https://m2.mtmt.hu/ eng 2026-10-25 01:56 JournalArticle 36120581 VALIDATED true Funding Agency and Grant Number: National Research, Development and Innovation Office; European Union; Hungarian Academy of Sciences [LP-2021-14, RRF-2.3.1-21-2022-00003]; New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund [NKP-23-4-I-SE-5, KDP-14-3/PALY-2021]; Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund [KDP-2020, 2022-1.1.1-KK-2022-00005]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund Funding text: This project was supported by the National Research, Development and Innovation Office (PharmaLab, RRF-2.3.1-21-2022-00015). The work was supported by the European Union's Horizon 2020 Research and Innovation Programme under grant agreement no. 739593 and by a Momentum Research Grant from the Hungarian Academy of Sciences (LP-2021-14 to ZVV). Project no. RRF-2.3.1-21-2022-00003 has been implemented with the support provided by the European Union. KT was supported by the New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (& Uacute;NKP-23-4-I-SE-5). Project no. KDP-14-3/PALY-2021 has been implemented with the support provided by the Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund, financed under the KDP-2020 funding scheme. Project no. 2022-1.1.1-KK-2022-00005 has been implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund. We acknowledge the support of Dr. Laszlo Hiripi who provided access to the Laboratory Animal Science Coordination Center at Semmelweis University, Dr. Laszlo Horvath who provided animal care and the assistance of Dr. Viktoria Toth and Dr. Daniel Kucsera in executing the animal surgeries. The authors declare that the research was not pre-registered in any independent, institutional registry. ChatGPT by OpenAI was utilized to enhance the clarity and grammatical accuracy of certain sentences. All suggestions provided by ChatGPT were carefully reviewed, modified or accepted by the human authors. 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Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060030"><a href="/gui2/?type=authors&mode=browse&sel=10060030" target="_blank">Kovács Tamás (<span class="authorship-author-name">Kovács Tamás</span> <span class="authorAux-mtmt"> Molekuláris orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Pharmacology and Pharmaceutical Research Development; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/HCEMM-SU Cardiometabolic Immunology Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lánczky András </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077413"><a href="/gui2/?type=authors&mode=browse&sel=10077413" target="_blank">Paál Ágnes (<span class="authorship-author-name">Paál Ágnes</span> <span class="authorAux-mtmt"> farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Pharmacology and Pharmaceutical Research Development; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/HCEMM-SU Cardiometabolic Immunology Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10091973"><a href="/gui2/?type=authors&mode=browse&sel=10091973" target="_blank">Hegedűs Zsombor I. (<span class="authorship-author-name">Hegedűs Zsombor</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Pharmacology and Pharmaceutical Research Development; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/HCEMM-SU Cardiometabolic Immunology Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074459"><a href="/gui2/?type=authors&mode=browse&sel=10074459" target="_blank">Sayour Nabil V. (<span class="authorship-author-name">Sayour Viktor Nabil</span> <span class="authorAux-mtmt"> farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Pharmacology and Pharmaceutical Research Development; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/HCEMM-SU Cardiometabolic Immunology Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10079755"><a href="/gui2/?type=authors&mode=browse&sel=10079755" target="_blank">Szabó Lilla (<span class="authorship-author-name">Szabó Lilla</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/HCEMM-SU Cardiometabolic Immunology Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Pharmacology and Pharmaceutical Research Development</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10091976"><a href="/gui2/?type=authors&mode=browse&sel=10091976" target="_blank">Kovács Andrea (<span class="authorship-author-name">Kovács Andrea</span> <span class="authorAux-mtmt"> hisztológia, immunológia, kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Pharmacology and Pharmaceutical Research Development; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/HCEMM-SU Cardiometabolic Immunology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bianchini Giampaolo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ocana Alberto </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028393"><a href="/gui2/?type=authors&mode=browse&sel=10028393" target="_blank">Varga Zoltán V. (<span class="authorship-author-name">Varga Zoltán</span> <span class="authorAux-mtmt"> kardiovaszkuláris kutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Pharmacology and Pharmaceutical Research Development; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/HCEMM-SU Cardiometabolic Immunology Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063867"><a href="/gui2/?type=authors&mode=browse&sel=10063867" target="_blank">Fekete János Tibor (<span class="authorship-author-name">Fekete János Tibor</span> <span class="authorAux-mtmt"> Prediktív biomarkerek</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék; <span title="HUN-REN Research Centre for Natural Sciences">HUN-REN RCNS</span>/<span title="Institute of Molecular Life Sciences">IMLS</span>/Enzim_417</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs ✉ (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Bioinformatika Tanszék; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Department of Biophysics</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36120581" target="_blank">Unlocking the power of immune checkpoint inhibitors: Targeting YAP1 reduces anti‐PD1 resistance in skin cutaneous melanoma</a></div> <div> <span class="journal-title">BRITISH JOURNAL OF PHARMACOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0007-1188">0007-1188</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1476-5381">1476-5381</a>)</span>: <span class="journal-volume">182</span> <span class="journal-issue">16</span> <span class="page"> pp 3903-3922 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/bph.70052" target="_blank" href="https://doi.org/10.1111/bph.70052"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001481245600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001481245600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105004218560" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105004218560"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40324810" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40324810&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105004218560&doi=10.1111%2Fbph.70052&partnerID=40&md5=07784d255fd55da3659c01ce19d0ef54" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105004218560&doi=10.1111%2Fbph.70052&partnerID=40&md5=07784d255fd55da3659c01ce19d0ef54"> Other URL </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="https://www.scopus.com/pages/publications/105004218560?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/105004218560?origin=resultslist"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 6</span> | Independent citation: 6 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 6 | Number of citations in Scopus:&nbsp;6 | WoS/Scopus assigned:&nbsp;6 | Number of citations with DOI:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36120581&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36120581</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (2022-1.1.1-KK-2022-00005), (KDP-14-3/PALY-2021), Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Funder: NRDIO, (ÚNKP-23-4-I-SE-5), (RRF-2.3.1-2022-00003), HCEMM(739593) Funder: Horizon 2020, (LP-2021-14) </div> <div class="lastModified">Last Modified: 2026.05.19. 11:48 Kinga Sonnevend (SE_AOK_Adm5_Élet_kutcsop, admin) </div> <div class="lockedBy">Centrally managed 2026.05.28. 12:32 Katalin Lévayné Deseő (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: National Research, Development and Innovation Office; European Union; Hungarian Academy of Sciences [LP-2021-14, RRF-2.3.1-21-2022-00003]; New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund [NKP-23-4-I-SE-5, KDP-14-3/PALY-2021]; Ministry of Culture and Innovation...</pre> </div></div>