https://m2.mtmt.hu/ hun 2026-09-23 00:39 JournalArticle 36084206 VALIDATED true * Megosztott szerzőség 0 false 2026-09-18T08:18:55.359+0000 2026-04-16T12:06:48.659+0000 2025-04-09T19:04:47.935+0000 true 10093553 Fi Tamás /api/admin/10093553 Admin true 2026-08-26T08:33:44.340+0000 2025-09-18T08:41:15.185+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2026-05-28T10:32:29.635+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Ungvari, Zoltan Treatment delay significantly increases mortality in colorectal cancer : a meta-analysis true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 47 3 5337 5353 5337 17 2025 Delaying the initiation of cancer treatment increases the risk of mortality, particularly in colorectal cancer (CRC), which is among the most common and deadliest malignancies. This study aims to explore the impact of treatment delays on mortality in CRC. A systematic literature search was conducted in PubMed, Web of Science, and Scopus for studies published between 2000 and 2025. Meta-analyses were performed using random-effects models with inverse variance method to calculate hazard ratios (HRs) for both overall and cancer-specific survival at 4-, 8-, and 12-week treatment delay intervals, with heterogeneity assessed through I2-statistics and publication bias evaluated using funnel plots and Egger's test. A total of 20 relevant studies were included in the meta-analysis. The analyses of all patients demonstrated a progressively increasing risk of 12-39% with longer treatment delays (4 weeks, HR = 1.12; 95% CI, 1.08-1.16; 8 weeks, HR = 1.24; 95% CI, 1.16-1.34; 12 weeks, HR = 1.39; 95% CI, 1.25-1.55). In particular, incrementally higher hazard ratios were observed for all-cause mortality at 4 weeks (HR = 1.14; 95% CI, 1.09-1.18), 8 weeks (HR = 1.29; 95% CI, 1.20-1.39), and 12 weeks (HR = 1.47; 95% CI, 1.31-1.64). In contrast, cancer-specific survival analysis showed a similar trend but did not reach statistical significance (4 weeks, HR = 1.07; 95% CI, 0.98-1.18; 8 weeks, HR = 1.15; 95% CI, 0.95-1.39; 12 weeks, HR = 1.23; 95% CI, 0.93-1.63). Treatment delays in colorectal cancer patients were associated with progressively worsening overall survival, with each 4-week delay increment leading to a substantially higher mortality risk. This study suggests that timely treatment initiation should be prioritized in clinical practice, as these efforts can lead to substantial improvements in survival rates. Funding 2051785 /api/funding/2051785 false true Funding 2051786 /api/funding/2051786 false true Funding 2051787 /api/funding/2051787 false true Funding 2051788 /api/funding/2051788 false true Funding 2051789 /api/funding/2051789 false true Funding 2051790 /api/funding/2051790 false true Funding 2051791 /api/funding/2051791 false true Funding 2051792 /api/funding/2051792 false true Funding 2051793 /api/funding/2051793 false true Funding 2051794 /api/funding/2051794 false true Funding 2051795 /api/funding/2051795 false true true 2025 true true true false true false GOLD 2026-09-18 true https://doi.org/10.1007/s11357-025-01648-z 33 0 32 26 5 32 27 19 19 21 21 21 21 27 6 0 33 27 32 26 0 4 4 Folyóiratcikk Journal Article 24 26 Könyvrészlet Chapter in Book 25 6 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 7 3 7 3 2026 0 26 24 26 24 D1 false false false false 2025-04-09T06:44:31.626+0000 Biofizikai Intézet (PTE / ÁOK); Bioinformatika Tanszék (SE / AOK / I); Doktori Iskola (SE); Megelőző Orvostani és Népegészségtani Intézet (SE / AOK / I); Onkológiai Biomarker Kutatócsoport (Lendület) (HRN TTK / MÉI) 8 48 5 9 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 126124311 /api/authorship/126124311 1 0.111 true false false Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true Ungvari Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126124312 /api/authorship/126124312 2 0.111 true false false Author 10058020 /api/author/10058020 Fekete Mónika true 10058020 true Fekete Mónika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126124313 /api/authorship/126124313 3 0.111 true false false Author 10063867 /api/author/10063867 Fekete János Tibor true 10063867 true Fekete János Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126124314 /api/authorship/126124314 4 0.111 true false false Author 10089009 /api/author/10089009 Lehoczki Andrea Marianna true true Lehoczki Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126124315 /api/authorship/126124315 5 0.11111111 false false false Buda Annamaria true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126124316 /api/authorship/126124316 6 0.111 false false false Author 10024232 /api/author/10024232 Munkácsy Gyöngyi true 10024232 true Munkácsy Gyöngyi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126124317 /api/authorship/126124317 7 0.111 false false false Author 10081446 /api/author/10081446 Varga Péter true true Varga Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126124318 /api/authorship/126124318 8 0.111 false false true Author 10090858 /api/author/10090858 Ungvári Anna Sára true true Ungvari Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126124319 /api/authorship/126124319 9 0.111 false true false Author 10000109 /api/author/10000109 Győrffy Balázs true 10000109 true Győrffy Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29221731 /api/publicationidentifier/29221731 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1007/s11357-025-01648-z https://doi.org/10.1007/s11357-025-01648-z false true PublicationIdentifier 29241893 /api/publicationidentifier/29241893 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001461696400001 https://www.webofscience.com/wos/woscc/full-record/001461696400001 