https://m2.mtmt.hu/ hun 2026-05-01 16:01 JournalArticle 36082734 VALIDATED true 0 false 2026-02-11T13:47:52.517+0000 2025-12-26T21:09:54.101+0000 2025-04-09T13:23:06.726+0000 true 10036276 Pongor Ildikó /api/admin/10036276 Admin true 10036276 2026-01-01T17:23:51.339+0000 2025-12-26T21:09:54.018+0000 true 521 Szuper Admin /api/admin/521 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Ráduly, Arnold Péter Sacubitril/Valsartan Improves Hemodynamic Parameters of Pulmonary and Systemic Circulation in Patients Awaiting Heart Transplantation true true /api/journal/10017543 REVIEWED true false 10017543 false 10017543 true 2077-0383 Journal FOREIGN 14 8 2539 2539 2025 Background/Objectives: Heart transplantation (HTX) is the definitive treatment for advanced heart failure (AdHF). The angiotensin receptor neprilysin inhibitor (ARNI) sacubitril/valsartan (S/V) has been shown to reduce heart failure (HF) hospitalizations and mortality when compared to conventionally administered HF medications (i.e. angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs)). Nevertheless, limited data are available on the hemodynamic (HD) effects of ARNI in patients with AdHF. Therefore, the aim of the present study was to compare echocardiographic, laboratory, and HD parameters relevant to HF before and after switching to ARNI in patients with AdHF awaiting HTX. Methods: A retrospective analysis was conducted utilizing available data on HD parameters, N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, data on kidney function, HF therapy, and comorbidities. The study cohort comprised 13 AdHF patients (3 women, 10 men; mean age 56.4 ± 9 years) of whom 53.8% presented with non-ischemic and 46.2% with ischemic etiology. All patients were awaiting heart transplantation (HTX) and were transitioned to ARNI therapy between 2018 and 2021. Results: After switching to ARNI, we observed significant improvements: in left ventricular ejection fraction (LVEF: 27.27 ± 1.04% vs. 23.65 ± 1.02%, p = 0.03; data are given as mean ± SEM after vs. before ARNI therapy, respectively), cardiac output (CO: 4.90 ± 0.35 L/min vs. 3.83 ± 0.24 L/min, p = 0.013), and stroke volume (SV: 70.9 ± 5.9 mL vs. 55.5 ± 4.12 mL, p = 0.013). Significant reductions in systemic vascular resistance (SVR: 1188 ± 79.8 vs. 1600 ± 100 DS/cm5, p = 0.004) and pulmonary vascular resistance (PVR: 232.5 ± 34.8 vs. 278.9 ± 31.7 DS/cm5, p = 0.04) were also noted. Central venous pressure (CVP), pulmonary arterial systolic and diastolic pressures (PAPs and PAPd), pulmonary capillary wedge pressure (PCWP), and NT-proBNP levels did not exhibit significant changes upon ARNI administration. Conclusions: Early transition to ARNI therapy offers significant benefits for invasively measured hemodynamic parameters in patients with AdHF, potentially aiding in the stabilization and improvement of this vulnerable patient population. true 2025 true true true false false GOLD 2026-02-11 false http://www.mdpi.com/journal/jcm 1 0 1 0 1 1 1 1 1 1 1 0 0 0 1 0 1 0 1 0 0 2 2 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 0 1 0 Q2 false false false false 2025-07-08T13:33:56.280+0000 Gottsegen György Országos Kardiovaszkuláris Int...; Kardiológiai Intézet (DE / ÁOK); Kardiológiai Tanszék (DE / ÁOK / KardI); Klinikai Fiziológiai Tanszék (DE / ÁOK / KardI) 8 28 4 14 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 126119716 /api/authorship/126119716 1 0.071 true false true Ráduly Arnold Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126119717 /api/authorship/126119717 2 0.071 true false false Saman Kothalawala Edward true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126119718 /api/authorship/126119718 3 0.071 false false false Author 10037252 /api/author/10037252 Balogh László true 10037252 true Balogh László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 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/api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126119724 /api/authorship/126119724 9 0.071 false false false Author 10057051 /api/author/10057051 Bódi Beáta true 10057051 true Bódi Beáta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126119725 /api/authorship/126119725 10 0.071428575 false false false Kovács Máté Balázs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126119726 /api/authorship/126119726 11 0.071 false false false Author 10029271 /api/author/10029271 Csanádi Zoltán true 10029271 true Csanádi Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126119727 /api/authorship/126119727 12 0.071 false false false Author 10000066 /api/author/10000066 Papp Zoltán true 10000066 true Papp Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126119728 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true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q1 FROM_LAST_YEAR true true Reference 65286965 /api/reference/65286965 1 10.1093/cvr/cvac013 false true Reference 65286966 /api/reference/65286966 2 10.1093/ejcts/ezy421 false true Reference 65286967 /api/reference/65286967 3 10.1093/eurheartj/ehaa1012 false true Reference 65286968 /api/reference/65286968 4 10.1093/eurheartj/ehab368 false true Reference 65286969 /api/reference/65286969 5 10.1056/NEJMoa1409077 false true Reference 65286970 /api/reference/65286970 6 10.2217/fca-2019-0089 false true Reference 65286971 /api/reference/65286971 7 10.1016/j.ihj.2022.04.003 false true Reference 65286972 /api/reference/65286972 8 10.1161/CIRCHEARTFAILURE.116.003430 false true Reference 65286973 /api/reference/65286973 9 false true Reference 65286974 /api/reference/65286974 10 10.15420/cfr.2018.43.1 false true