https://m2.mtmt.hu/ hun 2026-10-24 11:38 JournalArticle 36100250 VALIDATED true * Megosztott szerzőség 0 false 2026-10-09T16:55:41.191+0000 2026-03-02T13:11:28.247+0000 2025-04-22T08:42:40.189+0000 true 10081340 Pirmann Tamás /api/admin/10081340 Admin true 2026-06-03T02:40:37.012+0000 2025-04-24T07:54:42.395+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10099440 /api/admin/10099440 Csernyik Rita true true 2026-03-02T07:07:08.740+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Darida, Miklós Improvement in breast cancer survival across molecular subtypes in Hungary between 2011 and 2020 : a nationwide, retrospective study true true /api/journal/10025358 REVIEWED true false 10025358 false 10025358 true 2234-943X 2234-943X Journal FOREIGN 15 12 1465511 1465511 12 2025 Despite well-documented clinical differences across breast-cancer (BC) molecular subtypes and relevant changes in therapeutic interventions over the past decades, there remains a significant lack of up-to-date epidemiologic data and real-world outcomes, particularly in Central and Eastern Europe.This was a nationwide, retrospective study using the claims databases of the Hungarian National Health Insurance Fund (NHIF) that included patients who were newly diagnosed with BC between 2011 and 2020. BC subtypes were defined based on the therapies received. Overall survival (OS) and net survival rates were calculated.Between 2011 and 2020, 74,143 patients were newly diagnosed with BC based on ICD-10 diagnostic codes in the NHIF database and 80.1% of the cases could be classified into subtypes based on therapy. The most common subtype was HER2-/HR+ BC, identified in 61.9% of patients, followed by triple negative breast cancer (TNBC) in 8.4%, HER2+/HR+ BC in 6.2%, and HER2+/HR- BC in 3.6% of cases. The proportions of TNBC and HER2+/HR+ were higher among younger patients, than in elderly cohorts. The 5-year OS of the total BC population was 74.2% in patients diagnosed between 2015-2019. Patients with TNBC had the poorest 5-year OS (TNBC: 61.4%; HER2+/HR+: 86.5%; HER2-/HR+: 79.1%; HER2+/HR-: 71.9%). Net survival rates (i.e. survival rates after adjusting the effects of other causes of death) varied across diagnostic periods and molecular subtypes. In most cases, patients diagnosed later during the study period tended to have numerically better survival rates. Patients with HER2-/HR+ BC had the most favorable net survival, with 5-year net survival exceeding 92% during the whole observation period, while TNBC patients had the lowest 5-year net survival rates ranging between 63.6% and 65.8% during the study period.Our nationwide study describes the distribution and survival of BC patients with different subtypes based on a retrospective analysis of the health insurance fund database. There remains a significant room for improvement in the survival of more aggressive molecular subtypes including HR-/HER2+ and triple-negative BC, which are more common in younger age cohorts. Funding 2052126 /api/funding/2052126 false true Funding 2052127 /api/funding/2052127 false true Funding 2052128 /api/funding/2052128 false true true INTERNATIONAL 2025 true true true false true false GOLD 2026-10-09 true https://doi.org/10.3389/fonc.2025.1465511 10 0 10 9 1 9 10 8 10 10 10 9 9 9 1 0 10 9 10 9 0 4 4 Folyóiratcikk Journal Article 24 9 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 4 3 4 3 2026 0 6 6 6 6 Q2 false false false false 2025-04-21T13:25:34.661+0000 Anatómiai és Szövettani Tanszék (ÁTE / ATI); Egészségügyi Technológiaértékelő és Elemzési Kö... (SE / KSZE); HUN-REN-ÁTE Redoxbiológiai Laboratórium Kutatócso (ÁTE / ATI / ASZT); II. sz. Belgyógyászati Klinika és Nephrológiai,... (PTE / ÁOK); Onkológiai Tanszék (SE / AOK / K); Országos Onkológiai Intézet; Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I); Állatorvostudományi Egyetem 12 68 8 23 0 true 10099440 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 126221693 /api/authorship/126221693 1 0.04347826 true false false Darida Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126221694 /api/authorship/126221694 2 0.043 true false false Author 10060070 /api/author/10060070 Rubovszky Gábor true 10060070 true Rubovszky Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126221695 /api/authorship/126221695 3 0.043 false false true Author 10077079 /api/author/10077079 Kiss Zoltán true true Kiss Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126221696 /api/authorship/126221696 4 0.043 false false false Author 10027952 /api/author/10027952 Székely Borbála true 10027952 true Székely Borbála true false false AuthorshipType 1 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/api/author/10021022 Nagy Péter true 10021022 true Nagy Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126221712 /api/authorship/126221712 20 0.04347826 false false false Barcza Zsófia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126221713 /api/authorship/126221713 21 0.043 false false false Author 10003497 /api/author/10003497 Bogos Krisztina true 10003497 true Bogos Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126221714 /api/authorship/126221714 22 0.043 false true false Author 10000181 /api/author/10000181 Vokó Zoltán true 10000181 true Vokó Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126221715 /api/authorship/126221715 23 0.043 false true false Author 10013383 /api/author/10013383 Polgár Csaba true 10013383 true Polgár Csaba true false false 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https://www.scopus.com/pages/publications/105002612457?origin=resultslist false true Keyword 1168 /api/keyword/1168 true 1168 true Keyword 12792 /api/keyword/12792 true 12792 true Keyword 20010 /api/keyword/20010 true 20010 true Keyword 1193122 /api/keyword/1193122 true 1193122 true Keyword 1458305 /api/keyword/1458305 true 1458305 true Keyword 1506791 /api/keyword/1506791 true true SjrRating 11563053 /api/sjrrating/11563053 109 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1306 /api/classificationexternal/1306 true 1306 true Q2 DIRECT true true /api/publication/36100250 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Darida Miklós </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060070"><a href="/gui2/?type=authors&mode=browse&sel=10060070" target="_blank">Rubovszky Gábor<sup>*</sup> (<span class="authorship-author-name">Rubovszky Gábor</span> <span class="authorAux-mtmt"> klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077079"><a href="/gui2/?type=authors&mode=browse&sel=10077079" target="_blank">Kiss Zoltán ✉ (<span class="authorship-author-name">Kiss Zoltán</span> <span class="authorAux-mtmt"> A főbb mortalitásért felelős betegségek epidemi...