https://m2.mtmt.hu/ hun 2026-09-22 01:36 JournalArticle 36102520 VALIDATED true 0 false 2026-06-05T11:10:23.276+0000 2025-05-06T11:26:49.731+0000 2025-04-22T21:37:59.188+0000 true 10000786 Csala Miklós /api/author/10000786 Author Csala Miklós (Biokémia) true 10000786 2025-05-15T06:41:19.442+0000 2025-05-06T11:26:49.877+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Mayeka, James G. true true /api/journal/20068712 REVIEWED SCIENTIFIC AFRICAN 2468-2276 2468-2276 true false false 20068712 true 2468-2276 2468-2276 Journal FOREIGN 28 e02709 e02709 11 2025 Funding 2052533 /api/funding/2052533 (TKP2021-EGA-24) false true true true 2025 true true true false true false GOLD 2026-06-05 false https://www.journals.elsevier.com/scientific-african 2 0 2 2 0 2 2 0 2 2 2 2 2 2 0 0 2 2 2 2 0 1 1 Folyóiratcikk Journal Article 24 2 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 2 2 2 2 Q1 false 10012583 false false false 2025-05-05T11:26:49.580+0000 Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 4 20 2 10 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 126232812 /api/authorship/126232812 Mayeka, James G. 1 0.1 true false false Mayeka James G. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126232813 /api/authorship/126232813 Atilaw, Yoseph 2 0.1 false false false Atilaw Yoseph true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126232814 /api/authorship/126232814 Shadrack, Daniel M. 3 0.1 false false false Shadrack Daniel M. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126232815 /api/authorship/126232815 Sarnyai, Farkas [Sarnyai, Farkas (Molekuláris bioló...), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 4 0.1 false false false Author 10052722 /api/author/10052722 Sarnyai Farkas (Molekuláris biológia, biokémia) Sarnyai Farkas true 10052722 true Sarnyai Farkas true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126232816 /api/authorship/126232816 Csala, Miklós [Csala, Miklós (Biokémia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 5 0.1 false false false Author 10000786 /api/author/10000786 Csala Miklós (Biokémia) Csala Miklós true 10000786 true Csala Miklós true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126232817 /api/authorship/126232817 Németh, Krisztina [Németh, Krisztina (Genetika, immunbi...), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I) 6 0.1 false false false Author 10065572 /api/author/10065572 Németh Krisztina (Genetika, immunbiológia) Németh Krisztina true true Németh Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126232818 /api/authorship/126232818 Nyandoro, Stephen S. 7 0.1 false false false Nyandoro Stephen S. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126232819 /api/authorship/126232819 Tamási, Viola ✉ [Tamási, Viola (Cirokróm P450 enz...), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 8 0.1 false false true Author 10012583 /api/author/10012583 Tamási Viola (Cirokróm P450 enzimek szabályzása, farmakogenetika) Tamási Viola true 10012583 true Tamási Viola true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126232820 /api/authorship/126232820 Erdelyi, Mate ✉ 9 0.1 false false true Erdelyi Mate true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 126232821 /api/authorship/126232821 Munissi, Joan J.E. ✉ 10 0.1 false true true Munissi Joan J.E. