kezelésű 2026.05.28. 12:32 Lévayné Deseő Katalin (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: National Research, Development and Innovation Office (National Brain Research Program (NAP) [2017-1.2.1-NKP-2017-00002]; Hungarian Scientific Research Fund (OTKA) [K-128369]; National Research, Development and Innovation Office; [TKP2021-EGA-25]; [2024-1.1.1-KKV_FKUSZ-2024-00022]; [GINOP-2.1.1-15-2015-00369] Funding text: This work was supported b...</pre> </div></div>