</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/II. sz. Belgyógyászati Klinika és Nephrológiai, Diabetológiai Centrum</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027952"><a href="/gui2/?type=authors&mode=browse&sel=10027952" target="_blank">Székely Borbála (<span class="authorship-author-name">Székely Borbála</span> <span class="authorAux-mtmt"> patológia, onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Madaras Balázs </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026959"><a href="/gui2/?type=authors&mode=browse&sel=10026959" target="_blank">Horváth Zsolt (<span class="authorship-author-name">Horváth Zsolt</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kocsis Judit </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sipőcz István </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Várnai Máté </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Balogh Éva </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kovács Krisztina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Buga Viktória </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Karamousouli Eugenia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szabó Tamás G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080246"><a href="/gui2/?type=authors&mode=browse&sel=10080246" target="_blank">Rokszin György (<span class="authorship-author-name">Rokszin György Aurél</span> <span class="authorAux-mtmt"> Orvosi tudományok</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023209"><a href="/gui2/?type=authors&mode=browse&sel=10023209" target="_blank">Fábián Ibolya (<span class="authorship-author-name">Bajcsayné Fábián Ibolya</span> <span class="authorAux-mtmt"> Biomatematika</span>) </a> </span> <span class="author-affil">Állatorvostudományi Egyetem</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017547"><a href="/gui2/?type=authors&mode=browse&sel=10017547" target="_blank">Kenessey István (<span class="authorship-author-name">Kenessey István</span> <span class="authorAux-mtmt"> Patológia, onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064611"><a href="/gui2/?type=authors&mode=browse&sel=10064611" target="_blank">Wéber András (<span class="authorship-author-name">Wéber András</span> <span class="authorAux-mtmt"> Demográfia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021022"><a href="/gui2/?type=authors&mode=browse&sel=10021022" target="_blank">Nagy Péter (<span class="authorship-author-name">Nagy Péter</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Állatorvostudományi Egyetem">ÁTE</span>/<span title="Alaptudományi Intézet">ATI</span>/Anatómiai és Szövettani Tanszék; <span title="Állatorvostudományi Egyetem">ÁTE</span>/<span title="Alaptudományi Intézet">ATI</span>/<span title="Anatómiai és Szövettani Tanszék">ASZT</span>/HUN-REN-ÁTE Redoxbiológiai Laboratórium Kutatócso</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Barcza Zsófia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003497"><a href="/gui2/?type=authors&mode=browse&sel=10003497" target="_blank">Bogos Krisztina (<span class="authorship-author-name">Bogos Krisztina</span> <span class="authorAux-mtmt"> Tüdőgyógyászat, Klinikai Onkológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000181"><a href="/gui2/?type=authors&mode=browse&sel=10000181" target="_blank">Vokó Zoltán<sup>**</sup> (<span class="authorship-author-name">Vokó Zoltán</span> <span class="authorAux-mtmt"> A nem-fertőző betegségek</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Egészségügyi Technológiaértékelő és Elemzési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013383"><a href="/gui2/?type=authors&mode=browse&sel=10013383" target="_blank">Polgár Csaba (<span class="authorship-author-name">Polgár Csaba</span> <span class="authorAux-mtmt"> Sugárterápia, klinikai onkológia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36100250" target="_blank">Improvement in breast cancer survival across molecular subtypes in Hungary between 2011 and 2020 : a nationwide, retrospective study</a></div> <div> <span class="journal-title">FRONTIERS IN ONCOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2234-943X">2234-943X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2234-943X">2234-943X</a>)</span>: <span class="journal-volume">15</span> <span class="page"> Paper 1465511. 12 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3389/fonc.2025.1465511" target="_blank" href="https://doi.org/10.3389/fonc.2025.1465511"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001465396000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001465396000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105002612457" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105002612457"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40231260" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40231260&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/105002612457?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/105002612457?origin=resultslist"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 10</span> | Független: 9 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt:&nbsp;10 | WoS/Scopus jelölt:&nbsp;10 | DOI jelölt:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36100250&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36100250</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (National Tumor Biology Laboratory (2022–2.1.1-NL-2022-00010))), Hungarian Thematic Excellence Program((TKP2021-EGA-44)), HUN-REN Hungarian Research Network(1500207) </div> <div class="lastModified">Utolsó módosítás: 2026.03.02. 14:11 Csernyik Rita (MTMT központi admin) </div> <div class="lockedBy">Központi kezelésű 2026.03.02. 08:07 Csernyik Rita (MTMT központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div>