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 29264948 /api/publicationidentifier/29264948 DOI: 10.1016/j.sciaf.2025.e02709 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/j.sciaf.2025.e02709 https://doi.org/10.1016/j.sciaf.2025.e02709 false true PublicationIdentifier 29368405 /api/publicationidentifier/29368405 WoS: 001478548700001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001478548700001 https://www.webofscience.com/wos/woscc/full-record/001478548700001 false true PublicationIdentifier 29302896 /api/publicationidentifier/29302896 Scopus: 105003131626 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105003131626 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105003131626 true true SjrRating 11736341 /api/sjrrating/11736341 sjr:Q1 (2025) Scopus - Multidisciplinary SCIENTIFIC AFRICAN 2468-2276 2468-2276 39 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 Scopus - Multidisciplinary true 1000 true Q1 DIRECT true true Reference 65463960 /api/reference/65463960 1. Ahamad 2022: Development of small-molecule PCSK9 inhibitors for the treatment of hypercholesterolemia., Drug Discov. Today, 27, p. 1332, DOI: 10.1016/j.drudis.2022.01.014 1 10.1016/j.drudis.2022.01.014 false true Reference 65463961 /api/reference/65463961 2. Andrade 2015: Prevention of Cardiovascular Diseases 2 false true Reference 65463962 /api/reference/65463962 3. Youngblom 2016: Familial hypercholesterolemia 3 false true Reference 65463963 /api/reference/65463963 4. Go 2012: Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis., Yale J. Biol. Med., 85, p. 19 4 false true Reference 65463964 /api/reference/65463964 5. Tsouka 2018: Pharmacology of PCSK9 inhibitors: current status and future perspectives., Curr. Pharm. Des., 24, p. 3622, DOI: 10.2174/1381612824666181010144823 5 10.2174/1381612824666181010144823 false true Reference 65463965 /api/reference/65463965 6. Cariou 2011: Clinical aspects of PCSK9., Atherosclerosis, 216, p. 258, DOI: 10.1016/j.atherosclerosis.2011.04.018 6 10.1016/j.atherosclerosis.2011.04.018 false true Reference 65463966 /api/reference/65463966 7. Page 2016: PCSK9 inhibitors–mechanisms of action., Aust. Prescr., 39, p. 164, DOI: 10.18773/austprescr.2016.060 7 10.18773/austprescr.2016.060 false true Reference 65463967 /api/reference/65463967 8. Lambert 2009: Molecular basis of PCSK9 function., Atherosclerosis, 203, p. 1, DOI: 10.1016/j.atherosclerosis.2008.06.010 8 10.1016/j.atherosclerosis.2008.06.010 false true Reference 65463968 /api/reference/65463968 9. Xu 2018: Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol., Atherosclerosis, 268, p. 196, DOI: 10.1016/j.atherosclerosis.2017.08.031 9 10.1016/j.atherosclerosis.2017.08.031 false true Reference 65463969 /api/reference/65463969 10. Badia 2016: Targeting PCSK9 as a promising new mechanism for lowering low-density lipoprotein cholesterol., Pharm. Ther., 164, p. 183, DOI: 10.1016/j.pharmthera.2016.04.011 10 10.1016/j.pharmthera.2016.04.011 false true Reference 65463970 /api/reference/65463970 11. Lavecchia 2019: Recent advances in developing PCSK9 inhibitors for lipid-lowering therapy., Future Med. Chem., 11, p. 423, DOI: 10.4155/fmc-2018-0294 11 10.4155/fmc-2018-0294 false true Reference 65463971 /api/reference/65463971 12. Basak 2018: Small molecule phytocompounds as promoters of LDL-receptor and PCSK9 Inhibition: potential role as non-statin based cardio-protective agents.Cardioprot. Nat. Prod. Promises Hopes, p. 277 12 false true Reference 65463972 /api/reference/65463972 13. Scolaro 2018: Bioactive compounds as an alternative for drug co-therapy: overcoming challenges in cardiovascular disease prevention., Crit. Rev. Food Sci. Nutr., 58, p. 958, DOI: 10.1080/10408398.2016.1235546 13 10.1080/10408398.2016.1235546 false true Reference 65463973 /api/reference/65463973 14. Cui 2020: Beneficial impact of epigallocatechingallate on LDL-C through PCSK9/LDLR pathway by blocking HNF1alpha and activating FoxO3a., J. Transl. Med., 18, p. 195, DOI: 