https://m2.mtmt.hu/ hun 2026-09-23 00:43 JournalArticle 36089439 VALIDATED true Adam Nyul-Toth, Santny Shanmugarama, Roland Patai, and Rafal Gulej contributed equally to the manuscript. 0 false 2026-08-27T12:17:54.449+0000 2026-01-20T21:10:25.073+0000 2025-04-14T06:38:12.198+0000 true 10093553 Fi Tamás /api/admin/10093553 Admin true 2026-08-27T12:16:34.762+0000 2025-06-25T13:15:48.193+0000 true 10074913 Sághi-Keszthelyi Anna /api/admin/10074913 Admin true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-06-09T18:52:50.191+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Nyul-Toth, A. Endothelial IGF- 1R deficiency disrupts microvascular homeostasis, impairing skeletal muscle perfusion and endurance: implications for age-related sarcopenia true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 47 3 4187 4204 4187 18 2025 Aging is associated with a progressive decline in circulating insulin-like growth factor- 1 (IGF- 1) levels in humans, which has been implicated in the pathogenesis of sarcopenia. IGF- 1 is an anabolic hormone that plays a dual role in maintaining skeletal muscle health, acting both directly on muscle fibers to promote growth and indirectly by supporting the vascular network that sustains muscle perfusion. However, the microvascular consequences of IGF- 1 deficiency in aging muscle remain poorly understood. To elucidate how impaired IGF- 1 input affects skeletal muscle vasculature, we examined the effects of endothelial-specific IGF- 1 receptor (IGF- 1R) deficiency using a mouse model of endothelial IGF- 1R knockdown (VE-Cadherin-CreERT2/Igf1rf/f mice). These mice exhibited significantly reduced skeletal muscle endurance and attenuated hyperemic response to acetylcholine, an endothelium-dependent vasodilator. Additionally, they displayed microvascular rarefaction and impaired nitric oxide-dependent vasorelaxation, indicating a significant decline in microvascular health in skeletal muscle. These findings suggest that endothelial IGF- 1R signaling is critical for maintaining microvascular integrity, muscle perfusion, and function. Impaired IGF- 1 input to the microvascular endothelium may contribute to reduced muscle blood flow and exacerbate age-related sarcopenia. Enhancing vascular health by modulating IGF- 1 signaling could represent a potential therapeutic strategy to counteract age-related muscle decline. © The Author(s) 2025. Funding 2051921 /api/funding/2051921 false true Funding 2051922 /api/funding/2051922 false true Funding 2051923 /api/funding/2051923 false true Funding 2051924 /api/funding/2051924 false true Funding 2051925 /api/funding/2051925 false true Funding 2051926 /api/funding/2051926 false true true 2025 true true true false true false GOLD 2026-08-27 true https://doi.org/10.1007/s11357-025-01653-2 9 0 9 7 1 9 9 9 9 9 9 7 7 7 2 0 9 7 9 7 0 26 26 Folyóiratcikk Journal Article 24 9 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 3 3 3 3 2026 0 6 4 6 4 D1 false false false false 2025-06-24T13:15:47.643+0000 Doktori Iskola (SE); Gyermekgyógyászati Klinika (SE / AOK / K); HUN-REN-SE Cerebrovaszkuláris és Neurokognitív ... (SE / AOK / I / KKI); Megelőző Orvostani és Népegészségtani Intézet (SE / AOK / I); Transzlációs Medicina Intézet (SE / AOK / I) 11 46 5 20 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 126154014 /api/authorship/126154014 1 0.05 true false false Author 10045003 /api/author/10045003 Nyúl-Tóth Ádám true 10045003 true Nyul-Toth A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154015 /api/authorship/126154015 2 0.05 true false false Shanmugarama S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154016 /api/authorship/126154016 3 0.05 true false false Author 10052983 /api/author/10052983 Patai Roland true 10052983 true Patai R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154017 /api/authorship/126154017 4 0.05 true false false Author 10092932 /api/author/10092932 Gulej Rafal true true Gulej R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154018 /api/authorship/126154018 5 0.05 false false false Faakye J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154019 /api/authorship/126154019 6 0.05 false false false Author 10075082 /api/author/10075082 Nagy Dorina true true Nagy D. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154020 /api/authorship/126154020 7 0.05 false false false Nagykaldi M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154021 /api/authorship/126154021 8 0.05 false false false Author 10071509 /api/author/10071509 Kiss Tamás true true Kiss T. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154022 /api/authorship/126154022 9 0.05 false false false Author 10055259 /api/author/10055259 Csípő Tamás true 10055259 true Csipo T. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154023 /api/authorship/126154023 10 0.05 false false false Milan M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154024 /api/authorship/126154024 11 0.05 false false false Ekambaram S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154025 /api/authorship/126154025 12 0.05 false false false Negri S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154026 /api/authorship/126154026 13 0.05 false false false Nagaraja R.Y. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154027 /api/authorship/126154027 14 0.05 false false false Author 10071157 /api/author/10071157 Csiszar Anna true true Csiszar A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154028 /api/authorship/126154028 15 0.05 false false false Brown J.L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154029 /api/authorship/126154029 16 0.05 false false false Van Remmen H. