https://m2.mtmt.hu/ eng 2026-10-25 00:59 JournalArticle 36118820 VALIDATED true 0 false 2026-07-20T20:20:05.775+0000 2026-01-21T13:23:46.807+0000 2025-05-05T08:13:50.553+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-01-21T13:23:27.636+0000 2026-01-21T13:23:27.636+0000 2026-01-21T13:23:43.680+0000 true 10051300 Háromszéki-Virág Fruzsina /api/admin/10051300 Admin true 10051300 2026-01-21T13:23:46.814+0000 true 10051300 Háromszéki-Virág Fruzsina /api/admin/10051300 Admin true 10051300 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Mujtaba, Ayse Gunyakti Tri-Layered Bioactive Cutaneous Scaffold with Integrated Bioactive Metal Organic Frameworks to Promote Full-Thickness Infected Diabetic Wound Healing: Multifaceted Therapeutic Strategies true true /api/journal/10028278 REVIEWED true false 10028278 false 10028278 true 2192-2640 2192-2659 Journal FOREIGN 14 15 2500356 2500356 18 2025 Chronic infected diabetic wounds are complex and often lead to severe clinical outcomes such as sepsis, gangrene, and amputation. To address these challenges, herein we developed a novel tri-layered scaffold to provide multi-functional therapeutic support. The bottom poly (lactic-co-glycolic acid) (PLGA) fibrous layer contains doxycycline loaded CuBDC nanosheets for rapid antibacterial action. The porous PLGA/gelatin middle layer offers mechanical support and gamma-tocotrienol loaded ZIF-8 nanocrystals mitigates oxidative stress in the wound. The PLGA top sealing fibrous layer delivers insulin and Transforming growth factor beta (TGF-beta 1) from Zeolitic Imidazolate Framework-8 (ZIF-8) nanocrystals to promote epithelialization and modulate inflammation. Comprehensive in vitro and in vivo evaluations demonstrated that the scaffold effectively filled deep wounds, reduced bacterial load, controlled inflammation, and accelerated the tissue regeneration. Histopathological analyses showed enhanced epithelialization and partial granulation tissue remodeling. Biochemical assays indicated an increase in glutathione peroxidase (GPx) activity and a reduction in lipid peroxidation. Gene expression analysis revealed decreased levels of the pro-inflammatory TNF-alpha and increased levels of the anti-inflammatory IL-10, facilitating the transition to the proliferative phase. This multi-layered composite scaffold, with its antimicrobial, antioxidant, and anti-inflammatory activities, controlled release capabilities, presents a promising solution the healing process of deep, infected diabetic wounds. true 2025 true true true false false false NONE 2026-07-20 false 10 0 10 10 0 10 10 9 10 10 10 10 10 10 0 0 10 10 10 10 0 0 0 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 5 5 5 5 2026 0 5 5 5 5 D1 485599 false false false false 2025-08-03T08:15:31.194+0000 Orális Diagnosztikai Tanszék (SE / FOK) 1 4 1 9 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 126335957 /api/authorship/126335957 1 0.11111111 true false false Mujtaba Ayse Gunyakti true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126335958 /api/authorship/126335958 2 0.111 false false true Karakecili Ayse true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126335959 /api/authorship/126335959 3 0.11111111 false false false Topuz Berna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126335960 /api/authorship/126335960 4 0.11111111 false false false Batur Baris true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126335961 /api/authorship/126335961 5 0.11111111 false false false Onar Okan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126335962 /api/authorship/126335962 6 0.11111111 false false false Elcigir Mehmet Eray true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126335963 /api/authorship/126335963 7 0.11111111 false false false Oto Cagdas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126335964 /api/authorship/126335964 8 0.11111111 false false false Hanifehnezhad Alireza true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126335965 /api/authorship/126335965 9 0.111 false true false Author 10092814 /api/author/10092814 Orhan Kaan true true Orhan Kaan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29304673 /api/publicationidentifier/29304673 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true PublicationIdentifier 29304675 /api/publicationidentifier/29304675 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40259548 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40259548&dopt=Abstract false true PublicationIdentifier 31240460 /api/publicationidentifier/31240460 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202500356 https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202500356 true true Classification 12276 /api/classification/12276 true true Keyword 2694 /api/keyword/2694 true 2694 true Keyword 7975 /api/keyword/7975 true 7975 true Keyword 17264 /api/keyword/17264 true 17264 true Keyword 1002337 /api/keyword/1002337 true 1002337 true Keyword 1496149 /api/keyword/1496149 true true Keyword 1506322 /api/keyword/1506322 true true Keyword 1583069 /api/keyword/1583069 true true Keyword 1622320 /api/keyword/1622320 true true Keyword 3860905 /api/keyword/3860905 true true PredatorRating 11743939 /api/predatorrating/11743939 RatingType 10033 /api/ratingtype/10033 norveg true true 485599 true true SjrRating 11560957 /api/sjrrating/11560957 10 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2502 /api/classificationexternal/2502 true 2502 true D1 DIRECT true true /api/publication/36118820 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Mujtaba Ayse Gunyakti </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Karakecili Ayse ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Topuz Berna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Batur Baris </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Onar Okan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Elcigir Mehmet Eray </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Oto Cagdas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hanifehnezhad Alireza </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10092814"><a href="/gui2/?type=authors&mode=browse&sel=10092814" target="_blank">Orhan Kaan (<span class="authorship-author-name">Orhan Kaan</span> <span class="authorAux-mtmt"> Fogorvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oral Diagnosics</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36118820" target="_blank">Tri-Layered Bioactive Cutaneous Scaffold with Integrated Bioactive Metal Organic Frameworks to Promote Full-Thickness Infected Diabetic Wound Healing: Multifaceted Therapeutic Strategies</a></div> <div> <span class="journal-title">ADVANCED HEALTHCARE MATERIALS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2192-2640">2192-2640</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2192-2659">2192-2659</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">15</span> <span class="page"> Paper 2500356. 18 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1002/adhm.202500356" target="_blank" href="https://doi.org/10.1002/adhm.202500356"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001471355400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001471355400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105005170615" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105005170615"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40259548" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40259548&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202500356" target="_blank" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/adhm.202500356"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biomaterials&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Biomedical Engineering&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Norwegian Register for Scientific Journals</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 10</span> | Independent citation: 10 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 9 | Number of citations in Scopus:&nbsp;10 | WoS/Scopus assigned:&nbsp;10 | Number of citations with DOI:&nbsp;10 </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36118820</span> | <span class="status-data status-VALIDATED"> Validated </span> Core | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Last Modified: 2026.01.21. 14:23 Fruzsina Háromszéki-Virág (MTMT Központi admin) </div> </div></div>