10.1186/s12967-020-02362-4 14 10.1186/s12967-020-02362-4 false true Reference 65463974 /api/reference/65463974 15. Naeem 2022: The fate of flavonoids after oral administration: a comprehensive overview of its bioavailability., Crit. Rev. Food Sci. Nutr., 62, p. 6169, DOI: 10.1080/10408398.2021.1898333 15 10.1080/10408398.2021.1898333 false true Reference 65463975 /api/reference/65463975 16. Sarbu 2019: Synthetic flavonoids with antimicrobial activity: a review., J. Appl. Microbiol., 127, p. 1282, DOI: 10.1111/jam.14271 16 10.1111/jam.14271 false true Reference 65463976 /api/reference/65463976 17. Pandey 2016: Microbial production of natural and non-natural flavonoids: pathway engineering, directed evolution and systems/synthetic biology., Biotechnol. Adv., 34, p. 634, DOI: 10.1016/j.biotechadv.2016.02.012 17 10.1016/j.biotechadv.2016.02.012 false true Reference 65463977 /api/reference/65463977 18. Romano 2013: Novel insights into the pharmacology of flavonoids., Phytother. Res., 27, p. 1588, DOI: 10.1002/ptr.5023 18 10.1002/ptr.5023 false true Reference 65463978 /api/reference/65463978 19. Hoekstra 2016: A nonet of novel species of Monanthotaxis (Annonaceae) from around Africa., PhytoKeys, 69, p. 71, DOI: 10.3897/phytokeys.69.9292 19 10.3897/phytokeys.69.9292 false true Reference 65463979 /api/reference/65463979 20. Morikawa 2007: A novel regulatory pathway for cholesterol degradation via lactostatin., Biochem. Biophys. Res. Commun., 352, p. 697, DOI: 10.1016/j.bbrc.2006.11.090 20 10.1016/j.bbrc.2006.11.090 false true Reference 65463980 /api/reference/65463980 21. Trott 2010: AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading., J. Comput. Chem., 31, p. 455, DOI: 10.1002/jcc.21334 21 10.1002/jcc.21334 false true Reference 65463981 /api/reference/65463981 22. Petrilli 2020: From screening to targeted degradation: strategies for the discovery and optimization of small molecule ligands for PCSK9., Cell Chem. Biol., 27, p. 32, DOI: 10.1016/j.chembiol.2019.10.002 22 10.1016/j.chembiol.2019.10.002 false true Reference 65463982 /api/reference/65463982 23. Pettersen 2004: UCSF Chimera—A visualization system for exploratory research and analysis., J. Comput. Chem., 25, p. 1605, DOI: 10.1002/jcc.20084 23 10.1002/jcc.20084 false true Reference 65463983 /api/reference/65463983 24. O'Boyle 2011: Open Babel: an open chemical toolbox., J. Cheminf, 3, p. 1, DOI: 10.1186/1758-2946-3-33 24 10.1186/1758-2946-3-33 false true Reference 65463984 /api/reference/65463984 25. Abraham 2015: GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers., SoftwareX, 1, p. 19, DOI: 10.1016/j.softx.2015.06.001 25 10.1016/j.softx.2015.06.001 false true Reference 65463985 /api/reference/65463985 26. Wang 2004: Development and testing of a general amber force field., J. Comput. Chem., 25, p. 1157, DOI: 10.1002/jcc.20035 26 10.1002/jcc.20035 false true Reference 65463986 /api/reference/65463986 27. Shadrack 2020: A computational study on the role of water and conformational fluctuations in Hsp90 in response to inhibitors., J. Mol. Graph. Model., 96, DOI: 10.1016/j.jmgm.2019.107510 27 10.1016/j.jmgm.2019.107510 false true Reference 65463987 /api/reference/65463987 28. Bussi 2007: Canonical sampling through velocity rescaling., J. Chem. Phys., 126, DOI: 10.1063/1.2408420 28 10.1063/1.2408420 false true Reference 65463988 /api/reference/65463988 29. Berendsen 1984: Molecular dynamics with coupling to an external bath., J. Chem. Phys., 81, p. 3684, DOI: 10.1063/1.448118 29 10.1063/1.448118 false true Reference 65463989 /api/reference/65463989 30. Cheatham 1995: Molecular dynamics simulations on solvated biomolecular