https://m2.mtmt.hu/ eng 2026-10-25 07:51 JournalArticle 36092394 VALIDATED true Funding Agency and Grant Number: Semmelweis University Funding text: We extend our heartfelt appreciation to the team at the Division of Comparative Medicine, University of Oklahoma Health Sciences Center, including Dr. Shawn Lane, DVM, and Dr. Wendy Williams, DVM, for their exceptional support in animal care and for sharing their profound expertise with us. The 4.0 version of ChatGPT, developed by OpenAI, was used as a language tool to refine our writing, enhancing the clarity of our work. 0 false 2026-10-22T08:51:00.486+0000 2026-05-12T08:06:17.461+0000 2025-04-15T08:36:51.105+0000 true 10093553 Fi Tamás /api/admin/10093553 Admin true 2026-08-27T12:26:34.374+0000 2025-09-12T07:32:24.177+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-06-09T18:52:52.367+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Kallai, Attila Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging implications for vascular contributions to cognitive impairment and dementia (VCID). true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 47 3 2739 2775 2739 37 2025 Vascular contributions to cognitive impairment and dementia (VCID) represent a major public health challenge in the aging population, with age-related cerebromicrovascular dysfunction playing a critical role in its development. Understanding the mechanisms underlying cerebromicrovascular aging is crucial for devising strategies to mitigate this burden. Among the key hallmarks of aging, genomic instability and genetic heterogeneity have emerged as significant drivers of age-related diseases. Clonal hematopoiesis of indeterminate potential (CHIP) is a prominent manifestation of this instability, characterized by the non-malignant expansion of hematopoietic stem cell clones that harbor somatic mutations. CHIP is well-established as a contributor to atherosclerosis and cardiovascular disease through its promotion of chronic inflammation. Given that aging is also a major risk factor for cerebral small vessel disease (CSVD) and VCID, it is likely that the same aging processes driving large artery atherosclerosis in CHIP carriers also impair small vessels, including the cerebral microvasculature. While the role of CHIP in large vessel disease is well-documented, its specific contributions to cerebrovascular aging and microvascular dysfunction remain poorly understood. This review explores the potential role of CHIP in age-related cerebrovascular pathologies, with a particular focus on its contribution to CSVD. We discuss how CHIP-related mutations can promote inflammation and oxidative stress, potentially leading to endothelial dysfunction, dysregulation of cerebral blood flow (CBF), blood-brain barrier (BBB) disruption, microvascular inflammation, and cerebral microhemorrhages. Given the potential implications for VCID, elucidating these mechanisms is critical for developing targeted therapies aimed at reducing the burden of cognitive decline in aging populations. This review aims to highlight the current knowledge gaps and encourage further research into the intersection of CHIP, CSVD, and cognitive aging. 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<img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10096992"><a href="/gui2/?type=authors&mode=browse&sel=10096992" target="_blank">Kallai Attila (<span class="authorship-author-name">Kállai Attila</span> <span class="authorAux-mtmt"> Népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090858"><a href="/gui2/?type=authors&mode=browse&sel=10090858" target="_blank">Ungvari Anna ✉ (<span class="authorship-author-name">Ungvári Anna Sára</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059951"><a href="/gui2/?type=authors&mode=browse&sel=10059951" target="_blank">Csaban Dora (<span class="authorship-author-name">Csabán Dóra</span> <span class="authorAux-mtmt"> biomérnök</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065948"><a href="/gui2/?type=authors&mode=browse&sel=10065948" target="_blank">Orfi Zoltan (<span class="authorship-author-name">Őrfi Zoltán</span> <span class="authorAux-mtmt"> gyógyszerész, molekuláris biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089009"><a href="/gui2/?type=authors&mode=browse&sel=10089009" target="_blank">Lehoczki Andrea (<span class="authorship-author-name">Lehoczki Andrea Marianna</span> <span class="authorAux-mtmt"> hematológia, belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Harasztdombi Jozsef </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10095385"><a href="/gui2/?type=authors&mode=browse&sel=10095385" target="_blank">Yabluchanskiy Andriy (<span class="authorship-author-name">Yabluchanskiy Andriy</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009921"><a href="/gui2/?type=authors&mode=browse&sel=10009921" target="_blank">Benyó Zoltán (<span class="authorship-author-name">Benyó Zoltán</span> <span class="authorAux-mtmt"> Élettan és kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Institute of Clinical Pathophysiology">ICP</span>/HUN-REN-SE Cerebrovascular and Neurocognitive Diseases Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048535"><a href="/gui2/?type=authors&mode=browse&sel=10048535" target="_blank">Szappanos Ágnes (<span class="authorship-author-name">Szappanos Ágnes</span> <span class="authorAux-mtmt"> reumatológia és immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Cardiovascular Center; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Internal Medicine and Oncology">DIMO</span>/Department of Rheumatology and Clinical Immunology; <span title="Semmelweis University">SU</span>/<span title="Clinical Center of the Semmelweis University">CCSU</span>/Clinic for Rheumatology and Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini Stefano (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sorond Farzaneh </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011801"><a href="/gui2/?type=authors&mode=browse&sel=10011801" target="_blank">Sótonyi Péter (<span class="authorship-author-name">Sótonyi Péter</span> <span class="authorAux-mtmt"> Érsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Érsebészeti és Endovaszkuláris Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10036963"><a href="/gui2/?type=authors&mode=browse&sel=10036963" target="_blank">Andrikovics Hajnalka (<span class="authorship-author-name">Andrikovics Hajnalka</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36092394" target="_blank">Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging : implications for vascular contributions to cognitive impairment and dementia (VCID)..</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">47</span> <span class="journal-issue">3</span> <span class="page"> pp 2739-2775 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s11357-025-01654-1" target="_blank" href="https://doi.org/10.1007/s11357-025-01654-1"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001464370800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001464370800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105002347369" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105002347369"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40214958" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40214958&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Aging&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 11</span> | Independent citation: 6 | Self citation: 5 | Unknown citation: 0 | Number of citations in WoS: 10 | Number of citations in Scopus:&nbsp;11 | WoS/Scopus assigned:&nbsp;11 | Number of citations with DOI:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36092394&sort=publishedYear,desc&sort=title"> Number of cited publications: 30 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36092394</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (National Institute on Aging (RF1AG072295)), (National Institute of Neurological Disorders and Stroke (R01NS100782)), (R01 CA255840) Funder: NCI, (TKP2021-NKTA-47), Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Funder: NRDIO, (TKCS-2021/32), (EKÖP-2024–2) Funder: New National Excellence Program, (EKÖP-2024-9) </div> <div class="lastModified">Last Modified: 2026.05.12. 10:06 Edit Csajbók (SE_KK_Admin5_CSE, admin) </div> <div class="lockedBy">Centrally managed 2026.06.09. 20:52 Katalin Lévayné Deseő (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: Semmelweis University Funding text: We extend our heartfelt appreciation to the team at the Division of Comparative Medicine, University of Oklahoma Health Sciences Center, including Dr. Shawn Lane, DVM, and Dr. Wendy Williams, DVM, for their exceptional support in animal care and for sharing their profound expertise with us. The 4.0 version of ChatG...</pre> </div></div>