Reference 65286975 /api/reference/65286975 11 10.1002/ejhf.1236 false true Reference 65286976 /api/reference/65286976 12 10.1002/ejhf.2874 false true Reference 65286977 /api/reference/65286977 13 10.1016/j.cardfail.2020.12.013 false true Reference 65286978 /api/reference/65286978 14 10.1038/s41569-024-01046-6 false true Reference 65286979 /api/reference/65286979 15 10.1016/j.cardfail.2024.07.001 false true Reference 65286980 /api/reference/65286980 16 10.1007/s10741-020-09987-z false true Reference 65286981 /api/reference/65286981 17 10.1056/NEJMoa1812851 false true Reference 65286982 /api/reference/65286982 18 10.1001/jama.294.13.1664 false true Reference 65286983 /api/reference/65286983 19 10.1001/jama.294.13.1625 false true Reference 65286984 /api/reference/65286984 20 10.1016/j.jacc.2020.01.034 false true Reference 65286985 /api/reference/65286985 21 10.1002/ehf2.13285 false true Reference 65286986 /api/reference/65286986 22 10.1007/s11897-021-00501-6 false true Reference 65286987 /api/reference/65286987 23 10.1161/JAHA.119.012272 false true Reference 65286988 /api/reference/65286988 24 10.1161/CIRCHEARTFAILURE.119.006696 false true Reference 65286989 /api/reference/65286989 25 10.1093/cvr/cvaa200 false true Reference 65286990 /api/reference/65286990 26 10.1590/S1679-45082015RW3154 false true Reference 65286991 /api/reference/65286991 27 10.1016/j.cardfail.2023.06.021 false true Reference 65286992 /api/reference/65286992 28 10.1161/CIR.0000000000001016 false true Reference 65286993 /api/reference/65286993 29 10.1161/CIRCHEARTFAILURE.123.011003 false true /api/publication/36082734 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Ráduly Arnold Péter ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Saman Kothalawala Edward<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037252"><a href="/gui2/?type=authors&mode=browse&sel=10037252" target="_blank">Balogh László (<span class="authorship-author-name">Balogh László</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Kardiológiai Intézet">KardI</span>/Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Majoros Zsuzsanna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pólik Zsófia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fülöp László </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037011"><a href="/gui2/?type=authors&mode=browse&sel=10037011" target="_blank">Győry Ferenc (<span class="authorship-author-name">Győry Ferenc</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Kardiológiai Intézet">KardI</span>/Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059355"><a href="/gui2/?type=authors&mode=browse&sel=10059355" target="_blank">Nagy László (<span class="authorship-author-name">Nagy László</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057051"><a href="/gui2/?type=authors&mode=browse&sel=10057051" target="_blank">Bódi Beáta (<span class="authorship-author-name">Bódi Beáta</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Kardiológiai Intézet">KardI</span>/Klinikai Fiziológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kovács Máté Balázs </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029271"><a href="/gui2/?type=authors&mode=browse&sel=10029271" target="_blank">Csanádi Zoltán (<span class="authorship-author-name">Csanádi Zoltán</span> <span class="authorAux-mtmt"> Kardiológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Kardiológiai Intézet">KardI</span>/Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000066"><a href="/gui2/?type=authors&mode=browse&sel=10000066" target="_blank">Papp Zoltán (<span class="authorship-author-name">Papp Zoltán</span> <span class="authorAux-mtmt"> Szív élettan</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Kardiológiai Intézet">KardI</span>/Klinikai Fiziológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078593"><a href="/gui2/?type=authors&mode=browse&sel=10078593" target="_blank">Muk Balázs (<span class="authorship-author-name">Muk Balázs</span> <span class="authorAux-mtmt"> kardiológia, szívelégtelenség</span>) </a> </span> <span class="author-affil">Gottsegen György Országos Kardiovaszkuláris Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000190"><a href="/gui2/?type=authors&mode=browse&sel=10000190" target="_blank">Borbély Attila ✉ (<span class="authorship-author-name">Borbély Attila</span> <span class="authorAux-mtmt"> Experimentális és klinikai kardiológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Kardiológiai Intézet; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Kardiológiai Intézet">KardI</span>/Kardiológiai Tanszék; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Kardiológiai Intézet">KardI</span>/Klinikai Fiziológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36082734" target="_blank">Sacubitril/Valsartan Improves Hemodynamic Parameters of Pulmonary and Systemic Circulation in Patients Awaiting Heart Transplantation</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL MEDICINE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0383">2077-0383</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">8</span> <span class="page"> Paper 2539. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/jcm14082539" target="_blank" href="https://doi.org/10.3390/jcm14082539"> DOI 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class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 0 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36082734&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36082734</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.12.26. 22:09 Szuper Admin (admin) </div> </div></div>