systems: the particle mesh Ewald method leads to stable trajectories of DNA, RNA, and proteins., J. Am. Chem. Soc., 117, p. 4193, DOI: 10.1021/ja00119a045 30 10.1021/ja00119a045 false true Reference 65463990 /api/reference/65463990 31. Hess 1997: LINCS: a linear constraint solver for molecular simulations., J. Comput. Chem., 18, p. 1463, DOI: 10.1002/(SICI)1096-987X(199709)18:12&lt;1463::AID-JCC4&gt;3.0.CO;2-H 31 10.1002/(SICI)1096-987X(199709)18:12&lt;1463::AID-JCC4&gt;3.0.CO;2-H false true Reference 65463991 /api/reference/65463991 32. Kumari 2014: g_mmpbsa—A GROMACS tool for high-throughput MM-PBSA calculations., J. Chem. Inf. Model., 54, p. 1951, DOI: 10.1021/ci500020m 32 10.1021/ci500020m false true Reference 65463992 /api/reference/65463992 33. Shadrack 2021: Luteolin: a blocker of SARS-CoV-2 cell entry based on relaxed complex scheme, molecular dynamics simulation, and metadynamics., J. Mol. Model., 27, p. 1, DOI: 10.1007/s00894-021-04833-x 33 10.1007/s00894-021-04833-x false true Reference 65463993 /api/reference/65463993 34. Panichpol 1978: Novel flavonoids from the stem of Popowia cauliflora., Phytochemistry, 17, p. 1363, DOI: 10.1016/S0031-9422(00)94590-4 34 10.1016/S0031-9422(00)94590-4 false true Reference 65463994 /api/reference/65463994 35. Zhou 2021: Design, synthesis and biological evaluation of nobiletin derivatives as multifunctional agents for the treatment of Alzheimer's disease., ChemistrySelect, 6, p. 569, DOI: 10.1002/slct.202004239 35 10.1002/slct.202004239 false true Reference 65463995 /api/reference/65463995 36. Xianrui 2016: Isolation and identification of the constituents from Scutellaria indica L., J. Zhejiang Univ. Technol., p. 88 36 false true Reference 65463996 /api/reference/65463996 37. Tomas-Barberán 1988: Antifungal epicuticular methylated flavonoids from Helichrysum nitens., Phytochemistry, 27, p. 753, DOI: 10.1016/0031-9422(88)84087-1 37 10.1016/0031-9422(88)84087-1 false true Reference 65463997 /api/reference/65463997 38. Salem 2005: Antiprotozoal compounds from Psorothamnus polydenius., J. Nat. Prod., 68, p. 108, DOI: 10.1021/np049682k 38 10.1021/np049682k false true Reference 65463998 /api/reference/65463998 39. Peralta 2014: Flavanoids from Dalea elegans: chemical reassignment and determination of kinetics parameters related to their anti-tyrosinase activity., Phytochem. Lett., 10, p. 260, DOI: 10.1016/j.phytol.2014.10.012 39 10.1016/j.phytol.2014.10.012 false true Reference 65463999 /api/reference/65463999 40. Petrilli 2020: From screening to targeted degradation: strategies for the discovery and optimization of small molecule ligands for PCSK9., Cell Chem. Biol., 27, p. 32, DOI: 10.1016/j.chembiol.2019.10.002 40 10.1016/j.chembiol.2019.10.002 false true Reference 65464000 /api/reference/65464000 41. Nemeth 2023: High fat diet and PCSK9 knockout modulates lipid profile of the liver and changes the expression of lipid homeostasis related genes., Nutr. Metab., 20, p. 19, DOI: 10.1186/s12986-023-00738-z 41 10.1186/s12986-023-00738-z false true Reference 65464001 /api/reference/65464001 42. Luo 2009: Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice., J. Lipid Res., 50, p. 1581, DOI: 10.1194/jlr.M800542-JLR200 42 10.1194/jlr.M800542-JLR200 false true Reference 65464002 /api/reference/65464002 43. Seidah 2022: Expanding biology of PCSK9: roles in atherosclerosis and Beyond., Curr. Atheroscler. Rep., 24, p. 821, DOI: 10.1007/s11883-022-01057-z 43 10.1007/s11883-022-01057-z false true Reference 65464003 /api/reference/65464003 44. Maxwell 2004: Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype., Proc. Natl. Acad. Sci. USA, 101, p. 