false true PublicationIdentifier 29241912 /api/publicationidentifier/29241912 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105002176007 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https://www.scopus.com/inward/record.uri?eid=2-s2.0-105002176007&doi=10.1007%2Fs11357-025-01648-z&partnerID=40&md5=28c1504ca2608845460fab587062fd06 false true PublicationIdentifier 31846350 /api/publicationidentifier/31846350 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true NONE IDENTICAL https://www.scopus.com/pages/publications/105002176007?origin=resultslist https://www.scopus.com/pages/publications/105002176007?origin=resultslist false true Keyword 3375201 /api/keyword/3375201 true true SjrRating 11627782 /api/sjrrating/11627782 2 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3401 /api/classificationexternal/3401 true 3401 true D1 DIRECT true true /api/publication/36084206 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058020"><a href="/gui2/?type=authors&mode=browse&sel=10058020" target="_blank">Fekete Mónika<sup>*</sup> (<span class="authorship-author-name">Fekete Mónika</span> <span class="authorAux-mtmt"> Népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063867"><a href="/gui2/?type=authors&mode=browse&sel=10063867" target="_blank">Fekete János Tibor<sup>*</sup> (<span class="authorship-author-name">Fekete János Tibor</span> <span class="authorAux-mtmt"> Prediktív biomarkerek</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Onkológiai Biomarker Kutatócsoport (Lendület)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089009"><a href="/gui2/?type=authors&mode=browse&sel=10089009" target="_blank">Lehoczki Andrea<sup>*</sup> (<span class="authorship-author-name">Lehoczki Andrea Marianna</span> <span class="authorAux-mtmt"> hematológia, belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Buda Annamaria </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024232"><a href="/gui2/?type=authors&mode=browse&sel=10024232" target="_blank">Munkácsy Gyöngyi (<span class="authorship-author-name">Munkácsy Gyöngyi</span> <span class="authorAux-mtmt"> onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Onkológiai Biomarker Kutatócsoport (Lendület)</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081446"><a href="/gui2/?type=authors&mode=browse&sel=10081446" target="_blank">Varga Péter (<span class="authorship-author-name">Varga Péter</span> <span class="authorAux-mtmt"> foglalkozás-orvostan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090858"><a href="/gui2/?type=authors&mode=browse&sel=10090858" target="_blank">Ungvari Anna ✉ (<span class="authorship-author-name">Ungvári Anna Sára</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000109"><a href="/gui2/?type=authors&mode=browse&sel=10000109" target="_blank">Győrffy Balázs (<span class="authorship-author-name">Győrffy Balázs</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Bioinformatika Tanszék; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Biofizikai Intézet; <span title="HUN-REN Természettudományi Kutatóközpont">HRN TTK</span>/<span title="Molekuláris Élettudományi Intézet">MÉI</span>/Onkológiai Biomarker Kutatócsoport (Lendület)</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36084206" target="_blank">Treatment delay significantly increases mortality in colorectal cancer : a meta-analysis</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">47</span> <span class="journal-issue">3</span> <span class="page"> pp 5337-5353 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s11357-025-01648-z" target="_blank" href="https://doi.org/10.1007/s11357-025-01648-z"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001461696400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001461696400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105002176007" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105002176007"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40198462" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40198462&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105002176007&doi=10.1007%2Fs11357-025-01648-z&partnerID=40&md5=28c1504ca2608845460fab587062fd06" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105002176007&doi=10.1007%2Fs11357-025-01648-z&partnerID=40&md5=28c1504ca2608845460fab587062fd06"> Egyéb URL </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/105002176007?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/105002176007?origin=resultslist"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 33</span> | Független: 27 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 19 | Scopus jelölt:&nbsp;19 | WoS/Scopus jelölt:&nbsp;21 | DOI jelölt:&nbsp;27 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36084206&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36084206</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (National Institute on Aging (RF1AG072295)), (National Institute of Neurological Disorders and Stroke (R01NS100782)), (R01 CA255840) Támogató: OOI, (TKP2021-NKTA-47), (TKCS-2021/32), Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Támogató: NKFIH, Nemzeti Gyógyszerkutatási és Fejlesztési Laboratórium (PharmaLab)(RRF-2.3.1-21-2022-00015) Támogató: NKFIH, (135784) Támogató: NKFIH, (101004093/EUniWell/EAC-A02- 2019/EAC-A02-2019-1), (EKÖP-2024–2) Támogató: New National Excellence Program, (EKÖP-2024-9) </div> <div class="lastModified">Utolsó módosítás: 2026.04.16. 14:06 Fi Tamás (SE_AOK_Nepegeszsegtan_Admin5_FT, admin) </div> <div class="lockedBy">Központi kezelésű 2026.05.28. 12:32 Lévayné Deseő Katalin (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: * Megosztott szerzőség</pre> </div></div>