https://m2.mtmt.hu/ eng 2026-10-25 02:49 JournalArticle 36072177 VALIDATED true Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States International Training Program in Geroscience, Doctoral College, Health Sciences Division/Institute of Preventive Medicine and Public Health, Semmelweis University, Budapest, Hungary Institute of Preventive Medicine and Public Health, Semmelweis University, Budapest, Hungary Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States International Training Program in Geroscience, Doctoral College/Institute of Translational Medicine, Semmelweis University, Budapest, Hungary Export Date: 09 April 2025; Cited By: 0; Correspondence Address: A. Ungvari; Institute of Preventive Medicine and Public Health, Semmelweis University, Budapest, Hungary; email: Ungann2004@gmail.com 0 false 2026-10-22T07:49:41.835+0000 2026-04-20T06:47:30.955+0000 2025-04-03T07:05:33.623+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-07-31T10:37:30.210+0000 2025-06-25T11:42:49.085+0000 true 10074913 Sághi-Keszthelyi Anna /api/admin/10074913 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Chandragiri, Siva Sai Functional ultrasound imaging reveals microvascular rarefaction, decreased cerebral blood flow, and impaired neurovascular coupling in a mouse model of paclitaxel-induced chemobrain true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 47 3 4813 4825 4813 13 2025 Chemotherapy-induced cognitive impairment (CICI), often referred to as "chemobrain," significantly affects the quality of life in cancer survivors. Although traditionally attributed to neuronal toxicity, emerging evidence suggests a key role of cerebrovascular dysfunction in its pathogenesis. We hypothesized that paclitaxel (PTX, Taxol) treatment induces long-term cerebrovascular dysfunction, including microvascular rarefaction, impaired neurovascular coupling (NVC), and altered cerebral blood flow (CBF), which contribute to CICI. Using a clinically relevant PTX treatment regimen in non-tumor-bearing mice, we evaluated the long-term effects of PTX on cerebrovascular health. Ultrasound localization microscopy (ULM) and functional ultrasound imaging (fUS) were employed to assess microvascular density, CBF, and NVC. PTX treatment resulted in a significant reduction in microvascular density in the cerebral cortex and hippocampus, key regions involved in cognitive function. PTX significantly reduced blood velocity in the middle cerebral artery. Moreover, PTX impaired NVC responses, as evidenced by a diminished CBF increase in response to whisker stimulation, indicative of impaired reactive hyperemia. In conclusion, these findings demonstrate that PTX induces long-lasting cerebrovascular dysfunction, including microvascular rarefaction, impaired NVC, and altered CBF dynamics, which likely contribute to CICI. This study underscores the critical role of cerebrovascular health in cognitive function and highlights the potential of targeting cerebrovascular pathways as a therapeutic approach for mitigating chemotherapy-induced cognitive deficits. 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false false 2025-06-24T11:42:48.394+0000 Doktori Iskola (SE); Megelőző Orvostani és Népegészségtani Intézet (SE / AOK / I); Transzlációs Medicina Intézet (SE / AOK / I) 10 43 3 15 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 126038502 /api/authorship/126038502 1 0.06666667 true false false Chandragiri Siva Sai true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038503 /api/authorship/126038503 2 0.067 true false false Author 10045003 /api/author/10045003 Nyúl-Tóth Ádám true 10045003 true Nyul-Toth Adam true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038504 /api/authorship/126038504 3 0.067 true false false Negri Sharon true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038505 /api/authorship/126038505 4 0.067 true false false Author 10052983 /api/author/10052983 Patai Roland true 10052983 true 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false false false Nagykaldi Mark true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038511 /api/authorship/126038511 10 0.067 false false false Author 10032249 /api/author/10032249 Mukli Péter true 10032249 true Mukli Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038512 /api/authorship/126038512 11 0.067 false false true Author 10090858 /api/author/10090858 Ungvári Anna Sára true true Ungvari Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038513 /api/authorship/126038513 12 0.067 false false false Author 10095385 /api/author/10095385 Yabluchanskiy Andriy true true Yabluchanskiy Andriy true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038514 /api/authorship/126038514 13 0.067 false false false Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true 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src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Chandragiri Siva Sai </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045003"><a href="/gui2/?type=authors&mode=browse&sel=10045003" target="_blank">Nyul-Toth Adam<sup>*</sup> (<span class="authorship-author-name">Nyúl-Tóth Ádám</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Negri Sharon<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052983"><a href="/gui2/?type=authors&mode=browse&sel=10052983" target="_blank">Patai Roland<sup>*</sup> (<span class="authorship-author-name">Patai Roland</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10092932"><a href="/gui2/?type=authors&mode=browse&sel=10092932" target="_blank">Gulej Rafal<sup>*</sup> (<span class="authorship-author-name">Gulej Rafal</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10099172"><a href="/gui2/?type=authors&mode=browse&sel=10099172" target="_blank">Csik Boglarka (<span class="authorship-author-name">Csík Boglárka</span> <span class="authorAux-mtmt"> Népegészségtan - öregedés, egészséges öregedés</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shanmugarama Santny </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kordestan Kiana Vali </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nagykaldi Mark </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032249"><a href="/gui2/?type=authors&mode=browse&sel=10032249" target="_blank">Mukli Peter (<span class="authorship-author-name">Mukli Péter</span> <span class="authorAux-mtmt"> Élettan, megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090858"><a href="/gui2/?type=authors&mode=browse&sel=10090858" target="_blank">Ungvari Anna ✉ (<span class="authorship-author-name">Ungvári Anna Sára</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10095385"><a href="/gui2/?type=authors&mode=browse&sel=10095385" target="_blank">Yabluchanskiy Andriy (<span class="authorship-author-name">Yabluchanskiy Andriy</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini Stefano (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Institute for Preventive Medicine and Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar Anna (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36072177" target="_blank">Functional ultrasound imaging reveals microvascular rarefaction, decreased cerebral blood flow, and impaired neurovascular coupling in a mouse model of paclitaxel-induced chemobrain</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">47</span> <span class="journal-issue">3</span> <span class="page"> pp 4813-4825 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s11357-025-01624-7" target="_blank" href="https://doi.org/10.1007/s11357-025-01624-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001451473600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001451473600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105001008868" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105001008868"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40131589" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40131589&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="https://www.scopus.com/pages/publications/105001008868?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/105001008868?origin=resultslist"> Other URL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://link.springer.com/10.1007/s11357-025-01624-7" target="_blank" href="https://link.springer.com/10.1007/s11357-025-01624-7"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Aging&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 8</span> | Independent citation: 3 | Self citation: 5 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus:&nbsp;8 | WoS/Scopus assigned:&nbsp;8 | Number of citations with DOI:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36072177&sort=publishedYear,desc&sort=title"> Number of cited publications: 19 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36072177</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (TKP2021-NKTA-47), (RRF-2.3.1-21-2022-00003), (EKÖP-2024–2) Funder: New National Excellence Program </div> <div class="lastModified">Last Modified: 2026.04.20. 08:47 Tamás Fi (SE_AOK_Nepegeszsegtan_Admin5_FT, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States International Training...</pre> </div></div>