7100, DOI: 10.1073/pnas.0402133101 44 10.1073/pnas.0402133101 false true Reference 65464004 /api/reference/65464004 45. Poirier 2008: The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2., J. Biol. Chem., 283, p. 2363, DOI: 10.1074/jbc.M708098200 45 10.1074/jbc.M708098200 false true Reference 65464005 /api/reference/65464005 46. Canuel 2013: Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1)., PLoS One, 8, DOI: 10.1371/journal.pone.0064145 46 10.1371/journal.pone.0064145 false true Reference 65464006 /api/reference/65464006 47. Liu 2020: Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer., Nature, 588, p. 693, DOI: 10.1038/s41586-020-2911-7 47 10.1038/s41586-020-2911-7 false true Reference 65464007 /api/reference/65464007 48. Demers 2015: PCSK9 induces CD36 degradation and affects long-chain fatty acid uptake and triglyceride metabolism in adipocytes and in mouse liver., Arterioscler. Thromb. Vasc. Biol., 35, p. 2517, DOI: 10.1161/ATVBAHA.115.306032 48 10.1161/ATVBAHA.115.306032 false true Reference 65464008 /api/reference/65464008 49. Luquero 2021: PCSK9 functions in atherosclerosis are not limited to plasmatic LDL-cholesterol regulation., Front. Cardiovasc. Med., 8, DOI: 10.3389/fcvm.2021.639727 49 10.3389/fcvm.2021.639727 false true Reference 65464009 /api/reference/65464009 50. Resurreccion-Magno 2005: Antihyperglycaemic flavonoids from Syzygium samarangense (Blume) merr. and perry., Phytother. Res., 19, p. 246, DOI: 10.1002/ptr.1658 50 10.1002/ptr.1658 false true Reference 65464010 /api/reference/65464010 51. Amor 2004: Prolyl endopeptidase inhibitors from Syzygium samarangense (Blume) Merr. & LM Perry., Zeitschr. Naturforsch. C, 59, p. 86, DOI: 10.1515/znc-2004-1-218 51 10.1515/znc-2004-1-218 false true Reference 65464011 /api/reference/65464011 52. Moghaddam 2021: Natural AMPK activators in cardiovascular disease prevention., Front. Pharmacol., 12 52 false true Reference 65464012 /api/reference/65464012 53. Xu 2013: Transcriptional control of hepatic lipid metabolism by SREBP and ChREBP., Semin. Liver. Dis., 33, p. 301, DOI: 10.1055/s-0033-1358523 53 10.1055/s-0033-1358523 false true Reference 65464013 /api/reference/65464013 54. Choi 2016: DMC (2′, 4′-dihydroxy-6′-methoxy-3′, 5′-dimethylchalcone) improves glucose tolerance as a potent AMPK activator., Metabolism, 65, p. 533, DOI: 10.1016/j.metabol.2015.12.010 54 10.1016/j.metabol.2015.12.010 false true Reference 65464014 /api/reference/65464014 55. Costet 2006: Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c., J. Biol. Chem., 281, p. 6211, DOI: 10.1074/jbc.M508582200 55 10.1074/jbc.M508582200 false true Reference 65464015 /api/reference/65464015 56. Karasawa 2011: Sterol regulatory element–binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor–deficient mice., Arterioscler. Thromb. Vasc. Biol., 31, p. 1788, DOI: 10.1161/ATVBAHA.110.219659 56 10.1161/ATVBAHA.110.219659 false true Reference 65464016 /api/reference/65464016 57. Hu 2021: New insight into metformin-induced cholesterol-lowering effect crosstalk between glucose and cholesterol homeostasis via ChREBP (carbohydrate-responsive element-binding protein)-mediated PCSK9 (proprotein convertase subtilisin/kexin type 9) regulation., Arterioscler. Thromb. Vasc. Biol., 41, p. e208, DOI: 10.1161/ATVBAHA.120.315708 57 10.1161/ATVBAHA.120.315708 false true Reference 65464017 /api/reference/65464017 58. Hardie 2004: The AMP-activated protein kinase pathway–new players upstream and downstream., J. Cell Sci., 117, p. 5479, DOI: 10.1242/jcs.01540 58 10.1242/jcs.01540 false true Reference 65464018 /api/reference/65464018 59. Wang 2018: AMPK-mediated regulation