https://m2.mtmt.hu/ hun 2026-09-23 00:31 JournalArticle 36106218 APPROVED true Export Date: 09 July 2025; Cited By: 0; Correspondence Address: J. Fazakas; Department of Surgery, Transplantation and Interventional Gastroenterology, Semmelweis University, Budapest, 1085, Hungary; email: jancsidora@gmail.com 0 false 2026-06-28T10:39:47.824+0000 2025-10-16T10:20:33.817+0000 2025-04-24T09:52:08.304+0000 true 10072667 Zátroch István /api/author/10072667 Author Zátroch István (aneszteziológia és intenzív terápia) true 2025-12-16T18:19:05.749+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Zátroch, István true true /api/journal/10017543 REVIEWED JOURNAL OF CLINICAL MEDICINE 2077-0383 true false 10017543 false 10017543 true 2077-0383 Journal FOREIGN 14 9 2925 2925 12 2025 Background/Objectives: In chronic liver disease, a rebalanced coagulation state often results in an increased risk of thrombosis, particularly in the splanchnic region. While systemic coagulation abnormalities are well documented, alterations in regional (portal) hemostasis remain underexplored. This study aimed to compare systemic and portal hemostasis during liver transplantation and to determine whether systemic parameters can accurately predict regional coagulation status. Methods: Thirty-five liver transplant recipients were included in this study. Systemic blood samples (S1–S5) were collected from the external jugular vein at five surgical time points, while portal blood samples (R3) were obtained immediately before reperfusion simultaneously with S3. All samples were analyzed using ClotPro® viscoelastic assays, conventional coagulation tests, and blood gas analysis. Results: The EX-test comparison between S3 and R3 samples revealed a discrepancy between systemic and regional hemostasis in 45.7% of patients. Among these, eight regional samples exhibited hypocoagulation characterized by coagulation factor consumption and hyperfibrinolysis. Another eight samples demonstrated hypercoagulation with fibrinolytic shutdown, which was confirmed by a fibrin-rich thrombus identified via scanning electron microscopy. Systemic samples failed to predict these regional variations. Conclusions: Regional (portal) hemostasis significantly differs from systemic coagulation and cannot be accurately predicted using systemic assays alone. These findings suggest that fibrinolytic shutdown in the portal vein may contribute to intraoperative and long-term graft damage, highlighting a potential need for regional coagulation assessment during liver transplantation. true true 2025 true true true false true false GOLD 2026-06-28 true https://doi.org/10.3390/jcm14092925 1 0 1 1 0 1 1 0 0 0 0 0 0 1 0 0 1 1 1 1 0 4 4 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 1 1 1 Q2 false 10009579 false false false 2025-04-23T11:36:30.844+0000 Aneszteziológiai és Intenzív Terápiás Tanszék (SE / AOK / K); Digitális Egészségtudományi Intézet (SE / EKK); Doktori Iskola (SE); Sebészeti, Transzplantációs és Gasztroenterológ... (SE / AOK / K) 4 19 4 4 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 126249680 /api/authorship/126249680 Zátroch, István [Zátroch, István (aneszteziológia é...), szerző] Doktori Iskola (SE) 1 0.25 true false false Author 10072667 /api/author/10072667 Zátroch István (aneszteziológia és intenzív terápia) Zátroch István true true Zátroch István true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126249681 /api/authorship/126249681 Dinya, Elek [Dinya, Elek (Orvosi biometria), szerző] Digitális Egészségtudományi Intézet (SE / EKK) 2 0.25 false false false Author 10009579 /api/author/10009579 Dinya Elek (Orvosi biometria) Dinya Elek true 10009579 true Dinya Elek true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126249682 /api/authorship/126249682 Smudla, Anikó [Smudla, Anikó (aneszteziológia é...), szerző] Sebészeti, Transzplantációs és Gasztroenterológ... (SE / AOK / K); Aneszteziológiai és Intenzív Terápiás Tanszék (SE / AOK / K) 3 0.25 false false false Author 10024161 /api/author/10024161 Smudla Anikó (aneszteziológia és intenzív terápia) Smudla Anikó true 10024161 true Smudla Anikó true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126249683 /api/authorship/126249683 Fazakas, János ✉ [Fazakas, János (Aneszteziológia é...), szerző] Aneszteziológiai és Intenzív Terápiás Tanszék (SE / AOK / K); Sebészeti, Transzplantációs és Gasztroenterológ... (SE / AOK / K) 4 0.25 false true true Author 10024159 /api/author/10024159 Fazakas