Hungarian Brain Research Program(NAP2022-I-4/2022)
Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002)
(János Bolyai Research Scholarship)
Szakterületek:
Gyógyszerészet, farmakogenomika, gyógyszerkutatás és tervezés, gyógyszeres kezelés
Migraine has been linked to chronotype, but with mixed results. Here, we tested chronotype
in association with physical and mental health and headache characteristics in a large
database of migraine patients and controls. A sample of the UK Biobank ( n = 360,081;
58.3% female, mean age: 56.38) was used. Data included self‐reported chronotype, mental
(neuroticism, depression, stress) and physical (body fat percentage, overall health
rating) health factors, and migraine diagnosis based on ICD‐10 G43 diagnosis from
healthcare data. Morning type controls ( C morning , n = 210,775), evening type controls
( C evening , n = 129,174), morning type migraine patients ( M morning , n = 12,194),
and evening type migraine patients ( M evening , n = 7938) were compared. Additionally,
in a subsample of questionnaire‐based migraine ( n = 15,356), chronotype was tested
in association with headache‐related features. One‐way ANOVA, Kruskal–Wallis test
and chi‐squared test were run in SPSS 28 with Bonferroni correction. Evening chronotype
was more frequent among migraine patients with an OR = 1.06, 95% CI [1.03; 1.09] compared
to controls ( χ 2 = 16.523, p < 0.001). The M evening group showed the worst level
of all mental and physical health variables, while the C morning group reported the
best values. Migraine patients with morning or evening chronotype showed a highly
similar headache symptom profile, but the M evening subgroup expressed a higher disability
( t = −3.965, p < 0.001). In conclusion, evening chronotype was associated with
the worst physical and mental health status and the highest headache‐related disability
among migraine patients, suggesting a need for elevated medical attention on chronotype
in migraine.