of lipid metabolism by phosphorylation., Biol. Pharm. Bull., 41, p. 985, DOI: 10.1248/bpb.b17-00724 59 10.1248/bpb.b17-00724 false true Reference 65464019 /api/reference/65464019 60. Kim 2021: Prenylated flavonoid glycosides with PCSK9 mRNA expression inhibitory activity from the aerial parts of Epimedium koreanum., Molecules, 26, p. 3590, DOI: 10.3390/molecules26123590 60 10.3390/molecules26123590 false true Reference 65464020 /api/reference/65464020 61. Zelcer 2009: LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor., Science, 325, p. 100, DOI: 10.1126/science.1168974 61 10.1126/science.1168974 false true Reference 65464021 /api/reference/65464021 62. Maxwell 2003: Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice., J. Lipid Res., 44, p. 2109, DOI: 10.1194/jlr.M300203-JLR200 62 10.1194/jlr.M300203-JLR200 false true Reference 65464022 /api/reference/65464022 63. Horton 2003: Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes., Proc. Natl. Acad. Sci., 100, p. 12027, DOI: 10.1073/pnas.1534923100 63 10.1073/pnas.1534923100 false true Reference 65464023 /api/reference/65464023 64. Duan 2012: Peroxisome proliferator-activated receptor γ activation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression., J. Biol. Chem., 287, p. 23667, DOI: 10.1074/jbc.M112.350181 64 10.1074/jbc.M112.350181 false true Reference 65464024 /api/reference/65464024 65. Tao 2013: Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6., J. Lipid Res., 54, p. 2745, DOI: 10.1194/jlr.M039339 65 10.1194/jlr.M039339 false true Reference 65464025 /api/reference/65464025 66. Cui 2020: Beneficial impact of epigallocatechingallate on LDL-C through PCSK9/LDLR pathway by blocking HNF1α and activating FoxO3a., J. Transl. Med., 18, p. 1, DOI: 10.1186/s12967-020-02362-4 66 10.1186/s12967-020-02362-4 false true Reference 65464026 /api/reference/65464026 67. Bastos 2009: Studies on the antimicrobial activity and brine shrimp toxicity of Zeyheria tuberculosa (Vell.) Bur. (Bignoniaceae) extracts and their main constituents., Ann. Clin. Microbiol. Antimicrob., 8, p. 1, DOI: 10.1186/1476-0711-8-16 67 10.1186/1476-0711-8-16 false true Reference 65464027 /api/reference/65464027 68. Gao 2018: Pinostrobin inhibits proprotein convertase subtilisin/kexin-type 9 (PCSK9) gene expression through the modulation of FoxO3a protein in HepG2 cells., J. Agric. Food Chem., 66, p. 6083, DOI: 10.1021/acs.jafc.8b02559 68 10.1021/acs.jafc.8b02559 false true Reference 65464028 /api/reference/65464028 69. Nhoek 2018: Discovery of flavonoids from Scutellaria baicalensis with inhibitory activity against PCSK 9 expression: isolation, synthesis and their biological evaluation., Molecules, 23, p. 504, DOI: 10.3390/molecules23020504 69 10.3390/molecules23020504 false true Reference 65464029 /api/reference/65464029 70. Kwon 2008: Molecular basis for LDL receptor recognition by PCSK9., Proc. Natl. Acad. Sci, 105, p. 1820, DOI: 10.1073/pnas.0712064105 70 10.1073/pnas.0712064105 false true Reference 65464030 /api/reference/65464030 71. Evison 2020: A small molecule inhibitor of PCSK9 that antagonizes LDL receptor binding via interaction with a cryptic PCSK9 binding groove., Bioorg. Med. Chem., 28, DOI: 10.1016/j.bmc.2020.115344 71 10.1016/j.bmc.2020.115344 false true Reference 65464031 /api/reference/65464031 72. Lo Surdo 2011: Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH., EMBo Rep., 12, p. 1300, DOI: 10.1038/embor.2011.205 72 10.1038/embor.2011.205 false true Reference 65464032 /api/reference/65464032 73. Abdelwahed 2020: Pseurotin A as a novel suppressor of hormone dependent breast cancer progression and recurrence by inhibiting