https://m2.mtmt.hu/ hun 2026-09-21 13:40 JournalArticle 36072177 VALIDATED true Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States International Training Program in Geroscience, Doctoral College, Health Sciences Division/Institute of Preventive Medicine and Public Health, Semmelweis University, Budapest, Hungary Institute of Preventive Medicine and Public Health, Semmelweis University, Budapest, Hungary Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States International Training Program in Geroscience, Doctoral College/Institute of Translational Medicine, Semmelweis University, Budapest, Hungary Export Date: 09 April 2025; Cited By: 0; Correspondence Address: A. Ungvari; Institute of Preventive Medicine and Public Health, Semmelweis University, Budapest, Hungary; email: Ungann2004@gmail.com 0 false 2026-07-31T10:40:00.945+0000 2026-04-20T06:47:30.955+0000 2025-04-03T07:05:33.623+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-07-31T10:37:30.210+0000 2025-06-25T11:42:49.085+0000 true 10074913 Sághi-Keszthelyi Anna /api/admin/10074913 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Chandragiri, Siva Sai Functional ultrasound imaging reveals microvascular rarefaction, decreased cerebral blood flow, and impaired neurovascular coupling in a mouse model of paclitaxel-induced chemobrain true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 47 3 4813 4825 4813 13 2025 Chemotherapy-induced cognitive impairment (CICI), often referred to as "chemobrain," significantly affects the quality of life in cancer survivors. Although traditionally attributed to neuronal toxicity, emerging evidence suggests a key role of cerebrovascular dysfunction in its pathogenesis. We hypothesized that paclitaxel (PTX, Taxol) treatment induces long-term cerebrovascular dysfunction, including microvascular rarefaction, impaired neurovascular coupling (NVC), and altered cerebral blood flow (CBF), which contribute to CICI. Using a clinically relevant PTX treatment regimen in non-tumor-bearing mice, we evaluated the long-term effects of PTX on cerebrovascular health. Ultrasound localization microscopy (ULM) and functional ultrasound imaging (fUS) were employed to assess microvascular density, CBF, and NVC. PTX treatment resulted in a significant reduction in microvascular density in the cerebral cortex and hippocampus, key regions involved in cognitive function. PTX significantly reduced blood velocity in the middle cerebral artery. Moreover, PTX impaired NVC responses, as evidenced by a diminished CBF increase in response to whisker stimulation, indicative of impaired reactive hyperemia. In conclusion, these findings demonstrate that PTX induces long-lasting cerebrovascular dysfunction, including microvascular rarefaction, impaired NVC, and altered CBF dynamics, which likely contribute to CICI. This study underscores the critical role of cerebrovascular health in cognitive function and highlights the potential of targeting cerebrovascular pathways as a therapeutic approach for mitigating chemotherapy-induced cognitive deficits. Funding 2051570 /api/funding/2051570 false true Funding 2051571 /api/funding/2051571 false true Funding 2051572 /api/funding/2051572 false true true 2025 true true true false true false NONE 2026-07-31 false 8 0 8 3 3 7 8 7 8 8 8 3 3 3 5 0 8 3 8 3 0 19 19 Folyóiratcikk Journal Article 24 7 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 1 1 1 1 2026 0 7 2 7 2 D1 false false false false 2025-06-24T11:42:48.394+0000 Doktori Iskola (SE); Megelőző Orvostani és Népegészségtani Intézet (SE / AOK / I); Transzlációs Medicina Intézet (SE / AOK / I) 10 43 3 15 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 126038502 /api/authorship/126038502 1 0.06666667 true false false Chandragiri Siva Sai true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038503 /api/authorship/126038503 2 0.067 true false false Author 10045003 /api/author/10045003 Nyúl-Tóth Ádám true 10045003 true Nyul-Toth Adam true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038504 /api/authorship/126038504 3 0.067 true false false Negri Sharon true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038505 /api/authorship/126038505 4 0.067 true false false Author 10052983 /api/author/10052983 Patai Roland true 10052983 true Patai Roland true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038506 /api/authorship/126038506 5 0.067 true false false Author 10092932 /api/author/10092932 Gulej Rafal true true Gulej Rafal true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038507 /api/authorship/126038507 6 0.067 false false false Author 10099172 /api/author/10099172 Csík Boglárka true true Csik Boglarka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038508 /api/authorship/126038508 7 0.06666667 false false false Shanmugarama Santny true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038509 /api/authorship/126038509 8 0.06666667 false false false Kordestan Kiana Vali true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038510 /api/authorship/126038510 9 0.06666667 false false false Nagykaldi Mark true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038511 /api/authorship/126038511 10 0.067 false false false Author 10032249 /api/author/10032249 Mukli Péter true 10032249 true Mukli Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038512 /api/authorship/126038512 11 0.067 false false true Author 10090858 /api/author/10090858 Ungvári Anna Sára true true Ungvari Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038513 /api/authorship/126038513 12 0.067 false false false Author 10095385 /api/author/10095385 Yabluchanskiy Andriy true true Yabluchanskiy Andriy true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038514 /api/authorship/126038514 13 0.067 false false false Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true Ungvari Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038515 /api/authorship/126038515 14 0.067 false false false Author 10074557 /api/author/10074557 Tarantini Stefano true true Tarantini Stefano true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 126038516 /api/authorship/126038516 15 0.067 false true false Author 10071157 /api/author/10071157 Csiszar Anna true true Csiszar Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29191781 /api/publicationidentifier/29191781 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1007/s11357-025-01624-7 https://doi.org/10.1007/s11357-025-01624-7 false true PublicationIdentifier 29191782 /api/publicationidentifier/29191782 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001451473600001 https://www.webofscience.com/wos/woscc/full-record/001451473600001 false true PublicationIdentifier 29191784 /api/publicationidentifier/29191784 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105001008868 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105001008868 false true PublicationIdentifier 29191783 /api/publicationidentifier/29191783 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 40131589 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40131589&dopt=Abstract false true PublicationIdentifier 31846659 /api/publicationidentifier/31846659 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true NONE IDENTICAL https://www.scopus.com/pages/publications/105001008868?origin=resultslist https://www.scopus.com/pages/publications/105001008868?origin=resultslist false true PublicationIdentifier 31857533 /api/publicationidentifier/31857533 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://link.springer.com/10.1007/s11357-025-01624-7 https://link.springer.com/10.1007/s11357-025-01624-7 false true Keyword 169 /api/keyword/169 true 169 true Keyword 1481 /api/keyword/1481 true 1481 true Keyword 14195 /api/keyword/14195 true 14195 true Keyword 14938 /api/keyword/14938 true 14938 true Keyword 1014859 /api/keyword/1014859 true 1014859 true Keyword 1038116 /api/keyword/1038116 true 1038116 true Keyword 1038254 /api/keyword/1038254 true 1038254 true Keyword 1039436 /api/keyword/1039436 true 1039436 true Keyword 1070178 /api/keyword/1070178 true 1070178 true Keyword 1493412 /api/keyword/1493412 true true Keyword 1493413 /api/keyword/1493413 true true Keyword 1576867 /api/keyword/1576867 true true Keyword 3853303 /api/keyword/3853303 true true SjrRating 11627782 /api/sjrrating/11627782 2 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3401 /api/classificationexternal/3401 true 3401 true D1 DIRECT true true /api/publication/36072177 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Chandragiri Siva Sai </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045003"><a href="/gui2/?type=authors&mode=browse&sel=10045003" target="_blank">Nyul-Toth Adam<sup>*</sup> (<span class="authorship-author-name">Nyúl-Tóth Ádám</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Negri Sharon<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052983"><a href="/gui2/?type=authors&mode=browse&sel=10052983" target="_blank">Patai Roland<sup>*</sup> (<span class="authorship-author-name">Patai Roland</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10092932"><a href="/gui2/?type=authors&mode=browse&sel=10092932" target="_blank">Gulej Rafal<sup>*</sup> (<span class="authorship-author-name">Gulej Rafal</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10099172"><a href="/gui2/?type=authors&mode=browse&sel=10099172" target="_blank">Csik Boglarka (<span class="authorship-author-name">Csík Boglárka</span> <span class="authorAux-mtmt"> Népegészségtan - öregedés, egészséges öregedés</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shanmugarama Santny </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kordestan Kiana Vali </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nagykaldi Mark </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032249"><a href="/gui2/?type=authors&mode=browse&sel=10032249" target="_blank">Mukli Peter (<span class="authorship-author-name">Mukli Péter</span> <span class="authorAux-mtmt"> Élettan, megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090858"><a href="/gui2/?type=authors&mode=browse&sel=10090858" target="_blank">Ungvari Anna ✉ (<span class="authorship-author-name">Ungvári Anna Sára</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10095385"><a href="/gui2/?type=authors&mode=browse&sel=10095385" target="_blank">Yabluchanskiy Andriy (<span class="authorship-author-name">Yabluchanskiy Andriy</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini Stefano (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar Anna (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36072177" target="_blank">Functional ultrasound imaging reveals microvascular rarefaction, decreased cerebral blood flow, and impaired neurovascular coupling in a mouse model of paclitaxel-induced chemobrain</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">47</span> <span class="journal-issue">3</span> <span class="page"> pp 4813-4825 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s11357-025-01624-7" target="_blank" href="https://doi.org/10.1007/s11357-025-01624-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001451473600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001451473600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105001008868" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105001008868"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="40131589" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40131589&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/pages/publications/105001008868?origin=resultslist" target="_blank" href="https://www.scopus.com/pages/publications/105001008868?origin=resultslist"> Egyéb URL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://link.springer.com/10.1007/s11357-025-01624-7" target="_blank" href="https://link.springer.com/10.1007/s11357-025-01624-7"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 8</span> | Független: 3 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 7 | Scopus jelölt:&nbsp;8 | WoS/Scopus jelölt:&nbsp;8 | DOI jelölt:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36072177&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 19 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36072177</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (TKP2021-NKTA-47), (RRF-2.3.1-21-2022-00003), (EKÖP-2024–2) Támogató: New National Excellence Program </div> <div class="lastModified">Utolsó módosítás: 2026.04.20. 08:47 Fi Tamás (SE_AOK_Nepegeszsegtan_Admin5_FT, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States International Training...</pre> </div></div>