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154030 /api/authorship/126154030 17 0.05 false false true Author 10090858 /api/author/10090858 Ungvári Anna Sára true true Ungvari A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154031 /api/authorship/126154031 18 0.05 false false false Author 10095385 /api/author/10095385 Yabluchanskiy Andriy true true Yabluchanskiy A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154032 /api/authorship/126154032 19 0.05 false false false Author 10074557 /api/author/10074557 Tarantini Stefano true true Tarantini S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154033 /api/authorship/126154033 20 0.05 false true false Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true Ungvari Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29233881 /api/publicationidentifier/29233881 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1007/s11357-025-01653-2 https://doi.org/10.1007/s11357-025-01653-2 false true PublicationIdentifier 29277335 /api/publicationidentifier/29277335 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001461728200001 https://www.webofscience.com/wos/woscc/full-record/001461728200001 true true PublicationIdentifier 29233880 /api/publicationidentifier/29233880 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105002184854 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105002184854 false true PublicationIdentifier 29234042 /api/publicationidentifier/29234042 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40199795 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40199795&dopt=Abstract true true PublicationIdentifier 31233889 /api/publicationidentifier/31233889 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://link.springer.com/10.1007/s11357-025-01653-2 https://link.springer.com/10.1007/s11357-025-01653-2 false true Keyword 4654 /api/keyword/4654 true 4654 true Keyword 5393 /api/keyword/5393 true 5393 true Keyword 6341 /api/keyword/6341 true 6341 true Keyword 14195 /api/keyword/14195 true 14195 true Keyword 1038318 /api/keyword/1038318 true 1038318 true Keyword 1244506 /api/keyword/1244506 true 1244506 true Keyword 1510714 /api/keyword/1510714 true true Keyword 3856490 /api/keyword/3856490 true true Keyword 3856491 /api/keyword/3856491 true true Keyword 3856492 /api/keyword/3856492 true true SjrRating 11627782 /api/sjrrating/11627782 2 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3401 /api/classificationexternal/3401 true 3401 true D1 DIRECT true true /api/publication/36089439 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10045003"><a href="/gui2/?type=authors&mode=browse&sel=10045003" target="_blank">Nyul-Toth A. (<span class="authorship-author-name">Nyúl-Tóth Ádám</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shanmugarama S.<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052983"><a href="/gui2/?type=authors&mode=browse&sel=10052983" target="_blank">Patai R.<sup>*</sup> (<span class="authorship-author-name">Patai Roland</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10092932"><a href="/gui2/?type=authors&mode=browse&sel=10092932" target="_blank">Gulej R.<sup>*</sup> (<span class="authorship-author-name">Gulej Rafal</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Faakye J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075082"><a href="/gui2/?type=authors&mode=browse&sel=10075082" target="_blank">Nagy D. (<span class="authorship-author-name">Nagy Dorina</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Klinikai Kórélettani Intézet">KKI</span>/HUN-REN-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nagykaldi M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071509"><a href="/gui2/?type=authors&mode=browse&sel=10071509" target="_blank">Kiss T. (<span class="authorship-author-name">Kiss Tamás</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Klinikai Kórélettani Intézet">KKI</span>/HUN-REN-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055259"><a href="/gui2/?type=authors&mode=browse&sel=10055259" target="_blank">Csipo T. (<span class="authorship-author-name">Csípő Tamás</span> <span class="authorAux-mtmt"> kardiológia, vaszkuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Milan M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ekambaram S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Negri S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nagaraja R.Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar A. (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Brown J.L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Van Remmen H. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090858"><a href="/gui2/?type=authors&mode=browse&sel=10090858" target="_blank">Ungvari A. ✉ (<span class="authorship-author-name">Ungvári Anna Sára</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10095385"><a href="/gui2/?type=authors&mode=browse&sel=10095385" target="_blank">Yabluchanskiy A. (<span class="authorship-author-name">Yabluchanskiy Andriy</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini S. (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Z. (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36089439" target="_blank">Endothelial IGF- 1R deficiency disrupts microvascular homeostasis, impairing skeletal muscle perfusion and endurance: implications for age-related sarcopenia</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">47</span> <span class="journal-issue">3</span> <span class="page"> pp 4187-4204 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s11357-025-01653-2" target="_blank" href="https://doi.org/10.1007/s11357-025-01653-2"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001461728200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001461728200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105002184854" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105002184854"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40199795" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40199795&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://link.springer.com/10.1007/s11357-025-01653-2" target="_blank" href="https://link.springer.com/10.1007/s11357-025-01653-2"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 9</span> | Független: 7 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 9 | Scopus jelölt:&nbsp;9 | WoS/Scopus jelölt:&nbsp;9 | DOI jelölt:&nbsp;9 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36089439&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 26 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36089439</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (National Institute on Aging (RF1AG072295)), (National Institute of Neurological Disorders and Stroke (R01NS100782)), (R01 CA255840) Támogató: OOI, (TKP2021-NKTA-47), Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Támogató: NKFIH, (EKÖP-2024–2) Támogató: New National Excellence Program </div> <div class="lastModified">Utolsó módosítás: 2026.01.20. 22:10 Fi Tamás (SE_AOK_Nepegeszsegtan_Admin5_FT, admin) </div> <div class="lockedBy">Központi kezelésű 2026.06.09. 20:52 Lévayné Deseő Katalin (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Adam Nyul-Toth, Santny Shanmugarama, Roland Patai, and Rafal Gulej contributed equally to the manuscript.</pre> </div></div>