PCSK9 secretion and interaction with LDL receptor., Pharmacol. Res., 158, DOI: 10.1016/j.phrs.2020.104847 73 10.1016/j.phrs.2020.104847 false true Reference 65464033 /api/reference/65464033 74. Guarnieri 2019: Fragment-based design of small molecule PCSK9 inhibitors using simulated annealing of chemical potential simulations., PLoS One, 14, DOI: 10.1371/journal.pone.0225780 74 10.1371/journal.pone.0225780 false true Reference 65464034 /api/reference/65464034 75. I. Basu, K. Sinha, N.A. Shah, Z. S. Shah, S. Chakrabarty, Allosteric Modulation of PCSK9-LDLR Interaction: can structureless loops be drug targets?, ChemRxiv. 26434 [Preprint] October 2022; https://doi.org/10.26434/chemrxiv-2022-1w1q3., DOI: 10.26434/chemrxiv-2022-1w1q3 75 10.26434/chemrxiv-2022-1w1q3 false true /api/publication/36102520 Mayeka James G. et al. Flavonoids from the leaves of Monanthotaxis filipes modulate PCSK9 and LDLR. (2025) SCIENTIFIC AFRICAN 2468-2276 2468-2276 28<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Mayeka James G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Atilaw Yoseph </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shadrack Daniel M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052722"><a href="/gui2/?type=authors&mode=browse&sel=10052722" target="_blank">Sarnyai Farkas (<span class="authorship-author-name">Sarnyai Farkas</span> <span class="authorAux-mtmt"> Molekuláris biológia, biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000786"><a href="/gui2/?type=authors&mode=browse&sel=10000786" target="_blank">Csala Miklós (<span class="authorship-author-name">Csala Miklós</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065572"><a href="/gui2/?type=authors&mode=browse&sel=10065572" target="_blank">Németh Krisztina (<span class="authorship-author-name">Németh Krisztina</span> <span class="authorAux-mtmt"> Genetika, immunbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nyandoro Stephen S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012583"><a href="/gui2/?type=authors&mode=browse&sel=10012583" target="_blank">Tamási Viola ✉ (<span class="authorship-author-name">Tamási Viola</span> <span class="authorAux-mtmt"> Cirokróm P450 enzimek szabályzása, farmakogenetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Erdelyi Mate ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Munissi Joan J.E. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36102520" target="_blank">Flavonoids from the leaves of Monanthotaxis filipes modulate PCSK9 and LDLR</a></div> <div> <span class="journal-title">SCIENTIFIC AFRICAN</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2468-2276">2468-2276</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2468-2276">2468-2276</a>)</span>: <span class="journal-volume">28</span> <span class="page"> Paper e02709. 11 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.sciaf.2025.e02709" target="_blank" href="https://doi.org/10.1016/j.sciaf.2025.e02709"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001478548700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001478548700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105003131626" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105003131626"> Scopus </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 2 | Függő: 0 | Nem jelölt: 0 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36102520&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36102520</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (TKP2021-EGA-24) </div> <div class="lastModified">Utolsó módosítás: 2025.05.06. 13:26 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> </div></div>