https://m2.mtmt.hu/ hun 2026-09-21 17:50 JournalArticle 36089437 VALIDATED true Boglarka Csik, Ádám Nyúl-Tóth, and Rafal Gulej contributed equally. 0 false 2026-09-10T07:51:50.851+0000 2026-04-16T13:09:09.872+0000 2025-04-14T06:37:38.357+0000 true 10093553 Fi Tamás /api/admin/10093553 Admin true 2026-07-31T10:01:12.465+0000 2025-09-18T07:18:23.026+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-06-09T18:52:49.068+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Csik, B. Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age-Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice true true /api/journal/1035676 REVIEWED true false 1035676 false 1035676 true 1474-9718 1474-9726 Journal FOREIGN 24 7 e70048 e70048 23 2025 With advancing age, neurovascular dysfunction manifests as impaired neurovascular coupling (NVC), microvascular rarefaction, and blood–brain barrier (BBB) disruption, contributing to vascular cognitive impairment (VCI). Our previous research established a causal link between vascular senescence induced cerebromicrovascular dysfunction and cognitive decline in accelerated aging models. The present study examines whether chronological aging promotes endothelial senescence, adversely affecting neurovascular health, and whether senolytic therapies can enhance neurovascular function and cognitive performance in aged mice. We used transgenic p16-3MR mice to identify and eliminate senescent cells and employed genetic (ganciclovir) and pharmacological (ABT263/Navitoclax) senolytic approaches. Evaluations included spatial memory performance, NVC responses, cortical microvascular density, BBB permeability, and detection of senescent endothelial cells via flow cytometry. Brain endothelial cells exhibited heightened sensitivity to aging-induced senescence, undergoing senescence at a greater rate and earlier than other brain cell types, particularly during middle age. This microvascular endothelial cell senescence was associated with NVC dysfunction, microvascular rarefaction, BBB disruption, and deteriorating cognitive performance. On the other hand, senolytic treatments in aged mice improved NVC responses, BBB integrity, microvascular density, and learning capabilities. Notably, these findings suggest that the most effective time window for senolytic treatment is in middle-aged mice, where early intervention could better prevent neurovascular dysfunction and mitigate age-related cognitive impairment. © 2025 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. 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(SE / AOK / I / TMI); Gyermekgyógyászati Klinika (SE / AOK / K); Megelőző Orvostani és Népegészségtani Intézet (SE / AOK / I); Transzlációs Medicina Intézet (SE / AOK / I) 10 45 5 21 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 126153992 /api/authorship/126153992 1 0.048 true false false Author 10099172 /api/author/10099172 Csík Boglárka true true Csik B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126153993 /api/authorship/126153993 2 0.048 true false false Author 10045003 /api/author/10045003 Nyúl-Tóth Ádám true 10045003 true Nyúl-Tóth Á. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126153994 /api/authorship/126153994 3 0.048 true false false Author 10092932 /api/author/10092932 Gulej Rafal true true Gulej R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126153995 /api/authorship/126153995 4 0.048 false false false Author 10052983 /api/author/10052983 Patai Roland true 10052983 true Patai R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126153996 /api/authorship/126153996 5 0.048 false false false Author 10071509 /api/author/10071509 Kiss Tamás true true Kiss T. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126153997 /api/authorship/126153997 6 0.04761905 false false false Delfavero J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126153998 /api/authorship/126153998 7 0.04761905 false false false Nagaraja R.Y. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126153999 /api/authorship/126153999 8 0.04761905 false false false Balasubramanian P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 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/api/authorship/126154010 19 0.04761905 false false false Oh T.G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154011 /api/authorship/126154011 20 0.048 false false false Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true Ungvari Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126154012 /api/authorship/126154012 21 0.048 false true true Author 10071157 /api/author/10071157 Csiszar Anna true true Csiszar A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29233874 /api/publicationidentifier/29233874 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1111/acel.70048 https://doi.org/10.1111/acel.70048 false true PublicationIdentifier 29233875 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journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1302 /api/classificationexternal/1302 true 1302 true D1 DIRECT true true /api/publication/36089437 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10099172"><a href="/gui2/?type=authors&mode=browse&sel=10099172" target="_blank">Csik B. (<span class="authorship-author-name">Csík Boglárka</span> <span class="authorAux-mtmt"> Népegészségtan - öregedés, egészséges öregedés</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045003"><a href="/gui2/?type=authors&mode=browse&sel=10045003" target="_blank">Nyúl-Tóth Á.<sup>*</sup> (<span class="authorship-author-name">Nyúl-Tóth Ádám</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10092932"><a href="/gui2/?type=authors&mode=browse&sel=10092932" target="_blank">Gulej R.<sup>*</sup> (<span class="authorship-author-name">Gulej Rafal</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052983"><a href="/gui2/?type=authors&mode=browse&sel=10052983" target="_blank">Patai R. (<span class="authorship-author-name">Patai Roland</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071509"><a href="/gui2/?type=authors&mode=browse&sel=10071509" target="_blank">Kiss T. (<span class="authorship-author-name">Kiss Tamás</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/ELKH-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Delfavero J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nagaraja R.Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Balasubramanian P. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shanmugarama S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090858"><a href="/gui2/?type=authors&mode=browse&sel=10090858" target="_blank">Ungvari A. (<span class="authorship-author-name">Ungvári Anna Sára</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chandragiri S.S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kordestan K.V. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nagykaldi M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032249"><a href="/gui2/?type=authors&mode=browse&sel=10032249" target="_blank">Mukli P. (<span class="authorship-author-name">Mukli Péter</span> <span class="authorAux-mtmt"> Élettan, megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yabluchanskiy A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Negri S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini S. (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Conley S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Oh T.G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Z. (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar A. ✉ (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36089437" target="_blank">Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age-Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice</a></div> <div> <span class="journal-title">AGING CELL</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1474-9718">1474-9718</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1474-9726">1474-9726</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">7</span> <span class="page"> Paper e70048. 23 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1111/acel.70048" target="_blank" href="https://doi.org/10.1111/acel.70048"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001457628100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001457628100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105001828425" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105001828425"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40167015" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40167015&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/105001828425?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/105001828425?origin=resultslist"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cell Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 26</span> | Független: 19 | Függő: 7 | Nem jelölt: 0 | WoS jelölt: 25 | Scopus jelölt:&nbsp;26 | WoS/Scopus jelölt:&nbsp;26 | DOI jelölt:&nbsp;26 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36089437&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 22 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36089437</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (National Institute of Neurological Disorders and Stroke (R01NS100782)), (TKP2021-NKTA-47), Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Támogató: NKFIH, (135784) Támogató: NKFIH, (101004093/EUniWell/EAC-A02-2019/EAC-A02-2019-1) </div> <div class="lastModified">Utolsó módosítás: 2026.04.16. 15:09 Fi Tamás (SE_AOK_Nepegeszsegtan_Admin5_FT, admin) </div> <div class="lockedBy">Központi kezelésű 2026.06.09. 20:52 Lévayné Deseő Katalin (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Boglarka Csik, Ádám Nyúl-Tóth, and Rafal Gulej contributed equally.</pre> </div></div>