János (Aneszteziológia és intenzív terápia) Fazakas János true 10024159 true Fazakas János true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 29273646 /api/publicationidentifier/29273646 DOI: 10.3390/jcm14092925 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/jcm14092925 https://doi.org/10.3390/jcm14092925 false true PublicationIdentifier 29401309 /api/publicationidentifier/29401309 WoS: 001486981900001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001486981900001 https://www.webofscience.com/wos/woscc/full-record/001486981900001 true true PublicationIdentifier 29401308 /api/publicationidentifier/29401308 Scopus: 105004932411 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105004932411 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105004932411 true true PublicationIdentifier 29911812 /api/publicationidentifier/29911812 PubMed: 40363956 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40363956 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40363956&dopt=Abstract false true SjrRating 11603514 /api/sjrrating/11603514 sjr:Q2 (2025) Scopus - Medicine (miscellaneous) JOURNAL OF CLINICAL MEDICINE 2077-0383 638 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true Q2 DIRECT true true Reference 65489444 /api/reference/65489444 1. 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Transplant., 11, p. 209, DOI: 10.23873/2074-0506-2019-11-3-209-217 28 10.23873/2074-0506-2019-11-3-209-217 false true /api/publication/36106218 Zátroch István et al. Fibrinolytic Dysregulation in Regional Hemostasis During Liver Transplantation: A Viscoelastometry-Based Pilot Study. (2025) JOURNAL OF CLINICAL MEDICINE 2077-0383 14 9<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10072667"><a href="/gui2/?type=authors&mode=browse&sel=10072667" target="_blank">Zátroch István (<span class="authorship-author-name">Zátroch István</span> <span class="authorAux-mtmt"> aneszteziológia és intenzív terápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009579"><a href="/gui2/?type=authors&mode=browse&sel=10009579" target="_blank">Dinya Elek (<span class="authorship-author-name">Dinya Elek</span> <span class="authorAux-mtmt"> Orvosi biometria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Egészségügyi Közszolgálati Kar">EKK</span>/Digitális Egészségtudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024161"><a href="/gui2/?type=authors&mode=browse&sel=10024161" target="_blank">Smudla Anikó (<span class="authorship-author-name">Smudla Anikó</span> <span class="authorAux-mtmt"> aneszteziológia és intenzív terápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Aneszteziológiai és Intenzív Terápiás Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024159"><a href="/gui2/?type=authors&mode=browse&sel=10024159" target="_blank">Fazakas János ✉ (<span class="authorship-author-name">Fazakas János</span> <span class="authorAux-mtmt"> Aneszteziológia és intenzív terápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Aneszteziológiai és Intenzív Terápiás Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36106218" target="_blank">Fibrinolytic Dysregulation in Regional Hemostasis During Liver Transplantation: A Viscoelastometry-Based Pilot Study</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL MEDICINE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0383">2077-0383</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">9</span> <span class="page"> Paper 2925. 12 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/jcm14092925" target="_blank" href="https://doi.org/10.3390/jcm14092925"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001486981900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001486981900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105004932411" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105004932411"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40363956" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40363956&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36106218&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36106218</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.10.16. 12:20 Szabad Viktória (SE_EKK_Admin5_SZV, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 09 July 2025; Cited By: 0; Correspondence Address: J. Fazakas; Department of Surgery, Transplantation and Interventional Gastroenterology, Semmelweis University, Budapest, 1085, Hungary; email: jancsidora@gmail.com</pre> </div></div>