https://m2.mtmt.hu/ hun 2026-09-21 08:43 JournalArticle 36077164 ADMIN_APPROVED true 0 false 2026-08-27T09:43:55.451+0000 2025-04-07T08:56:29.227+0000 2025-04-07T08:21:51.560+0000 true 10095366 Havas Petra Gabriella /api/admin/10095366 Admin true 2025-04-14T11:50:24.896+0000 2025-04-14T11:50:24.896+0000 2025-04-07T08:56:29.234+0000 true 10095366 Havas Petra Gabriella /api/admin/10095366 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Steinhoff, Bernhard J Effectiveness During 12-Month Adjunctive Brivaracetam Treatment in Patients with Focal-Onset Seizures in a Real-Life Setting A Prospective, Observational Study in Europe. true true /api/journal/10032890 REVIEWED true false 10032890 false 10032890 true 2193-8253 2193-6536 Journal FOREIGN 14 2 627 642 627 16 2025 Efficacy/tolerability of adjunctive brivaracetam (BRV) for focal-onset seizures (FOS) in patients aged ≥ 16 years was established in randomized controlled trials. This study aimed to evaluate the effectiveness of adjunctive BRV in patients (≥ 16 years) with FOS with/without focal to bilateral tonic-clonic seizures in daily clinical practice.A 12-month, prospective, real-world, noninterventional study in nine European countries (EP0077/NCT02687711). BRV was prescribed per clinical practice and European Summary of Product Characteristics. Eligible patients had never received BRV before inclusion. Treating physicians made the decision to prescribe BRV, independently of study participation. Primary effectiveness outcome: BRV retention rate at 12 months; secondary effectiveness outcomes: 50% responder rate, seizure freedom.A total of 544 patients received ≥ 1 BRV dose (mean age: 43.6 years; 52.8% female; mean time since diagnosis: 22.7 years). Patients had a mean of 7.3 lifetime antiseizure medications (ASMs) and median of 3.7 FOS/28 days during 3-month retrospective baseline. Median total ASM drug load (including BRV) was 3.0 at BRV initiation (n = 539) and 3.3 at study end (n = 314). At 12 months, 57.7% of 541 patients remained on BRV, 60.4% of 230 were responders (≥ 50% seizure reduction since baseline), and 13.8% of 269 were seizure-free since BRV initiation. Historical levetiracetam use appeared not to impact retention rate (56.6% of 320 and 59.3% of 221 patients with and without historical levetiracetam use, respectively). 36.0% of 544 patients had drug-related treatment-emergent adverse events (TEAEs), mostly (≥ 5% of patients) drug ineffective (11.4%) and seizure (6.3%). The three most common drug-related TEAEs leading to permanent BRV discontinuation (of 544 patients) were drug ineffective (10.1%), seizure (5.1%), and behavior disorder (3.3%).Adjunctive BRV was effective in clinical practice in patients with predominantly difficult-to-treat FOS, as shown by BRV retention rate of 57.7% at 12 months, which is in line with real-world retention rates for other new-generation ASMs. true 2025 true true true false true false GOLD 2026-08-27 true https://doi.org/10.1007/s40120-024-00697-4 6 0 6 4 0 6 6 6 6 6 6 4 4 4 2 0 6 4 6 4 0 0 0 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 4 2 4 2 2026 0 2 2 2 2 Q1 false 10045415 false false false 2025-04-06T08:56:29.040+0000 Országos Klinikai Idegtudományi Intézet 1 18 1 10 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 126079036 /api/authorship/126079036 1 0.1 true false true Steinhoff Bernhard J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126079037 /api/authorship/126079037 2 0.1 false false false Christensen Jakob true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126079038 /api/authorship/126079038 3 0.1 false false false Doherty Colin P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126079039 /api/authorship/126079039 4 0.1 false false false Majoie Marian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126079040 /api/authorship/126079040 5 0.1 false false false Schulz Anne-Liv true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126079041 /api/authorship/126079041 6 0.1 false false false Brock Fiona true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126079042 /api/authorship/126079042 7 0.1 false false false Bourikas Dimitrios true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126079043 /api/authorship/126079043 8 0.1 false false false Leunikava Iryna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126079044 /api/authorship/126079044 9 0.1 false false false Author 10045415 /api/author/10045415 Kelemen Anna true 10045415 true Kelemen Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126079045 /api/authorship/126079045 10 0.1 false true false Rubio-Nazabal Eduardo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29203614 /api/publicationidentifier/29203614 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1007/s40120-024-00697-4 https://doi.org/10.1007/s40120-024-00697-4 false true PublicationIdentifier 29203615 /api/publicationidentifier/29203615 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001426315900001 https://www.webofscience.com/wos/woscc/full-record/001426315900001 false true 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/api/keyword/1036085 true 1036085 true Keyword 1123827 /api/keyword/1123827 true 1123827 true Keyword 1577840 /api/keyword/1577840 true true Keyword 1683197 /api/keyword/1683197 true true Keyword 1864116 /api/keyword/1864116 true true Keyword 3854645 /api/keyword/3854645 true true Keyword 3854646 /api/keyword/3854646 true true SjrRating 11607518 /api/sjrrating/11607518 67 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2728 /api/classificationexternal/2728 true 2728 true Q1 DIRECT true true /api/publication/36077164 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Steinhoff Bernhard J ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Christensen Jakob </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Doherty Colin P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Majoie Marian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schulz Anne-Liv </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Brock Fiona </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bourikas Dimitrios </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Leunikava Iryna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045415"><a href="/gui2/?type=authors&mode=browse&sel=10045415" target="_blank">Kelemen Anna (<span class="authorship-author-name">Kelemen Anna</span> <span class="authorAux-mtmt"> Epileptológia, Gyermekneurológia, Neurológia</span>) </a> </span> <span class="author-affil">Országos Klinikai Idegtudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rubio-Nazabal Eduardo </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36077164" target="_blank">Effectiveness During 12-Month Adjunctive Brivaracetam Treatment in Patients with Focal-Onset Seizures in a Real-Life Setting : A Prospective, Observational Study in Europe..</a></div> <div> <span class="journal-title">NEUROLOGY AND THERAPY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2193-8253">2193-8253</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2193-6536">2193-6536</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">2</span> <span class="page"> pp 627-642 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s40120-024-00697-4" target="_blank" href="https://doi.org/10.1007/s40120-024-00697-4"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001426315900001" target="_blank" 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class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 4 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 6 | Scopus jelölt:&nbsp;6 | WoS/Scopus jelölt:&nbsp;6 | DOI jelölt:&nbsp;6 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36077164</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2025.04.07. 10:56 Havas Petra Gabriella (SE_KK_Idegsebeszet_Admin5_HP, admin) </div> </div></div>